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公开(公告)号：US08112973B2
公开(公告)日：2012-02-14
申请号：US12493992
申请日：2009-06-29
IPC分类号： B65B55/22
CPC分类号： A61B17/06114 , A61B17/06138 , A61B17/06166 , A61B2017/00526 , A61B2017/00889 , A61B2017/06142 , A61B2050/314 , A61L17/005 , A61L2300/404
摘要： A method of making a packaged antimicrobial suture having improved shelf life. The method comprising the steps of providing an inner package having a source of antimicrobial agent, providing an adsorbent material effective to adsorb a portion of the antimicrobial agent over time, positioning a suture within the inner package, the suture comprising one or more surfaces, covering the inner package with an outer package having an inner surface and subjecting the suture, the inner package and the inner surface of the outer package to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the suture and the inner package, thereby substantially inhibiting bacterial colonization on the suture and the inner package, wherein the packaged antimicrobial suture exhibits improved shelf life. A packaged antimicrobial suture and a method of increasing the shelf life of a packaged antimicrobial medical device are also provided.
摘要翻译： 制备具有改善的保存期限的包装的抗微生物缝合线的方法。 该方法包括以下步骤：提供具有抗微生物剂来源的内包装，提供有效吸附一部分抗微生物剂的吸附材料随时间推移，将缝合线定位在内包装内，缝合线包括一个或多个表面，覆盖 具有外包装的内包装具有内表面并使缝合线，内包装和外包装的内表面经受足以使有效量的抗微生物剂从抗微生物剂来源蒸发的时间，温度和压力条件 缝合线和内包装，从而基本上抑制缝合线和内包装上的细菌定居，其中包装的抗微生物缝合线展现出改善的保质期。 还提供了包装的抗微生物缝合线和增加包装的抗微生物医疗装置的保质期的方法。
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2.发明申请PACKAGED ANTIMICROBIAL MEDICAL DEVICE HAVING IMPROVED SHELF LIFE AND METHOD OF PREPARING SAME 有权具有改进的保质期的包装抗微生物医疗装置及其制备方法公开(公告)号：US20120267263A1
公开(公告)日：2012-10-25
申请号：US13501063
申请日：2010-06-29
申请人： Jerry Fischer , Howard Scalzo , Henry Pokropinski
发明人： Jerry Fischer , Howard Scalzo , Henry Pokropinski
CPC分类号： A61B17/06114 , A61B17/06138 , A61B17/06166 , A61B2017/00526 , A61B2017/00889 , A61B2017/06142 , A61B2050/314 , A61L2/232 , A61L17/005 , A61L2202/24 , A61L2300/404
摘要： A method of making a packaged antimicrobial suture having improved shelf life. The method comprising the steps of providing an inner package having a source of antimicrobial agent, providing an adsorbent material effective to adsorb a portion of the antimicrobial agent over time, positioning a suture within the inner package, the suture comprising one or more surfaces, covering the inner package with an outer package having an inner surface and subjecting the suture, the inner package and the inner surface of the outer package to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the suture and the inner package, thereby substantially inhibiting bacterial colonization on the suture and the inner package, wherein the packaged antimicrobial suture exhibits improved shelf life. A packaged antimicrobial suture and a method of increasing the shelf life of a packaged antimicrobial medical device are also provided.
摘要翻译： 制备具有改善的保存期限的包装的抗微生物缝合线的方法。 该方法包括以下步骤：提供具有抗微生物剂来源的内包装，提供有效吸附一部分抗微生物剂的吸附材料随时间推移，将缝合线定位在内包装内，缝合线包括一个或多个表面，覆盖 具有外包装的内包装具有内表面并使缝合线，内包装和外包装的内表面经受足以使有效量的抗微生物剂从抗微生物剂来源蒸发的时间，温度和压力条件 缝合线和内包装，从而基本上抑制缝合线和内包装上的细菌定居，其中包装的抗微生物缝合线展现出改善的保质期。 还提供了包装的抗微生物缝合线和增加包装的抗微生物医疗装置的保质期的方法。
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3.发明授权Packaged antimicrobial medical device having improved shelf life and method of preparing same 有权具有改进的保存期限的包装抗微生物药物装置及其制备方法公开(公告)号：US09474524B2
公开(公告)日：2016-10-25
申请号：US13501063
申请日：2010-06-29
CPC分类号： A61B17/06114 , A61B17/06138 , A61B17/06166 , A61B2017/00526 , A61B2017/00889 , A61B2017/06142 , A61B2050/314 , A61L2/232 , A61L17/005 , A61L2202/24 , A61L2300/404
摘要： A method of making a packaged antimicrobial suture having improved shelf life. The method comprising the steps of providing an inner package having a source of antimicrobial agent, providing an adsorbent material effective to adsorb a portion of the antimicrobial agent over time, positioning a suture within the inner package, the suture comprising one or more surfaces, covering the inner package with an outer package having an inner surface and subjecting the suture, the inner package and the inner surface of the outer package to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the suture and the inner package, thereby substantially inhibiting bacterial colonization on the suture and the inner package, wherein the packaged antimicrobial suture exhibits improved shelf life. A packaged antimicrobial suture and a method of increasing the shelf life of a packaged antimicrobial medical device are also provided.
摘要翻译： 制备具有改善的保存期限的包装的抗微生物缝合线的方法。 该方法包括以下步骤：提供具有抗微生物剂来源的内包装，提供有效吸附一部分抗微生物剂的吸附材料随时间推移，将缝合线定位在内包装内，缝合线包括一个或多个表面，覆盖 具有外包装的内包装具有内表面并使缝合线，内包装和外包装的内表面经受足以使有效量的抗微生物剂从抗微生物剂来源蒸发的时间，温度和压力条件 缝合线和内包装，从而基本上抑制缝合线和内包装上的细菌定居，其中包装的抗微生物缝合线展现出改善的保质期。 还提供了包装的抗微生物缝合线和增加包装的抗微生物医疗装置的保质期的方法。
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公开(公告)号：US06881434B2
公开(公告)日：2005-04-19
申请号：US10209202
申请日：2002-07-31
CPC分类号： A61L17/145
摘要： A process for improving the knot tensile strength of a braided suture while maintaining its first throw holding characteristics includes the steps of applying a biocompatible co-polymer to the braided suture and then heating the suture to a temperature above the flow point of the co-polymer. An outer coat is applied to the suture after the heating step. The suture may be scoured with a solvent before the co-polymer is applied or the co-polymer may be applied simultaneously with the scouring step. The co-polymer preferably comprises one or more lactones, more preferably, ε-caprolactone and glycolide. This process may be used with bioabsorbable sutures, such as those comprising filaments made of polyglycolide and polylactide.
摘要翻译： 编织缝合线的结节拉伸强度同时保持其第一次保持特性的方法包括以下步骤：将生物相容的共聚物施加到编织缝合线上，然后将缝合线加热至高于共聚物流动点的温度 。 在加热步骤之后，将外涂层施加到缝合线上。 在施加共聚物之前，可以用溶剂洗涤缝合线，或者可以在冲刷步骤的同时施加共聚物。 共聚物优选包含一种或多种内酯，更优选ε-己内酯和乙交酯。 该方法可以与生物可吸收缝合线一起使用，例如包括由聚乙交酯和聚丙交酯制成的细丝的那些。
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公开(公告)号：US08156718B2
公开(公告)日：2012-04-17
申请号：US12417518
申请日：2009-04-02
IPC分类号： B65B55/02
CPC分类号： A61B17/06114 , A61B17/06166 , A61B50/00 , A61B2017/00889 , A61L17/005 , A61L2300/202 , A61L2300/404 , A61L2300/606
摘要： A method of making a packaged antimicrobial suture comprising the steps of providing a containment compartment that is substantially free of an antimicrobial agent; positioning a suture within the containment compartment, said suture comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof; placing the containment compartment having the suture in an outer package; and subjecting the outer package, the containment compartment and the suture to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the suture to the containment compartment, while retaining an effective amount of said antimicrobial agent on the suture, thereby substantially inhibiting bacterial colonization on the suture and the containment compartment.
摘要翻译： 一种制备包装的抗微生物缝合线的方法，包括以下步骤：提供基本上不含抗微生物剂的容纳隔室; 将缝合线定位在容纳隔室内，所述缝合线包括一个或多个表面，其上设置有抗微生物剂，所述抗微生物剂选自卤代羟基醚，酰氧基二苯醚及其组合; 将具有缝合线的容纳隔室放置在外包装中; 并且将外包装，容纳隔室和缝合线经受足够的时间，温度和压力条件，以将有效量的抗微生物剂从缝线转移到容纳隔室，同时将有效量的所述抗微生物剂保留在缝合线上 从而基本上抑制缝合线和容纳隔室上的细菌定植。
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公开(公告)号：US06841083B2
公开(公告)日：2005-01-11
申请号：US10184043
申请日：2002-06-27
IPC分类号： B01D65/02 , B01D65/08 , B01F1/00 , B01F3/04 , B01F13/02 , B08B3/10 , B01D53/22 , B29B13/00 , B29C47/00
CPC分类号： B08B3/102 , B01D65/02 , B01D65/08 , B01D2321/185 , B01F1/00 , B01F3/04262 , B01F13/0233 , B01F2003/04148 , B01F2003/04312 , B01F2003/04361
摘要： A device for scouring a coating from a fibrous material includes a tank for immersing a plurality of fibers in scouring solvent therein. The device also includes a bubbling device positioned therein and having a chamber formed between a base plate and a cover plate with a plurality of holes. The plurality of fibers is mounted within the tank above the cover plate and holes of the bubbling device, so that gas bubbles produced thereby move through the scouring solvent and through the plurality of fibers. The holes are arranged in a pattern on the cover plate that corresponds to a shape assumed by the plurality of fibers when mounted within the tank. A process for scouring a coating from a fibrous material is also disclosed and involves immersing a plurality of fibers in a scouring solvent and producing a plurality of gas bubbles that move through the solvent and the plurality of fibers. The process also involves arranging and mounting the plurality of fibers to assume a shape that corresponds to a pattern formed by the plurality of holes.
摘要翻译： 用于从纤维材料中冲洗涂层的装置包括用于将多根纤维浸入其中的冲刷溶剂中的罐。 该装置还包括定位在其中的起泡装置，并具有形成在基板和具有多个孔的盖板之间的室。 多个纤维被安装在罐的上方的盖板和发泡装置的孔之上，使得由此产生的气泡移动通过冲刷溶剂并通过多根纤维。 孔被布置在盖板上的图案中，其对应于当安装在罐中时由多根纤维假定的形状。 还公开了一种用于从纤维材料中冲洗涂层的方法，其中包括将多根纤维浸入冲刷溶剂中并产生移动通过溶剂和多根纤维的多个气泡。 该方法还涉及布置和安装多根纤维以呈现对应于由多个孔形成的图案的形状。
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公开(公告)号：US09597072B2
公开(公告)日：2017-03-21
申请号：US13449184
申请日：2012-04-17
CPC分类号： A61B17/06114 , A61B17/06166 , A61B50/00 , A61B2017/00889 , A61L17/005 , A61L2300/202 , A61L2300/404 , A61L2300/606
摘要： A method of making a packaged antimicrobial suture comprising the steps of providing a containment compartment that is substantially free of an antimicrobial agent; positioning a suture within the containment compartment, said suture comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof; placing the containment compartment having the suture in an outer package; and subjecting the outer package, the containment compartment and the suture to time, temperature and pressure conditions sufficient to transfer an effective amount of the antimicrobial agent from the suture to the containment compartment, while retaining an effective amount of said antimicrobial agent on the suture, thereby substantially inhibiting bacterial colonization on the suture and the containment compartment.
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公开(公告)号：US20090148492A1
公开(公告)日：2009-06-11
申请号：US12261620
申请日：2008-10-30
CPC分类号： A61F2/02 , A61B17/0057 , A61B17/12022 , A61B17/12109 , A61B17/12159 , A61B17/12172 , A61B17/12177 , A61B17/1219 , A61B2017/00004 , A61L31/041 , A61L31/141 , A61L31/148 , A61L31/16 , A61L2300/404 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/426 , A61L2300/43 , A61L2430/36 , D01D5/34 , D01F1/10 , D01F1/103 , D04H1/42 , Y10T442/2525 , Y10T442/3146 , Y10T442/3154 , Y10T442/3163 , Y10T442/3171 , Y10T442/637 , Y10T442/638 , Y10T442/64 , Y10T442/641 , Y10T442/642 , C08L75/04 , C08L67/04
摘要： A method of making a biocompatible, implantable medical device, including a vascular closure device is disclosed. The method includes forming a biocompatible polymer into at least one fiber and randomly orienting the at least one fiber into a fibrous structure having at least one interstitial spaces. Polymeric materials may be utilized to fabricate any of these devices. The polymeric materials may include additives such as drugs or other bioactive agents as well as antibacterial agents. In such instances, at least one agent, in therapeutic dosage, is incorporated into at least one of the fibrous structure and the at least one fiber.
摘要翻译： 公开了制造生物相容性可植入医疗装置的方法，包括血管闭合装置。 该方法包括将生物相容性聚合物形成至少一种纤维，并将至少一种纤维随机定向成具有至少一个间隙的纤维结构。 可以使用聚合材料来制造任何这些装置。 聚合物材料可以包括添加剂如药物或其他生物活性剂以及抗菌剂。 在这种情况下，将治疗剂量中的至少一种试剂并入纤维结构和至少一种纤维中的至少一种。
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公开(公告)号：US20120199502A1
公开(公告)日：2012-08-09
申请号：US13449184
申请日：2012-04-17
CPC分类号： A61B17/06114 , A61B17/06166 , A61B50/00 , A61B2017/00889 , A61L17/005 , A61L2300/202 , A61L2300/404 , A61L2300/606
摘要： A method of making a packaged antimicrobial suture comprising the steps of providing a containment compartment that is substantially free of an antimicrobial agent; positioning a suture within the containment compartment, said suture comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof; placing the containment compartment having the suture in an outer package; and subjecting the outer package, the containment compartment and the suture to time, temperature and pressure conditions sufficient to transfer an effective amount of the antimicrobial agent from the suture to the containment compartment, while retaining an effective amount of said antimicrobial agent on the suture, thereby substantially inhibiting bacterial colonization on the suture and the containment compartment.
摘要翻译： 一种制备包装的抗微生物缝合线的方法，包括以下步骤：提供基本上不含抗微生物剂的容纳隔室; 将缝合线定位在容纳隔室内，所述缝合线包括一个或多个表面，其上设置有抗微生物剂，所述抗微生物剂选自卤代羟基醚，酰氧基二苯醚及其组合; 将具有缝合线的容纳隔室放置在外包装中; 以及使外包装，容纳隔室和缝合线经受足以将有效量的抗微生物剂从缝线转移到容纳隔室的时间，温度和压力条件，同时将有效量的所述抗微生物剂保留在缝合线上， 从而基本上抑制缝合线和容纳隔室上的细菌定植。
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公开(公告)号：US20060091034A1
公开(公告)日：2006-05-04
申请号：US11301364
申请日：2005-12-13
IPC分类号： A61B19/02
CPC分类号： A61L17/005 , A61B17/06114 , A61B17/06166 , A61B50/00 , A61L2300/202 , A61L2300/404
摘要： A method for making an antimicrobial suture comprising the steps of positioning an antimicrobial agent source within a package comprising an inner surface, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof; positioning a medical device within the package; and subjecting the package, the antimicrobial agent source and the medical device to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the medical device, thereby substantially inhibiting bacterial colonization on the medical device. Alternatively, the packaged medical device is produced according to the steps of positioning a medical device within a package; exposing the package having the medical device to an antimicrobial agent source; and subjecting the package having the medical device and the antimicrobial agent source to time, temperature and pressure conditions sufficient to transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the medical device within the package, thereby substantially inhibiting bacterial colonization on the medical device.
摘要翻译： 一种用于制备抗微生物缝合线的方法，包括以下步骤：将抗微生物剂源定位在包含内表面的包装中，所述抗微生物剂选自卤代羟基醚，酰氧基二苯醚及其组合; 将医疗设备定位在包装内; 以及使所述包装，所述抗微生物剂源和所述医疗装置经受足以将有效量的所述抗微生物剂从所述抗微生物剂来源蒸发转移到所述医疗装置的时间，温度和压力条件，从而基本上抑制所述医疗装置上的细菌定植 。 或者，根据将医疗装置定位在包装内的步骤来制造包装的医疗装置; 将具有医疗装置的包装暴露于抗微生物剂源; 以及将具有医疗装置和抗微生物剂源的包装经受足以将有效量的抗微生物剂从抗微生物剂源转移到包装内的医疗装置的时间，温度和压力条件，从而基本上抑制细菌定植 医疗装置。
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