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1.发明授权Method for inhibiting production of IGE and method for enhancing production of IGG using interleukin 9 and inhibitors thereof 失效用于抑制IGE生产的方法和使用白介素9及其抑制剂增强IGG生产的方法
公开(公告)号：US5132109A
公开(公告)日：1992-07-21
申请号：US593238
申请日：1990-10-05
申请人： Bernard Dugas , Catherine Druez , Pierre Braquet , Jean M. Mencia-Huerta , Catherine Uyttenhove , Jean-Christophe Renauld , Jacques Van Snick
发明人： Bernard Dugas , Catherine Druez , Pierre Braquet , Jean M. Mencia-Huerta , Catherine Uyttenhove , Jean-Christophe Renauld , Jacques Van Snick
IPC分类号： A61K38/00 , A61K38/17 , A61K38/20 , A61K39/395 , A61K45/00 , A61P37/00 , A61P37/04 , A61P37/06 , A61P43/00 , C07K14/54 , C07K14/715 , C07K16/24 , C12N5/08 , C12P21/02
CPC分类号： C07K16/247 , A61K38/2026 , A61K38/2033 , C07K14/7155 , C07K16/244 , A61K38/00
摘要： A method for inhibiting production of IgE, and a method for enhancing production of IgG are taught. The methods are linked to the role of interleukin 9 in antibody production. Specifically, production of IgG is potentiated by administering either to a subject or a cell culture a combination of interleukin 4 and interleukin 9. Production of IgE is inhibited by administering an amount of an interleukin 9 inhibitor to a subject.
摘要翻译： 教导了抑制IgE产生的方法以及增强IgG产生的方法。 该方法与抗体生产中白细胞介素9的作用有关。 具体地，通过向受试者或细胞培养物施用白细胞介素4和白介素9的组合来增强IgG的产生。通过向受试者施用一定量的白介素9抑制剂来抑制IgE的产生。
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2.发明授权Methods for producing antibodies which specifically bind to interleukin-9 receptor 失效产生特异性结合白细胞介素-9受体的抗体的方法
公开(公告)号：US5962269A
公开(公告)日：1999-10-05
申请号：US456489
申请日：1995-06-01
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , C07H15/12 , C07H21/04 , C07K14/715 , C07K16/28 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/09 , C12N15/70 , C12P21/08 , C12Q1/00 , C12R1/19 , C12R1/91 , C12P21/04 , C07K16/00
CPC分类号： C07K16/2866 , C07K14/7155 , A61K38/00
摘要： The invention describes nucleic acid sequences which code for the interleukin 9 receptor (IL9-R) molecule. These sequences may be used as probes to identify cells expressing the molecule, and as agents to transfect recipient cells.
摘要翻译： 本发明描述了编码白介素9受体（IL9-R）分子的核酸序列。 这些序列可以用作探针以鉴定表达分子的细胞，以及作为转染受体细胞的试剂。
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3.发明授权Nucleic acid sequences coding for or complementary to nucleic acid sequences coding for interleukin 9 receptor 失效编码白细胞介素9受体的核酸序列编码或互补的核酸序列
公开(公告)号：US5789237A
公开(公告)日：1998-08-04
申请号：US164614
申请日：1993-12-08
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , C07H15/12 , C07H21/04 , C07K14/715 , C07K16/28 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/09 , C12N15/70 , C12P21/08 , C12Q1/00 , C12R1/19 , C12R1/91 , C12N15/12
CPC分类号： C07K16/2866 , C07K14/7155 , A61K38/00
摘要： The invention describes nucleic acid sequences which code for the interleukin 9 receptor (IL9-R) molecule. These sequences may be used as probes to identify cells expressing the molecule, and as agents to transfect recipient cells.
摘要翻译： 本发明描述了编码白介素9受体（IL9-R）分子的核酸序列。 这些序列可以用作探针以鉴定表达分子的细胞，以及作为转染受体细胞的试剂。
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公开(公告)号：US5246701A
公开(公告)日：1993-09-21
申请号：US807260
申请日：1991-12-13
申请人： Bernard Dugas , Catherine Druez , Pierre Braquet , Jean M. Mencia-Huerta , Catherine Uyttenhove , Jean-Christophe Renauld , Jacques Van Snick
发明人： Bernard Dugas , Catherine Druez , Pierre Braquet , Jean M. Mencia-Huerta , Catherine Uyttenhove , Jean-Christophe Renauld , Jacques Van Snick
IPC分类号： A61K38/00 , A61K38/17 , A61K38/20 , C07K14/715 , C07K16/24
CPC分类号： C07K16/247 , C07K14/7155 , C07K16/244 , A61K38/00 , Y10S424/805
摘要： A method for inhibiting production of IgE, and a method for enhancing production of IgG are taught. The methods are linked to the role of interleukin 9 in antibody production. Specifically, production of IgG is potentiated by administering either to a subject or a cell culture a combination of interleukin 4 and interleukin 9. Production of IgE is inhibited by administering an amount of an interleukin 9 inhibitor to a subject.
摘要翻译： 教导了抑制IgE产生的方法以及增强IgG产生的方法。 该方法与抗体生产中白细胞介素9的作用有关。 具体地，通过向受试者或细胞培养物施用白细胞介素4和白介素9的组合来增强IgG的产生。通过向受试者施用一定量的白介素9抑制剂来抑制IgE的产生。
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公开(公告)号：US07371383B2
公开(公告)日：2008-05-13
申请号：US10412703
申请日：2003-04-11
申请人： Jennifer Lynne Reed , William Dall'Acqua , Jacques Van Snick , Jean-Christophe Renauld , Francoise Cormont , Catherine Uyttenhove
发明人： Jennifer Lynne Reed , William Dall'Acqua , Jacques Van Snick , Jean-Christophe Renauld , Francoise Cormont , Catherine Uyttenhove
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要： The application describes neutralizing chimeric and humanized anti-human IL-9 antibodies, and the use thereof to identify neutralizing epitopes on human IL-9 and as medicaments to prevent and treat asthma, bronchial hyperresponsiveness, atopic allergy, and other related disorders. Particularly disclosed are recombinant antibodies derived from three murine anti-human IL-9 antibodies identified infra as MH9A3, MH9D1, and MH9L1.
摘要翻译： 本申请描述了中和嵌合和人源化抗人IL-9抗体，以及其用于鉴定人IL-9上的中和表位以及用于预防和治疗哮喘，支气管高反应性，特应性变态反应和其它相关疾病的药物。 特别公开的是衍生自以下鉴定的三种鼠抗人IL-9抗体作为MH9A3，MH9D1和MH9L1的重组抗体。
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公开(公告)号：US07094396B2
公开(公告)日：2006-08-22
申请号：US10638234
申请日：2003-08-08
IPC分类号： A61K38/20
CPC分类号： A61K39/001 , A61K39/0005 , A61K2039/6081 , Y10S514/826
摘要： The methods of this invention relate to immunizing animals with conjugates of cytokines and a carrier to induce a prolonged high titre antibody response specific for the cytokine. This invention also relates to the treatment of pathological conditions, e.g., eosinophilia and allograft rejection, associated with the production of cytokines, in particular interleukins, e.g., IL-4, IL-5, IL-9, and IL-13, by immunization with the cytokine conjugates or by administration of antibodies specific for the cytokine. This invention also relates to compositions comprising the cytokine conjugates and the conjugates per se.
摘要翻译： 本发明的方法涉及用细胞因子和载体的缀合物免疫动物以诱导对细胞因子特异性的延长的高滴度抗体应答。 本发明还涉及通过免疫来治疗与细胞因子特别是白细胞介素例如IL-4，IL-5，IL-9和IL-13的产生有关的嗜酸粒细胞增多和同种异体移植排斥的病理状况 与细胞因子缀合物或通过施用对细胞因子特异的抗体。 本发明还涉及包含细胞因子共轭物和缀合物本身的组合物。
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公开(公告)号：US06645486B1
公开(公告)日：2003-11-11
申请号：US09490586
申请日：2000-01-25
IPC分类号： A61K3820
CPC分类号： A61K39/001 , A61K39/0005 , A61K2039/6081 , Y10S514/826
摘要： The methods of this invention relate to immunizing animals with conjugates of cytokines and a carrier to induce a prolonged high titre antibody response specific for the cytokine. This invention also relates to the treatment of pathological conditions, e.g., eosinophilia and allograft rejection, associated with the production of cytokines, in particular interleukins, e.g., IL-4, IL-5, IL-9, and IL-13, by immunization with the cytokine conjugates or by administration of antibodies specific for the cytokine. This invention also relates to compositions comprising the cytokine conjugates and the conjugates per se.
摘要翻译： 本发明的方法涉及用细胞因子和载体的缀合物免疫动物以诱导对细胞因子特异性的延长的高滴度抗体应答。 本发明还涉及通过免疫来治疗与细胞因子特别是白细胞介素例如IL-4，IL-5，IL-9和IL-13的产生有关的嗜酸粒细胞增多和同种异体移植排斥的病理状况 与细胞因子缀合物或通过施用对细胞因子特异的抗体。 本发明还涉及包含细胞因子共轭物和缀合物本身的组合物。
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公开(公告)号：US20080299134A1
公开(公告)日：2008-12-04
申请号：US12049566
申请日：2008-03-17
申请人： Jennifer Lynne Reed , William Dall'Acqua , Jacques Van Snick , Jean-Christophe Renauld , Francoise Cormont , Catherine Uyttenhove
发明人： Jennifer Lynne Reed , William Dall'Acqua , Jacques Van Snick , Jean-Christophe Renauld , Francoise Cormont , Catherine Uyttenhove
IPC分类号： A61K39/395 , C07K16/18 , A61P43/00
CPC分类号： C07K16/244 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要： The application describes neutralizing chimeric and humanized anti-human IL-9 antibodies, and the use thereof to identify neutralizing epitopes on human IL-9 and as medicaments to prevent and treat asthma, bronchial hyperresponsiveness, atopic allergy, and other related disorders. Particularly disclosed are recombinant antibodies derived from three murine anti-human IL-9 antibodies identified infra as MH9A3, MH9D1, and MH9L1.
摘要翻译： 该应用描述了中和嵌合和人源化抗人IL-9抗体，以及其用于鉴定人IL-9上的中和表位以及用作预防和治疗哮喘，支气管高反应性，特应性变态反应和其它相关疾病的药物。 特别公开的是衍生自以下鉴定的三种鼠抗人IL-9抗体作为MH9A3，MH9D1和MH9L1的重组抗体。
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公开(公告)号：US5116951A
公开(公告)日：1992-05-26
申请号：US585229
申请日：1990-09-19
IPC分类号： C07K14/705 , A61K38/00 , C07K1/00 , C07K14/00 , C07K14/715 , C12P21/00 , G01N33/53
CPC分类号： C07K14/7155 , A61K38/00
摘要： The invention relates to substantially pure interleukin 9 receptor molecules and the use thereof. The uses include use as an interleukin-9 inhibitor, as a diagnostic agent for determining interleukin-9, and as a screening agent for pharmaceuticals. The interleukin-9 receptor is characterized as a glycoprotein of about 94 kilodaltons which, upon digestion with N-glycosidase F, yields a peptide of about 54 kilodaltons.
摘要翻译： 本发明涉及基本上纯的白介素9受体分子及其用途。 作为白细胞介素-9抑制剂的使用，可以列举作为白细胞介素-9的测定用诊断剂，作为药物的筛选剂。 白细胞介素-9受体的特征在于约94千道尔顿的糖蛋白，其在用N-糖苷酶F消化后产生约54千道尔顿的肽。
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公开(公告)号：US5180678A
公开(公告)日：1993-01-19
申请号：US832192
申请日：1992-02-06
IPC分类号： C07K14/705 , A61K38/00 , C07K1/00 , C07K14/00 , C07K14/715 , C12P21/00 , G01N33/53
CPC分类号： C07K14/7155 , A61K38/00
摘要： The invention relates to substantially pure interleukin 9 receptor molecules and the use thereof. The uses include use as an interleukin-9 inhibitor, as a diagnostic agent for determining interleukin-9, and as a screening agent for pharmaceuticals. The interleukin-9 receptor is characterized as a glycoprotein of about 64 kilodaltons which, upon digestion with N-glycosidase F, yields a peptide of about 54 kilodaltons.
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