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公开(公告)号：US20140212504A1
公开(公告)日：2014-07-31
申请号：US14243639
申请日：2014-04-02
IPC分类号： A61K9/16 , A61K31/496 , A61K31/7048 , A61K38/29 , A61K45/06 , A61K31/58 , A61K31/465 , A61K31/7036 , A61K9/00
CPC分类号： A61K9/1617 , A61K9/0075 , A61K9/008 , A61K9/0082 , A61K9/10 , A61K9/14 , A61K9/1611 , A61K9/1694 , A61K31/465 , A61K31/496 , A61K31/58 , A61K31/7036 , A61K31/7048 , A61K38/29 , A61K45/06 , A61K47/02 , A61K47/24 , A61M15/0065 , A61M2205/3306
摘要： Phospholipid based powders for drug delivery applications are disclosed. The powders comprise a polyvalent cation in an amount effective to increase the gel-to-liquid crystal transition temperature of the particle compared to particles without the polyvalent cation. The powders are hollow and porous and are preferably administered via inhalation.
摘要翻译： 公开了用于药物递送应用的基于磷脂的粉末。 与没有多价阳离子的颗粒相比，粉末包含有效增加颗粒的凝胶 - 液晶的转变温度的多价阳离子。 粉末是中空的和多孔的，并且优选通过吸入给药。
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公开(公告)号：US20090047358A1
公开(公告)日：2009-02-19
申请号：US12258163
申请日：2008-10-24
IPC分类号： A61K9/14 , A61K38/21 , A61K31/58 , A61K31/7036 , A61P43/00 , F26B3/06 , A61K31/137 , A61K38/28 , A61K31/351
CPC分类号： A61K9/0075 , A61K9/008 , A61K9/0082 , A61K9/10 , A61K9/1611 , A61K9/1617 , A61K9/1694 , A61K38/29 , A61K47/02 , A61M15/0065 , A61M2205/3306
摘要： Phospholipid based powders for drug delivery applications are disclosed. The powders comprise a polyvalent cation in an amount effective to increase the gel-to-liquid crystal transition temperature of the particle compared to particles without the polyvalent cation. The powders are hollow and porous and are preferably administered via inhalation.
摘要翻译： 公开了用于药物递送应用的基于磷脂的粉末。 与没有多价阳离子的颗粒相比，粉末包含有效增加颗粒的凝胶 - 液晶的转变温度的多价阳离子。 粉末是中空的和多孔的，并且优选通过吸入给药。
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3.发明申请STABLE METAL ION-LIPID POWDERED PHARMACEUTICAL COMPOSITIONS FOR DRUG DELIVERY 有权稳定的金属离子粉末药物组合物用于药物递送公开(公告)号：US20130095153A1
公开(公告)日：2013-04-18
申请号：US13707563
申请日：2012-12-06
IPC分类号： A61K47/24
CPC分类号： A61K9/1617 , A61K9/0075 , A61K9/008 , A61K9/0082 , A61K9/10 , A61K9/14 , A61K9/1611 , A61K9/1694 , A61K31/465 , A61K31/496 , A61K31/58 , A61K31/7036 , A61K31/7048 , A61K38/29 , A61K45/06 , A61K47/02 , A61K47/24 , A61M15/0065 , A61M2205/3306
摘要： A microparticle for drug delivery comprises an active agent and an excipient, the excipient comprising a metal ion-lipid complex. The metal ion is chosen from the group consisting of lanthanide metals, actinide metals, group IIa and IIIb metals, transition metals or mixtures thereof. The lipid comprises a phospholipid. The complex results in a glass transition temperature increase of the microparticle.
摘要翻译： 用于药物递送的微粒包括活性剂和赋形剂，所述赋形剂包含金属离子 - 脂质复合物。 金属离子选自镧系金属，锕系金属，IIa族和IIIb族金属，过渡金属或其混合物。 脂质包含磷脂。 复合物导致微粒的玻璃化转变温度升高。
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4.发明申请STABLE METAL ION-LIPID POWDERED PHARMACEUTICAL COMPOSITIONS FOR DRUG DELIVERY 审中-公开稳定的金属离子粉末药物组合物用于药物递送公开(公告)号：US20140377361A1
公开(公告)日：2014-12-25
申请号：US14478573
申请日：2014-09-05
IPC分类号： A61K9/16 , A61K31/7036 , A61K31/496 , A61K9/14
CPC分类号： A61K9/1617 , A61K9/0075 , A61K9/008 , A61K9/0082 , A61K9/10 , A61K9/14 , A61K9/1611 , A61K9/1694 , A61K31/465 , A61K31/496 , A61K31/58 , A61K31/7036 , A61K31/7048 , A61K38/29 , A61K45/06 , A61K47/02 , A61K47/24 , A61M15/0065 , A61M2205/3306
摘要： A microparticle for drug delivery comprises an active agent and an excipient, the excipient comprising a metal ion-lipid complex. The metal ion is chosen from the group consisting of lanthanide metals, actinide metals, group IIa and IIIb metals, transition metals or mixtures thereof. The lipid comprises a phospholipid. The complex results in a glass transition temperature increase of the microparticle.
摘要翻译： 用于药物递送的微粒包括活性剂和赋形剂，所述赋形剂包含金属离子 - 脂质复合物。 金属离子选自镧系金属，锕系金属，IIa族和IIIb族金属，过渡金属或其混合物。 脂质包含磷脂。 复合物导致微粒的玻璃化转变温度升高。
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公开(公告)号：US20100329984A1
公开(公告)日：2010-12-30
申请号：US12875966
申请日：2010-09-03
IPC分类号： A61K49/00 , A61K9/14 , A61P25/00 , A61P29/00 , A61P11/08 , A61P37/08 , A61P11/00 , A61P31/00 , A61P35/00 , A61P9/00
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： A respiratory dispersion for pulmonary delivery comprises one or more bioactive agents, a suspension medium, and a plurality of perforated microstructures having a mean aerodynamic diameter of less than 5 μm. The suspension medium comprises at least one propellant and permeates the perforated microstructures.
摘要翻译： 用于肺部递送的呼吸分散体包含平均空气动力学直径小于5μm的一种或多种生物活性剂，悬浮介质和多个穿孔微结构。 悬浮介质包括至少一种推进剂并渗透穿孔微结构。
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公开(公告)号：US20140206638A1
公开(公告)日：2014-07-24
申请号：US14247546
申请日：2014-04-08
IPC分类号： A61K31/7036 , A61K9/00 , A61K9/16
CPC分类号： A61K9/0075 , A61K9/1617 , A61K31/7036
摘要： The present invention is directed to the administration of aminoglycosides. In particular, the present invention is directed to compositions and methods for the pulmonary administration of aminoglycosides. According to a preferred embodiment, compositions and methods are provided for the localized treatment of respiratory infections.
摘要翻译： 本发明涉及氨基糖苷类的施用。 特别地，本发明涉及用于肺部给予氨基糖苷类的组合物和方法。 根据优选的实施方案，提供组合物和方法用于呼吸道感染的局部治疗。
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公开(公告)号：US20180303753A1
公开(公告)日：2018-10-25
申请号：US15758643
申请日：2016-09-07
申请人： Keith Try UNG , Jeffry G. WEERS , Daniel HUANG , Nagaraja RAO , Yoen-Ju SON
发明人： Keith Try UNG , Jeffry G. WEERS , Daniel HUANG , Nagaraja RAO , Yoen-Ju SON
CPC分类号： A61K9/0075 , A61K9/1617 , A61K9/1682 , A61K9/1688 , A61K38/2221 , A61K39/0011 , A61K39/395 , A61K2039/5158 , A61K2039/55522
摘要： Disclosed are inhalation formulations of dry powders comprising particles and processes which yield particles to effectively bypass unwanted deposition in the mouth and throat. Embodiments of the invention are characterized by an inertial parameter which provide an in vitro total lung dose of greater than 80% of a nominal dose. Embodiments of formulations include neat formulations containing active agent only; formulations of active agent and buffer; and formulations comprising active agent, a glass-forming, and/or a shell-forming excipient. Also provided are methods for making the dry powder formulations. The powder formulations are useful for the treatment of diseases and conditions especially respiratory diseases and conditions.
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