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1.
公开(公告)号:US07902303B2
公开(公告)日:2011-03-08
申请号:US11606918
申请日:2006-12-01
申请人: Jean-Dean Yang , Jui-Hsiang Chen , Meng-Yow Hsieh , Pei Pei Cheng
发明人: Jean-Dean Yang , Jui-Hsiang Chen , Meng-Yow Hsieh , Pei Pei Cheng
CPC分类号: C08G18/428 , A61L27/18 , C08G18/4277 , C08G18/758 , C08G63/08 , C08G63/912 , C08G2230/00 , Y10S606/908 , Y10S606/91 , C08L67/04
摘要: An aliphatic polyester polymer compositions and preparation method thereof. The invention provides a bioresorbable aliphatic polyester copolymer, comprising the reaction product of a first polyester, a second polyester, and a coupling agent. Specifically, the first polyester and second polyester have the same repeat units, but different weight average molecular weights. Methods for preparing the aliphatic polyester copolymer are provided, in which the first polyester reacts with the second polyester in the presence of the coupling agent, undergoing copolymerization.
摘要翻译: 脂肪族聚酯聚合物组合物及其制备方法。 本发明提供了生物可再吸收的脂族聚酯共聚物,其包含第一聚酯,第二聚酯和偶联剂的反应产物。 具体地说,第一聚酯和第二聚酯具有相同的重复单元,但是重均分子量不同。 提供了制备脂族聚酯共聚物的方法,其中第一聚酯在偶联剂存在下与第二聚酯反应进行共聚。
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2.
公开(公告)号:US20070155943A1
公开(公告)日:2007-07-05
申请号:US11606918
申请日:2006-12-01
申请人: Jean-Dean Yang , Jui-Hsiang Chen , Meng-Yow Hsieh , Pei Cheng
发明人: Jean-Dean Yang , Jui-Hsiang Chen , Meng-Yow Hsieh , Pei Cheng
IPC分类号: C08G18/42
CPC分类号: C08G18/428 , A61L27/18 , C08G18/4277 , C08G18/758 , C08G63/08 , C08G63/912 , C08G2230/00 , Y10S606/908 , Y10S606/91 , C08L67/04
摘要: An aliphatic polyester polymer compositions and preparation method thereof. The invention provides a bioresorbable aliphatic polyester copolymer, comprising the reaction product of a first polyester, a second polyester, and a coupling agent. Specifically, the first polyester and second polyester have the same repeat units, but different weight average molecular weights. Methods for preparing the aliphatic polyester copolymer are provided, in which the first polyester reacts with the second polyester in the presence of the coupling agent, undergoing copolymerization.
摘要翻译: 脂肪族聚酯聚合物组合物及其制备方法。 本发明提供了生物可再吸收的脂族聚酯共聚物,其包含第一聚酯,第二聚酯和偶联剂的反应产物。 具体地说,第一聚酯和第二聚酯具有相同的重复单元,但是重均分子量不同。 提供了制备脂族聚酯共聚物的方法,其中第一聚酯在偶联剂存在下与第二聚酯反应进行共聚。
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公开(公告)号:US08614190B2
公开(公告)日:2013-12-24
申请号:US13172776
申请日:2011-06-29
申请人: Shen-Hua Peng , Hsin-Hsin Shen , Liang-Yo Yang , Meng-Yow Hsieh , Pei-Shan Li , Wei-Lin Yu , Tsai-Yu Lin , Po-Liang Lai , Jui-Sheng Sun , Chih-Hung Chang , Yi-Hung Lin
发明人: Shen-Hua Peng , Hsin-Hsin Shen , Liang-Yo Yang , Meng-Yow Hsieh , Pei-Shan Li , Wei-Lin Yu , Tsai-Yu Lin , Po-Liang Lai , Jui-Sheng Sun , Chih-Hung Chang , Yi-Hung Lin
IPC分类号: A61P19/08 , A61K38/18 , A61K31/74 , C07K14/51 , C07K14/475
CPC分类号: A61L27/50 , A61L27/18 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要: Thermal responsive compositions for treating bone diseases are provided. The thermal responsive composition for treating bone diseases includes a bone growth factor and a biodegradable copolymer. The biodegradable copolymer has a structure of Formula (I) or Formula (II): A-B-BOX-B-A Formula (I) B-A-B-(BOX-B-A-B)n-BOX-B-A-B Formula (II) wherein, A includes a hydrophilic polyethylene glycol polymer, B includes a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2, 2′-Bis(2-oxazoline) and used for coupling the blocks A-B or B-A-B, and n is an integer and the same or more than 0.
摘要翻译: 提供了用于治疗骨疾病的热应答组合物。 用于治疗骨疾病的热应答组合物包括骨生长因子和可生物降解的共聚物。 生物降解性共聚物具有式(I)或式(II)的结构:AB-BOX-B-AFormula(I)BAB-(BOX-BAB)n-BOX-BA-BFormula(II)其中,A包括亲水 聚乙二醇聚合物,B包括疏水性聚酯聚合物,BOX是2,2'-双(2-恶唑啉)的双官能团单体,用于偶联嵌段AB或BAB,并且n是整数并且相同或多于 0。
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公开(公告)号:US20120010139A1
公开(公告)日:2012-01-12
申请号:US13172776
申请日:2011-06-29
申请人: Shen-Hua Peng , Hsin-Hsin Shen , Liang-Yo Yang , Meng-Yow Hsieh , Pei-Shan Li , Wei-Lin Yu , Tsai-Yu Lin , Po-Liang Lai , Jui-Sheng Sun , Chih-Hung Chang , Yi-Hung Lin
发明人: Shen-Hua Peng , Hsin-Hsin Shen , Liang-Yo Yang , Meng-Yow Hsieh , Pei-Shan Li , Wei-Lin Yu , Tsai-Yu Lin , Po-Liang Lai , Jui-Sheng Sun , Chih-Hung Chang , Yi-Hung Lin
CPC分类号: A61L27/50 , A61L27/18 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要: Thermal responsive compositions for treating bone diseases are provided. The thermal responsive composition for treating bone diseases includes a bone growth factor and a biodegradable copolymer. The biodegradable copolymer has a structure of Formula (I) or Formula (II): A-B-BOX-B-A (Formula I) and B-A-B-(BOX-B-A-B)n-BOX-B-A-B Formula (II), wherein, A includes a hydrophilic polyethylene glycol polymer, B includes a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2,2′-Bis(2-oxazoline) and used for coupling the blocks A-B or B-A-B, and n is an integer and the same or more than 0.
摘要翻译: 提供了用于治疗骨疾病的热应答组合物。 用于治疗骨疾病的热应答组合物包括骨生长因子和可生物降解的共聚物。 生物降解性共聚物具有式(I)或式(II)的结构:AB-BOX-BA(式I)和BAB-(BOX-BAB)n-BOX-BAB式(II),其中,A包括亲水 聚乙二醇聚合物,B包括疏水性聚酯聚合物,BOX是2,2'-双(2-恶唑啉)的双官能团单体,用于偶联嵌段AB或BAB,并且n为整数并且相同或多于 0。
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公开(公告)号:US08211959B2
公开(公告)日:2012-07-03
申请号:US12570588
申请日:2009-09-30
申请人: Hsin-Hsin Shen , Chin-Fu Chen , Meng-Yow Hsieh , Miao-Tzu Chen , Wen-Fu Lee
发明人: Hsin-Hsin Shen , Chin-Fu Chen , Meng-Yow Hsieh , Miao-Tzu Chen , Wen-Fu Lee
IPC分类号: C08F299/04 , C08F283/10
CPC分类号: C08G63/912 , C08G63/08 , C08G63/664 , C08G63/668 , C08G63/91
摘要: Biodegradable copolymer hydrogels are provided. The biodegradable copolymer hydrogels have a structure of Formula (I) or Formula (II) A-B—BOX—B-A Formula (I) B-A-B—(BOX—B-A-B)n-BOX—B-A-B Formula (II), wherein, A comprises a hydrophilic polyethylene glycol polymer (A); B comprises a hydrophobic polyester polymer (B); BOX is bifunctional group monomer of 2,2′-Bis(2-oxazoline) and used for coupling the blocks A-B or B-A-B; and n is an integer, equal to or greater than 0.
摘要翻译: 提供可生物降解的共聚物水凝胶。 可生物降解的共聚物水凝胶具有式(I)或式(II)AB-BOX-BA式(I)BAB-(BOX-BAB)n-BOX-BAB式(II)的结构,其中A包含亲水聚乙烯 乙二醇聚合物(A); B包含疏水性聚酯聚合物(B); BOX是2,2'-双(2-恶唑啉)的双官能团单体,用于偶联嵌段A-B或B-A-B; 并且n是等于或大于0的整数。
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