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1.发明申请公开(公告)号：US20130238021A1
公开(公告)日：2013-09-12
申请号：US13695039
申请日：2011-04-29
CPC分类号： A61B17/06166 , A61B17/0644 , A61B2017/00526 , A61B2017/0417 , A61B2017/0427 , A61B2017/06038 , A61B2017/06176 , A61L17/00 , B26D7/01 , D02J3/02 , Y10T83/051 , Y10T83/748
摘要： A self-retaining suture has a suture thread less than 1 millimeter nominal diameter. A plurality of retainers is cut into the suture thread using a high accuracy retainer cutting machine. The retainer cutting machine has sufficient accuracy and repeatability to cut consistent and effective retainers at high density on suture threads less than 1 mm nominal diameter.
摘要翻译： 自固位缝合线具有小于1毫米公称直径的缝线。 使用高精度保持器切割机将多个保持器切割成缝合线。 保持切割机具有足够的精度和重复性，可以在小于1mm公称直径的缝合线上以高密度切割一致且有效的保持器。
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公开(公告)号：US20130180966A1
公开(公告)日：2013-07-18
申请号：US13695112
申请日：2011-05-04
申请人： Jeffrey M. Gross , William L. D'Agostino , Lev Drubetsky , Alexander Naimagon , Jacob D. Conner , Kevin R. Whitworth , Ryan T. Woolsey , Fred M. Dickey
发明人： Jeffrey M. Gross , William L. D'Agostino , Lev Drubetsky , Alexander Naimagon , Jacob D. Conner , Kevin R. Whitworth , Ryan T. Woolsey , Fred M. Dickey
摘要： A laser-machining system and method is disclosed for forming retainers on a suture thread. The laser system is preferably a femtosecond laser system which is capable of creating submicron features on the suture thread while preserving strength of the suture thread. The laser-machining system enables creation of retainers and self-retaining suture systems in configurations which are difficult and/or impossible to achieve using mechanical cutting technology.
摘要翻译： 公开了一种用于在缝合线上形成保持器的激光加工系统和方法。 激光系统优选是飞秒激光系统，其能够在保持缝合线的强度的同时在缝合线上产生亚微米特征。 激光加工系统能够在使用机械切割技术难以和/或不可能实现的结构中创建保持器和自固位缝合系统。
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公开(公告)号：US10420546B2
公开(公告)日：2019-09-24
申请号：US13695089
申请日：2011-05-04
IPC分类号： A61B17/06 , A61B17/04 , A61B17/064 , A61B17/00 , B23K26/06 , B23K26/08 , B23K26/14 , B23K26/361 , B23K26/03 , B23K26/362 , B23K37/04 , A61B90/00
摘要： Self-retaining suture systems including a suture thread bearing a plurality of laser-cut retainers are disclosed. A laser system allows the creation of retainers and self-retaining suture systems in configurations which are difficult and/or impossible to achieve using mechanical cutting technology.
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公开(公告)号：US20130238022A1
公开(公告)日：2013-09-12
申请号：US13695089
申请日：2011-05-04
IPC分类号： A61B17/04
摘要： Self-retaining suture systems including a suture thread bearing a plurality of laser-cut retainers are disclosed. A laser system allows the creation of retainers and self-retaining suture systems in configurations which are difficult and/or impossible to achieve using mechanical cutting technology.
摘要翻译： 公开了包括具有多个激光切割保持器的缝合线的自固定缝线系统。 激光系统允许在使用机械切割技术难以和/或不可能实现的构造中创建保持器和自固位缝合系统。
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公开(公告)号：US11007296B2
公开(公告)日：2021-05-18
申请号：US13883066
申请日：2011-11-03
申请人： Jeffrey M. Gross , Lev Drubetsky , Alexander Naimagon , Rui Avelar , William L. D'Agostino , Kevin Don Nelson , Brent B. Crow , Nickolas B. Griffin
发明人： Jeffrey M. Gross , Lev Drubetsky , Alexander Naimagon , Rui Avelar , William L. D'Agostino , Kevin Don Nelson , Brent B. Crow , Nickolas B. Griffin
摘要： A drug-eluting self-retaining suture comprises a filament, a plurality of retainers, and a drug impregnated in or coated on the filament. The shape and distribution of retainers modifies the in vivo release kinetics of the drug. The drug release kinetics may be modified uniformly or region by region. The self-retaining suture may for example be used for reattaching severed nerves and release nerve growth factor or other regeneration accelerating agents into the region of the nerve injury.
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公开(公告)号：US20130317545A1
公开(公告)日：2013-11-28
申请号：US13883066
申请日：2011-11-03
申请人： Jeffrey M. Gross , Lev Drubetsky , Alexander Naimagon , Rui Avelar , William L. D'Agostino , Kevin Don Nelson , Brent B. Crow , Nickolas B. Griffin
发明人： Jeffrey M. Gross , Lev Drubetsky , Alexander Naimagon , Rui Avelar , William L. D'Agostino , Kevin Don Nelson , Brent B. Crow , Nickolas B. Griffin
CPC分类号： A61L17/005 , A61B17/0401 , A61B2017/00526 , A61B2017/00893 , A61B2017/06057 , A61B2017/0608 , A61B2017/06176 , A61L2300/414 , A61L2300/602 , A61L2430/32
摘要： A drug-eluting self-retaining suture comprises a filament, a plurality of retainers, and a drug impregnated in or coated on the filament. The shape and distribution of retainers modifies the in vivo release kinetics of the drug. The drug release kinetics may be modified uniformly or region by region. The self-retaining suture may for example be used for reattaching severed nerves and release nerve growth factor or other regeneration accelerating agents into the region of the nerve injury.
摘要翻译： 药物洗脱自固位缝合线包括长丝，多个保持器和浸渍在或涂覆在丝上的药物。 保持器的形状和分布改变了药物的体内释放动力学。 药物释放动力学可以均匀地或逐个区域地修饰。 自固位缝线可以例如用于重新连接切断的神经并将神经生长因子或其他再生促进剂释放到神经损伤的区域中。
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公开(公告)号：US08118834B1
公开(公告)日：2012-02-21
申请号：US12340530
申请日：2008-12-19
申请人： Alexei Goraltchouk , Alexander Naimagon , Gerald F. Cummings , Lev Drubetsky , Robert A. Herrmann
发明人： Alexei Goraltchouk , Alexander Naimagon , Gerald F. Cummings , Lev Drubetsky , Robert A. Herrmann
IPC分类号： A61B17/04
CPC分类号： A61B17/06166 , A61B2017/00004 , A61B2017/00858 , A61B2017/06057 , A61B2017/06176
摘要： A self-retaining suture comprises a composite filament. The filament has retainers on the surface such that the filament can engage and retain tissue without knots. The filament comprises at least two materials having different properties. A surface material of the filament has properties which enhance the formation, elevation and/or deployment of the retainers. A core material of the filament has properties which enhance the tensile strength of the filament. The surgical filament is thin and flexible and may be used for suturing. Methods for manufacturing the filament and retainers are also described.
摘要翻译： 自固位缝合线包括复合长丝。 灯丝在表面上具有保持器，使得灯丝可以接合并保持组织而不发出结。 长丝包含至少两种具有不同性质的材料。 长丝的表面材料具有增强保持器的形成，升高和/或展开的性质。 长丝的芯材具有提高长丝抗拉强度的性质。 外科手术细丝薄而柔软，可用于缝合。 还描述了制造丝和保持器的方法。
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公开(公告)号：US20110046668A1
公开(公告)日：2011-02-24
申请号：US12808081
申请日：2008-12-19
申请人： Alexei Goraltchouk , Lev Drubetsky , Gerald F. Cummings , Robert A. Herrmann , Alexander Naimagon
发明人： Alexei Goraltchouk , Lev Drubetsky , Gerald F. Cummings , Robert A. Herrmann , Alexander Naimagon
CPC分类号： A61B17/06166 , A61B2017/00526 , A61B2017/06176 , A61B2017/0619
摘要： Provided herein are sutures to be used in a procedure applied to tissue, and methods for forming such sutures. A suture can include an elongated suture body and a plurality of heat-contact mediated retainers extending from and along the elongated suture body. The heat-contact mediated retainers can be formed by temporarily contacting the elongated suture body with one or more heated element.
摘要翻译： 本文提供了用于施用于组织的程序中的缝线以及用于形成这种缝合线的方法。 缝合线可以包括细长的缝线体和从细长的缝合线本体延伸的多个热接触介质保持器。 热接触介质的保持器可以通过将细长缝合线体与一个或多个加热元件暂时接触而形成。
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公开(公告)号：US09044225B1
公开(公告)日：2015-06-02
申请号：US13349231
申请日：2012-01-12
申请人： Alexei Goraltchouk , Alexander Naimagon , Gerald F. Cummings , Lev Drubetsky , Robert A. Herrmann
发明人： Alexei Goraltchouk , Alexander Naimagon , Gerald F. Cummings , Lev Drubetsky , Robert A. Herrmann
CPC分类号： A61B17/06166 , A61B2017/00004 , A61B2017/00858 , A61B2017/06057 , A61B2017/06176
摘要： A self-retaining suture comprises a composite filament. The filament has retainers on the surface such that the filament can engage and retain tissue without knots. The filament comprises at least two materials having different properties. A surface material of the filament has properties which enhance the formation, elevation and/or deployment of the retainers. A core material of the filament has properties which enhance the tensile strength of the filament. The surgical filament is thin and flexible and may be used for suturing. Methods for manufacturing the filament and retainers are also described.
摘要翻译： 自固位缝合线包括复合长丝。 灯丝在表面上具有保持器，使得灯丝可以接合并保持组织而不发出结。 长丝包含至少两种具有不同性质的材料。 长丝的表面材料具有增强保持器的形成，升高和/或展开的性质。 长丝的芯材具有提高长丝抗拉强度的性质。 外科手术细丝薄而柔软，可用于缝合。 还描述了制造丝和保持器的方法。
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10.发明授权Self-retaining sutures with bi-directional retainers or uni-directional retainers 有权带双向保持器或单向保持器的自固定缝合线公开(公告)号：US08876865B2
公开(公告)日：2014-11-04
申请号：US12937776
申请日：2009-04-14
申请人： Alexei Goraltchouk , Lev Drubetsky , Gerald F. Cummings , Robert A. Herrmann , Alexander Naimagon
发明人： Alexei Goraltchouk , Lev Drubetsky , Gerald F. Cummings , Robert A. Herrmann , Alexander Naimagon
CPC分类号： A61B17/06166 , A61B17/08 , A61B2017/00526 , A61B2017/06176 , A61B2017/081
摘要： Provided herein are sutures for use in a procedure applied to tissue, and methods for forming such sutures. Some sutures include bi-directional retainers, each of which can be deployed in two directions, but once deployed in one direction, resist motion in the opposite direction. Other sutures include uni-directional retainers that are conical in shape, and include tissue engaging protrusions that extend from edges and/or angled walls of the conical retainers.
摘要翻译： 本文提供了用于在组织中施用的步骤的缝合线以及用于形成这种缝合线的方法。 一些缝合线包括双向保持器，每个保持器可以在两个方向上展开，但是一旦沿一个方向展开，则抵抗相反方向的运动。 其他缝合线包括形状为圆锥形的单向保持器，并且包括从锥形保持器的边缘和/或成角度的壁延伸的组织接合突起。
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