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公开(公告)号：US20120177684A1
公开(公告)日：2012-07-12
申请号：US13423847
申请日：2012-03-19
申请人： Janine T. Bryan , Michelle K. Brownlow , Li Shi , Danilo Casimiro , William L. McClements , Brian K. Meyer , Binghua Hu
发明人： Janine T. Bryan , Michelle K. Brownlow , Li Shi , Danilo Casimiro , William L. McClements , Brian K. Meyer , Binghua Hu
CPC分类号： A61K39/12 , A61K2039/5258 , A61K2039/55505 , A61K2039/55577 , A61K2039/70 , C12N7/00 , C12N2710/20023 , C12N2710/20034
摘要： The present invention relates to pharmaceutical compositions comprising virus-like particles (VLPs) of HPV, said VLPs adsorbed to an aluminum adjuvant, and an ISCOM-type adjuvant comprising a saponin, cholesterol, and a phospholipid. In preferred embodiments, the aluminum adjuvant comprises amorphous aluminum hydroxyphosphate sulfate. Another aspect of the invention provides multi-dose HPV vaccine formulations comprising HPV VLPs and an antimicrobial preservative selected from the group consisting of: m-cresol, phenol and benzyl alcohol. Also provided are methods of using the disclosed pharmaceutical compositions and formulations to induce an immune response against HPV in a human patient and to prevent HPV infection.
摘要翻译： 本发明涉及包含HPV病毒样颗粒（VLP），所述VLP吸附于铝佐剂的ISMA型佐剂和包含皂角苷，胆固醇和磷脂的ISCOM型佐剂的药物组合物。 在优选的实施方案中，铝佐剂包括无定形的羟基磷酸氢铝硫酸盐。 本发明的另一方面提供了包含HPV VLP和选自间甲酚，苯酚和苄醇的抗微生物防腐剂的多剂量HPV疫苗制剂。 还提供了使用所公开的药物组合物和制剂在人类患者中诱导针对HPV的免疫应答并防止HPV感染的方法。
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公开(公告)号：US07709010B2
公开(公告)日：2010-05-04
申请号：US12074783
申请日：2008-03-06
申请人： Janine T. Bryan , Michelle K. Brownlow , Li Shi , Danilo Casimiro , William L. McClements , Brian K. Meyer , Binghua Hu
发明人： Janine T. Bryan , Michelle K. Brownlow , Li Shi , Danilo Casimiro , William L. McClements , Brian K. Meyer , Binghua Hu
IPC分类号： A61K45/00
CPC分类号： A61K39/12 , A61K2039/5258 , A61K2039/55505 , A61K2039/55577 , A61K2039/70 , C12N7/00 , C12N2710/20023 , C12N2710/20034
摘要： The present invention relates to pharmaceutical compositions comprising virus-like particles (VLPs) of HPV, said VLPs adsorbed to an aluminum adjuvant, and an ISCOM-type adjuvant comprising a saponin, cholesterol, and a phospholipid. In preferred embodiments, the aluminum adjuvant comprises amorphous aluminum hydroxyphosphate sulfate. Another aspect of the invention provides multi-dose HPV vaccine formulations comprising HPV VLPs and an antimicrobial preservative selected from the group consisting of: m-cresol, phenol and benzyl alcohol. Also provided are methods of using the disclosed pharmaceutical compositions and formulations to induce an immune response against HPV in a human patient and to prevent HPV infection.
摘要翻译： 本发明涉及包含HPV病毒样颗粒（VLP），所述VLP吸附于铝佐剂的ISMA型佐剂和包含皂角苷，胆固醇和磷脂的ISCOM型佐剂的药物组合物。 在优选的实施方案中，铝佐剂包括无定形的羟基磷酸氢铝硫酸盐。 本发明的另一方面提供了包含HPV VLP和选自间甲酚，苯酚和苄醇的抗微生物防腐剂的多剂量HPV疫苗制剂。 还提供了使用所公开的药物组合物和制剂在人类患者中诱导针对HPV的免疫应答并防止HPV感染的方法。
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公开(公告)号：US20080248062A1
公开(公告)日：2008-10-09
申请号：US12074783
申请日：2008-03-06
申请人： Janine T. Bryan , Michelle K. Brownlow , Li Shi , Danilo Casimiro , William L. McClements , Brian K. Meyer , Binghua Hu
发明人： Janine T. Bryan , Michelle K. Brownlow , Li Shi , Danilo Casimiro , William L. McClements , Brian K. Meyer , Binghua Hu
CPC分类号： A61K39/12 , A61K2039/5258 , A61K2039/55505 , A61K2039/55577 , A61K2039/70 , C12N7/00 , C12N2710/20023 , C12N2710/20034
摘要： The present invention relates to pharmaceutical compositions comprising virus-like particles (VLPs) of HPV, said VLPs adsorbed to an aluminum adjuvant, and an ISCOM-type adjuvant comprising a saponin, cholesterol, and a phospholipid. In preferred embodiments, the aluminum adjuvant comprises amorphous aluminum hydroxyphosphate sulfate. Another aspect of the invention provides multi-dose HPV vaccine formulations comprising HPV VLPs and an antimicrobial preservative selected from the group consisting of: m-cresol, phenol and benzyl alcohol. Also provided are methods of using the disclosed pharmaceutical compositions and formulations to induce an immune response against HPV in a human patient and to prevent HPV infection.
摘要翻译： 本发明涉及包含HPV病毒样颗粒（VLP），所述VLP吸附于铝佐剂的ISMA型佐剂和包含皂角苷，胆固醇和磷脂的ISCOM型佐剂的药物组合物。 在优选的实施方案中，铝佐剂包括无定形的羟基磷酸氢铝硫酸盐。 本发明的另一方面提供了包含HPV VLP和选自间甲酚，苯酚和苄醇的抗微生物防腐剂的多剂量HPV疫苗制剂。 还提供了使用所公开的药物组合物和制剂在人类患者中诱导针对HPV的免疫应答并防止HPV感染的方法。
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公开(公告)号：US20100189744A1
公开(公告)日：2010-07-29
申请号：US12732318
申请日：2010-03-26
CPC分类号： A61K39/12 , A61K2039/5258 , A61K2039/55505 , A61K2039/55577 , A61K2039/70 , C12N7/00 , C12N2710/20023 , C12N2710/20034
摘要： The present invention relates to pharmaceutical compositions comprising virus-like particles (VLPs) of HPV, said VLPs adsorbed to an aluminum adjuvant, and an ISCOM-type adjuvant comprising a saponin, cholesterol, and a phospholipid. In preferred embodiments, the aluminum adjuvant comprises amorphous aluminum hydroxyphosphate sulfate. Another aspect of the invention provides multi-dose HPV vaccine formulations comprising HPV VLPs and an antimicrobial preservative selected from the group consisting of: m-cresol, phenol and benzyl alcohol. Also provided are methods of using the disclosed pharmaceutical compositions and formulations to induce an immune response against HPV in a human patient and to prevent HPV infection.
摘要翻译： 本发明涉及包含HPV病毒样颗粒（VLP），所述VLP吸附于铝佐剂的ISMA型佐剂和包含皂角苷，胆固醇和磷脂的ISCOM型佐剂的药物组合物。 在优选的实施方案中，铝佐剂包括无定形的羟基磷酸氢铝硫酸盐。 本发明的另一方面提供了包含HPV VLP和选自间甲酚，苯酚和苄醇的抗微生物防腐剂的多剂量HPV疫苗制剂。 还提供了使用所公开的药物组合物和制剂在人类患者中诱导针对HPV的免疫应答并防止HPV感染的方法。
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公开(公告)号：US06689366B1
公开(公告)日：2004-02-10
申请号：US09857337
申请日：2001-06-04
申请人： Kathrin U. Jansen , Jessica C. Ling , Steven W. Ludmerer , William L. McClements , Xin-Min Wang
发明人： Kathrin U. Jansen , Jessica C. Ling , Steven W. Ludmerer , William L. McClements , Xin-Min Wang
IPC分类号： C12N1537
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C12N2710/20022 , C12N2710/20023
摘要： The invention is a series of synthetic virus-like particles comprising a heterologous conformational epitope useful in the characterization of human papillomavirus infection, and useful to vaccinate individual for protection against HPV 6 and HPV 11 infections, and assays employing the synthetic virus-like particles.
摘要翻译： 本发明是一系列合成病毒样颗粒，其包含可用于表征人乳头瘤病毒感染的异源构象表位，并且可用于预防个体以防HPV 6和HPV 11感染以及使用合成病毒样颗粒的测定。
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公开(公告)号：US07033797B2
公开(公告)日：2006-04-25
申请号：US10737528
申请日：2003-12-16
申请人： Kathrin U. Jansen , Jessica C. Ling , Steven W. Ludmerer , William L. McClements , Xin-Min Wang
发明人： Kathrin U. Jansen , Jessica C. Ling , Steven W. Ludmerer , William L. McClements , Xin-Min Wang
IPC分类号： C12N21/06
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C12N2710/20022 , C12N2710/20023
摘要： The invention is a series of synthetic virus-like particles comprising a heterologous conformational epitope useful in the characterization of human papillomavirus infection, and useful to vaccinate individual for protection against HPV 6 and HPV 11 infections, and assays employing the synthetic virus-like particles.
摘要翻译： 本发明是一系列合成病毒样颗粒，其包含可用于表征人乳头瘤病毒感染的异源构象表位，并且可用于预防个体以防HPV 6和HPV 11感染以及使用合成病毒样颗粒的测定。
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公开(公告)号：US4405712A
公开(公告)日：1983-09-20
申请号：US279443
申请日：1981-07-01
CPC分类号： C12N15/86 , C12N2740/13043
摘要： The production of vectors composed of portions of retrovirus, particularly of Moloney sarcoma virus DNA including the "LTR" sequence which can activate genes and additional viral sequences which can "rescue" these genes into a replicating virus particle.
摘要翻译： 由逆转录病毒部分，特别是包括可激活基因的“LTR”序列的莫洛尼肉瘤病毒DNA部分组成的载体的产生，以及可以将这些基因“拯救”到复制型病毒颗粒中的另外的病毒序列。
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8.发明授权Polypeptides for inducing a protective immune response against Staphylococcus epidermidis 失效用于诱导对表皮葡萄球菌的保护性免疫应答的多肽公开(公告)号：US08124108B2
公开(公告)日：2012-02-28
申请号：US12524075
申请日：2008-01-18
申请人： Annaliesa S. Anderson , Tessie McNeely , James C. Cook, III , William L. McClements , Donna L. Montgomery
发明人： Annaliesa S. Anderson , Tessie McNeely , James C. Cook, III , William L. McClements , Donna L. Montgomery
IPC分类号： A61K39/085 , A61K39/02 , C07K14/31
CPC分类号： A61K39/085 , A61K2039/55505
摘要： The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides. SEQ ID NO: 1 is a truncated derivative of a full-length S. epidermidis polypeptide. The full-length naturally occurring polypeptide is referred to herein as full-length ORF1319e. A His-tagged derivative of SEQ ID NO: 1 was found to produce a protective immune response against S. epidermidis.
摘要翻译： 本发明的特征在于包含与SEQ ID NO：1结构相关的氨基酸序列的多肽和这种多肽的用途。 SEQ ID NO：1是全长表皮葡萄球菌多肽的截短的衍生物。 全长天然存在的多肽在本文中称为全长ORF1319e。 发现SEQ ID NO：1的His标签衍生物对表皮葡萄球菌产生保护性免疫应答。
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9.发明申请POLYPEPTIDES FOR INDUCING A PROTECTIVE IMMUNE RESPONSE AGAINST STAPHYLOCOCCUS EPIDERMIDIS 审中-公开用于诱导针对斑马鱼肺炎的保护性免疫应答的多肽公开(公告)号：US20100104591A1
公开(公告)日：2010-04-29
申请号：US12531107
申请日：2008-03-14
申请人： Annaliesa S. Anderson , Tessie McNeely , James C. Cook III , William L. McClements , Donna L. Montgomery
发明人： Annaliesa S. Anderson , Tessie McNeely , James C. Cook III , William L. McClements , Donna L. Montgomery
CPC分类号： A61K39/085
摘要： The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides. SEQ ID NO: 1 is a truncated derivative of a full-length S. epidermidis polypeptide. The full-length naturally occurring polypeptide is referred to herein as full-length ORF2695e. A His-tagged derivative of SEQ ID NO: 1 was found to produce a protective immune response against S. epidermidis.
摘要翻译： 本发明的特征在于包含与SEQ ID NO：1结构相关的氨基酸序列的多肽和这种多肽的用途。 SEQ ID NO：1是全长表皮葡萄球菌多肽的截短的衍生物。 全长天然存在的多肽在本文中称为全长ORF2695e。 发现SEQ ID NO：1的His标签衍生物对表皮葡萄球菌产生保护性免疫应答。
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公开(公告)号：US07001995B1
公开(公告)日：2006-02-21
申请号：US09642405
申请日：2000-08-21
申请人： Michael P Neeper , William L. McClements , Kathrin U. Jansen , Loren D. Schultz , Ling Chen , Xin-Min Wang
发明人： Michael P Neeper , William L. McClements , Kathrin U. Jansen , Loren D. Schultz , Ling Chen , Xin-Min Wang
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/10343 , C12N2710/20022
摘要： Synthetic DNA molecules encoding papillomavirus proteins are provided. The codons of the synthetic molecules are codons preferred by the projected host cell. The synthetic molecules may be used as a polynucleotide vaccine which provides effective immunoprophylaxis against papillomavirus infection through stimulation of neutralizing antibody and cell-mediated immunity.
摘要翻译： 提供编码乳头瘤病毒蛋白的合成DNA分子。 合成分子的密码子是被投影的宿主细胞优选的密码子。 合成分子可以用作多核苷酸疫苗，其通过刺激中和抗体和细胞介导的免疫来提供对乳头瘤病毒感染的有效免疫预防。
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