公开(公告)号：US06685730B2

公开(公告)日：2004-02-03

申请号：US10254233

申请日：2002-09-25

申请人： Jennifer L. West ,  Rebekah Drezek ,  Scott Sershen ,  Nancy J. Halas

发明人： Jennifer L. West ,  Rebekah Drezek ,  Scott Sershen ,  Nancy J. Halas

IPC分类号： A61N5067

CPC分类号： A61L24/02 ,  A61B18/20 ,  A61B18/203 ,  A61B18/28 ,  A61B2017/00508 ,  A61B2018/00452 ,  A61B2018/0047 ,  A61K41/0052 ,  A61K41/008 ,  A61K47/6923 ,  A61K47/6929 ,  A61L24/001 ,  A61L24/0089 ,  A61L26/0004 ,  A61L26/0095 ,  A61L2400/12 ,  B82Y5/00

摘要： This invention is generally in the field of improved methods for the localized delivery of heat and the use thereof for the repair of tissue. The method involves localized induction of hyperthermia in tissue or materials by delivering nanoparticles to the tissue or materials and exposing the nanoparticles to an excitation source under conditions wherein they emit heat. The generation of heat effects the joining of the tissue or materials.

摘要翻译： 本发明通常在用于局部传递热量的改进方法及其用于组织修复的用途领域中。 该方法包括通过将纳米颗粒递送到组织或材料并将纳米颗粒暴露于其发射热的条件下的激发源来在组织或材料中局部诱导热疗。 热的产生影响组织或材料的接合。

公开(公告)号：US06593101B2

公开(公告)日：2003-07-15

申请号：US09821843

申请日：2001-03-28

申请人： Rebecca R. Richards-Kortum ,  Andrés F. Zuluaga ,  Rebekah Drezek ,  Colin Smithpeter ,  Tom Collier

发明人： Rebecca R. Richards-Kortum ,  Andrés F. Zuluaga ,  Rebekah Drezek ,  Colin Smithpeter ,  Tom Collier

IPC分类号： C12Q102

CPC分类号： G01N1/30 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/4331 ,  Y10T436/13

摘要： Methods for enhancing contrast during imaging to assess cell and nuclear morphology of a sample. A contrast agent such as acetic acid, toluidine blue, hypertonic saline, hypotonic saline, Lugol's iodine, an absorbing dye, a liposome, or a contrast agent linked to a marker are applied to a sample. The sample is analyzed with an imaging device to create image data, and the sample is diagnosed using the image data.

公开(公告)号：US06187289B1

公开(公告)日：2001-02-13

申请号：US09175234

申请日：1998-10-20

申请人： Rebecca Richards-Kortum ,  Rebekah Drezek ,  Colin Smithpeter ,  Andres F. Zuluaga

发明人： Rebecca Richards-Kortum ,  Rebekah Drezek ,  Colin Smithpeter ,  Andres F. Zuluaga

IPC分类号： A61K4900

CPC分类号： G01N33/52 ,  A61B5/0071 ,  A61B5/4331 ,  G01N1/30 ,  G01N2015/1488

摘要： A method for using acetic acid as a contrast agent during reflectance confocal imaging of normal and neoplastic tissue, particularly epithelium. In one aspect, the invention includes a method of using acetic acid as a contrast agent for confocal imaging of cells, including applying acetic acid to the diagnostic tissue sample in sufficient concentration to induce a small scale alteration of the index of refraction of nuclei in the cells; and imaging such cells using a reflectance confocal imaging system.

摘要翻译： 在正常和肿瘤组织，特别是上皮的反射共聚焦成像期间使用乙酸作为造影剂的方法。 一方面，本发明包括使用乙酸作为细胞共聚焦显像的造影剂的方法，包括以足够的浓度向诊断组织样品中加入乙酸以诱导细胞核中的折射指数的小规模改变 细胞; 并使用反射共聚焦成像系统对这样的细胞进行成像。

公开(公告)号：US20140086828A1

公开(公告)日：2014-03-27

申请号：US13700582

申请日：2011-05-31

申请人： Aaron E. Foster ,  Laura B. Carpin ,  Adham S. Bear ,  Rebekah Drezek ,  Adam Yuh Lin

发明人： Aaron E. Foster ,  Laura B. Carpin ,  Adham S. Bear ,  Rebekah Drezek ,  Adam Yuh Lin

IPC分类号： A61K47/48 ,  A61K49/00 ,  A61K51/12

CPC分类号： A61K47/6901 ,  A61K31/7088 ,  A61K33/24 ,  A61K35/17 ,  A61K38/04 ,  A61K38/16 ,  A61K45/06 ,  A61K47/6923 ,  A61K2300/00

摘要： The present invention concerns methods and compositions utilizing gold nanoparticles for therapy for a medical condition, such as cancer. In particular aspects, the nanoparticles are included with or in a T cell to facilitate targeting of the nanoparticles to a desired location in vivo and/or to facilitate therapeutic treatment for the condition. In specific cases, the nanoparticle/T cell compositions further comprise microRNAs and/or peptides, and so forth.

摘要翻译： 本发明涉及利用金纳米颗粒治疗诸如癌症的医学病症的方法和组合物。 在特定方面，纳米颗粒包含在T细胞中或在T细胞中，以促进纳米颗粒靶向体内所需的位置和/或促进该病症的治疗性治疗。 在具体情况下，纳米颗粒/ T细胞组合物还包含微RNA和/或肽等等。

公开(公告)号：US06639674B2

公开(公告)日：2003-10-28

申请号：US09821836

申请日：2001-03-28

申请人： Konstantin Sokolov ,  Rebekah Drezek ,  Urs Utzinger ,  Rebecca Richards-Kortum

发明人： Konstantin Sokolov ,  Rebekah Drezek ,  Urs Utzinger ,  Rebecca Richards-Kortum

IPC分类号： G01J400

CPC分类号： A61B5/444 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0088 ,  G01N21/21

摘要： Methods and apparatus for assessing the size of a scattering element of a sample. Primary radiation is generated from a source. The primary radiation is polarized to produce polarized primary radiation. The polarized primary radiation is directed to the sample to generate reflected radiation. The reflected radiation is directed through a polarizer to produce filtered reflected radiation, the polarizer being configured to select reflected radiation parallel and perpendicular to the polarization of the polarized primary radiation. The filtered radiation is detected, and a depolarization ratio is calculated using the detected filtered radiation. The size of the scattering element is calculated using the depolarization ratio.