利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

80 条记录 (耗时 0.044 秒)

    Substituted Diazabicycloalkane Derivates
    1.
    发明申请
    Substituted Diazabicycloalkane Derivates 有权
    取代的二氮杂双环烷烃衍生物

    公开(公告)号：US20080275048A1

    公开(公告)日：2008-11-06

    申请号：US12132009

    申请日：2008-06-03

    申请人： Jennifer M. Frost ,  Jianguo Ji ,  Tao Li ,  Diana L. Nersesian ,  Karin R. Tietje

    发明人： Jennifer M. Frost ,  Jianguo Ji ,  Tao Li ,  Diana L. Nersesian ,  Karin R. Tietje

    IPC分类号： A61K31/53 ,  A61K31/506 ,  A61K31/501 ,  A61K31/497 ,  A61K31/4439 ,  A61K31/4178 ,  C07D403/14

    CPC分类号： A61K31/501 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/506 ,  A61K31/53

    摘要： Compounds of formula (I) Z-Ar1—Ar2   (I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.

    摘要翻译： 式（I）化合物<？in-line-formula description =“In-line Formulas”end =“lead”？> Z-Ar 1 -Ar 2 I）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中Z是二氮杂双环胺，Ar 1是5或6元芳环 和Ar 2 2选自未取代或取代的5或6元杂芳基环; 未取代或取代的双环杂芳基环; 3,4-（亚甲二氧基）苯基; 咔唑基; 四氢咔唑基; 萘基; 和苯基; 其中苯基在间位或对位被0,1,2或3个取代基取代。 该化合物可用于治疗由α7nAChR配体预防或改善的病症或病症。 还公开了包含式（I）化合物和使用这些化合物和组合物的方法的药物组合物。