利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

12 条记录 (耗时 0.045 秒)

    PROSTHESIS DEPLOYMENT DEVICE WITH TRANSLUCENT DISTAL END
    3.
    发明申请
    PROSTHESIS DEPLOYMENT DEVICE WITH TRANSLUCENT DISTAL END 有权
    具有透视距离的前置部署装置

    公开(公告)号：US20090228092A1

    公开(公告)日：2009-09-10

    申请号：US12467491

    申请日：2009-05-18

    申请人： Jennifer E. Raeder-Devens ,  Susan I. Shelso ,  James F. Hemerick ,  Eric M. Schneider ,  Heather L. Getty ,  Doreen M. Borgmann ,  Kakao Sisombath ,  Jeffrey A. Helgerson

    发明人： Jennifer E. Raeder-Devens ,  Susan I. Shelso ,  James F. Hemerick ,  Eric M. Schneider ,  Heather L. Getty ,  Doreen M. Borgmann ,  Kakao Sisombath ,  Jeffrey A. Helgerson

    IPC分类号： A61F2/06

    CPC分类号： A61F2/02 ,  A61F2/95 ,  A61F2/966 ,  B29C66/1122 ,  B29C66/5221 ,  B29C66/712 ,  B32B27/08 ,  B32B27/322 ,  Y10T29/49826

    摘要： A prosthesis delivery and deployment device includes an elongate and flexible outer catheter. The outer catheter has a tubular wall of layered construction, including a translucent inner liner running the complete catheter length, and three outer layers including a translucent distal layer, an opaque medial layer and an opaque proximal outer layer. The outer layers are adjacent one another and are bonded to the liner. A braid composed of helically wound metal filaments is disposed between the liner and the proximal and medial outer layers, and includes a distal portion between the liner and a proximal portion of the distal outer layer. The liner and distal outer layer provide a translucent distal region of the catheter that is adapted to constrain a radially self-expanding prosthesis in a radially reduced, axially elongated state. Because the stent constraining region is translucent, an endoscope can be used to visually monitor the stent when so constrained. Radiopaque markers can be mounted to the outer catheter and to an inner catheter used to deploy the prosthesis, to afford a combined visual and fluoroscopic monitoring for enhanced accuracy in positioning the prosthesis, both before and during its deployment.

    摘要翻译： 假体递送和展开装置包括细长且柔性的外导管。 外导管具有分层结构的管状壁，其包括运行完整导管长度的半透明内衬，以及包括半透明远侧层，不透明中间层和不透明近侧外层的三个外层。 外层彼此相邻并且结合到衬垫上。 由螺旋缠绕的金属细丝构成的编织物设置在衬垫和近侧和内侧外层之间，并且包括位于衬垫和远端外层的近侧部分之间的远侧部分。 衬垫和远端外层提供导管的半透明远侧区域，其适于以径向减小的轴向伸长状态约束径向自扩张假体。 由于支架约束区域是半透明的，所以当受到限制时，可以使用内窥镜来视觉监测支架。 不透射线的标记物可以安装到外导管和用于部署假体的内导管，以在组装之前和期间提供组合的视觉和荧光透视监测，以提高假体定位的准确性。

    Prosthesis deployment device with translucent distal end
    4.
    发明授权
    Prosthesis deployment device with translucent distal end 有权
    具有半透明末端的假体部署装置

    公开(公告)号：US06726712B1

    公开(公告)日：2004-04-27

    申请号：US09569445

    申请日：2000-05-12

    申请人： Jennifer E. Raeder-Devens ,  Susan I. Shelso ,  James F. Hemerick ,  Eric M. Schneider ,  Heather L. Getty ,  Doreen M. Borgmann ,  Kakao Sisombath ,  Jeffrey A. Helgerson

    发明人： Jennifer E. Raeder-Devens ,  Susan I. Shelso ,  James F. Hemerick ,  Eric M. Schneider ,  Heather L. Getty ,  Doreen M. Borgmann ,  Kakao Sisombath ,  Jeffrey A. Helgerson

    IPC分类号： A61F206

    CPC分类号： A61F2/02 ,  A61F2/95 ,  A61F2/966 ,  B29C66/1122 ,  B29C66/5221 ,  B29C66/712 ,  B32B27/08 ,  B32B27/322 ,  Y10T29/49826

    摘要： A prosthesis delivery and deployment device includes an elongated and flexible outer catheter. The outer catheter has a tubular wall of layered construction, including a translucent inner liner running the complete catheter length, and three outer layers including a translucent distal layer, an opaque medial layer and an opaque proximal outer layer. The outer layers are adjacent one another and are bonded to the liner. A braid composed of helically wound metal filaments is disposed between the liner and the proximal and medial outer layers, and includes a distal portion between the liner and a proximal portion of the distal outer layer. The liner and distal outer layer provide a translucent distal region of the catheter that is adapted to constrain a radially self-expanding prosthesis in a radially reduced, axially elongated state. Because the stent constraining region is translucent, an endoscope can be used to visually monitor the stent when so constrained. Radiopaque markers can be mounted to the outer catheter and to an inner catheter used to deploy the prosthesis, to afford a combined visual and fluoroscopic monitoring for enhanced accuracy in positioning the prosthesis, both before and during its deployment.

    摘要翻译： 假体递送和展开装置包括细长且柔性的外导管。 外导管具有分层结构的管状壁，其包括运行完整导管长度的半透明内衬，以及包括半透明远侧层，不透明内侧层和不透明近侧外层的三个外层。 外层彼此相邻并且结合到衬垫上。 由螺旋缠绕的金属细丝构成的编织物设置在衬垫和近侧和内侧外层之间，并且包括位于衬垫和远端外层的近侧部分之间的远侧部分。 衬垫和远端外层提供导管的半透明远侧区域，其适于以径向减小的轴向伸长状态约束径向自扩张假体。 由于支架约束区域是半透明的，所以当受到限制时，可以使用内窥镜来视觉监测支架。 不透射线的标记物可以安装到外导管和用于部署假体的内导管，以在组装之前和期间提供组合的视觉和荧光透视监测，以提高假体的定位精度。

    Process for fabricating a prosthesis
    5.
    发明授权
    Process for fabricating a prosthesis 有权
    制造假体的方法

    公开(公告)号：US06295714B1

    公开(公告)日：2001-10-02

    申请号：US09510209

    申请日：2000-02-22

    申请人： Suranjan Roychowdhury ,  Leonard Pinchuk ,  Eugen Hofmann ,  Susanne Hankh ,  Michael G. O'Connor ,  Jennifer E. Raeder-Devens ,  Jeannine B. Baden ,  Daniel J. Klima

    发明人： Suranjan Roychowdhury ,  Leonard Pinchuk ,  Eugen Hofmann ,  Susanne Hankh ,  Michael G. O'Connor ,  Jennifer E. Raeder-Devens ,  Jeannine B. Baden ,  Daniel J. Klima

    IPC分类号： B21D3900

    CPC分类号： A61F2/90 ,  A61F2/958 ,  A61F2002/30451 ,  A61F2002/9522 ,  A61F2220/0058 ,  A61F2240/001 ,  Y10T29/49798 ,  Y10T29/49927

    摘要： A body implantable stent is formed of a plurality of strands arranged in two sets of coaxial helices, wound in opposite directions to form multiple crossings. At selected crossings, the adjacent strands are welded to one another, while at the remaining crossings the strands are free for limited movement relative to one another. The welds are formed in patterns that preferably enhance radial strength and rigidity, while having a minimal impact on axial bending flexibility. Preferred weld patterns in this regard include rings or circumferential rows, and helices, particularly with a steeper pitch than that of the strands. Stent fabrication preferably involves resistance welding at the crossings, and use of a tool to reuniformly compress the stent around and against the distal end region of a balloon catheter used later to deliver the stent to a treatment site.

    摘要翻译： 身体可植入支架由多个绞合线构成，所述股线布置成两组同轴螺旋，沿相反方向缠绕以形成多个交叉。 在所选的交叉处，相邻的线条彼此焊接，而在剩余的交叉处，线条相对于彼此有限的移动是自由的。 焊缝以优选增强径向强度和刚度的图案形成，同时对轴向弯曲柔性具有最小的影响。 在这方面，优选的焊接图案包括环或周向排和螺旋，特别是具有比线的陡峭的间距。 支架制造优选地涉及在交叉点处的电阻焊接，以及使用工具将支架均匀地压缩在球囊导管的远端区域周围并抵靠以后用于将支架输送到治疗部位的远端区域。

    Drug-releasing coatings for medical devices
    6.
    发明授权
    Drug-releasing coatings for medical devices 失效
    用于医疗器械的药物释放涂层

    公开(公告)号：US6042875A

    公开(公告)日：2000-03-28

    申请号：US260971

    申请日：1999-03-02

    申请人： Ni Ding ,  Jennifer E. Raeder-Devens ,  Tuyethoa Thi Trinh

    发明人： Ni Ding ,  Jennifer E. Raeder-Devens ,  Tuyethoa Thi Trinh

    IPC分类号： A61F2/82 ,  A61L27/34 ,  A61L27/50 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  B05D3/00 ,  B05D3/02 ,  B05D3/04

    CPC分类号： A61L27/50 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/258 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/42 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2300/61 ,  A61L2300/802

    摘要： The invention is directed to medical devices having a drug-releasing coating and methods for making such coated devices. The coating permits timed or prolonged pharmacological activity on the surface of medical devices through a reservoir concept. Specifically, the coating comprises at least two layers: an outer layer containing at least one drug-ionic surfactant complex overlying a reservoir layer containing a polymer and the drug which is substantially free of an ionic surfactant. Upon exposure to body tissue of a medical device covered with such coating, the ionically bound drug in the outer layer is released into body fluid or tissue. Following release of such bound drug, the ionic surfactant binding sites in the outer layer are left vacant. To maintain the pharmacological activity after delivery of the ionically bound drug, additional amounts of the drug are embedded or incorporated in the reservoir layer in a manner which allows the drug, which is substantially free of ionic surfactants, to complex with the vacant binding sites of the ionic surfactant of the outer layer. As a result, the surface of the medical device is enriched with the drug to provide sustained pharmacological activity to prevent the adverse reaction due to the presence of the medical device. The invention is further directed to medical devices with stabilized drug-releasing coatings. The coatings are stabilized by exposure to a low energy, relatively non-penetrating energy source, e.g., gas plasma or an electron beam energy source.

    摘要翻译： 本发明涉及具有药物释放涂层的医疗装置及其制造方法。 涂层允许通过储存器概念在医疗装置的表面上定时或延长药理活性。 具体地说，该涂层包括至少两层：包含至少一种药物 - 离子表面活性剂复合物的外层，其中包含聚合物的储存层和基本上不含离子表面活性剂的药物。 在暴露于用这种涂层覆盖的医疗装置的身体组织上时，外层中的离子结合药物被释放到体液或组织中。 释放这种结合药物后，外层中的离子表面活性剂结合位点留空。 为了在输送离子结合的药物之后保持药理活性，将额外量的药物以允许基本上不含离子表面活性剂的药物与储存层中的空位结合位点复合的方式嵌入或并入储存层中 外层的离子表面活性剂。 结果，医疗装置的表面富含药物以提供持续的药理活性，以防止由于存在医疗装置而引起的不良反应。 本发明进一步涉及具有稳定的药物释放涂层的医疗装置。 通过暴露于低能量，相对非穿透能量源（例如气体等离子体或电子束能量源）来使涂层稳定。

    Drug-releasing coatings for medical devices
    10.
    发明授权
    Drug-releasing coatings for medical devices 失效

    公开(公告)号：US5879697A

    公开(公告)日：1999-03-09

    申请号：US841747

    申请日：1997-04-30

    申请人： Ni Ding ,  Jennifer E. Raeder-Devens ,  Tuyethoa Thi Trinh

    发明人： Ni Ding ,  Jennifer E. Raeder-Devens ,  Tuyethoa Thi Trinh

    IPC分类号： A61F2/82 ,  A61L27/34 ,  A61L27/50 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61F13/00

    CPC分类号： A61L27/50 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/258 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/42 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2300/61 ,  A61L2300/802

    摘要： The invention is directed to medical devices having a drug-releasing coating and methods for making such coated devices. The coating permits timed or prolonged pharmacological activity on the surface of medical devices through a reservoir concept. Specifically, the coating comprises at least two layers: an outer layer containing at least one drug-ionic surfactant complex overlying a reservoir layer containing a polymer and the drug which is substantially free of an ionic surfactant. Upon exposure to body tissue of a medical device covered with such coating, the ionically bound drug in the outer layer is released into body fluid or tissue. Following release of such bound drug, the ionic surfactant binding sites in the outer layer are left vacant. To maintain the pharmacological activity after delivery of the ionically bound drug, additional amounts of the drug are embedded or incorporated in the reservoir layer in a manner which allows the drug, which is substantially free of ionic surfactants, to complex with the vacant binding sites of the ionic surfactant of the outer layer. As a result, the surface of the medical device is enriched with the drug to provide sustained pharmacological activity to prevent the adverse reaction due to the presence of the medical device. The invention is further directed to medical devices with stabilized drug-releasing coatings. The coatings are stabilized by exposure to a low energy, relatively non-penetrating energy source, e.g., gas plasma or an electron beam energy source.