公开(公告)号：US20190381081A1

公开(公告)日：2019-12-19

申请号：US16449164

申请日：2019-06-21

Applicant: Janssen BioPharma, Inc.

Inventor： Guangyi WANG ,  David Bernard SMITH ,  Leonid BEIGELMAN ,  Jerome DEVAL ,  Marija PRHAVC

IPC: A61K31/708 ,  C07H19/20 ,  C07H19/06 ,  C07H19/16 ,  C07H19/10 ,  C07H19/12 ,  C07H19/207 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/706

Abstract: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.

公开(公告)号：US20210186969A1

公开(公告)日：2021-06-24

申请号：US17185750

申请日：2021-02-25

Applicant: Janssen BioPharma, Inc.

Inventor： Robert Than HENDRICKS ,  Leonid BEIGELMAN ,  David Bernard SMITH ,  Antitsa Dimitrova STOYCHEVA

IPC: A61K31/5025 ,  C07D487/04 ,  A61K31/13 ,  A61K31/196 ,  A61K31/215 ,  A61K31/351 ,  A61K31/4965 ,  A61K31/5377 ,  A61K31/7056 ,  A61K38/21 ,  C07B59/00

Abstract: Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection, with an aza-pyridone compounds. Examples of an orthomyxovirus viral infection include an influenza infection.

公开(公告)号：US20210179656A1

公开(公告)日：2021-06-17

申请号：US17178151

申请日：2021-02-17

Applicant: Janssen BioPharma, Inc.

Inventor： Leonid BEIGELMAN ,  Guangyi WANG ,  David Bernard SMITH ,  Jerome DEVAL ,  Marija PRHAVC

IPC: C07H19/06 ,  C07H19/207 ,  C07H19/16 ,  A61P31/16 ,  A61K45/06 ,  C07D405/04 ,  C07D405/14 ,  C07D473/18 ,  C07D473/34 ,  C07D487/04 ,  C07D493/04 ,  C07H19/00 ,  C07H19/14 ,  C12N9/12 ,  C07H19/10 ,  C07H19/12 ,  C07H19/20

Abstract: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.

公开(公告)号：US20200024297A1

公开(公告)日：2020-01-23

申请号：US16528414

申请日：2019-07-31

Applicant: Janssen BioPharma, Inc.

Inventor： Leonid BEIGELMAN ,  Guangyi WANG ,  David Bernard SMITH ,  Jerome DEVAL ,  Marija PRHAVC

IPC: C07H19/06 ,  C07H19/20 ,  C07H19/12 ,  C07H19/10 ,  C07H19/16 ,  C07H19/207 ,  C12N9/12 ,  C07H19/14 ,  C07H19/00 ,  C07D493/04 ,  C07D487/04 ,  C07D473/34 ,  C07D473/18 ,  C07D405/14 ,  C07D405/04 ,  A61K45/06 ,  A61P31/16

Abstract: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.

公开(公告)号：US20210139523A1

公开(公告)日：2021-05-13

申请号：US17063545

申请日：2020-10-05

Applicant: Janssen BioPharma, Inc.

Inventor： Leonid BEIGELMAN ,  Guangyi WANG ,  David Bernard SMITH

IPC: C07H19/10 ,  C07H19/06 ,  C07H19/20 ,  C07H19/173 ,  C07H19/213 ,  A61P31/14 ,  C07H19/16 ,  C07H19/207

Abstract: Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.