Compositions useful as inhibitors of protein kinases
    1.
    发明授权
    Compositions useful as inhibitors of protein kinases 失效
    可用作蛋白激酶抑制剂的组合物

    公开(公告)号:US08653088B2

    公开(公告)日:2014-02-18

    申请号:US12552003

    申请日:2009-09-01

    CPC分类号: C07D487/04

    摘要: The present invention provides a compound of formula I: or a pharmaceutically acceptable salt or mixtures thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK mammalian protein kinase, and more particularly inhibitors of GSK-3 mammalian protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.

    摘要翻译: 本发明提供式I化合物或其药学上可接受的盐或其混合物。 这些化合物是蛋白激酶的抑制剂,特别是GSK哺乳动物蛋白激酶的抑制剂,特别是GSK-3哺乳动物蛋白激酶的抑制剂。 本发明还提供包含本发明化合物的药学上可接受的组合物和利用这些化合物和组合物治疗各种蛋白激酶介导的病症的方法。

    Compositions Useful as Inhibitors of Protein Kinases
    2.
    发明申请
    Compositions Useful as Inhibitors of Protein Kinases 失效
    可用作蛋白激酶抑制剂的组合物

    公开(公告)号:US20090325968A1

    公开(公告)日:2009-12-31

    申请号:US12552003

    申请日:2009-09-01

    CPC分类号: C07D487/04

    摘要: The present invention provides a compound of formula I: or a pharmaceutically acceptable salt or mixtures thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK mammalian protein kinase, and more particularly inhibitors of GSK-3 mammalian protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.

    摘要翻译: 本发明提供式I化合物或其药学上可接受的盐或其混合物。 这些化合物是蛋白激酶的抑制剂,特别是GSK哺乳动物蛋白激酶的抑制剂,特别是GSK-3哺乳动物蛋白激酶的抑制剂。 本发明还提供包含本发明化合物的药学上可接受的组合物和利用这些化合物和组合物治疗各种蛋白激酶介导的病症的方法。

    Inhibitors of GSK-3 and uses thereof
    7.
    发明授权
    Inhibitors of GSK-3 and uses thereof 有权
    GSK-3抑制剂及其用途

    公开(公告)号:US06916798B2

    公开(公告)日:2005-07-12

    申请号:US10212471

    申请日:2002-08-02

    摘要: The present invention relates to compounds of formula I that are useful as GSK-3 inhibitors. The invention also relates to methods of using compounds of formula I or pharmaceutical compositions comprising compounds of formula I to inhibit GSK-3 activity. The invention further provides methods of utilizing these compounds and pharmaceutical compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. The invention also relates to methods for inhibiting Aurora-2 activity and for treating or preventing Aurora-2-mediated diseases using compounds of formula I or pharmaceutical compositions comprising compounds of formula I. The invention also relates to methods for inhibiting cyclin-dependent kinase-2 activity and for treating or preventing inhibiting cyclin-dependent kinase-2-mediated diseases using compounds of formula I or pharmaceutical compositions comprising compounds of formula I.

    摘要翻译: 本发明涉及可用作GSK-3抑制剂的式I化合物。 本发明还涉及使用式I化合物或包含式I化合物的药物组合物抑制GSK-3活性的方法。 本发明还提供了利用这些化合物和药物组合物治疗和预防各种疾病如糖尿病和阿尔茨海默病的方法。 本发明还涉及使用式I化合物或包含式I化合物的药物组合物抑制Aurora-2活性和治疗或预防Aurora-2介导的疾病的方法。本发明还涉及抑制细胞周期蛋白依赖性激酶 - 2活性,以及​​使用式I化合物或包含式I化合物的药物组合物治疗或预防抑制细胞周期蛋白依赖性激酶-2介导的疾病。