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1.发明申请Novel chelating agents and highly luminescent and stable chelates and their use 有权新型螯合剂和高度发光和稳定的螯合物及其用途公开(公告)号：US20050181393A1
公开(公告)日：2005-08-18
申请号：US11004061
申请日：2004-12-06
IPC分类号： C07D213/38 , C07D401/14 , C07D471/18 , C07F9/58 , C07F9/6512 , C07F9/6515 , C07F9/6524 , G01N33/532 , C12Q1/68 , C07H21/04
CPC分类号： C07D401/14 , C07D213/38 , C07F9/58 , C07F9/6512 , C07F9/6515 , C07F9/6524 , G01N33/532
摘要： This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
摘要翻译： 本发明涉及一组新型螯合剂，新螯合物，用所述螯合物或螯合剂标记的生物分子以及与所述螯合物，螯合剂或标记生物分子缀合的固体支持物。 特别地，本发明涉及用于寡核苷酸或寡肽的固相合成的新型螯合剂以及如此获得的寡核苷酸和寡肽。
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2.发明授权公开(公告)号：US08071626B2
公开(公告)日：2011-12-06
申请号：US12000770
申请日：2007-12-17
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： C07D213/38 , C07D401/14 , C07F9/58 , C07F9/6512 , C07F9/6515 , C07F9/6524 , G01N33/533
摘要： This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
摘要翻译： 本发明涉及一组新型螯合剂，新螯合物，用所述螯合物或螯合剂标记的生物分子以及与所述螯合物，螯合剂或标记生物分子缀合的固体支持物。 特别地，本发明涉及用于寡核苷酸或寡肽的固相合成的新型螯合剂以及如此获得的寡核苷酸和寡肽。
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3.发明授权公开(公告)号：US08143057B2
公开(公告)日：2012-03-27
申请号：US12580990
申请日：2009-10-16
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： C07D401/14 , C07D213/38 , C07F9/58 , C07F9/6512 , C07F9/6515 , C07F9/6524 , G01N33/532
摘要： This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
摘要翻译： 本发明涉及一组新型螯合剂，新螯合物，用所述螯合物或螯合剂标记的生物分子以及与所述螯合物，螯合剂或标记生物分子缀合的固体支持物。 特别地，本发明涉及用于寡核苷酸或寡肽的固相合成的新型螯合剂以及如此获得的寡核苷酸和寡肽。
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4.发明授权公开(公告)号：US07625930B2
公开(公告)日：2009-12-01
申请号：US11004061
申请日：2004-12-06
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： C07D401/14 , C07D213/38 , C07F9/58 , C07F9/6512 , C07F9/6515 , C07F9/6524 , G01N33/532
摘要： This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
摘要翻译： 本发明涉及一组新型螯合剂，新螯合物，用所述螯合物或螯合剂标记的生物分子以及与所述螯合物，螯合剂或标记生物分子缀合的固体支持物。 特别地，本发明涉及用于寡核苷酸或寡肽的固相合成的新型螯合剂以及如此获得的寡核苷酸和寡肽。
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5.发明申请NOVEL CHELATING AGENTS AND HIGHLY LUMINESCENT AND STABLE CHELATES AND THEIR USE 有权新型冷凝剂和高亮度和稳定的螯合物及其使用公开(公告)号：US20100036102A1
公开(公告)日：2010-02-11
申请号：US12580990
申请日：2009-10-16
CPC分类号： C07D401/14 , C07D213/38 , C07F9/58 , C07F9/6512 , C07F9/6515 , C07F9/6524 , G01N33/532
摘要： This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
摘要翻译： 本发明涉及一组新型螯合剂，新螯合物，用所述螯合物或螯合剂标记的生物分子以及与所述螯合物，螯合剂或标记生物分子缀合的固体支持物。 特别地，本发明涉及用于寡核苷酸或寡肽的固相合成的新型螯合剂以及如此获得的寡核苷酸和寡肽。
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6.发明申请Novel chelating agents and highly luminescent and stable chelates and their use 有权新型螯合剂和高度发光和稳定的螯合物及其用途公开(公告)号：US20080167443A1
公开(公告)日：2008-07-10
申请号：US12000770
申请日：2007-12-17
IPC分类号： C07D401/14 , C07D401/12 , C07D471/18 , C07K2/00 , C07H21/00
CPC分类号： C07D213/38 , C07D401/14 , C07F9/58 , C07F9/6512 , C07F9/6515 , C07F9/6524 , G01N33/533
摘要： This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
摘要翻译： 本发明涉及一组新型螯合剂，新螯合物，用所述螯合物或螯合剂标记的生物分子以及与所述螯合物，螯合剂或标记生物分子缀合的固体支持物。 特别地，本发明涉及用于寡核苷酸或寡肽的固相合成的新型螯合剂以及如此获得的寡核苷酸和寡肽。
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公开(公告)号：US20050084451A1
公开(公告)日：2005-04-21
申请号：US10928143
申请日：2004-08-30
IPC分类号： A61K49/00 , A61K51/00 , C07D405/04 , C07D405/14 , C07D471/18 , C07D491/02 , C07F5/00 , C07F9/6558 , G01N33/58
CPC分类号： G01N33/587 , C07D405/04 , C07D405/14 , C07F9/65586 , G01N33/582
摘要： This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
摘要翻译： 本发明涉及一组新型螯合剂，新螯合物，用所述螯合物或螯合剂标记的生物分子以及与所述螯合物，螯合剂或标记生物分子缀合的固体支持物。 特别地，本发明涉及用于寡核苷酸或寡肽的固相合成的新型螯合剂以及如此获得的寡核苷酸和寡肽。
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公开(公告)号：US20070286810A1
公开(公告)日：2007-12-13
申请号：US11448778
申请日：2006-06-08
申请人： Jari Hovinen , Veli-Matti Mukkala , Harri Hakala
发明人： Jari Hovinen , Veli-Matti Mukkala , Harri Hakala
IPC分类号： A61K49/10 , C07F5/00 , C08F277/00
CPC分类号： C08F230/04 , A61K49/0002 , A61K49/0019 , A61K49/0052 , C07D401/06 , C07D409/04
摘要： The invention concerns a method for preparing a particle comprising a lanthanide chelate, comprising polymerizing a lanthanide chelate derivative with one or more monomers, wherein the lanthanide chelate derivative has the formula M-L-Y (I), wherein Y is a lanthanide chelate; L is a linker and M is a polymerizable moiety.The invention concerns also the novel lanthanide chelate derivative M-L-Y (I). Further, the invention concerns a novel particle comprising a lanthanide chelate covalently bound to an organic polymer or copolymer via a linker.
摘要翻译： 本发明涉及一种制备包含镧系元素螯合物的颗粒的方法，包括使镧系螯合物衍生物与一种或多种单体聚合，其中所述镧系元素螯合衍生物具有式M-L-Y（I），其中Y是镧系元素螯合物; L是连接体，M是可聚合部分。 本发明还涉及新型镧系元素螯合衍生物M-L-Y（I）。 此外，本发明涉及包含通过连接体共价结合有机聚合物或共聚物的镧系螯合物的新型颗粒。
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公开(公告)号：US20070015284A1
公开(公告)日：2007-01-18
申请号：US11516740
申请日：2006-09-07
申请人： Ilkka Hemmila , Kaj Blomberg , Veli-Matti Mukkala , Harri Hakala
发明人： Ilkka Hemmila , Kaj Blomberg , Veli-Matti Mukkala , Harri Hakala
IPC分类号： G01N31/00
CPC分类号： G01N33/542 , C12Q1/682 , G01N21/64 , G01N33/582 , Y10S436/80 , Y10T436/108331 , Y10T436/15 , Y10T436/200833 , C12Q2527/125 , C12Q2563/107
摘要： The invention relates to an enhancement solution for an assay technology using lanthanide ions or their chelates as labels and dissociative fluorescence enhancement as a tool for detection, wherein said enhancement solution comprises a β-diketone of formula I wherein R1 is an aryl, optionally mono- or multi-substituted, and R2 is a straight or branched alkyl chain with 2 to 9 carbon atoms substituted with four or more fluorine atoms. The invention further relates to a bioaffinity assay using lanthanide ions or their chelates as labels and dissociative fluorescence enhancement as a tool for detection comprising the use of said enhancement solution.
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公开(公告)号：US07211440B2
公开(公告)日：2007-05-01
申请号：US10093034
申请日：2002-03-08
申请人： Iikka Hemmilä , Kaj Blomberg , Veli-Matti Mukkala , Harri Hakala
发明人： Iikka Hemmilä , Kaj Blomberg , Veli-Matti Mukkala , Harri Hakala
IPC分类号： G01N21/76 , G01N33/542 , G01N33/533 , G01N33/536 , G01N33/00 , G01N33/20
CPC分类号： G01N33/542 , C12Q1/682 , G01N21/64 , G01N33/582 , Y10S436/80 , Y10T436/108331 , Y10T436/15 , Y10T436/200833 , C12Q2527/125 , C12Q2563/107
摘要： The invention relates to an enhancement solution for an assay technology using lanthanide ions or their chelates as labels and dissociative fluorescence enhancement as a tool for detection, wherein said enhancement solution comprises a β-diketone of formula I wherein R1 is an aryl, optionally mono- or multi-substituted, and R2 is a straight or branched alkyl chain with 2 to 9 carbon atoms substituted with four or more fluorine atoms. The invention further relates to a bioaffinity assay using lanthanide ions or their chelates as labels and dissociative fluorescence enhancement as a tool for detection comprising the use of said enhancement solution.
摘要翻译： 本发明涉及使用镧系元素离子或其螯合物作为标记和解离荧光增强作为检测工具的测定技术的增强解决方案，其中所述增强溶液包含式I的β-二酮，其中R 1 >是任选的单取代或多取代的芳基，R 2是具有2-4个或更多个氟原子取代的具有2至9个碳原子的直链或支链烷基链。 本发明还涉及使用镧系元素离子或其螯合物作为标记和解离荧光增强作为检测工具的生物亲和力测定，其包括使用所述增强溶液。
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