公开(公告)号：US20080009688A1

公开(公告)日：2008-01-10

申请号：US11837146

申请日：2007-08-10

申请人： Jeffrey Dahlen ,  William Sell ,  John Burd ,  Paul Williams ,  Gaganbir Johal

发明人： Jeffrey Dahlen ,  William Sell ,  John Burd ,  Paul Williams ,  Gaganbir Johal

IPC分类号： A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/7239

摘要： A method of non-invasively measuring the presence, absence, or concentration of one or more analytes in a tissue of a subject includes exposing at least a portion of a tissue of the subject to electromagnetic radiation; obtaining electromagnetic radiation measurement data of electromagnetic radiation from the tissue; using a mathematical transformation to filter or smooth the electromagnetic radiation measurement data; and determining the presence, absence, or concentration of one or more analytes by determining a radiation signature of the filtered or smoothed electromagnetic radiation measurement data; correlating the radiation signature of the filtered or smoothed electromagnetic radiation measurement data with the presence, absence, or concentration of one or more analytes to determine the presence, absence, or concentration of one or more analytes in the subject.

摘要翻译： 非侵入性测量受试者组织中一种或多种分析物的存在，不存在或浓度的方法包括将受试者的组织的至少一部分暴露于电磁辐射; 从组织获取电磁辐射的电磁辐射测量数据; 使用数学变换来过滤或平滑电磁辐射测量数据; 以及通过确定经滤波或平滑的电磁辐射测量数据的辐射特征来确定一种或多种分析物的存在，不存在或浓度; 将经滤波或平滑的电磁辐射测量数据的辐射特征与一种或多种分析物的存在，不存在或浓度相关联，以确定受试者中一种或多种分析物的存在，不存在或浓度。

公开(公告)号：US20060224057A1

公开(公告)日：2006-10-05

申请号：US11420076

申请日：2006-05-24

申请人： John Burd ,  Paul Williams ,  Jeffrey Dahlen ,  William Sell

发明人： John Burd ,  Paul Williams ,  Jeffrey Dahlen ,  William Sell

IPC分类号： A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/7239

摘要： A method of non-invasively measuring the presence, absence, or concentration of one or more analytes in a tissue of a subject includes exposing at least a portion of a tissue of the subject to electromagnetic radiation; obtaining a measurement of electromagnetic radiation from the tissue; and determining the presence, absence, or concentration of one or more analytes by determining a radiation signature of the electromagnetic radiation; correlating the radiation signature of the electromagnetic radiation with at least one of concentration, presence, and absence of one or more analytes by utilizing a mathematic transformation such as a transformation based on a 1st or higher derivative of the measurement to determine the presence, absence, or concentration of one or more analytes in the subject.

摘要翻译： 非侵入性测量受试者组织中一种或多种分析物的存在，不存在或浓度的方法包括将受试者的组织的至少一部分暴露于电磁辐射; 获得来自组织的电磁辐射的测量; 以及通过确定所述电磁辐射的辐射特征来确定一种或多种分析物的存在，不存在或浓度; 将电磁辐射的辐射特征与一种或多种分析物的浓度，存在和不存在中的至少一种相关联，通过利用数学变换，例如基于第一或更高分子的第一或更高衍生物的变换 测量以确定受试者中一种或多种分析物的存在，不存在或浓度。

公开(公告)号：US20060258917A1

公开(公告)日：2006-11-16

申请号：US11460162

申请日：2006-07-26

申请人： John Burd ,  Paul Williams ,  William Sell

发明人： John Burd ,  Paul Williams ,  William Sell

IPC分类号： A61B5/00 ,  G06Q99/00 ,  G06F17/00

CPC分类号： A61B5/14532 ,  A61B5/0002 ,  A61B5/6887

摘要： An apparatus and method of use for enabling a NAM device are provided. The NAM device is configured to authenticate its use each time a measurement is requested. The operation of the NAM device is governed by a refillable media card that tracks a predetermined number of authorized uses. The NAM device confirms that remaining authorized uses are available on the refillable media card. In addition to tracking the number of authorized uses of the NAM device, the media card may also store the results of the measurements for tracking by a tracking server. When the number of authorized uses on the media card is depleted, the media card may be refilled by completing a refill transaction over a wired or wireless communication network. Alternatively, the media card may be refilled at a kiosk station or a new media card may be obtained for use with the NAM device.

摘要翻译： 提供了一种用于启用NAM设备的设备和方法。 NAM设备被配置为在每次请求测量时验证其使用。 NAM设备的操作由跟踪预定数量的授权用途的可再填充媒体卡控制。 NAM设备确认剩余的授权用途在可再充装的媒体卡上可用。 除了跟踪NAM设备的授权使用的数量之外，媒体卡还可以存储跟踪服务器进行跟踪的测量结果。 当媒体卡上的授权用途数量被耗尽时，可以通过在有线或无线通信网络上完成再填充交易来重新填充媒体卡。 或者，媒体卡可以在报亭站重新填充，或者可以获得与NAM设备一起使用的新媒体卡。

公开(公告)号：US20050085701A1

公开(公告)日：2005-04-21

申请号：US10824214

申请日：2004-04-14

申请人： John Burd ,  Gary Krantz ,  Jacob Fraden ,  Charles Kramer ,  Bart Chapman ,  William Sell

发明人： John Burd ,  Gary Krantz ,  Jacob Fraden ,  Charles Kramer ,  Bart Chapman ,  William Sell

IPC分类号： A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/14546

摘要： The present invention is related to non-invasive methods and instruments to detect the level of analyte concentrations in the tissue of a subject by measuring electromagnetic radiation signatures from the subject's conjunctiva. The spectra of mid-infrared radiation emitted from a subject's body are altered corresponding to the concentration of various compounds within the radiating tissue. In one aspect of the invention, an instrument floods the conjunctiva of the subject with electromagnetic radiation in the mid-infrared range and measures analyte concentrations based on mid-infrared radiation reflected back to the instrument.

摘要翻译： 本发明涉及通过测量来自受试者结膜的电磁辐射特征来检测受试者组织中分析物浓度水平的非侵入性方法和仪器。 从受试者身体发射的中红外辐射的光谱根据辐射组织内各种化合物的浓度而改变。 在本发明的一个方面，仪器用中红外范围内的电磁辐射泛滥受试者的结膜，并根据反射回仪器的中红外辐射测量分析物浓度。

公开(公告)号：US06958039B2

公开(公告)日：2005-10-25

申请号：US10824254

申请日：2004-04-14

申请人： John F. Burd ,  Gary Krantz ,  William Sell

发明人： John F. Burd ,  Gary Krantz ,  William Sell

IPC分类号： A61B3/117 ,  A61B5/00

CPC分类号： A61B5/1455 ,  A61B3/10 ,  A61B3/117 ,  A61B5/14532 ,  A61B5/14546

摘要： The present invention is related to optical non-invasive methods and instruments to detect the level of analyte concentrations in the tissue of a subject. The spectra of mid-infrared radiation emitted from a subject's body are altered corresponding to the concentration of various compounds within the radiating tissue. In one aspect of the invention, an instrument measures the level of mid-infrared radiation from the subject's body surface, such as the eye, and determines a specific analyte's concentration based on said analyte's distinctive mid-infrared radiation signature.

摘要翻译： 本发明涉及用于检测受试者组织中分析物浓度水平的光学非侵入性方法和仪器。 从受试者身体发射的中红外辐射的光谱根据辐射组织内各种化合物的浓度而改变。 在本发明的一个方面中，仪器测量来自对象的身体表面（例如眼睛）的中红外辐射的水平，并且基于所述分析物的特征性中红外辐射特征确定特定分析物的浓度。

公开(公告)号：US06975892B2

公开(公告)日：2005-12-13

申请号：US10824214

申请日：2004-04-14

申请人： John F. Burd ,  Gary Krantz ,  Jacob Fraden ,  Charles Kramer ,  Bart Chapman ,  William Sell

发明人： John F. Burd ,  Gary Krantz ,  Jacob Fraden ,  Charles Kramer ,  Bart Chapman ,  William Sell

IPC分类号： A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/14546

摘要： The present invention is related to non-invasive methods and instruments to detect the level of analyte concentrations in the tissue of a subject by measuring electromagnetic radiation signatures from the subject's conjunctiva. The spectra of mid-infrared radiation emitted from a subject's body are altered corresponding to the concentration of various compounds within the radiating tissue. In one aspect of the invention, an instrument floods the conjunctiva of the subject with electromagnetic radiation in the mid-infrared range and measures analyte concentrations based on mid-infrared radiation reflected back to the instrument.

公开(公告)号：US06968222B2

公开(公告)日：2005-11-22

申请号：US10428410

申请日：2003-05-02

申请人： John F. Burd ,  Jacob Fraden ,  Charles E. Kramer ,  Gary Krantz ,  William Sell

发明人： John F. Burd ,  Jacob Fraden ,  Charles E. Kramer ,  Gary Krantz ,  William Sell

IPC分类号： A61B3/117 ,  A61B5/00

CPC分类号： A61B5/14532 ,  A61B3/10 ,  A61B5/14546 ,  A61B5/1455

摘要： The present invention is related to optical non-invasive methods and instruments to detect the level of analyte concentrations in the tissue of a subject. The spectra of mid-infrared radiation emitted from a subject's body are altered corresponding to the concentration of various compounds within the radiating tissue. In one aspect of the invention, an instrument floods a body surface of the subject, such as the subject's eye, with radiation in the mid-infrared range and measures analyte concentrations based on mid-infrared radiation reflected back to the instrument.

摘要翻译： 本发明涉及用于检测受试者组织中分析物浓度水平的光学非侵入性方法和仪器。 从受试者身体发射的中红外辐射的光谱根据辐射组织内各种化合物的浓度而改变。 在本发明的一个方面中，仪器用对象眼睛的中心红外范围的辐射使物体的身体表面泛滥，并且基于反射回仪器的中红外辐射来测量分析物浓度。