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公开(公告)号：US6127401A
公开(公告)日：2000-10-03
申请号：US325140
申请日：1999-06-03
申请人： Jasbir Singh , Robert L. Hudkins , John P. Mallamo , Theodore L. Underiner , Rabindranath Tripathy
发明人： Jasbir Singh , Robert L. Hudkins , John P. Mallamo , Theodore L. Underiner , Rabindranath Tripathy
IPC分类号： A61K31/55 , A61K31/553 , A61P9/00 , A61P9/10 , A61P11/00 , A61P13/08 , A61P15/00 , A61P17/02 , A61P17/06 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D498/22
CPC分类号： C07D498/22
摘要： The present invention is directed to novel fused aryl and heteroaryl bridged indenopyrrolocarbazoles which are useful, inter alia, as therapeutic agents. The invention is also directed to methods for making and using the bridged indenopyrrolocarbazoles.
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公开(公告)号：US06359130B1
公开(公告)日：2002-03-19
申请号：US09572160
申请日：2000-05-17
申请人： Jasbir Singh , Robert L. Hudkins , John P. Mallamo , Theodore L. Underiner , Rabindranath Tripathy
发明人： Jasbir Singh , Robert L. Hudkins , John P. Mallamo , Theodore L. Underiner , Rabindranath Tripathy
IPC分类号： C07D49822
CPC分类号： C07D498/22
摘要： The present invention is directed to novel fused aryl and heteroaryl bridged indenopyrrolocarbazoles which are useful, inter alia, as therapeutic agents. The invention is also directed to methods for making and using the bridged indenopyrrolocarbazoles.
摘要翻译： 本发明涉及新的稠合芳基和杂芳基桥连茚并吡唑并唑，其特别可用作治疗剂。 本发明还涉及制备和使用桥连茚并吡唑并唑的方法。
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公开(公告)号：US08471005B2
公开(公告)日：2013-06-25
申请号：US13160890
申请日：2011-06-15
申请人： Henry J. Breslin , Sankar Chatterjee , James L. Diebold , Bruce D. Dorsey , Derek D. Dunn , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Rachael Hunter , Kurt A. Josef , Joseph Lisko , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Babu G. Sundar , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Linda Weinberg , Gregory J. Wells , Craig A. Zificsak
发明人： Henry J. Breslin , Sankar Chatterjee , James L. Diebold , Bruce D. Dorsey , Derek D. Dunn , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Rachael Hunter , Kurt A. Josef , Joseph Lisko , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Babu G. Sundar , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Linda Weinberg , Gregory J. Wells , Craig A. Zificsak
IPC分类号： C07D487/04 , C07D403/12 , A61K31/53 , A61K31/5377 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides a compound of formula I or a salt form thereof, wherein Q1, Q2, Q3, and Q4 are as defined herein. The compound of formula I has ALK and/or JAK2 inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译： 本发明提供式I化合物或其盐形式，其中Q 1，Q 2，Q 3和Q 4如本文所定义。 式I化合物具有ALK和/或JAK2抑制活性，可用于治疗增殖性疾病。
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公开(公告)号：US20120028919A1
公开(公告)日：2012-02-02
申请号：US13160890
申请日：2011-06-15
申请人： Henry J. Breslin , Sankar Chatterjee , James L. Diebold , Bruce D. Dorsey , Derek D. Dunn , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Rachael Hunter , Kurt A. Josef , Joseph Lisko , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Babu G. Sundar , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Linda Weinberg , Gregory J. Wells , Craig A. Zificsak
发明人： Henry J. Breslin , Sankar Chatterjee , James L. Diebold , Bruce D. Dorsey , Derek D. Dunn , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Rachael Hunter , Kurt A. Josef , Joseph Lisko , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Babu G. Sundar , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Linda Weinberg , Gregory J. Wells , Craig A. Zificsak
IPC分类号： A61K31/5377 , C07D223/16 , A61P35/00 , A61K31/53 , A61K31/695 , C07D487/04 , A61K31/55
CPC分类号： C07D487/04
摘要： The present invention provides a compound of formula I or a salt form thereof, wherein Q1, Q2, Q3, and Q4 are as defined herein. The compound of formula I has ALK and/or JAK2 inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译： 本发明提供式I化合物或其盐形式，其中Q 1，Q 2，Q 3和Q 4如本文所定义。 式I化合物具有ALK和/或JAK2抑制活性，可用于治疗增殖性疾病。
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5.发明授权Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-MET inhibitors 有权2,4-二氨基嘧啶作为ALK和c-MET抑制剂的稠合双环衍生物公开(公告)号：US08552186B2
公开(公告)日：2013-10-08
申请号：US13413322
申请日：2012-03-06
申请人： Gulzar Ahmed , Henry J. Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce D. Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Keith S. Learn , Joseph Lisko , Rong-qiang Liu , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Gregory J. Wells , Craig A. Zificsak
发明人： Gulzar Ahmed , Henry J. Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce D. Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Keith S. Learn , Joseph Lisko , Rong-qiang Liu , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Gregory J. Wells , Craig A. Zificsak
IPC分类号： C07D403/12
CPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译： 本发明提供式I或II化合物或其药学上可接受的盐形式，其中R1，R2，R3，R4，R5，A1，A2，A3，A4和A5如本文所定义。 式I或II的化合物具有ALK和/或c-Met抑制活性，并且可用于治疗增殖性疾病。
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6.发明申请Fused Bicyclic Derivatives of 2,4-Diaminopyrimidine as ALK and c-MET Inhibitors 有权2,4-二氨基嘧啶的双酚衍生物作为ALK和c-MET抑制剂公开(公告)号：US20120165519A1
公开(公告)日：2012-06-28
申请号：US13413322
申请日：2012-03-06
申请人： Gulzar Ahmed , Henry Joseph Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Keith S. Learn , Joseph G. Lisko , Rong-qiang Liu , Eugen Mesaros , Karen Milkiewicz , Gregory R. Ott , Jay P. Theroff , Tho V. Thieu , Rabindranath Tripathy , Theodore L. Underiner , Gregory J. Wells , Craig A. Zificsak
发明人： Gulzar Ahmed , Henry Joseph Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Keith S. Learn , Joseph G. Lisko , Rong-qiang Liu , Eugen Mesaros , Karen Milkiewicz , Gregory R. Ott , Jay P. Theroff , Tho V. Thieu , Rabindranath Tripathy , Theodore L. Underiner , Gregory J. Wells , Craig A. Zificsak
IPC分类号： C07D403/14 , C07D498/04 , C07D413/12 , C07D409/14 , C07D405/12 , C07D417/14 , C07D401/14 , C07D405/14 , C07D403/12 , C07D413/14
CPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译： 本发明提供式I或II化合物或其药学上可接受的盐形式，其中R1，R2，R3，R4，R5，A1，A2，A3，A4和A5如本文所定义。 式I或II的化合物具有ALK和/或c-Met抑制活性，并且可用于治疗增殖性疾病。
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7.发明申请FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND c-MET INHIBITORS 有权2,4-二氨基嘧啶作为ALK和c-MET抑制剂的熔融双相衍生物公开(公告)号：US20090221555A1
公开(公告)日：2009-09-03
申请号：US12162851
申请日：2007-10-23
申请人： Gulzar Ahmed , Adolph Bohnstedt , Henry Joseph Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Koc-Kan Ho , Keith S. Learn , Joseph G. Lisko , Rong-qiang Liu , Eugen Mesaros , Karen Milkiewicz , Gregory R. Ott , Jonathan Parrish , Jay P. Theroff , Tho V. Thieu , Rabindranath Tripathy , Theodore L. Underiner , Jason C. Wagner , Linda Weinberg , Gregory J. Wells , Ming You , Craig A. Zificsak
发明人： Gulzar Ahmed , Adolph Bohnstedt , Henry Joseph Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Koc-Kan Ho , Keith S. Learn , Joseph G. Lisko , Rong-qiang Liu , Eugen Mesaros , Karen Milkiewicz , Gregory R. Ott , Jonathan Parrish , Jay P. Theroff , Tho V. Thieu , Rabindranath Tripathy , Theodore L. Underiner , Jason C. Wagner , Linda Weinberg , Gregory J. Wells , Ming You , Craig A. Zificsak
IPC分类号： A61K31/55 , C07D239/02 , A61K31/505 , C07D403/00 , C07D413/14 , A61K31/5377 , C07D413/00 , C07D403/14
CPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译： 本发明提供式I或II化合物或其药学上可接受的盐形式，其中R1，R2，R3，R4，R5，A1，A2，A3，A4和A5如本文所定义。 式I或II的化合物具有ALK和/或c-Met抑制活性，并且可用于治疗增殖性疾病。
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8.发明授权Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-Met inhibitors 有权2,4-二氨基嘧啶作为ALK和c-Met抑制剂的稠合双环衍生物公开(公告)号：US08148391B2
公开(公告)日：2012-04-03
申请号：US12162851
申请日：2007-10-23
申请人： Gulzar Ahmed , Henry Joseph Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Keith S. Learn , Joseph G. Lisko , Rong-Qiang Liu , Eugen Florin Mesaros , Karen Milkiewicz , Gregory R. Ott , Jay P. Theroff , Tho V. Thieu , Rabindranath Tripathy , Theodore L. Underiner , Gregory J. Wells , Craig A. Zificsak
发明人： Gulzar Ahmed , Henry Joseph Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Keith S. Learn , Joseph G. Lisko , Rong-Qiang Liu , Eugen Florin Mesaros , Karen Milkiewicz , Gregory R. Ott , Jay P. Theroff , Tho V. Thieu , Rabindranath Tripathy , Theodore L. Underiner , Gregory J. Wells , Craig A. Zificsak
IPC分类号： A61K31/505 , C07D239/02
CPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译： 本发明提供式I或II化合物或其药学上可接受的盐形式，其中R1，R2，R3，R4，R5，A1，A2，A3，A4和A5如本文所定义。 式I或II的化合物具有ALK和/或c-Met抑制活性，并且可用于治疗增殖性疾病。
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公开(公告)号：US20100152196A1
公开(公告)日：2010-06-17
申请号：US12708306
申请日：2010-02-18
申请人： Nadine C. Becknell , James L. Diebold , Diane E. Gingrich , Robert L. Hudkins , Dandu R. Reddy , Ming Tao , Theodore L. Underiner , Allison L. Zulli
发明人： Nadine C. Becknell , James L. Diebold , Diane E. Gingrich , Robert L. Hudkins , Dandu R. Reddy , Ming Tao , Theodore L. Underiner , Allison L. Zulli
IPC分类号： A61K31/501 , A61K31/506 , A61K31/4439 , A61K31/4162 , C07D487/14 , A61P25/16 , A61P25/00 , A61P25/28
CPC分类号： C07D487/14 , C07D487/04
摘要： The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
摘要翻译： 本发明一般涉及选择的稠合吡咯并唑，包括其药物组合物和用其治疗疾病的方法。 本发明还涉及制备这些稠合的吡咯并咔唑的中间体和方法。
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公开(公告)号：US07514440B2
公开(公告)日：2009-04-07
申请号：US11744030
申请日：2007-05-03
IPC分类号： A61K31/497 , C07D401/00
CPC分类号： C07D487/14 , C07D487/04 , C07D513/14 , C09B57/00 , C09B57/08
摘要： The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
摘要翻译： 本发明一般涉及选择的稠合吡咯并唑，包括其药物组合物和用其治疗疾病的方法。 本发明还涉及制备这些稠合的吡咯并咔唑的中间体和方法。
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