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1.发明申请Compositions And Methods For The Diagnosis, Treatment, And Prevention Of Amyotrophic Lateral Sclerosis And Related Neurological Diseases 有权肌萎缩性侧索硬化症及相关神经系统疾病诊断，治疗及预防的组成及方法公开(公告)号：US20100152125A1
公开(公告)日：2010-06-17
申请号：US12532309
申请日：2008-03-20
IPC分类号： A61K31/7034 , C12Q1/02 , A61K31/195 , A61K31/343 , A61K31/55 , A61K31/4015 , A61K31/4709 , A61K31/415 , A61K31/416 , A61K31/4439 , A61K31/15 , C07H21/00 , C12N5/00 , C07C381/00 , C07D307/78 , C07D223/04 , C07D207/18 , C07H15/00 , C07D413/14 , C07D407/02 , C07D231/56 , C07D231/10 , C07D401/02 , C07C243/12 , C07D209/04 , A61P25/28
CPC分类号： A61K31/16 , A61K31/35 , A61K31/4015 , A61K31/404 , A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/4402 , A61K31/4439 , A61K31/517 , A61K31/55 , A61K31/63 , A61K31/635 , G01N33/6896 , G01N2500/10 , G01N2800/28
摘要： One aspect of the invention relates to a method of treating or preventing a neurodegenerative disease, comprising the step of administering to a patient in need thereof a therapeutically effective amount of an inhibitor of the formation of advanced glycation end products. Another aspect of the invention relates to a proteasome activity-based screening assay to select compounds which may be useful for treating or preventing a neurodegenerative disease, and the materials used therein. Yet another aspect of the invention relates to molecules, and methods of use thereof, which bind at or adjacent to SOD-I Trp32, including molecules that bind in a site adjacent to SOD-I Trp32 whether or not it is oxidized, for treating or preventing neurodegenerative disease.
摘要翻译： 本发明的一个方面涉及一种治疗或预防神经变性疾病的方法，其包括向有需要的患者施用治疗有效量的形成晚期糖基化终产物的抑制剂的步骤。 本发明的另一方面涉及基于蛋白酶体活性的筛选测定法，以选择可用于治疗或预防神经变性疾病的化合物及其中使用的材料。 本发明的另一方面涉及在SOD-1 Trp32或其附近结合的分子及其使用方法，包括在与SOD-1 Trp32相邻的位点中结合的分子，无论其是否被氧化，用于治疗或 预防神经变性疾病。
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2.发明授权Compositions and methods for the diagnosis, treatment, and prevention of amyotrophic lateral sclerosis and related neurological diseases 有权用于诊断，治疗和预防肌萎缩性侧索硬化症及相关神经系统疾病的组合物和方法公开(公告)号：US08609649B2
公开(公告)日：2013-12-17
申请号：US12532309
申请日：2008-03-20
IPC分类号： A61K31/7034 , A61K31/195 , A61K31/343 , A61K31/55 , A61K31/4015 , A61K31/4709 , A61K31/415 , A61K31/416 , A61K31/4439 , A61K31/15
CPC分类号： A61K31/16 , A61K31/35 , A61K31/4015 , A61K31/404 , A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/4402 , A61K31/4439 , A61K31/517 , A61K31/55 , A61K31/63 , A61K31/635 , G01N33/6896 , G01N2500/10 , G01N2800/28
摘要： One aspect of the invention relates to a method of treating or preventing a neurodegenerative disease, comprising the step of administering to a patient in need thereof a therapeutically effective amount of an inhibitor of the formation of advanced glycation end products. Another aspect of the invention relates to a proteasome activity-based screening assay to select compounds which may be useful for treating or preventing a neurodegenerative disease, and the materials used therein. Yet another aspect of the invention relates to molecules, and methods of use thereof, which bind at or adjacent to SOD-I Trp32, including molecules that bind in a site adjacent to SOD-I Trp32 whether or not it is oxidized, for treating or preventing neurodegenerative disease.
摘要翻译： 本发明的一个方面涉及一种治疗或预防神经变性疾病的方法，其包括向有需要的患者施用治疗有效量的形成晚期糖基化终产物的抑制剂的步骤。 本发明的另一方面涉及基于蛋白酶体活性的筛选测定法，以选择可用于治疗或预防神经变性疾病的化合物及其中使用的材料。 本发明的另一方面涉及在SOD-1 Trp32或其附近结合的分子及其使用方法，包括在与SOD-1 Trp32相邻的位点中结合的分子，无论其是否被氧化，用于治疗或 预防神经变性疾病。
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公开(公告)号：US08945941B2
公开(公告)日：2015-02-03
申请号：US12302126
申请日：2007-05-24
CPC分类号： G01N1/30 , G01N1/312 , G01N33/4833 , G01N2001/305 , H01J49/0004 , Y10T436/24 , Y10T436/25
摘要： Aspects of the present invention relate to a method for the preparation of samples for MALDI MS imaging. Certain embodiments relate to a method of matrix deposition for samples, wherein tissue sections are prepared via a synergistic combination of fixation with matrix. In certain embodiments, tissue is fixed with cold solvent, according to well-established histology protocols, and in the presence of matrix, allowing for high resolution spatial mapping of protein, lipid, sugar, and/or nucleic acid distribution. In certain embodiments, the present invention relates to fixation with matrix of whole organisms. In certain embodiments, animals are perfused with fixation and matrix mixtures, which allows for direct mass spectrometry analysis.
摘要翻译： 本发明的方面涉及用于制备用于MALDI MS成像的样品的方法。 某些实施方案涉及用于样品的基质沉积方法，其中通过固定与基质的协同组合来制备组织切片。 在某些实施方案中，根据公认的组织学方案，并在基质的存在下，用冷溶剂固定组织，允许蛋白质，脂质，糖和/或核酸分布的高分辨率空间映射。 在某些实施方案中，本发明涉及用整个生物体的基质固定。 在某些实施方案中，用固定和基质混合物灌注动物，其允许直接质谱分析。
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公开(公告)号：US20090325222A1
公开(公告)日：2009-12-31
申请号：US12302126
申请日：2007-05-24
IPC分类号： G01N33/48
CPC分类号： G01N1/30 , G01N1/312 , G01N33/4833 , G01N2001/305 , H01J49/0004 , Y10T436/24 , Y10T436/25
摘要： Aspects of the present invention relate to a method for the preparation of samples for MALDI MS imaging. Certain embodiments relate to a method of matrix deposition for samples, wherein tissue sections are prepared via a synergistic combination of fixation with matrix. In certain embodiments, tissue is fixed with cold solvent, according to well-established histology protocols, and in the presence of matrix, allowing for high resolution spatial mapping of protein, lipid, sugar, and/or nucleic acid distribution. In certain embodiments, the present invention relates to fixation with matrix of whole organisms. In certain embodiments, animals are perfused with fixation and matrix mixtures, which allows for direct mass spectrometry analysis.
摘要翻译： 本发明的方面涉及用于制备用于MALDI MS成像的样品的方法。 某些实施方案涉及用于样品的基质沉积方法，其中通过固定与基质的协同组合来制备组织切片。 在某些实施方案中，根据公认的组织学方案，并在基质的存在下，用冷溶剂固定组织，允许蛋白质，脂质，糖和/或核酸分布的高分辨率空间映射。 在某些实施方案中，本发明涉及用整个生物体的基质固定。 在某些实施方案中，用固定和基质混合物灌注动物，其允许直接质谱分析。
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公开(公告)号：US20120134978A1
公开(公告)日：2012-05-31
申请号：US13375886
申请日：2010-06-02
申请人： Jeffrey N. Agar
发明人： Jeffrey N. Agar
CPC分类号： C12Y115/01001 , C12N9/0089
摘要： A stabilized superoxide dismutase (SOD1) analogue, wherein the side chains of two amino acids on two different SOD1 monomers are connected is provided. A method of producing a stabilized superoxide disumutase (SOD1) analogue comprises reacting a first SOD1 monomer, a second SOD1 monomer, and a cross-linker.
摘要翻译： 提供稳定的超氧化物歧化酶（SOD1）类似物，其中两个不同SOD1单体上的两个氨基酸的侧链连接。 制备稳定的超氧化物歧化酶（SOD1）类似物的方法包括使第一SOD1单体，第二SOD1单体和交联剂反应。
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