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    Amine derivatives
    2.
    发明授权
    Amine derivatives 失效
    胺衍生物

    公开(公告)号：US4317819A

    公开(公告)日：1982-03-02

    申请号：US213680

    申请日：1980-12-05

    申请人： John W. Clitherow ,  Barry J. Price ,  John Bradshaw ,  Michael Martin-Smith

    发明人： John W. Clitherow ,  Barry J. Price ,  John Bradshaw ,  Michael Martin-Smith

    IPC分类号： A61K31/155 ,  A61K31/335 ,  A61K31/38 ,  A61P1/00 ,  C07C67/00 ,  C07C209/00 ,  C07C211/27 ,  C07C213/00 ,  C07C217/48 ,  C07C239/00 ,  C07C275/12 ,  C07C279/04 ,  C07C279/28 ,  C07C301/00 ,  C07C311/64 ,  C07C325/00 ,  C07C335/08 ,  C07D233/64 ,  C07D295/096 ,  C07D307/38 ,  C07D307/42 ,  C07D307/52 ,  C07D333/14 ,  A61K31/17 ,  C07C127/17 ,  C07C129/12

    CPC分类号： C07D295/096 ,  C07C279/28 ,  C07D307/38 ,  C07D307/42 ,  C07D307/52 ,  C07D333/14 ,  Y10S514/886 ,  Y10S514/926 ,  Y10S514/927

    摘要： The invention provides compounds of general formula ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in whichY and Z, which may be the same or different, each represent oxygen, sulphur, .dbd.CHNO.sub.2 or .dbd.NR.sub.3 where R.sub.3 is hydrogen, nitro, cyano, lower alkyl, aryl, alkylsulphonyl or arylsulphonyl;p has a value from 2 to 12;R.sub.1 represents ##STR2## in which R.sub.4 and R.sub.5 which may be the same or different, each represent hydrogen, lower alkyl, cycloalkyl, lower alkenyl, aralkyl or lower alkyl interrupted by an oxygen atom or a group >N-R.sub.6 in which R.sub.6 represents hydrogen or lower alkyl, or R.sub.4 and R.sub.5 together with the nitrogen atom to which they are attached form a 5 to 7-membered saturated heterocyclic ring which may contain an additional oxygen atom or the group >NR.sub.6 ;Q represents a furan or thiophen ring in which incorporation into the rest of the molecule is through bonds at the 2 and 5 positions, or a benzene ring in which incorporation into the rest of the molecule is through bonds at the 1 and 3 or 1 and 4 positions;X represents --CH.sub.2 --, --O-- or --S--;n represents zero or 1;m represents 2, 3 or 4 and Alk represents a straight chain alkylene group of 1 to 3 carbon atoms,andR.sub.2 represents lower alkyl or the group--(CH.sub.2).sub.y E(CH.sub.2).sub.x Gin whichy represents 2, 3 or 4 or can additionally represent zero or 1 when E is a --CH.sub.2 -- group, x represents zero, 1 or 2;E represents --CH.sub.2 --, --O-- or --S--; andG represents a monocyclic 5 or 6 membered carbocyclic or heterocyclic aromatic ring, or G represents the group ##STR3## where Q' represents any of the rings defined for Q; Alk' represents any of the groups defined for Alk; and R.sub.4 ' and R.sub.5 ' which may be the same or different represent any of the groups defined for R.sub.4 or R.sub.5.The compounds of formula (I) have pharmacological activity as selective histamine H.sub.2 -antagonists.

    摘要翻译： 本发明提供了通式（I）的化合物及其生理上可接受的盐，水合物和生物前体，其中Y和Z可以相同或不同，各自表示氧，硫，= CHNO 2或= NR 3，其中R 3 是氢，硝基，氰基，低级烷基，芳基，烷基磺酰基或芳基磺酰基; p的值为2到12; R 1表示其中可以相同或不同的R 4和R 5各自表示氢，低级烷基，环烷基，低级烯基，芳烷基或被氧原子间隔的低级烷基或基团> N-R6，其中R 6表示 氢或低级烷基，或R4和R5与它们所连接的氮原子一起形成可含有另外的氧原子或基团> NR 6的5至7元饱和杂环; Q表示呋喃或噻吩环，其中与分子的其余部分结合通过2和5位的键，或苯环，其中结合到分子的其余部分通过1和3或1的键和 4个职位; X表示-CH 2 - ， - O-或-S-; n表示0或1; m表示2,3或4，Alk表示1〜3个碳原子的直链亚烷基，R2表示低级烷基或 - （CH2）yE（CH2）xG，y表示2,3或4或可以 当E是-CH 2 - 基时，x代表0或1; E表示-CH 2 - ， - O-或-S-; 并且G表示单环5或6元碳环或杂环芳环，或G表示基团，其中Q'表示为Q定义的任何环; Alk'代表为Alk定义的任何组; 和可以相同或不同的R 4'和R 5'表示对于R 4或R 5定义的任何基团。 式（I）化合物具有作为选择性组胺H2拮抗剂的药理学活性。

    Amine derivatives
    3.
    发明授权
    Amine derivatives 失效
    胺衍生物

    公开(公告)号：US4264614A

    公开(公告)日：1981-04-28

    申请号：US95065

    申请日：1979-11-16

    申请人： John W. Clitherow ,  Barry J. Price ,  John Bradshaw

    发明人： John W. Clitherow ,  Barry J. Price ,  John Bradshaw

    IPC分类号： A61K31/155 ,  A61K31/335 ,  A61K31/38 ,  A61P1/00 ,  C07C67/00 ,  C07C209/00 ,  C07C211/27 ,  C07C213/00 ,  C07C217/48 ,  C07C239/00 ,  C07C275/12 ,  C07C279/04 ,  C07C279/28 ,  C07C301/00 ,  C07C311/64 ,  C07C325/00 ,  C07C335/08 ,  C07D233/64 ,  C07D295/096 ,  C07D307/38 ,  C07D307/42 ,  C07D307/52 ,  C07D333/14 ,  A61K31/34 ,  C07D307/68 ,  C07D333/38

    CPC分类号： C07D295/096 ,  C07C279/28 ,  C07D307/38 ,  C07D307/42 ,  C07D307/52 ,  C07D333/14 ,  Y10S514/886 ,  Y10S514/926 ,  Y10S514/927

    摘要： The invention provides compounds of general formula ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in whichY and Z, which may be the same or different, each represent oxygen, sulphur, =CHNO.sub.2 or =NR.sub.3 where R.sub.3 is hydrogen, nitro, cyano, lower alkyl, aryl, alkylsulphonyl or arylsulphonyl;p has a value from 2 to 12;R.sub.1 represents ##STR2## in which R.sub.4 and R.sub.5 which may be the same or different, each represent hydrogen, lower alkyl, cycloalkyl, lower alkenyl, aralkyl or lower alkyl interrupted by an oxygen atom or a group >N-R.sub.6 in which R.sub.6 represents hydrogen or lower alkyl, or R.sub.4 and R.sub.5 together with the nitrogen atom to which they are attached form a 5 to 7-membered saturated heterocyclic ring which may contain an additional oxygen atom or the group >NR.sub.6 ;Q represents a furan or thiophen ring in which incorporation into the rest of the molecule is through bonds at the 2 and 5 positions, or a benzene ring in which incorporation into the rest of the molecule is through bonds at the 1 and 3 or 1 and 4 positions;X represents --CH.sub.2 --, --O-- or --S--;n represents zero or 1;m represents 2, 3 or 4 andAlk represents a straight chain alkylenegroup of 1 to 3 carbon atoms;and R.sub.2 represents lower alkyl or the group--(CH.sub.2).sub.y E(CH.sub.2).sub.x Gin whichY represents 2, 3 or 4 or can additionallyrepresent zero or 1 when E is a --CH.sub.2 -- group;x represents zero, 1 or 2;E represents --CH.sub.2 --, --0-- or --S--; andG represents a monocyclic 5 or 6 membered carbocyclic or heterocyclic aromatic ring, or G represents the group ##STR3## where Q' represents any of the rings defined for Q;Alk' represents any of the groups defined for Alk;and R.sub.4 ' and R.sub.5 ' which may be the same or different represent any of the groups defined for R.sub.4 or R.sub.5.The compounds of formula (I) have pharmacological activity as selective histamine H.sub.2 -antagonists.

    摘要翻译： 本发明提供了通式（I）的化合物及其生理上可接受的盐，水合物和生物前体，其中Y和Z可以相同或不同，各自表示氧，硫，= CHNO 2或= NR 3，其中R 3 是氢，硝基，氰基，低级烷基，芳基，烷基磺酰基或芳基磺酰基; p的值为2到12; R 1表示其中可以相同或不同的R 4和R 5各自表示氢，低级烷基，环烷基，低级烯基，芳烷基或被氧原子间隔的低级烷基或基团> N-R6，其中R 6表示 氢或低级烷基，或R4和R5与它们所连接的氮原子一起形成可含有另外的氧原子或基团> NR 6的5至7元饱和杂环; Q表示呋喃或噻吩环，其中与分子的其余部分结合通过2和5位的键，或苯环，其中结合到分子的其余部分通过1和3或1的键和 4个职位; X表示-CH 2 - ， - O-或-S-; n表示0或1; m表示2,3或4，Alk表示1〜3个碳原子的直链亚烷基; 并且R 2表示低级烷基或基团 - （CH 2）y E（CH 2）x G，其中Y表示2,3或4，或者当E是-CH 2 - 基时，可以另外表示0或1; x表示零，1或2; E表示-CH 2 - ， - O-或-S-; 并且G表示单环5或6元碳环或杂环芳环，或G表示基团，其中Q'表示为Q定义的任何环; Alk'代表为Alk定义的任何组; 和可以相同或不同的R 4'和R 5'表示对于R 4或R 5定义的任何基团。 式（I）化合物具有作为选择性组胺H2拮抗剂的药理学活性。

    Methods for enhancing plant growth using diacyl ureas
    4.
    发明申请
    Methods for enhancing plant growth using diacyl ureas 有权
    使用二酰基脲增强植物生长的方法

    公开(公告)号：US20030145640A1

    公开(公告)日：2003-08-07

    申请号：US10207505

    申请日：2002-07-29

    发明人： Frank William Dean

    IPC分类号： C05C009/00 ,  A01N047/34 ,  C07C275/12

    CPC分类号： C07C275/50 ,  A01N47/34

    摘要： The present invention is directed to new compositions of matter comprising the reaction products of a carboxylic acid and a urea having the formula 1 where R1, R2, R3 and R4 are the same or different and are selected from the group consisting of hydrogen, substituted and unsubstituted alkyl, allyl, vinyl and alkoxyl groups having from 1-6 carbon atoms, substituted and unsubstituted phenyl groups and the halides. Preferably, the reaction product of the present invention is N,Nnull-diformylurea or N,Nnull-diacetylurea. These reaction products, e.g., diformylurea, have been found to produce significantly improved growth in a variety of agricultural products when applied to the seed, to the surrounding soil or to the foliage of the emerging plant. Because of the similarity in the carbon, nitrogen, oxygen structure of these reaction products with many biological compounds, it is believed that the reaction products of the present invention may find use in a variety of biological applications.

    摘要翻译： 本发明涉及包含羧酸和具有下式的脲的反应产物的新物质组合物，其中R 1，R 2，R 3和R 4相同或不同，并且选自氢，取代和未取代的 具有1-6个碳原子的烷基，烯丙基，乙烯基和烷氧基，取代和未取代的苯基和卤化物。 优选地，本发明的反应产物是N，N'-二甲酰基脲或N，N'-二乙酰脲。 已经发现，这些反应产物，例如二甲酰基脲，当应用于种子，周围土壤或新兴植物的叶子时，可以显着改善各种农产品的生长。 由于这些反应产物与许多生物化合物的碳，氮，氧结构相似，据信本发明的反应产物可用于各种生物应用。

    Amine derivatives
    6.
    发明授权
    Amine derivatives 失效
    胺衍生物

    公开(公告)号：US4366164A

    公开(公告)日：1982-12-28

    申请号：US213407

    申请日：1980-12-05

    申请人： John W. Clitherow ,  Barry Price ,  John Bradshaw ,  Michael Martin-Smith

    发明人： John W. Clitherow ,  Barry Price ,  John Bradshaw ,  Michael Martin-Smith

    IPC分类号： A61K31/155 ,  A61K31/335 ,  A61K31/38 ,  A61P1/00 ,  C07C67/00 ,  C07C209/00 ,  C07C211/27 ,  C07C213/00 ,  C07C217/48 ,  C07C239/00 ,  C07C275/12 ,  C07C279/04 ,  C07C279/28 ,  C07C301/00 ,  C07C311/64 ,  C07C325/00 ,  C07C335/08 ,  C07D233/64 ,  C07D295/096 ,  C07D307/38 ,  C07D307/42 ,  C07D307/52 ,  C07D333/14 ,  C07D333/38

    CPC分类号： C07D295/096 ,  C07C279/28 ,  C07D307/38 ,  C07D307/42 ,  C07D307/52 ,  C07D333/14 ,  Y10S514/886 ,  Y10S514/926 ,  Y10S514/927

    摘要： The invention provides compounds of general formula ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in whichY and Z, which may be the same or different, each represent oxygen, sulphur, .dbd.CHNO.sub.2 or .dbd.NR.sub.3 where R.sub.3 is hydrogen, nitro, cyano, lower alkyl, aryl, alkylsulphonyl or arylsulphonyl;p has a value from 2 to 12;R.sub.1 represents ##STR2## in which R.sub.4 and R.sub.5 which may be the same or different, each represent hydrogen, lower alkyl, cycloalkyl, lower alkenyl, aralkyl or lower alkyl interrupted by an oxygen atom or a group >N-R.sub.6 in which R.sub.6 represents hydrogen or lower alkyl, or R.sub.4 and R.sub.5 together with the nitrogen atom to which they are attached from a 5 to 7-membered saturated heterocyclic ring which may contain an additional oxygen atom or the group >NR.sub.6 ;Q represents a furan or thiophen ring in which incorporation into the rest of the molecule is through bonds at the 2 and 5 positions, or a benzene ring in which incorporation into the rest of the molecule is through bonds at the 1 and 3 or 1 and 4 positions;x represents --CH.sub.2 --, --O-- or --S--;n represents zero or 1;m represents 2, 3 or 4 andAlk represents a straight chain alkylene group of 1 to 3 carbon atoms;andR.sub.2 represents lower alkyl or the group--(CH.sub.2).sub.y E(CH.sub.2).sub.x Gin whichy represents 2, 3 or 4 or can additionally represent zero or 1 when E is a --CH.sub.2 -- group;x represents zero, 1 or 2;E represents --CH.sub.2 --, --O-- or --S--; andG represents a monocyclic 5 or 6 membered carbocyclic or heterocyclic aromatic ring; or G represents the group ##STR3## where Q' represents any of the rings defined for Q; Alk' represents any of the groups defined for Alk;and R.sub.4 ' and R.sub.5 ' which may be the same or different represent any of the groups defined for R.sub.4 or R.sub.5.The compounds of formula (I) have pharmacological activity as selective histamine H.sub.2 -antagonists.

    摘要翻译： 本发明提供了通式（I）的化合物及其生理上可接受的盐，水合物和生物前体，其中Y和Z可以相同或不同，各自表示氧，硫，= CHNO 2或= NR 3，其中R 3 是氢，硝基，氰基，低级烷基，芳基，烷基磺酰基或芳基磺酰基; p的值为2到12; R 1表示其中可以相同或不同的R 4和R 5各自表示氢，低级烷基，环烷基，低级烯基，芳烷基或被氧原子间隔的低级烷基或基团> N-R6，其中R 6表示 氢或低级烷基，或R 4和R 5与它们所连接的氮原子一起可以含有另外的氧原子或基团> NR 6的5至7元饱和杂环; Q表示呋喃或噻吩环，其中与分子的其余部分结合通过2和5位的键，或苯环，其中结合到分子的其余部分通过1和3或1的键和 4个职位; x表示-CH 2 - ， - O-或-S-; n表示0或1; m表示2,3或4，Alk表示1〜3个碳原子的直链亚烷基。 并且R 2表示低级烷基或基团 - （CH 2）y E（CH 2）x G，其中y表示2,3或4，或当E是-CH 2 - 基团时可另外表示0或1; x表示零，1或2; E表示-CH 2 - ， - O-或-S-; G表示单环5或6元碳环或杂环芳环; 或G表示组，其中Q'表示为Q定义的任何环; Alk'代表为Alk定义的任何组; 和可以相同或不同的R 4'和R 5'表示对于R 4或R 5定义的任何基团。 式（I）化合物具有作为选择性组胺H2拮抗剂的药理学活性。

    UREA AND URETHANE GROUP CONTAINING ANTI-SETTLING RHEOLOGY CONTROL ADDITIVE
    7.
    发明申请
    UREA AND URETHANE GROUP CONTAINING ANTI-SETTLING RHEOLOGY CONTROL ADDITIVE 审中-公开

    公开(公告)号：US20200308106A1

    公开(公告)日：2020-10-01

    申请号：US16954656

    申请日：2018-12-20

    申请人： BYK-Chemie GmbH

    发明人： Christiane Knappke-Bongartz ,  René Nagelsdiek ,  Sylvia Bühne ,  Jan Von Haaren ,  Agnetha Klein ,  Christoph Verlinden

    IPC分类号： C07C275/12

    摘要： The present invention relates to a urea and urethane group containing product comprising one or more species of formula (I) R1—O—(C═O)—NH—R2—NH—(C═O)—NH—R3—NH—[—(C═O)—NH—R4—NH—(C═O)—NH—R3—NH—]n—(C═O)—NH—R2—NH—(C═O)—O—R1 (I), wherein R1 independently represents a non-aromatic hydrocarbyl group having 14 to 30 carbon atoms; R2 independently represents alkyl-substituted aromatic hydrocarbyl groups having 7 to 12 carbon atoms; R3 independently represents hydrocarbyl groups having 2 to 36 carbon atoms, which can be interrupted by 1 to 17 ether oxygen atoms in case of aliphatic hydrocarbyl groups; R4 independently represents hydrocarbyl groups having 2 to 36 carbon atoms; n is an integer from 0 to 200; and wherein on average from 40 mol-% to 100 mol-% of all R3 and R4 groups contained in the one or more species of formula (I) are acyclic aliphatic hydrocarbyl groups which, in case of R3, can be interrupted by 1 to 17 ether oxygen atoms. The invention further relates to a method of manufacturing such product, liquid compositions containing such products and the use of the liquid compositions as rheology control additive, preferably as anti-settling agent. Furthermore, the present invention relates to a process for rheology adjustment, comprising the step of adding such liquid composition to a variety of compositions and formulations.