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26 条记录 (耗时 0.026 秒)

    Stable reverse and multiple fluorocarbon emulsions
    7.
    发明授权
    Stable reverse and multiple fluorocarbon emulsions 失效
    稳定的反向和多氟碳乳液

    公开(公告)号：US5904933A

    公开(公告)日：1999-05-18

    申请号：US478824

    申请日：1995-06-07

    申请人： Jean G. Riess ,  Marie-Pierre Krafft

    发明人： Jean G. Riess ,  Marie-Pierre Krafft

    IPC分类号： A61K9/107 ,  A61K9/00 ,  A61K9/113 ,  A61K47/06 ,  B01J13/00 ,  A61K9/127

    CPC分类号： A61K9/0026 ,  A61K9/113 ,  B01F2003/0838 ,  Y10S514/832 ,  Y10S514/937 ,  Y10S514/938

    摘要： Stable reverse water-in-fluorocarbon emulsions and water-in-fluorocarbon-in-water multiple emulsions comprising the reverse fluorocarbon emulsions. The reverse emulsions comprise a continuous phase which is a highly fluorinated or perfluorinated compound, a discontinuous aqueous phase and a fluorinated surfactant or mixture of surfactants. The multiple emulsions comprise an aqueous continuous phase and a discontinuous phase comprising globules formed of aqueous droplets dispersed into a highly fluorinated or perfluorinated compound. The emulsions can contain pharmacologically active agents, and are particularly suitable for pulmonary drug delivery.

    摘要翻译： 包含反向碳氟化合物乳液的稳定的反向含氟碳乳液和含氟碳水化合物的多重乳液。 反向乳液包括连续相，其是高度氟化或全氟化合物，不连续水相和氟化表面活性剂或表面活性剂的混合物。 多重乳液包含水性连续相和不连续相，其包含由分散在高度氟化或全氟化合物中的水性液滴形成的小球。 乳剂可以含有药理活性剂，特别适用于肺部药物递送。

    Iodine-containing fluorocarbon contrast agents
    10.
    发明授权
    Iodine-containing fluorocarbon contrast agents 失效
    含碘碳氟造影剂

    公开(公告)号：US5582813A

    公开(公告)日：1996-12-10

    申请号：US188396

    申请日：1994-01-27

    申请人： Jean G. Riess ,  Leila Zarif ,  Veronique Sanches ,  Jacques Greiner

    发明人： Jean G. Riess ,  Leila Zarif ,  Veronique Sanches ,  Jacques Greiner

    IPC分类号： A61K49/04 ,  A61K51/12 ,  B01J13/00

    CPC分类号： A61K49/0461 ,  A61K2123/00 ,  Y10S514/938

    摘要： The present invention relates to nonterminally iodinated fluorinated compositions. The compositions, including, dispersions, emulsions, microemulsions, and gels are useful for biomedical applications, particularly radiography and scintigraphy. The compounds used in the invention preferably have the following general formula:R.sub.F CH.dbd.CIR.sup.1wherein,R.sub.F is a linear, branched, or cyclic first fluorocarbon radical, having 2 to 12 carbon atoms in which 50 to 100% of the hydrogen atoms have been replaced by fluorine atoms; andR.sup.1 is selected from the group consisting of a second fluorocarbon radical and a hydrocarbon radical, wherein,the second fluorocarbon radical is linear, branched, or cyclic, having 2 to 12 carbon atoms in which 50 to 100% of the hydrogen atoms have been replaced by fluorine atoms; andthe hydrocarbon radical is linear, branched, or cyclic, having 2 to 14 carbon atoms.

    摘要翻译： 本发明涉及非最终碘化的氟化组合物。 组合物，包括分散体，乳液，微乳液和凝胶可用于生物医学应用，特别是放射摄影和闪烁扫描。 本发明中使用的化合物优选具有以下通式：RFCH = CIR1其中，RF是具有2至12个碳原子的直链，支链或环状的第一碳氟基，其中50至100％的氢原子已被 氟原子; 并且R 1选自第二氟烃基和烃基，其中，第二氟烃基为直链，支链或环状，具有2至12个碳原子，其中50至100％的氢原子已经被 被氟原子取代; 烃基是直链，支链或环状的，具有2至14个碳原子。