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1.发明申请STABLE METAL ION-LIPID POWDERED PHARMACEUTICAL COMPOSITIONS FOR DRUG DELIVERY 审中-公开稳定的金属离子粉末药物组合物用于药物递送公开(公告)号：US20140377361A1
公开(公告)日：2014-12-25
申请号：US14478573
申请日：2014-09-05
IPC分类号： A61K9/16 , A61K31/7036 , A61K31/496 , A61K9/14
CPC分类号： A61K9/1617 , A61K9/0075 , A61K9/008 , A61K9/0082 , A61K9/10 , A61K9/14 , A61K9/1611 , A61K9/1694 , A61K31/465 , A61K31/496 , A61K31/58 , A61K31/7036 , A61K31/7048 , A61K38/29 , A61K45/06 , A61K47/02 , A61K47/24 , A61M15/0065 , A61M2205/3306
摘要： A microparticle for drug delivery comprises an active agent and an excipient, the excipient comprising a metal ion-lipid complex. The metal ion is chosen from the group consisting of lanthanide metals, actinide metals, group IIa and IIIb metals, transition metals or mixtures thereof. The lipid comprises a phospholipid. The complex results in a glass transition temperature increase of the microparticle.
摘要翻译： 用于药物递送的微粒包括活性剂和赋形剂，所述赋形剂包含金属离子 - 脂质复合物。 金属离子选自镧系金属，锕系金属，IIa族和IIIb族金属，过渡金属或其混合物。 脂质包含磷脂。 复合物导致微粒的玻璃化转变温度升高。
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公开(公告)号：US20140212504A1
公开(公告)日：2014-07-31
申请号：US14243639
申请日：2014-04-02
IPC分类号： A61K9/16 , A61K31/496 , A61K31/7048 , A61K38/29 , A61K45/06 , A61K31/58 , A61K31/465 , A61K31/7036 , A61K9/00
CPC分类号： A61K9/1617 , A61K9/0075 , A61K9/008 , A61K9/0082 , A61K9/10 , A61K9/14 , A61K9/1611 , A61K9/1694 , A61K31/465 , A61K31/496 , A61K31/58 , A61K31/7036 , A61K31/7048 , A61K38/29 , A61K45/06 , A61K47/02 , A61K47/24 , A61M15/0065 , A61M2205/3306
摘要： Phospholipid based powders for drug delivery applications are disclosed. The powders comprise a polyvalent cation in an amount effective to increase the gel-to-liquid crystal transition temperature of the particle compared to particles without the polyvalent cation. The powders are hollow and porous and are preferably administered via inhalation.
摘要翻译： 公开了用于药物递送应用的基于磷脂的粉末。 与没有多价阳离子的颗粒相比，粉末包含有效增加颗粒的凝胶 - 液晶的转变温度的多价阳离子。 粉末是中空的和多孔的，并且优选通过吸入给药。
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3.发明申请STABLE METAL ION-LIPID POWDERED PHARMACEUTICAL COMPOSITIONS FOR DRUG DELIVERY 有权稳定的金属离子粉末药物组合物用于药物递送公开(公告)号：US20130095153A1
公开(公告)日：2013-04-18
申请号：US13707563
申请日：2012-12-06
IPC分类号： A61K47/24
CPC分类号： A61K9/1617 , A61K9/0075 , A61K9/008 , A61K9/0082 , A61K9/10 , A61K9/14 , A61K9/1611 , A61K9/1694 , A61K31/465 , A61K31/496 , A61K31/58 , A61K31/7036 , A61K31/7048 , A61K38/29 , A61K45/06 , A61K47/02 , A61K47/24 , A61M15/0065 , A61M2205/3306
摘要： A microparticle for drug delivery comprises an active agent and an excipient, the excipient comprising a metal ion-lipid complex. The metal ion is chosen from the group consisting of lanthanide metals, actinide metals, group IIa and IIIb metals, transition metals or mixtures thereof. The lipid comprises a phospholipid. The complex results in a glass transition temperature increase of the microparticle.
摘要翻译： 用于药物递送的微粒包括活性剂和赋形剂，所述赋形剂包含金属离子 - 脂质复合物。 金属离子选自镧系金属，锕系金属，IIa族和IIIb族金属，过渡金属或其混合物。 脂质包含磷脂。 复合物导致微粒的玻璃化转变温度升高。
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公开(公告)号：US20100329984A1
公开(公告)日：2010-12-30
申请号：US12875966
申请日：2010-09-03
IPC分类号： A61K49/00 , A61K9/14 , A61P25/00 , A61P29/00 , A61P11/08 , A61P37/08 , A61P11/00 , A61P31/00 , A61P35/00 , A61P9/00
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： A respiratory dispersion for pulmonary delivery comprises one or more bioactive agents, a suspension medium, and a plurality of perforated microstructures having a mean aerodynamic diameter of less than 5 μm. The suspension medium comprises at least one propellant and permeates the perforated microstructures.
摘要翻译： 用于肺部递送的呼吸分散体包含平均空气动力学直径小于5μm的一种或多种生物活性剂，悬浮介质和多个穿孔微结构。 悬浮介质包括至少一种推进剂并渗透穿孔微结构。
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5.发明申请CONTROLLED RELEASE CYTOTOXIC AGENT COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS 有权受控释放的细胞毒性剂组合物和治疗情况的方法公开(公告)号：US20090324552A1
公开(公告)日：2009-12-31
申请号：US12493611
申请日：2009-06-29
申请人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
发明人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
IPC分类号： A61K35/74
CPC分类号： A61K31/00 , A61K9/0046
摘要： Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with cytotoxic agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
摘要翻译： 本文公开的是通过将这些组合物和制剂直接施用到或通过灌注到目标耳结构中来治疗耳科疾病或具有细胞毒性剂组合物和制剂的制剂局部施用于患有耳科疾病或病症的个体的组合物和方法 （s）。
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6.发明申请CONTROLLED RELEASE ION CHANNEL MODULATOR COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS 有权控制释放离子通道调节剂组合物和治疗口臭的方法公开(公告)号：US20100015228A1
公开(公告)日：2010-01-21
申请号：US12506664
申请日：2009-07-21
申请人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
发明人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
IPC分类号： A61K9/10
CPC分类号： A61K9/0046 , A61K9/0019 , A61K9/06 , A61K9/122 , A61K9/127 , A61K9/1647 , A61K9/5153 , A61K9/7007 , A61K31/24 , A61K31/27 , A61K31/44 , A61K31/444 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/40
摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with ion channel modulators. In these methods, the ion channel modulator compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the ion channel modulator compositions and formulations onto the auris interna target areas, or via perfusion into the auris interna structures.
摘要翻译： 本文公开了用离子通道调节剂治疗耳部疾病的组合物和方法。 在这些方法中，离子通道调节剂组合物和制剂通过将离子通道调节剂组合物和制剂直接施用到内耳目标区域上，或通过灌注到内耳结构中而局部施用于患有耳科疾病的个体。
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7.发明申请公开(公告)号：US20100009952A1
公开(公告)日：2010-01-14
申请号：US12466310
申请日：2009-05-14
申请人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Michael Christopher SCAIFE , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Carl LEBEL , Andrew M. TRAMMEL , Jeffrey P. Harris
发明人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Michael Christopher SCAIFE , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Carl LEBEL , Andrew M. TRAMMEL , Jeffrey P. Harris
IPC分类号： A61K31/573 , A61P27/16
CPC分类号： A61K9/0046 , A61K9/06 , A61K31/573 , A61K45/06 , A61K47/10
摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
摘要翻译： 本文公开了用类固醇，NSAID和/或腺苷三磷酸酶（“ATPase”）调节剂治疗耳部疾病的组合物和方法。 在这些方法中，通过将这些组合物和制剂直接施用到或通过灌注到目标耳结构中，将甾体，NSAID和/或ATP酶组合物和制剂局部施用于患有耳科疾病的个体。
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8.发明申请公开(公告)号：US20100036000A1
公开(公告)日：2010-02-11
申请号：US12506127
申请日：2009-07-20
申请人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
发明人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
CPC分类号： A61K9/0046 , A61K8/042 , A61K9/0019 , A61K9/0024 , A61K9/06 , A61K9/10 , A61K9/14 , A61K9/1641 , A61K31/43 , A61K31/496 , A61K31/522 , A61K31/573 , A61K31/7036 , A61K47/02 , A61K47/10 , A61K47/34
摘要： Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
摘要翻译： 本文公开的是通过将这些组合物和制剂直接施用到或通过灌注到目标耳结构中来治疗耳科疾病或病症的组合物和方法，所述抗微生物剂组合物和制剂局部施用于患有耳科疾病或病症的个体 （s）。
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9.发明申请CONTROLLED RELEASE COMPOSITIONS FOR MODULATING FREE-RADICAL INDUCED DAMAGE AND METHODS OF USE THEREOF 有权用于调节免费诱发的损伤的控制释放组合物及其使用方法公开(公告)号：US20100022661A1
公开(公告)日：2010-01-28
申请号：US12506616
申请日：2009-07-21
申请人： Jay LICHTER , Benedikt Vollrath , Sergio G. Duron , Carl Lebel , Febrice Plu , Qiang Ye , Luis A. DELLAMARY , Andrew M. Trammel , Michael Christopher Scaife , Jeffrey P. Harris
发明人： Jay LICHTER , Benedikt Vollrath , Sergio G. Duron , Carl Lebel , Febrice Plu , Qiang Ye , Luis A. DELLAMARY , Andrew M. Trammel , Michael Christopher Scaife , Jeffrey P. Harris
CPC分类号： A61K9/0046 , A61K9/0019 , A61K9/06 , A61K9/122 , A61K9/127 , A61K9/1647 , A61K9/5153 , A61K9/7007 , A61K31/05 , A61K31/135 , A61K31/498 , A61K38/05 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/40
摘要： Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with free-radical modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
摘要翻译： 本文公开了用于治疗耳部疾病或病症的组合物和方法，所述耳科疾病或病症具有自由基调节剂组合物和通过直接将这些组合物和制剂直接施用于灌注或通过灌注至局部给予患有耳科疾病或病症的个体的制剂 目标耳结构。
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10.发明申请CONTROLLED-RELEASE OTIC STRUCTURE MODULATING AND INNATE IMMUNE SYSTEM MODULATING COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS 审中-公开控制释放的油性结构调节和免疫系统调节组合物和治疗病情的方法公开(公告)号：US20100021416A1
公开(公告)日：2010-01-28
申请号：US12506091
申请日：2009-07-20
申请人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
发明人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
CPC分类号： A61K31/663 , A61K9/0046 , A61K31/5513 , A61K31/66 , A61K38/1748 , A61K38/29 , A61K38/39 , A61K38/47 , A61K38/4886 , A61K47/34 , A61K2300/00
摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with otic structure modulating compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).
摘要翻译： 本文公开的是通过将这些组合物和组合物直接施用到或通过灌注到目标耳结构中来治疗耳部疾病的组合物和方法，其中耳用结构调节组合物局部施用于患有耳科疾病的个体。
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