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1.发明授权Monoclonal antibody for differentiating HIV-2 from HIM-1 seropositive individuals 失效用于区分HIV-2与HIM-1血清阳性个体的单克隆抗体
公开(公告)号：US5374518A
公开(公告)日：1994-12-20
申请号：US952482
申请日：1992-09-28
申请人： Jeffrey C. Hunt , Virender K. Sarin , Sushil G. Devare , Ilse I. E. Tribby , Suresh M. Desai , James M. Casey
发明人： Jeffrey C. Hunt , Virender K. Sarin , Sushil G. Devare , Ilse I. E. Tribby , Suresh M. Desai , James M. Casey
IPC分类号： G01N33/569 , C07K14/16 , C07K16/10 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/577 , C12Q1/70 , C07K15/06 , G01N31/22 , G01N33/53
CPC分类号： C07K14/005 , C07K16/1063 , C12N2740/16122 , Y10S435/974 , Y10S435/975 , Y10S930/221
摘要： A mouse monoclonal antibody is provided which detects HIV-2 seropositive individuals and differentiates them from HIV-1 seropositive individuals. The monoclonal antibody is specific for an epitope of HIV-2 gp41 which lies outside the characterized immunodominant region. The epitope recognized by the monoclonal antibody has the amino acid sequence HTTVPW.
摘要翻译： 提供了一种检测HIV-2血清阳性个体并将其与HIV-1血清阳性个体区分开的小鼠单克隆抗体。 单克隆抗体对位于特征性免疫显性区域之外的HIV-2 gp41的表位是特异性的。 由单克隆抗体识别的表位具有氨基酸序列HTTVPW。
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2.发明授权Mouse monoclonal antibodies to hiv-1p24 and their use in diagnostic tests 失效HIV-1P24小鼠单克隆抗体及其在诊断检测中的应用
公开(公告)号：US5173399A
公开(公告)日：1992-12-22
申请号：US204798
申请日：1988-06-10
IPC分类号： G01N33/569 , A61K39/395 , C07K16/10 , C12N5/20 , C12P21/08 , C12R1/91 , G01N33/577
CPC分类号： C07K16/1054 , Y10S435/971 , Y10S435/974 , Y10S435/975
摘要： The present invention provides monoclonal antibodies demonstrating specific reactivity with HIV-1 p24. One monoclonal antibody designated 31-42-19 recognizes an unique epitope on HIV-1 p24 that is not immunogenic in humans. 31-42-19 also reacts with an antigenically cross reactive epitope on HIV-2 p24. Another monoclonal antibody designated 31-90-25 recognizes an epitope within a highly immunogenic region of HIV-1 p24. The present invention also provides cell lines capable of producing these monoclonal antibodies. The invention also includes a highly sensitive enzyme immunoassay for the detection of HIV-1 p24 in biological fluids, using a monoclonal antibody mixture. The present invention further provides methods for the use of these monoclonal antibodies for the detection of anti-HIV-1 p24 antibodies and HIV-2 p24 antigen in biological samples.
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公开(公告)号：US07531639B2
公开(公告)日：2009-05-12
申请号：US10940261
申请日：2004-09-14
申请人： Sheng C. Lou , Jeffrey C. Hunt , John G. Konrath , Xiaoxing Qiu , James W. Scheffel , Joan D. Tyner
发明人： Sheng C. Lou , Jeffrey C. Hunt , John G. Konrath , Xiaoxing Qiu , James W. Scheffel , Joan D. Tyner
IPC分类号： C12P21/08
CPC分类号： C07K16/1054 , C07K7/08 , C07K14/005 , C07K14/161 , C07K2317/34 , C12N2740/16211 , C12N2740/16222 , G01N33/56983 , G01N33/68
摘要： The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample.
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4.发明申请公开(公告)号：US20120100632A1
公开(公告)日：2012-04-26
申请号：US13024093
申请日：2011-02-09
申请人： Sheng C. Lou , Jeffrey C. Hunt , John G. Konrath , Xiaoxing Qiu , James W. Scheffel , Joan D. Tyner
发明人： Sheng C. Lou , Jeffrey C. Hunt , John G. Konrath , Xiaoxing Qiu , James W. Scheffel , Joan D. Tyner
IPC分类号： G01N33/53 , C12N5/12 , C07K14/155 , C07K16/10
CPC分类号： C07K16/1054 , C07K7/08 , C07K14/005 , C07K14/161 , C07K2317/34 , C12N2740/16211 , C12N2740/16222 , G01N33/56983 , G01N33/68
摘要： The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample.
摘要翻译： 本发明涉及可用于检测人类免疫缺陷病毒（HIV）的新型单克隆抗体。 这些抗体表现出非常高的灵敏度，非常宽的特异性范围，并且结合新的共享的非交叉反应性表位。 特别地，本发明的单克隆抗体可用于检测患者样品中的HIV-1抗原和HIV-2核心抗原。
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公开(公告)号：US5643733A
公开(公告)日：1997-07-01
申请号：US500222
申请日：1995-07-10
IPC分类号： C07K14/20 , G01N33/53 , G01N33/543 , G01N33/554 , G01N33/569
CPC分类号： C07K14/20 , C07K2319/00 , Y10S530/825
摘要： This invention relates generally to an assay for Lyme disease which detects the antibody to Borrelia burgdorferi, the causative agent of Lyme disease. More specifically, the assay employs antigens derived from amino acid regions in the flagellum of Borrelia burgdorferi. These antigens are immunoreactive with antibodies to Borrelia burgdorferi but are not substantially immunoreactive with antibodies to Treponema pallidum, the syphilis causing agent. DNA sequences of the antigens, clones and vectors containing the DNA sequences are also disclosed. Polypeptides derived therefrom can be used as reagents for the detection of antibody to Borrelia burgdorferi in the body fluids from individuals with Lyme disease.
摘要翻译： 本发明一般涉及莱姆病的检测方法，该检测法检测勃氏疏螺旋体的抗体，其是莱姆病的致病因子。 更具体地，该测定使用来源于布氏疏螺旋体鞭毛中的氨基酸区域的抗原。 这些抗原与布氏疏螺旋体的抗体具有免疫反应性，但与梅毒螺旋体梅毒引发剂的抗体基本上不具有免疫反应性。 还公开了抗原的DNA序列，克隆和含有DNA序列的载体。 从其衍生的多肽可用作检测来自具有莱姆病的个体的体液中的布氏疏螺旋体的抗体的试剂。
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公开(公告)号：US07531638B2
公开(公告)日：2009-05-12
申请号：US10940237
申请日：2004-09-14
申请人： Sheng C. Lou , Jeffrey C. Hunt , John G. Konrath , Xiaoxing Qiu , James W. Scheffel , Joan D. Tyner
发明人： Sheng C. Lou , Jeffrey C. Hunt , John G. Konrath , Xiaoxing Qiu , James W. Scheffel , Joan D. Tyner
IPC分类号： C12P21/08
CPC分类号： C07K16/1054 , C07K7/08 , C07K14/005 , C07K14/161 , C07K2317/34 , C12N2740/16211 , C12N2740/16222 , G01N33/56983 , G01N33/68
摘要： The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample.
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公开(公告)号：US5965702A
公开(公告)日：1999-10-12
申请号：US779704
申请日：1991-10-21
IPC分类号： C07K14/20
CPC分类号： C07K14/20 , C07K2319/00 , Y10S530/825
摘要： This invention relates generally to an assay for Lyme disease which detects the antibody to Borrelia burgdorferi, the causative agent of Lyme disease. More specifically, the assay employs antigens derived from amino acid regions in the flagellum of Borrelia burgdorferi. These antigens are immunoreactive with antibodies to Borrelia burgdorferi but are not substantially immunoreactive with antibodies to Treponema pallidum, the syphilis causing agent. DNA sequences of the antigens, clones and vectors containing the DNA sequences are also disclosed. Polypeptides derived therefrom can be used as reagents for the detection of antibody to Borrelia burgdorferi in the body fluids from individuals with Lyme disease.
摘要翻译： 本发明一般涉及莱姆病的检测方法，该检测法检测勃氏疏螺旋体的抗体，其是莱姆病的致病因子。 更具体地，该测定使用来源于布氏疏螺旋体鞭毛中的氨基酸区域的抗原。 这些抗原与布氏疏螺旋体的抗体具有免疫反应性，但与梅毒螺旋体梅毒引发剂的抗体基本上不具有免疫反应性。 还公开了抗原的DNA序列，克隆和含有DNA序列的载体。 从其衍生的多肽可用作检测来自具有莱姆病的个体的体液中的布氏疏螺旋体的抗体的试剂。
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8.发明授权Methods for the detection of HIV-1 or -2 antigens employing monoclonal antibodies that recognize a shared HIV-1/-2 epitope in the capsid p24/p26 proteins 有权使用识别衣壳p24 / p26蛋白中共享的HIV-1 / -2表位的单克隆抗体检测HIV-1或-2抗原的方法公开(公告)号：US07897332B2
公开(公告)日：2011-03-01
申请号：US10714689
申请日：2003-11-17
申请人： Sheng C. Lou , Jeffrey C. Hunt , John G. Konrath , Xiaoxing Qiu , James W. Scheffel , Joan D. Tyner
发明人： Sheng C. Lou , Jeffrey C. Hunt , John G. Konrath , Xiaoxing Qiu , James W. Scheffel , Joan D. Tyner
CPC分类号： C07K16/1054 , C07K7/08 , C07K14/005 , C07K14/161 , C07K2317/34 , C12N2740/16211 , C12N2740/16222 , G01N33/56983 , G01N33/68
摘要： The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample.
摘要翻译： 本发明涉及可用于检测人类免疫缺陷病毒（HIV）的新型单克隆抗体。 这些抗体表现出非常高的灵敏度，非常宽的特异性范围，并且结合新的共享的非交叉反应性表位。 特别地，本发明的单克隆抗体可用于检测患者样品中的HIV-1抗原和HIV-2核心抗原。
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公开(公告)号：US5643751A
公开(公告)日：1997-07-01
申请号：US500125
申请日：1995-07-10
CPC分类号： C07K14/20 , C07K2319/00 , Y10S530/825
摘要： This invention relates generally to an assay for Lyme disease which detects the antibody to Borrelia burgdorferi, the causative agent of Lyme disease. More specifically, the assay employs antigens derived from amino acid regions in the flagellum of Borrelia burgdorferi. These antigens are immunoreactive with antibodies to Borrelia burgdorferi but are not substantially immunoreactive with antibodies to Treponema pallidum, the syphilis causing agent. DNA sequences of the antigens, clones and vectors containing the DNA sequences are also disclosed. Polypeptides derived therefrom can be used as reagents for the detection of antibody to Borrelia burgdorferi in the body fluids from individuals with Lyme disease.
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10.发明授权Monoclonal antibodies that recognize a shared epitope between the human immunodeficiency virus type 1 (HIV-1) capsid (CA/p24) and the human immunodeficiency virus type 2 (HIV-2) capsid (CA/p26). 有权识别人类免疫缺陷病毒1型（HIV-1）衣壳（CA / p24）和人类免疫缺陷病毒2型（HIV-2）衣壳（CA / p26）之间的共享表位的单克隆抗体。公开(公告)号：US07531642B2
公开(公告)日：2009-05-12
申请号：US10940392
申请日：2004-09-14
申请人： Sheng C. Lou , Jeffrey C. Hunt , John G. Konrath , Xiaoxing Qiu , James W. Scheffel , Joan D. Tyner
发明人： Sheng C. Lou , Jeffrey C. Hunt , John G. Konrath , Xiaoxing Qiu , James W. Scheffel , Joan D. Tyner
IPC分类号： C12P21/08
CPC分类号： C07K16/1054 , C07K7/08 , C07K14/005 , C07K14/161 , C07K2317/34 , C12N2740/16211 , C12N2740/16222 , G01N33/56983 , G01N33/68
摘要： The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample.
摘要翻译： 本发明涉及可用于检测人类免疫缺陷病毒（HIV）的新型单克隆抗体。 这些抗体表现出非常高的灵敏度，非常宽的特异性范围，并且结合新的共享的非交叉反应性表位。 特别地，本发明的单克隆抗体可用于检测患者样品中的HIV-1抗原和HIV-2核心抗原。
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