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1.发明公开公开(公告)号：US20240316172A1
公开(公告)日：2024-09-26
申请号：US18425500
申请日：2024-01-29
发明人： Jeroen GEURTSEN , Jan Theunis POOLMAN , Kellen Cristhina FAE , Pieter Jan BURGHOUT , Eveline Marleen WEERDENBURG , Patricia IBARRA YON , Darren Robert ABBANAT , Stefan Jochen KEMMLER , Michael Thomas KOWARIK , Manuela MALLY , Veronica GAMBILLARA FONCK , Martin Edward BRAUN , Maria Paula CARRANZA SANDMEIER
CPC分类号： A61K39/0258 , A61P31/04 , A61P37/04 , C07K14/21 , C07K19/00 , C12N9/1051 , C12Y204/01 , A61K2039/575 , A61K2039/6037
摘要： A bioconjugate of an E. coli glucosylated O4 antigen polysaccharide covalently linked to a carrier protein and compositions thereof are provided. Also provided are recombinant host cells for producing the bioconjugate, and methods of producing the bioconjugate using the recombinant host cells. The recombinant host cells contain a nucleic acid encoding a glucosyl transferase capable of modifying the E. coli O4 antigen with glucose branching to produce the glucosylated O4 antigen polysaccharide. Bioconjugates of an E. coli glucosylated O4 antigen polysaccharide described herein can be used alone or in combination with one or more additional E. coli O-antigen polysaccharides to induce antibodies against an E. coli glucosylated antigen, and to vaccinate a subject against extra-intestinal pathogenic E. coli (ExPEC).
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2.发明申请公开(公告)号：US20210046171A1
公开(公告)日：2021-02-18
申请号：US16781526
申请日：2020-02-04
发明人： Jan Theunis POOLMAN , Bert JACQUEMYN , Darren Robert ABBANAT , Patricia Ibarra YON , Peter Wilhelmus Maria HERMANS , Michael Thomas KOWARIK , Michael Lukas WETTER , Stefan Jochen KEMMLER , Micha Andres HÄUPTLE , Veronica Gambillara FONCK , Manuela MALLY
IPC分类号： A61K39/108 , A61K47/64 , C08B37/00 , A61P31/04 , A61K39/385
摘要： Compositions and methods are described for inducing an immune response against extra-intestinal pathogenic Escherichia coli (ExPEC) to thereby provide immune protection against diseases associated with ExPEC. In particular, compositions and methods are described for using conjugates of E. coli polysaccharide antigens O25B, O1A, O2, and O6A covalently bound to a detoxified exotoxin A of Pseudomonas aeruginosa (EPA) carrier protein as vaccines for the prevention of invasive ExPEC disease caused by ExPEC serotypes O1A, O2, O6A and O25B.
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3.发明申请公开(公告)号：US20230062987A1
公开(公告)日：2023-03-02
申请号：US17934781
申请日：2022-09-23
发明人： Jan Theunis POOLMAN , Bert JACQUEMYN , Darren Robert ABBANAT , Patricia Ibarra YON , Peter Wilhelmus Maria HERMANS , Michael Thomas KOWARIK , Michael Lukas WETTER , Stefan Jochen KEMMLER , Micha Andres HÄUPTLE , Veronica Gambillara FONCK , Manuela MALLY
IPC分类号： A61K39/108 , A61K47/64 , C08B37/00 , A61P31/04 , A61K39/385
摘要： Compositions and methods are described for inducing an immune response against extra-intestinal pathogenic Escherichia coli (ExPEC) to thereby provide immune protection against diseases associated with ExPEC. In particular, compositions and methods are described for using conjugates of E. coli polysaccharide antigens O25B, O1A, O2, and O6A covalently bound to a detoxified exotoxin A of Pseudomonas aeruginosa (EPA) carrier protein as vaccines for the prevention of invasive ExPEC disease caused by ExPEC serotypes O1A, O2, O6A and O25B.
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4.发明申请公开(公告)号：US20200316184A1
公开(公告)日：2020-10-08
申请号：US16822340
申请日：2020-03-18
发明人： Jeroen GEURTSEN , Jan Theunis POOLMAN , Kellen Cristhina FAE , Pieter Jan BURGHOUT , Eveline Marleen WEERDENBURG , Patricia IBARRA YON , Darren Robert ABBANAT , Stefan Jochen KEMMLER , Michael Thomas KOWARIK , Manuela MALLY , Veronica GAMBILLARA FONCK , Martin Edward BRAUN , Maria Paula CARRANZA SANDMEIER
摘要： A bioconjugate of an E. coli glucosylated O4 antigen polysaccharide covalently linked to a carrier protein and compositions thereof are provided. Also provided are recombinant host cells for producing the bioconjugate, and methods of producing the bioconjugate using the recombinant host cells. The recombinant host cells contain a nucleic acid encoding a glucosyl transferase capable of modifying the E. coli O4 antigen with glucose branching to produce the glucosylated O4 antigen polysaccharide. Bioconjugates of an E. coli glucosylated O4 antigen polysaccharide described herein can be used alone or in combination with one or more additional E. coli O-antigen polysaccharides to induce antibodies against an E. coli glucosylated antigen, and to vaccinate a subject against extra-intestinal pathogenic E. coli (ExPEC).
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公开(公告)号：US20230118878A1
公开(公告)日：2023-04-20
申请号：US17815705
申请日：2022-07-28
发明人： Jeroen GEURTSEN , Jan Theunis POOLMAN , Kellen Cristhina FAE , Pieter Jan BURGHOUT , Eveline Marleen WEERDENBURG , Patricia IBARRA YON , Darren Robert ABBANAT , Stefan Jochen KEMMLER , Michael Thomas KOWARIK , Manuela MALLY , Veronica GAMBILLARA FONCK , Martin Edward BRAUN , Maria Paula CARRANZA SANDMEIER
摘要： A bioconjugate of an E. coli glucosylated O4 antigen polysaccharide covalently linked to a carrier protein and compositions thereof are provided. Also provided are recombinant host cells for producing the bioconjugate, and methods of producing the bioconjugate using the recombinant host cells. The recombinant host cells contain a nucleic acid encoding a glucosyl transferase capable of modifying the E. coli O4 antigen with glucose branching to produce the glucosylated O4 antigen polysaccharide. Bioconjugates of an E. coli glucosylated O4 antigen polysaccharide described herein can be used alone or in combination with one or more additional E. coli O-antigen polysaccharides to induce antibodies against an E. coli glucosylated antigen, and to vaccinate a subject against extra-intestinal pathogenic E. coli (ExPEC).
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6.发明申请公开(公告)号：US20180243393A1
公开(公告)日：2018-08-30
申请号：US15754867
申请日：2016-08-24
发明人： Jan Theunis POOLMAN , Bert JACQUEMYN , Darren Robert ABBANAT , Patricia Ibarra YON , Peter Wilhelmus Maria HERMANS , Michael Thomas KOWARIK , Michael Lukas WETTER , Stefan Jochen KEMMLER , Micha Andres HÄUPTLE , Veronica GAMBILLARA FONCK , Manuela MALLY
IPC分类号： A61K39/108 , A61K39/385 , A61P31/04
摘要： Compositions and methods are described for inducing an immune response against extra-intestinal pathogenic Escherichia coli (ExPEC) to thereby provide immune protection against diseases associated with ExPEC. In particular, compositions and methods are described for using conjugates of E. coli polysaccharide antigens O25B, O1A, O2, and O6A covalently bound to a detoxified exotoxin A of Pseudomonas aeruginosa (EPA) carrier protein as vaccines for the prevention of invasive ExPEC disease caused by ExPEC serotypes O1A, O2, O6A and O25B.
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7.发明公开公开(公告)号：US20230190926A1
公开(公告)日：2023-06-22
申请号：US17938454
申请日：2022-10-06
发明人： Jeroen GEURTSEN , Pieter Jan BURGHOUT , Eveline Marleen WEERDENBURG , Jan Theunis POOLMAN , Kellen Cristhina FAE , Patricia IBARRA YON , Darren Robert ABBANAT , Stefan Jochen KEMMLER , Michael Thomas KOWARIK , Manuela MALLY , Veronica GAMBILLARA FONCK , Martin Edward BRAUN , Maria Paula CARRANZA SANDMEIER
IPC分类号： A61K39/385 , A61K39/108 , A61K39/02 , A61K47/64 , A61K39/085 , A61K39/095 , A61K39/102 , A61K39/09 , A61K39/104
CPC分类号： A61K39/385 , A61K39/0258 , A61K39/107 , A61K47/646 , A61K39/085 , A61K39/095 , A61K39/102 , A61K39/092 , A61K39/104 , A61K2039/6037
摘要： Methods of producing bioconjugates of O-antigen polysaccharides covalently linked to a carrier protein using recombinant host cells are provided. The recombinant host cells used in the methods described herein encode a particular oligosaccharyl transferase enzyme depending on the O-antigen polysaccharide bioconjugate to be produced. The oligosaccharyl transferase enzymes can be PglB oligosaccharyl transferase or variants thereof. Also provided are compositions containing the bioconjugates, and methods of using the bioconjugates and compositions described herein to vaccinate a subject against extra-intestinal pathogenic E. coli. (ExPEC).
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公开(公告)号：US20210154286A1
公开(公告)日：2021-05-27
申请号：US17165333
申请日：2021-02-02
发明人： Michael T. KOWARIK , Michael L. WETTER , Stefan J. KEMMLER , Micha A. HÄUPTLE , Veronica GAMBILLARA , Manuela MALLY
IPC分类号： A61K39/108 , A61K39/02 , C08B37/00 , A61K47/64 , C07K14/21
摘要： Provided herein is an E. coli O polysaccharide, O25B. Also provided herein are prokaryotic host cells containing enzymes (e.g., glycosyltransferases) used in O25B production. The host cells provided herein produce O25B bioconjugates, wherein said bioconjugates contain O25B linked to a carrier protein. Further provided herein are compositions, e.g., pharmaceutical compositions, including O25B and/or bioconjugates containing O25B. Such compositions can be used as vaccines against infection with ExPEC, and may further include one or more additional bioconjugates.
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公开(公告)号：US20230364214A1
公开(公告)日：2023-11-16
申请号：US18305948
申请日：2023-04-24
发明人： Michael T. KOWARIK , Michael L. WETTER , Stefan J. KEMMLER , Micha A. HÄUPTLE , Veronica GAMBILLARA , Manuela MALLY
IPC分类号： A61K39/108 , A61K39/02 , C08B37/00 , A61K47/64 , C07K14/21
CPC分类号： A61K39/0258 , A61K39/02 , C08B37/0063 , C08B37/0066 , A61K47/646 , C07K14/21 , C07K14/245
摘要： Provided herein is an E. coli O polysaccharide, O25B. Also provided herein are prokaryotic host cells containing enzymes (e.g., glycosyltransferases) used in O25B production. The host cells provided herein produce O25B bioconjugates, wherein said bioconjugates contain O25B linked to a carrier protein. Further provided herein are compositions, e.g., pharmaceutical compositions, including O25B and/or bioconjugates containing O25B. Such compositions can be used as vaccines against infection with ExPEC, and may further include one or more additional bioconjugates.
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