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公开(公告)号：US07381420B2
公开(公告)日：2008-06-03
申请号：US11607045
申请日：2006-12-01
IPC分类号： A61K47/00 , C07C69/74 , C07C61/00 , C07C61/08 , C07C51/58 , C07C53/38 , C07C55/36 , C07C57/64 , C07C59/00 , C07C62/00 , C07C63/00 , C07C65/00
CPC分类号： A61K49/085 , A61K49/14 , C07C229/24 , C07C271/22 , C07C2603/18 , C07K1/13 , G01N33/532 , G01N33/58
摘要： This invention concerns novel labeling reactants suitable for labeling of a biospecific binding reactant using solid-phase synthesis. The novel reactants are derivatives of diethylenetriaminepentaacetic acid (DTPA), wherein a suitable group is linked to the DTPA molecule, thus allowing site specific introduction of the ligand of the derivatives to bioactive molecules on solid phase in an oligopeptide synthesizer.
摘要翻译： 本发明涉及适用于使用固相合成标记生物特异性结合反应物的新型标记反应物。 新型反应物是二亚乙基三胺五乙酸（DTPA）的衍生物，其中合适的基团连接到DTPA分子，从而允许将衍生物的配体现场特异性引入寡聚合成器中固相上的生物活性分子。
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公开(公告)号：US20070134162A1
公开(公告)日：2007-06-14
申请号：US11607045
申请日：2006-12-01
CPC分类号： A61K49/085 , A61K49/14 , C07C229/24 , C07C271/22 , C07C2603/18 , C07K1/13 , G01N33/532 , G01N33/58
摘要： This invention concerns novel labeling reactants suitable for labeling of a biospecific binding reactant using solid-phase synthesis. The novel reactants are derivatives of diethylenetriaminepentaacetic acid (DTPA), wherein a suitable group is linked to the DTPA molecule, thus allowing site specific introduction of the ligand of said derivatives to bioactive molecules on solid phase in an oligopeptide synthesizer.
摘要翻译： 本发明涉及适用于使用固相合成标记生物特异性结合反应物的新型标记反应物。 新型反应物是二亚乙基三胺五乙酸（DTPA）的衍生物，其中合适的基团与DTPA分子连接，从而允许所述衍生物的配体在寡肽合成仪中固相上的生物活性分子的位点特异性引入。
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3.发明申请Novel chelating agents and highly luminescent and stable chelates and their use 有权新型螯合剂和高度发光和稳定的螯合物及其用途公开(公告)号：US20050181393A1
公开(公告)日：2005-08-18
申请号：US11004061
申请日：2004-12-06
IPC分类号： C07D213/38 , C07D401/14 , C07D471/18 , C07F9/58 , C07F9/6512 , C07F9/6515 , C07F9/6524 , G01N33/532 , C12Q1/68 , C07H21/04
CPC分类号： C07D401/14 , C07D213/38 , C07F9/58 , C07F9/6512 , C07F9/6515 , C07F9/6524 , G01N33/532
摘要： This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
摘要翻译： 本发明涉及一组新型螯合剂，新螯合物，用所述螯合物或螯合剂标记的生物分子以及与所述螯合物，螯合剂或标记生物分子缀合的固体支持物。 特别地，本发明涉及用于寡核苷酸或寡肽的固相合成的新型螯合剂以及如此获得的寡核苷酸和寡肽。
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4.发明授权Luminescent lanthanide (III) chelates, chelating agents and conjugates derived thereof 有权发光镧系元素（III）螯合物，螯合剂和衍生自它们的共轭物公开(公告)号：US08221719B2
公开(公告)日：2012-07-17
申请号：US12676604
申请日：2008-09-05
申请人： Jari Peuralahti , Jari Hovinen , Janne Ketola , Lassi Jaakkola , Veli-Matti Mukkala , Päivi Liitti
发明人： Jari Peuralahti , Jari Hovinen , Janne Ketola , Lassi Jaakkola , Veli-Matti Mukkala , Päivi Liitti
CPC分类号： C07D405/14 , C07D409/14 , G01N33/533 , G01N33/543 , G01N33/582
摘要： This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
摘要翻译： 本发明涉及一组新型螯合剂，新螯合物，用所述螯合物或螯合剂标记的生物分子以及与所述螯合物，螯合剂或标记生物分子缀合的固体支持物。 特别地，本发明涉及用于寡核苷酸或寡肽的固相合成的新型螯合剂以及如此获得的寡核苷酸和寡肽。
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5.发明授权公开(公告)号：US08071626B2
公开(公告)日：2011-12-06
申请号：US12000770
申请日：2007-12-17
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： C07D213/38 , C07D401/14 , C07F9/58 , C07F9/6512 , C07F9/6515 , C07F9/6524 , G01N33/533
摘要： This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
摘要翻译： 本发明涉及一组新型螯合剂，新螯合物，用所述螯合物或螯合剂标记的生物分子以及与所述螯合物，螯合剂或标记生物分子缀合的固体支持物。 特别地，本发明涉及用于寡核苷酸或寡肽的固相合成的新型螯合剂以及如此获得的寡核苷酸和寡肽。
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6.发明授权公开(公告)号：US08143057B2
公开(公告)日：2012-03-27
申请号：US12580990
申请日：2009-10-16
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： C07D401/14 , C07D213/38 , C07F9/58 , C07F9/6512 , C07F9/6515 , C07F9/6524 , G01N33/532
摘要： This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
摘要翻译： 本发明涉及一组新型螯合剂，新螯合物，用所述螯合物或螯合剂标记的生物分子以及与所述螯合物，螯合剂或标记生物分子缀合的固体支持物。 特别地，本发明涉及用于寡核苷酸或寡肽的固相合成的新型螯合剂以及如此获得的寡核苷酸和寡肽。
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7.发明授权公开(公告)号：US07625930B2
公开(公告)日：2009-12-01
申请号：US11004061
申请日：2004-12-06
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： C07D401/14 , C07D213/38 , C07F9/58 , C07F9/6512 , C07F9/6515 , C07F9/6524 , G01N33/532
摘要： This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
摘要翻译： 本发明涉及一组新型螯合剂，新螯合物，用所述螯合物或螯合剂标记的生物分子以及与所述螯合物，螯合剂或标记生物分子缀合的固体支持物。 特别地，本发明涉及用于寡核苷酸或寡肽的固相合成的新型螯合剂以及如此获得的寡核苷酸和寡肽。
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公开(公告)号：US20070166228A1
公开(公告)日：2007-07-19
申请号：US11653867
申请日：2007-01-17
CPC分类号： C07C229/76 , A61K49/085 , A61K49/10 , A61K49/103 , A61K51/0478 , C07C251/60 , C07C331/28 , G01N33/533
摘要： This invention concerns novel neutral labeling reactants. The novel reactants are derivatives of diethylenetriaminepentaacetic acid (DTPA) diamides, wherein a suitable group is linked to the molecule allowing introduction of the chelating agent or the neutral chelate to bioactive molecules.
摘要翻译： 本发明涉及新的中性标记反应物。 新型反应物是二亚乙基三胺五乙酸（DTPA）二酰胺的衍生物，其中合适的基团与分子连接，允许螯合剂或中性螯合物引入生物活性分子。
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9.发明申请Luminescent lanthanide (III) chelates, chelating agents and conjugates derived thereof 有权发光镧系元素（III）螯合物，螯合剂和衍生自它们的共轭物公开(公告)号：US20100204442A1
公开(公告)日：2010-08-12
申请号：US12676604
申请日：2008-09-05
申请人： Jari Peuralahti , Jari Hovinen , Janne Ketola , Lassi Jaakkola , Veli-Matti Mukkala , Päivi Liitti
发明人： Jari Peuralahti , Jari Hovinen , Janne Ketola , Lassi Jaakkola , Veli-Matti Mukkala , Päivi Liitti
CPC分类号： C07D405/14 , C07D409/14 , G01N33/533 , G01N33/543 , G01N33/582
摘要： This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
摘要翻译： 本发明涉及一组新型螯合剂，新螯合物，用所述螯合物或螯合剂标记的生物分子以及与所述螯合物，螯合剂或标记生物分子缀合的固体支持物。 特别地，本发明涉及用于寡核苷酸或寡肽的固相合成的新型螯合剂以及如此获得的寡核苷酸和寡肽。
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10.发明申请Novel chelating agents and highly luminescent and stable chelates and their use 有权新型螯合剂和高度发光和稳定的螯合物及其用途公开(公告)号：US20080167443A1
公开(公告)日：2008-07-10
申请号：US12000770
申请日：2007-12-17
IPC分类号： C07D401/14 , C07D401/12 , C07D471/18 , C07K2/00 , C07H21/00
CPC分类号： C07D213/38 , C07D401/14 , C07F9/58 , C07F9/6512 , C07F9/6515 , C07F9/6524 , G01N33/533
摘要： This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
摘要翻译： 本发明涉及一组新型螯合剂，新螯合物，用所述螯合物或螯合剂标记的生物分子以及与所述螯合物，螯合剂或标记生物分子缀合的固体支持物。 特别地，本发明涉及用于寡核苷酸或寡肽的固相合成的新型螯合剂以及如此获得的寡核苷酸和寡肽。
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