公开(公告)号：US20190381081A1

公开(公告)日：2019-12-19

申请号：US16449164

申请日：2019-06-21

Applicant: Janssen BioPharma, Inc.

Inventor： Guangyi WANG ,  David Bernard SMITH ,  Leonid BEIGELMAN ,  Jerome DEVAL ,  Marija PRHAVC

IPC: A61K31/708 ,  C07H19/20 ,  C07H19/06 ,  C07H19/16 ,  C07H19/10 ,  C07H19/12 ,  C07H19/207 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/706

Abstract: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.

公开(公告)号：US20190169221A1

公开(公告)日：2019-06-06

申请号：US16324862

申请日：2017-08-10

Applicant: Janssen BioPharma, Inc.

Inventor： Guangyi WANG ,  Leonid BEIGELMAN ,  Jerome DEVAL ,  Christian Andreas JEKLE

IPC: C07H19/16 ,  C07H19/14 ,  C07H19/052 ,  C07H19/20 ,  C07H19/12 ,  A61P31/14

Abstract: Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Picornaviridae and/or Flaviviridae viral infections with one or more nucleotide analogs.

公开(公告)号：US20210179656A1

公开(公告)日：2021-06-17

申请号：US17178151

申请日：2021-02-17

Applicant: Janssen BioPharma, Inc.

Inventor： Leonid BEIGELMAN ,  Guangyi WANG ,  David Bernard SMITH ,  Jerome DEVAL ,  Marija PRHAVC

IPC: C07H19/06 ,  C07H19/207 ,  C07H19/16 ,  A61P31/16 ,  A61K45/06 ,  C07D405/04 ,  C07D405/14 ,  C07D473/18 ,  C07D473/34 ,  C07D487/04 ,  C07D493/04 ,  C07H19/00 ,  C07H19/14 ,  C12N9/12 ,  C07H19/10 ,  C07H19/12 ,  C07H19/20

Abstract: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.

公开(公告)号：US20200277321A1

公开(公告)日：2020-09-03

申请号：US16648405

申请日：2018-09-18

Applicant: JANSSEN BIOPHARMA, INC.

Inventor： Leonid BEIGELMAN ,  Jerome DEVAL ,  Marija PRHAVC

IPC: C07H7/06 ,  A61P31/14 ,  C07H9/04 ,  A61P31/16

Abstract: Disclosed herein are compounds of the Formula (I) and pharmaceutically acceptable salts thereof: (I) where the variables in Formula (I) are described herein. Methods of synthesizing such compounds and methods of using them to treat diseases and/or conditions such as a Picornaviridae, Flaviviridae, Filoviridae, Pneumoviridae and/or Coronaviridae viral infections are also disclosed.

公开(公告)号：US20200024297A1

公开(公告)日：2020-01-23

申请号：US16528414

申请日：2019-07-31

Applicant: Janssen BioPharma, Inc.

Inventor： Leonid BEIGELMAN ,  Guangyi WANG ,  David Bernard SMITH ,  Jerome DEVAL ,  Marija PRHAVC

IPC: C07H19/06 ,  C07H19/20 ,  C07H19/12 ,  C07H19/10 ,  C07H19/16 ,  C07H19/207 ,  C12N9/12 ,  C07H19/14 ,  C07H19/00 ,  C07D493/04 ,  C07D487/04 ,  C07D473/34 ,  C07D473/18 ,  C07D405/14 ,  C07D405/04 ,  A61K45/06 ,  A61P31/16

Abstract: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.