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公开(公告)号：US08026082B2
公开(公告)日：2011-09-27
申请号：US11921903
申请日：2006-06-09
申请人： Janine Bryan , Michelle K. Brownlow , Loren D. Schultz , Maria C. Losada , Kathrin Ute Jansen , Myra Kurtz , Stuart Kurtz, legal representative
发明人： Janine Bryan , Michelle K. Brownlow , Loren D. Schultz , Maria C. Losada , Kathrin Ute Jansen , Myra Kurtz
IPC分类号： C12P21/02
CPC分类号： C12N15/81
摘要： The present invention provides a synthetic gene control region which comprises a gene regulatory sequence comprising a binding site for a gene regulatory protein of a yeast strain, and a promoter from filamentous fungal strain located downstream of the gene regulatory sequence; wherein the promoter can be recognized by the general transcription factors and RNA polymerase of the yeast strain; wherein the gene regulatory sequence is capable of regulating transcription initiated by the filamentous fungal promoter in the yeast strain.
摘要翻译： 本发明提供合成基因控制区，其包含基因调控序列，其包含酵母菌株的基因调节蛋白的结合位点和位于基因调控序列下游的丝状真菌菌株的启动子; 其中所述启动子可被酵母菌株的一般转录因子和RNA聚合酶识别; 其中所述基因调控序列能够调节由所述酵母菌株中丝状真菌启动子引发的转录。
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公开(公告)号：US20100041097A1
公开(公告)日：2010-02-18
申请号：US11921903
申请日：2006-06-09
申请人： Janine Bryan , Michelle K. Brownlow , Loren D. Schultz , Maria C. Losada , Kathrin Ute Jansen , Myra Kurtz , Stuart Kurtz
发明人： Janine Bryan , Michelle K. Brownlow , Loren D. Schultz , Maria C. Losada , Kathrin Ute Jansen , Myra Kurtz , Stuart Kurtz
CPC分类号： C12N15/81
摘要： The present invention provides a synthetic gene control region which comprises a gene regulatory sequence comprising a binding site for a gene regulatory protein of a yeast strain, and a promoter from filamentous fungal strain located downstream of the gene regulatory sequence; wherein the promoter can be recognized by the general transcription factors and RNA polymerase of the yeast strain; wherein the gene regulatory sequence is capable of regulating transcription initiated by the filamentous fungal promoter in the yeast strain.
摘要翻译： 本发明提供合成基因控制区，其包含基因调控序列，其包含酵母菌株的基因调节蛋白的结合位点和位于基因调控序列下游的丝状真菌菌株的启动子; 其中所述启动子可被酵母菌株的一般转录因子和RNA聚合酶识别; 其中所述基因调控序列能够调节由所述酵母菌株中丝状真菌启动子引发的转录。
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公开(公告)号：US20080226660A1
公开(公告)日：2008-09-18
申请号：US10594064
申请日：2005-03-18
CPC分类号： C07K14/005 , A61K2039/5258 , C12N7/00 , C12N2710/20022 , C12N2710/20023
摘要： Synthetic DNA molecules encoding the HPV 52 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV 52 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. In alternative embodiments of the invention, the nucleotide sequence of the synthetic molecule is altered to eliminate transcription termination signals that are recognized by yeast. The synthetic molecules may be used to produce HPV 52 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV 52 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity and may also be useful for treatment of existing HPV infections.
摘要翻译： 提供了编码HPV 52 L1蛋白的合成DNA分子。 具体地，本发明提供编码HPV 52 L1蛋白的多核苷酸，其中所述多核苷酸在酵母细胞中用于高水平表达的密码子优化。 在本发明的替代实施方案中，改变合成分子的核苷酸序列以消除由酵母识别的转录终止信号。 合成分子可用于产生HPV 52病毒样颗粒（VLP），并且生产包含HPV 52 VLP的疫苗和药物组合物。 本发明的疫苗通过中和抗体和细胞介导的免疫提供对乳头瘤病毒感染的有效免疫预防，并且还可用于治疗现有的HPV感染。
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公开(公告)号：US07700103B2
公开(公告)日：2010-04-20
申请号：US10594064
申请日：2005-03-18
CPC分类号： C07K14/005 , A61K2039/5258 , C12N7/00 , C12N2710/20022 , C12N2710/20023
摘要： Synthetic DNA molecules encoding the HPV 52 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV 52 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. In alternative embodiments of the invention, the nucleotide sequence of the synthetic molecule is altered to eliminate transcription termination signals that are recognized by yeast. The synthetic molecules may be used to produce HPV 52 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV 52 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity and may also be useful for treatment of existing HPV infections.
摘要翻译： 提供了编码HPV 52 L1蛋白的合成DNA分子。 具体地，本发明提供编码HPV 52 L1蛋白的多核苷酸，其中所述多核苷酸在酵母细胞中用于高水平表达的密码子优化。 在本发明的替代实施方案中，改变合成分子的核苷酸序列以消除由酵母识别的转录终止信号。 合成分子可用于产生HPV 52病毒样颗粒（VLP），并且生产包含HPV 52 VLP的疫苗和药物组合物。 本发明的疫苗通过中和抗体和细胞介导的免疫提供对乳头瘤病毒感染的有效免疫预防，并且还可用于治疗现有的HPV感染。
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公开(公告)号：US20080138361A1
公开(公告)日：2008-06-12
申请号：US11805453
申请日：2007-05-23
IPC分类号： A61K39/12 , A61P31/20 , C07K14/025 , C12P21/00
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/5258 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
摘要： Synthetic DNA molecules encoding the HPV45 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV45 L1 protein, wherein said polynucleotides have been codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV45 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV45 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity.
摘要翻译： 提供了编码HPV45 L1蛋白的合成DNA分子。 具体地，本发明提供了编码HPV45 L1蛋白的多核苷酸，其中所述多核苷酸已被密码子优化用于酵母细胞中的高水平表达。 合成分子可用于产生HPV45病毒样颗粒（VLP），以及产生包含HPV45 VLP的疫苗和药物组合物。 本发明的疫苗通过中和抗体和细胞介导的免疫来提供对乳头瘤病毒感染的有效免疫预防。
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公开(公告)号：US07976848B2
公开(公告)日：2011-07-12
申请号：US12321797
申请日：2009-01-26
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K48/00 , A61K2039/5256 , A61K2039/5258 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2800/22
摘要： Synthetic DNA molecules encoding the HPV58 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV58 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV58 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV58 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity and are also useful for treatment of existing HPV infections.
摘要翻译： 提供编码HPV58 L1蛋白的合成DNA分子。 具体地，本发明提供了编码HPV58L1蛋白的多核苷酸，其中所述多核苷酸在酵母细胞中用于高水平表达的密码子优化。 合成分子可用于产生HPV58病毒样颗粒（VLP），以及产生包含HPV58 VLP的疫苗和药物组合物。 本发明的疫苗通过中和抗体和细胞介导的免疫提供对乳头瘤病毒感染的有效免疫预防性，并且也可用于治疗现有的HPV感染。
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公开(公告)号：US07744892B2
公开(公告)日：2010-06-29
申请号：US12578995
申请日：2009-10-14
CPC分类号： C07K14/005 , A61K2039/5258 , C12N7/00 , C12N2710/20022 , C12N2710/20023
摘要： Synthetic DNA molecules encoding the HPV 52 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV 52 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. In alternative embodiments of the invention, the nucleotide sequence of the synthetic molecule is altered to eliminate transcription termination signals that are recognized by yeast. The synthetic molecules may be used to produce HPV 52 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV 52 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity and may also be useful for treatment of existing HPV infections.
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公开(公告)号：US07482015B2
公开(公告)日：2009-01-27
申请号：US11805453
申请日：2007-05-23
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/5258 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
摘要： Synthetic DNA molecules encoding the HPV45 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV45 L1 protein, wherein said polynucleotides have been codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV45 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV45 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity.
摘要翻译： 提供了编码HPV45 L1蛋白的合成DNA分子。 具体地，本发明提供了编码HPV45 L1蛋白的多核苷酸，其中所述多核苷酸已被密码子优化用于酵母细胞中的高水平表达。 合成分子可用于产生HPV45病毒样颗粒（VLP），以及产生包含HPV45 VLP的疫苗和药物组合物。 本发明的疫苗通过中和抗体和细胞介导的免疫来提供对乳头瘤病毒感染的有效免疫预防。
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公开(公告)号：US20100272749A1
公开(公告)日：2010-10-28
申请号：US12321797
申请日：2009-01-26
CPC分类号： C07K14/005 , A61K48/00 , A61K2039/5256 , A61K2039/5258 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2800/22
摘要： Synthetic DNA molecules encoding the HPV58 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV58 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV58 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV58 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity and are also useful for treatment of existing HPV infections.
摘要翻译： 提供编码HPV58 L1蛋白的合成DNA分子。 具体地，本发明提供了编码HPV58L1蛋白的多核苷酸，其中所述多核苷酸在酵母细胞中用于高水平表达的密码子优化。 合成分子可用于产生HPV58病毒样颗粒（VLP），以及产生包含HPV58 VLP的疫苗和药物组合物。 本发明的疫苗通过中和抗体和细胞介导的免疫提供对乳头瘤病毒感染的有效免疫预防性，并且也可用于治疗现有的HPV感染。
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公开(公告)号：US20100035818A1
公开(公告)日：2010-02-11
申请号：US12578995
申请日：2009-10-14
IPC分类号： A61K38/16 , C07K14/005 , C12P21/00 , A61P37/00
CPC分类号： C07K14/005 , A61K2039/5258 , C12N7/00 , C12N2710/20022 , C12N2710/20023
摘要： Synthetic DNA molecules encoding the HPV 52 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV 52 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. In alternative embodiments of the invention, the nucleotide sequence of the synthetic molecule is altered to eliminate transcription termination signals that are recognized by yeast. The synthetic molecules may be used to produce HPV 52 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV 52 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity and may also be useful for treatment of existing HPV infections.
摘要翻译： 提供了编码HPV 52 L1蛋白的合成DNA分子。 具体地，本发明提供编码HPV 52 L1蛋白的多核苷酸，其中所述多核苷酸在酵母细胞中用于高水平表达的密码子优化。 在本发明的替代实施方案中，改变合成分子的核苷酸序列以消除由酵母识别的转录终止信号。 合成分子可用于产生HPV 52病毒样颗粒（VLP），并且生产包含HPV 52 VLP的疫苗和药物组合物。 本发明的疫苗通过中和抗体和细胞介导的免疫提供对乳头瘤病毒感染的有效免疫预防，并且还可用于治疗现有的HPV感染。
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