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    Protein kinase inhibitors and uses thereof
    2.
    发明授权
    Protein kinase inhibitors and uses thereof 失效
    蛋白激酶抑制剂及其用途

    公开(公告)号：US06825190B2

    公开(公告)日：2004-11-30

    申请号：US10172888

    申请日：2002-06-14

    申请人： Young-Choon Moon ,  Jeremy Green ,  Robert Davies ,  Deborah Choquette ,  Albert Pierce ,  Mark Ledeboer

    发明人： Young-Choon Moon ,  Jeremy Green ,  Robert Davies ,  Deborah Choquette ,  Albert Pierce ,  Mark Ledeboer

    IPC分类号： C07D41304

    CPC分类号： C07D413/04 ,  C07D413/14

    摘要： Described herein are benzisoxazole compounds of formula I: or a pharmaceutically acceptable derivative or prodrug thereof, wherein A-B is N—O or O—N; Ar is an optionally substituted C5-10 aryl group; R1 is hydrogen or an optionally substituted group selected from C1-10 aliphatic, C5-10 aryl, C6-12 aralkyl, C3-10 heterocyclyl, or C4-12 heterocyclylalkyl; and T, n, R2 and R3 are as described in the specification. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK-3 and JAK mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.

    摘要翻译： 本文描述的是式I的苯并异恶唑化合物：或其药学上可接受的衍生物或前药，其中A-B是N-O或O-N; Ar是任选取代的C 5-10芳基; R 1是氢或任选取代的基团，其选自C 1-10脂族基，C 5-10芳基，C 6-12芳烷基，C 3-10杂环基或C 4-12杂环基烷基; 和T，n，R 2和R 3如说明书中所述。 这些化合物是蛋白激酶的抑制剂，特别是GSK-3和JAK哺乳动物蛋白激酶的抑制剂。 本发明还提供包含本发明化合物的药学上可接受的组合物和利用这些化合物和组合物治疗各种蛋白激酶介导的病症的方法。

    Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
    9.
    发明授权
    Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases 失效
    c-Jun N-末端激酶（JNK）和其他蛋白激酶的抑制剂

    公开(公告)号：US06642227B2

    公开(公告)日：2003-11-04

    申请号：US10121035

    申请日：2002-04-10

    申请人： Jingrong Cao ,  Jeremy Green ,  Young-Choon Moon ,  Jian Wang ,  Mark Ledeboer ,  Edmund Harrington ,  Huai Gao

    发明人： Jingrong Cao ,  Jeremy Green ,  Young-Choon Moon ,  Jian Wang ,  Mark Ledeboer ,  Edmund Harrington ,  Huai Gao

    IPC分类号： C07D40904

    CPC分类号： C07D409/14 ,  C07D409/04 ,  C07D417/14

    摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable derivative o thereof, wherein A, B, Ra, R1, R2, R3, and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli; Lck and Src kinase. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

    摘要翻译： 本发明提供式I化合物或其药学上可接受的衍生物o，其中A，B，R a，R 1，R 2，R 3和R 4如上所述 在规范中。 这些化合物是蛋白激酶的抑制剂，特别是JNK的抑制剂，哺乳动物蛋白激酶涉及细胞增殖，细胞死亡和对细胞外刺激的反应; Lck和Src激酶。 本发明还涉及生产这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病的方法。