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1.发明申请公开(公告)号：US20050238529A1
公开(公告)日：2005-10-27
申请号：US11111585
申请日：2005-04-21
申请人： Jen Lin , Cagatay Yanar , Michael Brandt , Xinyan Yan , Wenping Zhang
发明人： Jen Lin , Cagatay Yanar , Michael Brandt , Xinyan Yan , Wenping Zhang
IPC分类号： C22C21/10
CPC分类号： C22C21/10
摘要： A heat treatable aluminum alloy for shaped castings includes from about 3.5-5.5% Zn, from about 1-1.5% Mg, less than about 1% Si, less than about 0.30% Mn, and less than about 0.3% Fe and other incidental impurities.
摘要翻译： 用于成型铸件的可热处理的铝合金包括约3.5-5.5％的Zn，约1-1.5％的Mg，小于约1％的Si，小于约0.30％的Mn和小于约0.3％的Fe和其他附带的杂质 。
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2.发明申请Heat treatable Al-Zn-Mg-Cu alloy for aerospace and automotive castings 审中-公开用于航空和汽车铸件的可热处理的Al-Zn-Mg-Cu合金公开(公告)号：US20050238528A1
公开(公告)日：2005-10-27
申请号：US11111212
申请日：2005-04-21
申请人： Jen Lin , Cagatay Yanar , Michael Brandt , Xinyan Yan , Wenping Zhang
发明人： Jen Lin , Cagatay Yanar , Michael Brandt , Xinyan Yan , Wenping Zhang
IPC分类号： C22C21/10
CPC分类号： C22C21/10
摘要： A heat treatable aluminum alloy for shaped castings includes from about 3.5-5.5% Zn, from about 1-3% Mg, about 0.05-0.5% Cu, and less than about 1% Si.
摘要翻译： 用于成型铸件的可热处理的铝合金包括约3.5-5.5％的Zn，约1-3％的Mg，约0.05-0.5％的Cu和小于约1％的Si。
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公开(公告)号：US20050191204A1
公开(公告)日：2005-09-01
申请号：US11045845
申请日：2005-01-28
申请人： Jen Lin , Cagatay Yanar , Wenping Zhang , Pal Jacobsen , Geir Grasmo , Michael Brandt , Moustapha Mbaye , Martijn Vos , Michael Glazoff , Knut Pettesen , Svein Jorgensen , Terje Johnsen
发明人： Jen Lin , Cagatay Yanar , Wenping Zhang , Pal Jacobsen , Geir Grasmo , Michael Brandt , Moustapha Mbaye , Martijn Vos , Michael Glazoff , Knut Pettesen , Svein Jorgensen , Terje Johnsen
摘要： An aluminum alloy for shaped castings, the alloy having the following composition ranges in weight percent: about 6.0-8.5% silicon, less than 0.4% magnesium, less than 0.1% cerium, less than 0.2% iron, copper in a range from about 0.1% to about 0.5% and/or zinc in a range from about 1% to about 4%, the alloy being particularly suited for T5 heat treatment.
摘要翻译： 一种用于成型铸件的铝合金，具有以下组成的合金的重量百分比范围为：约6.0-8.5％的硅，小于0.4％的镁，小于0.1％的铈，小于0.2％的铁，铜的范围为约0.1 ％至约0.5％和/或约1％至约4％范围内的锌，该合金特别适用于T5热处理。
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4.发明申请HIGH STRENGTH, HIGH STRESS CORROSION CRACKING RESISTANT AND CASTABLE Al-Zn-Mg-Cu-Zr ALLOY FOR SHAPE CAST PRODUCTS 审中-公开高强度，高应力腐蚀开裂耐腐蚀和可变形Al-Zn-Mg-Cu-Zr合金公开(公告)号：US20120261035A1
公开(公告)日：2012-10-18
申请号：US13449273
申请日：2012-04-17
申请人： JEN C. LIN , Xinyan Yan , Wenping Zhang , James P. Moran , John M. Newman , Ralph R. Sawtell , Gerald D. Scott , Michael Brandt , Bob R. Fors , Rick A. Borns , Moustapha Mbaye
发明人： JEN C. LIN , Xinyan Yan , Wenping Zhang , James P. Moran , John M. Newman , Ralph R. Sawtell , Gerald D. Scott , Michael Brandt , Bob R. Fors , Rick A. Borns , Moustapha Mbaye
摘要： The present invention provides an Al—Zn—Mg—Cu casting alloy that provides high strength for automotive and aerospace applications and optimized stress corrosion cracking resistance in highly corrosive and tensile environments. The inventive alloy composition includes about 3.5 wt. % to about 5.5 wt. % Zn; about 1.0 wt. % to about 3.0 wt. % Mg; about 0.5 wt. % to about 1.2 wt. % Cu; less than about 1.0 wt. % Si; less than about 0.30 wt. % Mn; less than about 0.30 wt. % Fe; and a balance of Al and incidental impurities.
摘要翻译： 本发明提供了一种Al-Zn-Mg-Cu铸造合金，其在高腐蚀性和拉伸环境中为汽车和航空航天应用提供高强度和优化的抗应力腐蚀开裂性。 本发明的合金组合物包含约3.5wt。 ％至约5.5wt。 ％Zn; 约1.0重量％ ％至约3.0wt。 ％Mg; 约0.5wt。 ％至约1.2wt。 ％Cu; 小于约1.0wt。 ％Si; 小于约0.30重量％ ％Mn; 小于约0.30重量％ ％Fe; 以及Al和杂质的平衡。
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5.发明申请HIGH STRENGTH, HIGH STRESS CORROSION CRACKING RESISTANT AND CASTABLE Al-Zn-Mg-Cu-Zr ALLOY FOR SHAPE CAST PRODUCTS 审中-公开高强度，高应力腐蚀开裂耐腐蚀和可变形Al-Zn-Mg-Cu-Zr合金公开(公告)号：US20080066833A1
公开(公告)日：2008-03-20
申请号：US11856631
申请日：2007-09-17
申请人： Jen C. Lin , Xinyan Yan , Wenping Zhang , James P. Moran , John M. Newman , Ralph R. Sawtell , Gerald D. Scott , Michael Brandt , Bob R. Fors , Rick A. Borns , Moustapha Mbaye
发明人： Jen C. Lin , Xinyan Yan , Wenping Zhang , James P. Moran , John M. Newman , Ralph R. Sawtell , Gerald D. Scott , Michael Brandt , Bob R. Fors , Rick A. Borns , Moustapha Mbaye
摘要： The present invention provides an Al—Zn—Mg—Cu casting alloy that provides high strength for automotive and aerospace applications and optimized stress corrosion cracking resistance in highly corrosive and tensile environments. The inventive alloy composition includes about 3.5 wt. % to about 5.5 wt. % Zn; about 1.0 wt. % to about 3.0 wt. % Mg; about 0.5 wt. % to about 1.2 wt. % Cu; less than about 1.0 wt. % Si; less than about 0.30 wt. % Mn; less than about 0.30 wt. % Fe; and a balance of Al and incidental impurities.
摘要翻译： 本发明提供了一种Al-Zn-Mg-Cu铸造合金，其在高腐蚀性和拉伸环境中为汽车和航空航天应用提供高强度和优化的抗应力腐蚀开裂性。 本发明的合金组合物包含约3.5wt。 ％至约5.5wt。 ％Zn; 约1.0重量％ ％至约3.0wt。 ％Mg; 约0.5wt。 ％至约1.2wt。 ％Cu; 小于约1.0wt。 ％Si; 小于约0.30重量％ ％Mn; 小于约0.30重量％ ％Fe; 以及Al和杂质的平衡。
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公开(公告)号：US06846673B2
公开(公告)日：2005-01-25
申请号：US10112755
申请日：2002-04-02
申请人： Michael Brandt , Reinhard Franze , Ulrich Pessara
发明人： Michael Brandt , Reinhard Franze , Ulrich Pessara
CPC分类号： C07K14/505 , A61K38/00 , C07K2319/02 , C07K2319/036 , C07K2319/75 , C12N15/10 , C12N15/625
摘要： A process for selecting human cells for the production of human proteins by endogenous gene activation allows human proteins to be produced in economically feasible quantities and in a form suitable for producing a pharmaceutical composition. Also disclosed is a process for producing human proteins in a cell line identified in this matter.
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7.发明授权Methods for identifying human cell lines useful for endogenous gene activation isolated human cell lines identified thereby, and uses thereof 有权用于鉴定用于内源基因激活的人细胞系分离鉴定的人细胞系的方法及其用途公开(公告)号：US06555373B1
公开(公告)日：2003-04-29
申请号：US09607277
申请日：2000-06-30
申请人： Anne Stern , Michael Brandt , Konrad Honold , Johannes Auer , Hans Koll , Reinhard Franze , Ulrich Pessara
发明人： Anne Stern , Michael Brandt , Konrad Honold , Johannes Auer , Hans Koll , Reinhard Franze , Ulrich Pessara
IPC分类号： C12N502
CPC分类号： C07K14/505 , A61K38/00 , C07K2319/02 , C07K2319/036 , C07K2319/75 , C12N15/10 , C12N15/625 , C12P21/005
摘要： The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of human EPO as a pharmaceutical preparation. Furthermore the invention concerns a process for the production of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO gene in human cells as well as a process for the large-scale production of EPO in human cells.
摘要翻译： 本发明涉及由于内源性人EPO基因的活化能够产生足够数量和纯度的EPO以使作为药物制剂的人EPO成本有效的生产的人细胞。 此外，本发明涉及生产这种人EPO产生细胞的方法，用于激活人细胞内源性EPO基因的DNA构建体以及在人细胞中大规模生产EPO的方法。
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公开(公告)号：US06544748B2
公开(公告)日：2003-04-08
申请号：US09985357
申请日：2001-11-02
申请人： Anne Stern , Michael Brandt , Konrad Honold , Johannes Auer , Hans Koll
发明人： Anne Stern , Michael Brandt , Konrad Honold , Johannes Auer , Hans Koll
IPC分类号： C12Q168
CPC分类号： C07K14/505 , A61K38/00 , C07K2319/02 , C07K2319/036 , C07K2319/75 , C12N15/10 , C12N15/625 , C12P21/005
摘要： The invention relates to human cells which are capable, on the basis of an activation of the endogenous human EPO gene, of producing EPO in a sufficient amount and purity to make possible a cost-effective production of human EPO as a pharmaceutical preparation. The invention furthermore relates to a method for the preparation of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO in human cells, and a method for the large technical production of EPO in human cells.
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公开(公告)号：US06391633B1
公开(公告)日：2002-05-21
申请号：US09463380
申请日：2000-01-21
申请人： Anne Stern , Michael Brandt , Konrad Honold , Johannes Auer , Hans Koll
发明人： Anne Stern , Michael Brandt , Konrad Honold , Johannes Auer , Hans Koll
IPC分类号： C12N506
CPC分类号： C07K14/505 , A61K38/00 , C07K2319/02 , C07K2319/036 , C07K2319/75 , C12N15/10 , C12N15/625 , C12P21/005
摘要： The invention relates to human cells which are capable, on the basis of an activation of the endogenous human EPO gene, of producing EPO in a sufficient amount and purity to make possible a cost-effective production of human EPO as a pharmaceutical preparation. The invention furthermore relates to a method for the preparation of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO inhuman cells, and a method for the large technical production of EPO in human cells.
摘要翻译： 本发明涉及能够以内源性人EPO基因的活化为基础的以足够量和纯度生产EPO的人细胞，从而使作为药物制剂的人EPO成本有效地生产成为可能。 本发明还涉及制备这种人EPO产生细胞的方法，用于激活内源性EPO非人细胞的DNA构建体，以及人细胞中大量技术生产EPO的方法。
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公开(公告)号：US07186529B2
公开(公告)日：2007-03-06
申请号：US10353767
申请日：2003-01-29
申请人： Anne Stern , Michael Brandt , Konrad Honold , Johannes Auer , Hans Koll
发明人： Anne Stern , Michael Brandt , Konrad Honold , Johannes Auer , Hans Koll
IPC分类号： C12P21/02
CPC分类号： C07K14/505 , A61K38/00 , C07K2319/02 , C07K2319/036 , C07K2319/75 , C12N15/10 , C12N15/625 , C12P21/005
摘要： The invention relates to human cells which are capable, on the basis of an activation of the endogenous human EPO gene, of producing EPO in a sufficient amount and purity to make possible a cost-effective production of human EPO as a pharmaceutical preparation. The invention furthermore relates to a method for the preparation of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO in human cells, and a method for the large technical production of EPO in human cells.
摘要翻译： 本发明涉及能够以内源性人EPO基因的活化为基础的以足够量和纯度生产EPO的人细胞，从而使作为药物制剂的人EPO成本有效地生产成为可能。 本发明还涉及一种制备这种人EPO产生细胞的方法，用于激活人细胞内源性EPO的DNA构建体，以及在人细胞中大量技术生产EPO的方法。
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