公开(公告)号：US20060255422A1

公开(公告)日：2006-11-16

申请号：US11491998

申请日：2006-07-25

申请人： JengPing Lu ,  James Boyce ,  Kathleen Boyce

发明人： JengPing Lu ,  James Boyce ,  Kathleen Boyce

IPC分类号： H01L31/00

CPC分类号： H01L27/1446 ,  H01L31/105

摘要： A high fill-factor photosensor array is formed comprising a P-layer, an I-layer, one or more semiconductor structures adjacent to the I-layer and each coupled to a N-layer, an electrically conductive electrode formed on top of the P-layer, and an additional semiconductor structure, adjacent to the N-layer and which is electrically connected to a voltage bias source. The bias voltage applied to the additional semiconductor structure charges the additional semiconductor structure, thereby creating a tunneling effect between the N-layer and the P-layer, wherein electrons leave the N-layer and reach the P-layer and the electrically conductive layer. The electrons then migrate and distribute uniformly throughout the electrically conductive layer, which ensures a uniform bias voltage across to the entire photosensor array. The biasing scheme in the invention allows to achieve mass production of photosensors without the use of wire bonding.

摘要翻译： 形成高填充因子光电传感器阵列，其包括P层，I层，与I层相邻并且各自耦合到N层的一个或多个半导体结构，形成在P的顶部上的导电电极 以及与N层相邻并且与电压偏置源电连接的附加半导体结构。 施加到附加半导体结构的偏置电压对附加的半导体结构进行充电，从而在N层和P层之间产生隧穿效应，其中电子离开N层并到达P层和导电层。 电子然后在整个导电层中均匀迁移和均匀分布，这确保跨越整个光电传感器阵列的均匀偏压。 本发明的偏置方案允许在不使用引线接合的情况下实现光电传感器的批量生产。

公开(公告)号：US20050133813A1

公开(公告)日：2005-06-23

申请号：US10740466

申请日：2003-12-22

申请人： JengPing Lu ,  James Boyce ,  Kathleen Boyce

发明人： JengPing Lu ,  James Boyce ,  Kathleen Boyce

IPC分类号： H01L29/74

CPC分类号： H01L27/1446 ,  H01L31/105

摘要： A high fill-factor photosensor array is formed comprising a P-layer, an I-layer, one or more semiconductor structures adjacent to the I-layer and each coupled to a N-layer, an electrically conductive electrode formed on top of the P-layer, and an additional semiconductor structure, adjacent to the N-layer and which is electrically connected to a voltage bias source. The bias voltage applied to the additional semiconductor structure charges the additional semiconductor structure, thereby creating a tunneling effect between the N-layer and the P-layer, wherein electrons leave the N-layer and reach the P-layer and the electrically conductive layer. The electrons then migrate and distribute uniformly throughout the electrically conductive layer, which ensures a uniform bias voltage across to the entire photosensor array. The biasing scheme in this invention allows to achieve mass production of photosensors without the use of wire bonding.

摘要翻译： 形成高填充因子光电传感器阵列，其包括P层，I层，与I层相邻并且各自耦合到N层的一个或多个半导体结构，形成在P的顶部上的导电电极 以及与N层相邻并且与电压偏置源电连接的附加半导体结构。 施加到附加半导体结构的偏置电压对附加的半导体结构进行充电，从而在N层和P层之间产生隧穿效应，其中电子离开N层并到达P层和导电层。 电子然后在整个导电层中均匀迁移和均匀分布，这确保跨越整个光电传感器阵列的均匀偏压。 本发明的偏置方案允许在不使用引线接合的情况下实现光电传感器的批量生产。

公开(公告)号：US20060131163A1

公开(公告)日：2006-06-22

申请号：US11014490

申请日：2004-12-16

申请人： Ping Mei ,  Jurgen Daniel ,  James Boyce ,  Kathleen Boyce ,  Jackson Ho ,  Rachel Lau ,  Yu Wang

发明人： Ping Mei ,  Jurgen Daniel ,  James Boyce ,  Kathleen Boyce ,  Jackson Ho ,  Rachel Lau ,  Yu Wang

IPC分类号： C25D21/12

CPC分类号： C25D5/02 ,  C23C18/28 ,  C25D5/56 ,  H04R19/04

摘要： Cells can include variable volumes defined between a flexible structure, such as a polymer layer, and a support surface, with the flexible structure and support surface being attached in a first region that surrounds a second region in which they are unattached. Various adhesion structures can attach the flexible structure and the support surface. When unstretched, the flexible structure can lie in a flat position on the support surface. In response to a stretching force away from the support surface, the flexible structure can move out of the flat position, providing the variable volume. Electrodes, such as on the flexible structure, on the support surface, and over the flexible structure, can have charge levels that couple with each other and with the variable volume. A support structure can include a device layer with signal circuitry that provides a signal path between an electrode and external circuitry. One or more ducts can provide fluid communication with each cell's variable volume. Arrays of such cells can be implemented for various applications, such as optical modulators, displays, printheads, and microphones.

摘要翻译： 细胞可以包括在诸如聚合物层的柔性结构和支撑表面之间限定的可变体积，其中柔性结构和支撑表面附接在围绕其未连接的第二区域的第一区域中。 各种粘合结构可以附接柔性结构和支撑表面。 当未拉伸时，柔性结构可以位于支撑表面上的平坦位置。 响应于远离支撑表面的拉伸力，柔性结构可以移出平坦位置，从而提供可变的体积。 诸如柔性结构的电极，在支撑表面上以及柔性结构上的电极可以具有彼此耦合并且具有可变体积的电荷水平。 支撑结构可以包括具有提供电极和外部电路之间的信号路径的信号电路的器件层。 一个或多个管道可以提供与每个电池的可变体积的流体连通。 可以对诸如光学调制器，显示器，打印头和麦克风的各种应用实现这种单元的阵列。

公开(公告)号：US20060211074A1

公开(公告)日：2006-09-21

申请号：US11331413

申请日：2006-01-12

申请人： James Boyce ,  Michael Brown ,  Jeffrey Fitzner ,  Thomas Kowski

发明人： James Boyce ,  Michael Brown ,  Jeffrey Fitzner ,  Thomas Kowski

IPC分类号： C12Q1/48 ,  C07D241/36 ,  C07F5/02

CPC分类号： C12N9/12 ,  C07D209/60 ,  C07D231/38 ,  C07D239/94 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D409/04 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07F5/022 ,  C12Q1/485 ,  G01N33/573

摘要： Various embodiments of the present invention are directed to kinase-directed, activity-based probes (“KABPs”) that tightly bind to, and label, kinases. Each KABP includes a binding group that is recognized and bound by one or more kinases, a reactive group that tightly, and generally irreversibly, binds to the kinase, a tag group that labels the kinase, or that serves a chemical handle for subsequent procedures and processes, and a linker group that links the tag group to one or more of the reactive group and the binding group. Additional embodiments of the present invention are directed to methods for identifying kinases within, and isolating kinases from, living cells by use of one or more KABPs.

摘要翻译： 本发明的各种实施方案涉及紧密结合并标记激酶的激酶导向的基于活性的探针（“KABP”）。 每个KABP包括被一个或多个激酶识别和结合的结合基团，紧密地并且通常不可逆地结合激酶的反应性基团，标记激酶的标签组，或用于随后的程序的化学处理， 进程和链接器组，链接器组将标签组链接到一个或多个反应组和绑定组。 本发明的另外的实施方案涉及用于通过使用一种或多种KABP鉴定活细胞内的激酶以及从活细胞分离激酶的方法。

公开(公告)号：US20070009977A1

公开(公告)日：2007-01-11

申请号：US11471286

申请日：2006-06-19

申请人： James Boyce ,  Michael Brown ,  Jeffrey Fitzner ,  Thomas Kowski

发明人： James Boyce ,  Michael Brown ,  Jeffrey Fitzner ,  Thomas Kowski

IPC分类号： C12Q1/48 ,  C07F5/02

CPC分类号： C12Q1/485 ,  C07D209/60 ,  C07D231/38 ,  C07D239/94 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D409/04 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07F5/022 ,  G01N33/573

摘要： Various embodiments of the present invention are related to kinase-directed, activity-based probes (“KABPs”) that bind to, and label, kinases. Each KABP includes a binding group that is recognized and bound by one or more kinases, a reactive group that tightly, and generally irreversibly, binds to the kinase, a tag group that provides a detectable label for the kinase-KABP pair, or that serves as a chemical handle for subsequent procedures and processes, and a linker group that links the tag group to one or more of the reactive group and the binding group, spacing the tag group from the reactive and binding groups. Additional embodiments of the present invention are directed to methods for identifying kinases within, and isolating kinases from, living cells by use of one or more KABPs.

摘要翻译： 本发明的各种实施方案涉及与激酶结合并标记激酶的激酶导向的基于活性的探针（“KABP”）。 每个KABP包括被一个或多个激酶识别和结合的结合基团，紧密且通常不可逆地与激酶结合的反应性基团，为激酶-KABP对提供可检测标记的标签组 作为后续程序和过程的化学处理，以及将标签组连接到反应性基团和结合基团中的一个或多个的连接基团，将标签基团与反应性和结合基团间隔开。 本发明的另外的实施方案涉及用于通过使用一种或多种KABP鉴定活细胞内的激酶以及从活细胞分离激酶的方法。

公开(公告)号：US20060089414A1

公开(公告)日：2006-04-27

申请号：US11186852

申请日：2005-07-22

申请人： Kurt Morgenstern ,  James Boyce ,  Stewart Chipman

发明人： Kurt Morgenstern ,  James Boyce ,  Stewart Chipman

IPC分类号： A61K31/195 ,  C07C275/12

CPC分类号： C07D401/14 ,  C07C229/16 ,  C07C275/14 ,  C07D311/82 ,  C07D401/12 ,  C07D471/22 ,  C09B11/08

摘要： Generic probes that bind to phosphorylated amino acid residues are provided as well as methods employing the probes for screening for kinase inhibitory activity, kinase activity, and phosphatase activity. Methods for distinguishing serine/threonine kinase phosphorylation from tyrosine kinase phosphorylation are also provided.

摘要翻译： 提供结合磷酸化氨基酸残基的通用探针以及使用探针筛选激酶抑制活性，激酶活性和磷酸酶活性的方法。 还提供了区分丝氨酸/苏氨酸激酶磷酸化与酪氨酸激酶磷酸化的方法。

公开(公告)号：US20050109544A1

公开(公告)日：2005-05-26

申请号：US10717742

申请日：2003-11-20

申请人： Thomas Ray ,  James Boyce

发明人： Thomas Ray ,  James Boyce

IPC分类号： E21B10/22 ,  E21B10/25 ,  E21B10/00

CPC分类号： E21B10/25

摘要： A drill bit (100) for drilling a wellbore that traverses subterranean formations includes a drill bit body (106) having a plurality of journal pins (112), each having a bearing surface (128), and a rotary cutter (104) rotatably mounted on each journal pin (112), each rotary cutter (104) including a bearing surface (126). A pressure-compensated reservoir (130) is in fluid communication with the bearing surfaces (126, 128) and has a lubricant therein. A seal element (144) is positioned between each journal pin (112) and rotary cutter (104) and retains the lubricant in the bearing surfaces (126, 128). The seal element (144) is formed from a nanocomposite material including a polymer host material and a plurality of nanostructures.

摘要翻译： 用于钻穿穿过地下地层的井筒的钻头（100）包括钻头体（106），钻头体（106）具有多个轴颈销（112），每个轴承销具有支承表面（128）和旋转切割器（104） 在每个轴颈销（112）上，每个旋转切割器（104）包括轴承表面（126）。 压力补偿储存器（130）与支承表面（126,128）流体连通并且在其中具有润滑剂。 密封元件（144）定位在每个轴颈销（112）和旋转切割器（104）之间，并将润滑剂保持在轴承表面（126,128）中。 密封元件（144）由包括聚合物主体材料和多个纳米结构的纳米复合材料形成。