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公开(公告)号:US07259172B2
公开(公告)日:2007-08-21
申请号:US10884435
申请日:2004-07-02
IPC分类号: C07D401/02 , C07D333/02 , A61K31/44
CPC分类号: C07F9/2491 , C07F9/3808 , C07F9/4006 , C07F9/4084 , C07F9/425 , C07F9/4407 , C07F9/572 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/6506 , C07F9/6524 , C07F9/65312 , C07F9/6539 , C07F9/65395 , C07F9/6541 , C07F9/65515 , C07F9/65517 , C07F9/655345 , C07F9/655354 , C07F9/65583 , C07F9/65586
摘要: The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic β-lactamase inhibitors presently available, and which do not require a β-lactam pharmacophore. The invention also provides pharmaceutical compositions and methods for inhibiting bacterial growth.
摘要翻译: 意图涉及细菌抗生素抗性,特别涉及克服细菌抗生素抗性的组合物和方法。 本发明提供了新型β-内酰胺酶抑制剂,其在结构上与目前可获得的天然产物和半合成β-内酰胺酶抑制剂无关,并且不需要β-内酰胺药效团。 本发明还提供用于抑制细菌生长的药物组合物和方法。
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公开(公告)号:US06921756B2
公开(公告)日:2005-07-26
申请号:US10411484
申请日:2003-04-08
IPC分类号: C07F9/24 , C07F9/38 , C07F9/40 , C07F9/42 , C07F9/44 , C07F9/572 , C07F9/58 , C07F9/60 , C07F9/6506 , C07F9/6524 , C07F9/653 , C07F9/6539 , C07F9/6541 , C07F9/655 , C07F9/6553 , C07F9/6558 , A61K31/662 , A61K31/66 , A61P31/04
CPC分类号: C07F9/65586 , C07F9/2491 , C07F9/3808 , C07F9/4006 , C07F9/4084 , C07F9/425 , C07F9/4407 , C07F9/572 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/6506 , C07F9/6524 , C07F9/65312 , C07F9/6539 , C07F9/65395 , C07F9/6541 , C07F9/65515 , C07F9/65517 , C07F9/655345 , C07F9/655354 , C07F9/65583
摘要: The invention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic β-lactamase inhibitors presently available, and which do not require a β-lactam pharmacophore. The invention also provides pharmaceutical compositions and methods for inhibiting bacterial growth.
摘要翻译: 本发明涉及细菌抗生素抗性,特别涉及克服细菌抗生素抗性的组合物和方法。 本发明提供了新型β-内酰胺酶抑制剂,其在结构上与目前可获得的天然产物和半合成β-内酰胺酶抑制剂无关,并且不需要β-内酰胺药效团。 本发明还提供用于抑制细菌生长的药物组合物和方法。
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公开(公告)号:US07514556B2
公开(公告)日:2009-04-07
申请号:US11830305
申请日:2007-07-30
IPC分类号: C07F9/142
CPC分类号: C07F9/2491 , C07F9/3808 , C07F9/4006 , C07F9/4084 , C07F9/425 , C07F9/4407 , C07F9/572 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/6506 , C07F9/6524 , C07F9/65312 , C07F9/6539 , C07F9/65395 , C07F9/6541 , C07F9/65515 , C07F9/65517 , C07F9/655345 , C07F9/655354 , C07F9/65583 , C07F9/65586
摘要: The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic β-lactamase inhibitors presently available, and which do not require a β-lactam pharmacophore. The invention also provides pharmaceutical compositions and methods for inhibiting bacterial growth.
摘要翻译: 意图涉及细菌抗生素抗性,特别涉及克服细菌抗生素抗性的组合物和方法。 本发明提供了新型β-内酰胺酶抑制剂,其在结构上与目前可获得的天然产物和半合成β-内酰胺酶抑制剂无关,并且不需要β-内酰胺药效团。 本发明还提供用于抑制细菌生长的药物组合物和方法。
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公开(公告)号:US06884791B2
公开(公告)日:2005-04-26
申请号:US10302124
申请日:2002-11-22
IPC分类号: C07F9/24 , C07F9/38 , C07F9/40 , C07F9/42 , C07F9/44 , C07F9/572 , C07F9/58 , C07F9/60 , C07F9/6506 , C07F9/6524 , C07F9/653 , C07F9/6539 , C07F9/6541 , C07F9/655 , C07F9/6553 , C07F9/6558 , A61K31/662 , A61K31/66 , A61P31/04
CPC分类号: C07F9/2491 , C07F9/3808 , C07F9/4006 , C07F9/4084 , C07F9/425 , C07F9/4407 , C07F9/572 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/6506 , C07F9/6524 , C07F9/65312 , C07F9/6539 , C07F9/65395 , C07F9/6541 , C07F9/65515 , C07F9/65517 , C07F9/655345 , C07F9/655354 , C07F9/65583 , C07F9/65586
摘要: The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic β-lactamase inhibitors presently available, and which do not require a β-lactam pharmacophore. The invention also provides pharmaceutical compositions and methods for inhibiting bacterial growth.
摘要翻译: 意图涉及细菌抗生素抗性,特别涉及克服细菌抗生素抗性的组合物和方法。 本发明提供了新型β-内酰胺酶抑制剂,其在结构上与目前可获得的天然产物和半合成β-内酰胺酶抑制剂无关,并且不需要β-内酰胺药效团。 本发明还提供用于抑制细菌生长的药物组合物和方法。
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公开(公告)号:US07205285B2
公开(公告)日:2007-04-17
申请号:US10628649
申请日:2003-07-28
申请人: Jeffrey M. Besterman , Jubrail Rahil , Rex Pratt
发明人: Jeffrey M. Besterman , Jubrail Rahil , Rex Pratt
CPC分类号: C07F9/65744 , C07F9/096 , C07F9/098 , C07F9/4093 , C07F9/657181 , C07F9/65742
摘要: The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic β-lactamase inhibitors presently available, and which do not possess a β-lactam pharmacophore. These new inhibitors are fully synthetic, allowing ready access to a wide variety of structurally related analogs. Certain embodiments of these new inhibitors also bind bacterial DD-peptidases, thus potentially acting both as β-lactamase inhibitors and as antibiotics.
摘要翻译: 本发明提供了新型β-内酰胺酶抑制剂,其在结构上与目前可获得的天然产物和半合成β-内酰胺酶抑制剂无关,并且不具有β-内酰胺药效团。 这些新的抑制剂是完全合成的,可以方便地访问各种结构相关的类似物。 这些新抑制剂的某些实施方案也结合细菌DD-肽酶,因此潜在地作为β-内酰胺酶抑制剂和抗生素起作用。
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公开(公告)号:US06608046B1
公开(公告)日:2003-08-19
申请号:US09582255
申请日:2000-09-01
申请人: Jeffrey M. Besterman , Jubrail Rahil , Rex Pratt
发明人: Jeffrey M. Besterman , Jubrail Rahil , Rex Pratt
IPC分类号: A61K31661
CPC分类号: C07F9/4093 , C07F9/096 , C07F9/098 , C07F9/657181 , C07F9/65742 , C07F9/65744
摘要: The invention provides novel &bgr;-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic &bgr;-lactamase inhibitors presently available, and which do not possess &bgr;-lactam pharmacophore. These new inhibitors are fully synthetic, allowing ready access to a wide variety of structurally related analogs. Certain embodiments of these new inhibitors also bind bacterial DD-peptidases, thus potentially acting both as &bgr;-lactamase inhibitors and as antibiotics.
摘要翻译: 本发明提供新颖的β-内酰胺酶抑制剂,其在结构上与目前可获得的天然产物和半合成β-内酰胺酶抑制剂无关,并且不具有β-内酰胺药效团。 这些新的抑制剂是完全合成的,可以方便地访问各种结构相关的类似物。 这些新抑制剂的某些实施方案也结合细菌DD-肽酶,因此潜在地作为β-内酰胺酶抑制剂和抗生素起作用。
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公开(公告)号:US07030103B2
公开(公告)日:2006-04-18
申请号:US10266213
申请日:2002-10-08
IPC分类号: C07F9/40 , C07F9/44 , A61K31/662 , A61K31/67 , A61K31/664
CPC分类号: C07F9/655354 , C07F9/2491 , C07F9/3808 , C07F9/4006 , C07F9/425 , C07F9/4407 , C07F9/572 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/6539 , C07F9/65395 , C07F9/6541 , C07F9/65515 , C07F9/65517 , C07F9/655345
摘要: The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic β-lactamase inhibitors presently available, and which do not require a β-lactam pharmacophore. The invention also provides pharmaceutical compositions and methods for inhibiting bacterial growth.
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公开(公告)号:US06472406B1
公开(公告)日:2002-10-29
申请号:US09610456
申请日:2000-07-05
IPC分类号: C07F940
CPC分类号: C07F9/655354 , C07F9/2491 , C07F9/3808 , C07F9/4006 , C07F9/425 , C07F9/4407 , C07F9/572 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/6539 , C07F9/65395 , C07F9/6541 , C07F9/65515 , C07F9/65517 , C07F9/655345
摘要: The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel &bgr;-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic &bgr;-lactamase inhibitors presently available, and which do not require a &bgr;-lactam pharmacophore. The invention also provides pharmaceutical compositions and methods for inhibiting bacterial growth.
摘要翻译: 意图涉及细菌抗生素抗性,特别涉及克服细菌抗生素抗性的组合物和方法。 本发明提供了新型β-内酰胺酶抑制剂,其在结构上与目前可获得的天然产物和半合成β-内酰胺酶抑制剂无关,并且不需要β-内酰胺药效团。 本发明还提供用于抑制细菌生长的药物组合物和方法。
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公开(公告)号:US20080132525A1
公开(公告)日:2008-06-05
申请号:US11566441
申请日:2006-12-04
申请人: Amal Wahhab , Jeffrey M. Besterman , Daniel Delorme , Isakovic Ljubomir , David Llewellyn , Jubrail Rahil , Oscar Saavedra , Robert Deziel
发明人: Amal Wahhab , Jeffrey M. Besterman , Daniel Delorme , Isakovic Ljubomir , David Llewellyn , Jubrail Rahil , Oscar Saavedra , Robert Deziel
IPC分类号: A61K31/52 , A61K31/44 , A61P35/00 , C07D471/02 , C07D473/00
CPC分类号: C07D487/04 , C07D471/04 , C07D473/34
摘要: The invention relates to the inhibition of DNA methyltransferase isoforms DNMT1 and DNMT3b2. The invention provides compounds and methods for inhibiting DNMT1 and DNMT3b2.
摘要翻译: 本发明涉及DNA甲基转移酶同工型DNMT1和DNMT3b2的抑制。 本发明提供了抑制DNMT1和DNMT3b2的化合物和方法。
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公开(公告)号:US06599889B2
公开(公告)日:2003-07-29
申请号:US09797308
申请日:2001-03-01
申请人: Jeffrey M. Besterman , Jubrail Rahil , Rex Pratt
发明人: Jeffrey M. Besterman , Jubrail Rahil , Rex Pratt
IPC分类号: A61K3167
CPC分类号: C07F9/65744 , C07F9/096 , C07F9/098 , C07F9/4093 , C07F9/657181 , C07F9/65742
摘要: The invention provides novel &bgr;-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic &bgr;-lactamase inhibitors presently available, and which do not possess a &bgr;-lactam pharmacophore. These new inhibitors are fully synthetic, allowing ready access to a wide variety of structurally related analogs. Certain embodiments of these new inhibitors also bind bacterial DD-peptidases, thus potentially acting both as &bgr;-lactamase inhibitors and as antibiotics.
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