公开(公告)号：US06685730B2

公开(公告)日：2004-02-03

申请号：US10254233

申请日：2002-09-25

申请人： Jennifer L. West ,  Rebekah Drezek ,  Scott Sershen ,  Nancy J. Halas

发明人： Jennifer L. West ,  Rebekah Drezek ,  Scott Sershen ,  Nancy J. Halas

IPC分类号： A61N5067

CPC分类号： A61L24/02 ,  A61B18/20 ,  A61B18/203 ,  A61B18/28 ,  A61B2017/00508 ,  A61B2018/00452 ,  A61B2018/0047 ,  A61K41/0052 ,  A61K41/008 ,  A61K47/6923 ,  A61K47/6929 ,  A61L24/001 ,  A61L24/0089 ,  A61L26/0004 ,  A61L26/0095 ,  A61L2400/12 ,  B82Y5/00

摘要： This invention is generally in the field of improved methods for the localized delivery of heat and the use thereof for the repair of tissue. The method involves localized induction of hyperthermia in tissue or materials by delivering nanoparticles to the tissue or materials and exposing the nanoparticles to an excitation source under conditions wherein they emit heat. The generation of heat effects the joining of the tissue or materials.

摘要翻译： 本发明通常在用于局部传递热量的改进方法及其用于组织修复的用途领域中。 该方法包括通过将纳米颗粒递送到组织或材料并将纳米颗粒暴露于其发射热的条件下的激发源来在组织或材料中局部诱导热疗。 热的产生影响组织或材料的接合。

公开(公告)号：US20070060950A1

公开(公告)日：2007-03-15

申请号：US10975205

申请日：2004-10-27

申请人： Farhad Khosravi ,  Suresh Pai ,  Celso Bagaoisan ,  Scott Sershen

发明人： Farhad Khosravi ,  Suresh Pai ,  Celso Bagaoisan ,  Scott Sershen

IPC分类号： A61B17/08

CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B2017/00004 ,  A61B2017/00495 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61B2090/062

摘要： An apparatus for sealing a puncture extending through tissue to a blood vessel includes a guidewire including an expandable tamp, a retaining sheath for covering the tamp, and a delivery sheath including a primary lumen for receiving the guidewire therethrough and a secondary lumen for delivering sealing compound into the puncture. The guidewire is advanced into the puncture with the tamp in a contracted condition, the tamp is expanded within the vessel after retracting the retaining sheath, and the guidewire is retracted to seal the puncture from the vessel. The delivery sheath is advanced over the guidewire, and sealing compound is introduced into the puncture through the delivery sheath. After introducing the sealing compound, the delivery sheath is removed, and an introducer sheath is advanced over the guidewire to provide access to perform a medical procedure via the vessel after removing the guidewire.

摘要翻译： 用于将延伸穿过组织的穿刺密封到血管的装置包括：导丝，包括可膨胀的夯，用于覆盖夯的保持护套;以及输送护套，其包括用于接收导丝的主腔，以及用于输送密封化合物的第二内腔 进入穿刺。 导丝在收缩状态下用夯实进入穿刺中，在缩回保持护套之后，在容器内膨胀，并且引导线缩回以密封穿孔。 输送护套在引导线上前进，并且密封化合物通过输送护套引入穿刺。 在引入密封化合物之后，移除输送护套，并且引导器护套在引导线上前进，以在移除引导线之后提供通过血管执行医疗程序的通路。

公开(公告)号：US20050149117A1

公开(公告)日：2005-07-07

申请号：US10745946

申请日：2003-12-24

申请人： Farhad Khosravi ,  Celso Bagaoisan ,  Suresh Pai ,  Scott Sershen

发明人： Farhad Khosravi ,  Celso Bagaoisan ,  Suresh Pai ,  Scott Sershen

IPC分类号： A61B17/00 ,  A61B17/08 ,  A61M5/178

CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B2017/00495 ,  A61B2017/00637 ,  A61B2017/0065

摘要： Apparatus and methods are provided for sealing a puncture extending through tissue to a blood vessel. A delivery sheath is introduced-into the puncture, and a sealing compound, e.g., precursor polymers that mix to create a hydrogel, is introduced through the delivery sheath into the puncture. The delivery sheath is then removed, an introducer sheath is advanced through the puncture into the vessel, and instruments are introduced through the introducer sheath into the vessel to perform a medical procedure. After completing the procedure, the introducer sheath is withdrawn. The sealing compound may expand into the puncture and/or tissue recoil of the surrounding tissue may cause the sealing compound to at least partially occlude the puncture to facilitate sealing and/or hemostasis.

摘要翻译： 提供了用于将延伸穿过组织的穿刺密封到血管的装置和方法。 将输送护套引入穿刺中，并且通过输送护套将密封化合物（例如混合以产生水凝胶的前体聚合物）引入穿刺中。 然后移出输送鞘，引导器护套穿过穿刺进入血管，并且将器械通过导引器鞘导入血管以执行医疗程序。 完成该程序后，引导器护套被取出。 密封化合物可能膨胀到周围组织的穿刺和/或组织反冲中，可能导致密封化合物至少部分地阻塞穿刺以便于密封和/或止血。

公开(公告)号：US20080082122A1

公开(公告)日：2008-04-03

申请号：US11854534

申请日：2007-09-12

申请人： Farhad Khosravi ,  Suresh Pai ,  Celso Bagaoisan ,  Scott Sershen ,  Marlon Moreno ,  Juan Domingo

发明人： Farhad Khosravi ,  Suresh Pai ,  Celso Bagaoisan ,  Scott Sershen ,  Marlon Moreno ,  Juan Domingo

IPC分类号： A61B17/08

CPC分类号： A61B17/0057 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61B2017/00654

摘要： An apparatus for sealing a puncture through tissue to a vessel includes an elongate occlusion member including an expandable member, a cartridge carried on the occlusion member, and a sealant carried within the cartridge. The cartridge includes an outer member and a pusher member within the outer member. The sealant is disposed within the outer member adjacent the expandable member distal to the pusher member. During use, the occlusion member is introduced into a puncture until the expandable member and the sealant extend from the puncture into the vessel. The expandable member is expanded, and withdrawn until the expanded expandable member contacts the vessel wall, thereby withdrawing the sealant back into the puncture. The outer member is withdrawn to expose the sealant within the puncture, while the pusher member prevents removal of the sealant, and then the cartridge, occlusion member, and pusher member are successively removed.

摘要翻译： 用于将通过组织的穿刺密封到容器的装置包括包括可扩张构件的细长阻塞构件，承载在闭塞构件上的药筒和在药筒内承载的密封剂。 该盒在外部构件内包括外部构件和推动构件。 密封剂设置在外部构件中，邻近可推动构件远离推动构件。 在使用期间，将阻塞构件引入穿刺中，直到可膨胀构件和密封剂从穿刺件延伸到容器中。 可膨胀构件被膨胀并且被抽出直到膨胀的可膨胀构件接触血管壁，从而将密封剂抽回到穿刺中。 取出外部构件以在穿刺中露出密封剂，同时推动器构件防止密封剂的移除，然后连续地移除盒，遮挡构件和推动构件。