公开(公告)号：US09051596B2

公开(公告)日：2015-06-09

申请号：US14111464

申请日：2012-04-13

申请人： Ji Seong Kim ,  Jin Young Lee ,  Jun Seong Park ,  Hyang Tae Choi ,  Han Byul Kim ,  Ji Hyun Bae

发明人： Ji Seong Kim ,  Jin Young Lee ,  Jun Seong Park ,  Hyang Tae Choi ,  Han Byul Kim ,  Ji Hyun Bae

IPC分类号： C12Q1/37 ,  G01N33/50

CPC分类号： C12Q1/37 ,  G01N33/502 ,  G01N2333/8146 ,  G01N2500/10

摘要： Disclosed is a method for screening a substance inhibiting inflammatory skin aging, comprising: treating an immune cell with an inflammatory stimulant; treating a skin cell with a candidate substance; treating the skin cell treated with the candidate substance, with the immune cell treated with the inflammatory stimulant; and measuring the concentration of matrix metalloproteinase-1 (MMP-1) in the skin cell treated with the immune cell.

摘要翻译： 公开了一种筛选抑制炎性皮肤老化的物质的方法，包括：用炎症刺激剂处理免疫细胞; 用候选物质治疗皮肤细胞; 治疗用候选物质处理的皮肤细胞，用免疫细胞用炎症刺激剂处理; 并测量用免疫细胞处理的皮肤细胞中基质金属蛋白酶-1（MMP-1）的浓度。

公开(公告)号：US20140038220A1

公开(公告)日：2014-02-06

申请号：US14111464

申请日：2012-04-13

申请人： Ji Seong Kim ,  Jin Young Lee ,  Jun Seong Park ,  Hyang Tae Choi ,  Han Byul Kim ,  Ji Hyun Bae

发明人： Ji Seong Kim ,  Jin Young Lee ,  Jun Seong Park ,  Hyang Tae Choi ,  Han Byul Kim ,  Ji Hyun Bae

IPC分类号： C12Q1/37

CPC分类号： C12Q1/37 ,  G01N33/502 ,  G01N2333/8146 ,  G01N2500/10

摘要： Disclosed is a method for screening a substance inhibiting inflammatory skin aging, comprising: treating an immune cell with an inflammatory stimulant; treating a skin cell with a candidate substance; treating the skin cell treated with the candidate substance, with the immune cell treated with the inflammatory stimulant; and measuring the concentration of matrix metalloproteinase-1 (MMP-1) in the skin cell treated with the immune cell.

摘要翻译： 公开了一种筛选抑制炎性皮肤老化的物质的方法，包括：用炎症刺激剂处理免疫细胞; 用候选物质治疗皮肤细胞; 治疗用候选物质处理的皮肤细胞，用免疫细胞用炎症刺激剂处理; 并测量用免疫细胞处理的皮肤细胞中基质金属蛋白酶-1（MMP-1）的浓度。

公开(公告)号：US20130101689A1

公开(公告)日：2013-04-25

申请号：US13808021

申请日：2011-07-04

申请人： Jin Young Lee ,  Hyang Tae Choi ,  Han Byul Kim ,  Ji Seong Kim

发明人： Jin Young Lee ,  Hyang Tae Choi ,  Han Byul Kim ,  Ji Seong Kim

IPC分类号： A61K36/60

CPC分类号： A61K36/605 ,  A61K8/0212 ,  A61K8/97 ,  A61K36/60 ,  A61K2800/78 ,  A61Q5/00 ,  A61Q5/12 ,  A61Q19/00 ,  A61Q19/008 ,  A61Q19/06 ,  A61Q19/08

摘要： The present invention relates to a composition containing a paper mulberry extract, and more particularly to a composition containing, as an active ingredient, a paper mulberry extract which has effects on enhancement of skin moisturization, inhibition of skin aging, alleviation of inflammation, antibacterial activity, pore size reduction, sebum control, skin complexion improvement, decomposition of subcutaneous fat, stimulation of melanin synthesis, and gray hair prevention.

摘要翻译： 本发明涉及一种含有桑叶提取物的组合物，更具体地说，涉及一种含有桑叶提取物作为活性成分的组合物，其具有增强皮肤保湿作用，抑制皮肤老化，减轻炎症，抗菌活性 ，孔径减少，皮脂控制，皮肤肤色改善，皮下脂肪分解，刺激黑色素合成和防止灰白色毛发。

公开(公告)号：US20130252247A1

公开(公告)日：2013-09-26

申请号：US13881312

申请日：2011-10-28

申请人： Hyang Tae Choi ,  Eui Dong Son ,  Jin Young Lee ,  Yong Joo Na ,  Ji Hyun Bae

发明人： Hyang Tae Choi ,  Eui Dong Son ,  Jin Young Lee ,  Yong Joo Na ,  Ji Hyun Bae

IPC分类号： G01N33/50

CPC分类号： G01N33/5044 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/148 ,  C12Q2600/158 ,  G01N33/5023 ,  G01N33/6881

摘要： The present invention relates to a kit for screening for skin-activating substances, and to a method for screening for skin-activating substances using same. More particularly, the present invention relates to a kit for screening for skin-activating substances and to a method for screening for skin-activating substances using same, in which candidates for inducing the expression of the klotho gene are separated from skin cells by the screening kit comprising the klotho gene, also known as the anti-aging gene, and the separated candidates are refined, thus screening for skin-activating substances such as moisturizing, anti-aging, or whitening substances.

摘要翻译： 本发明涉及用于皮肤激活物质筛选的试剂盒，以及使用该皮肤活化物质的皮肤激活物质的筛选方法。 更具体地说，本发明涉及一种用于皮肤激活物质筛选的试剂盒，以及使用该试剂盒筛选皮肤激活物质的方法，其中通过筛选将诱导klotho基因表达的候选物从皮肤细胞分离出来 将包含klotho基因（也称为抗衰老基因）的试剂盒和分离的候选物进行精制，从而筛选皮肤活化物质如保湿，抗衰老或增白物质。

公开(公告)号：US20110085996A1

公开(公告)日：2011-04-14

申请号：US12997822

申请日：2009-04-28

申请人： Myeong Hun Yeom ,  Jin Young Lee ,  Jung Sun Hwang ,  Nok Hyun Park ,  Jun Seong Park ,  Duck Hee Kim ,  Han Kon Kim

发明人： Myeong Hun Yeom ,  Jin Young Lee ,  Jung Sun Hwang ,  Nok Hyun Park ,  Jun Seong Park ,  Duck Hee Kim ,  Han Kon Kim

IPC分类号： A61K8/97 ,  A61K36/258 ,  A61Q17/04 ,  A61Q5/00 ,  A61Q19/02 ,  A61P17/16 ,  A61P17/18 ,  A61Q19/08 ,  A61Q19/00 ,  A61P17/00 ,  A61P17/06 ,  A61P29/00 ,  A61P17/10 ,  A61P17/14

CPC分类号： A61K36/258 ,  A61K8/97 ,  A61Q7/00 ,  A61Q19/02 ,  A61Q19/08

摘要： Provided are a use of a ginseng flower extract and a use of a ginseng seed extract. The ginseng seed extract includes ginseng seed oil or a ginseng seed residue extract. The uses include skin protection, anti-aging, anti-wrinkle, improvement of skin elasticity, skin whitening, skin moisturizing, prevention and improvement of skin dryness diseases such as atopy, removal of the horny layer, sebum control, anti-inflammation, prevention or improvement of skin troubles such as acne, improvement of skin complexion, prevention of hair loss, anti-dandruff, improvement of gloss and softness of hair, improvement of volume and elasticity of face or body, and improvement of facial or body line.

摘要翻译： 提供人参花提取物和人参种子提取物的用途。 人参种子提取物包括人参种子油或人参种子残渣提取物。 用途包括皮肤保护，抗衰老，抗皱，改善皮肤弹性，皮肤美白，皮肤保湿，预防和改善皮肤干燥性疾病如特应性，去除角质层，皮脂控制，抗炎，预防 或改善皮肤麻烦，例如痤疮，改善皮肤肤色，防止脱发，防头皮屑，改善头发的光泽和柔软度，改善面部或身体的体积和弹性，改善面部或身体线条。

公开(公告)号：US08101214B2

公开(公告)日：2012-01-24

申请号：US12745064

申请日：2008-11-13

申请人： Jun Seong Park ,  Jin Young Lee ,  Eun Joo Kim ,  Hye Yoon Park ,  Sung Il Park ,  Youn Joon Kim ,  Duck Hee Kim ,  Ih Seop Chang

发明人： Jun Seong Park ,  Jin Young Lee ,  Eun Joo Kim ,  Hye Yoon Park ,  Sung Il Park ,  Youn Joon Kim ,  Duck Hee Kim ,  Ih Seop Chang

IPC分类号： A61K36/00 ,  A61K8/97 ,  A61K36/736

CPC分类号： A61Q19/00 ,  A61K8/97

摘要： Disclosed is a combination for skin external use, which contains as an active ingredient an herbal extract complex consisting of Chinese herbal extracts of Granate bark, seed of Prunus armeniaca, Coix lacuma-jobi, Saururus chinensis and Perilla frutescens var. acuta. More particularly, disclosed is a composition for skin external use containing an herbal extract complex, which is prepared by mixing the Chinese herbs with each other at an optimal ratio to prepare an herbal mixture and extracting the herbal mixture to prepare an herbal extract complex, and thus shows the effects of promoting the differentiation of skin keratinocytes, restoring impaired skin barrier function and increasing skin moisturization compared to extracts obtained by extracting each of the herbs alone.

摘要翻译： 本发明公开了一种皮肤外用组合物，其含有作为活性成分的草药提取物复合物，其由中国草药提取物，花生酸树皮，李子种子，枸杞子，中华堇和紫苏等组成。 acuta。 更具体地，公开了含有草药提取物复合物的皮肤外用组合物，其通过以最佳比例混合中草药以制备草药混合物并提取草药混合物以制备草药提取物复合物而制备，以及 从而显示了与通过单独提取每种草药获得的提取物相比，促进皮肤角质化细胞分化，恢复受损的皮肤屏障功能和增加皮肤保湿的效果。

公开(公告)号：US08524296B2

公开(公告)日：2013-09-03

申请号：US12919891

申请日：2009-02-27

申请人： Jun Seong Park ,  Hye Yoon Park ,  Jin Young Lee ,  Eun Joo Kim ,  Il Young Kwak ,  Kyung Hee Suh ,  Duck Hee Kim ,  Han Kon Kim

发明人： Jun Seong Park ,  Hye Yoon Park ,  Jin Young Lee ,  Eun Joo Kim ,  Il Young Kwak ,  Kyung Hee Suh ,  Duck Hee Kim ,  Han Kon Kim

IPC分类号： C12G1/00 ,  A23B7/00 ,  A61K36/00

CPC分类号： A61K8/97 ,  A23L7/104 ,  A23L33/105 ,  A61K36/75 ,  A61K36/752 ,  A61K2800/85 ,  A61Q19/00 ,  Y02A50/473

摘要： The present invention relates to a method for fermenting natural products with salt and fermented extracts prepared thereby. The method comprises: adding a predetermined amount of salt to at least one of natural products, including medicinal herbs and cereals; naturally fermenting the salted material; and extracting the fermented salted material with a solvent. Accordingly, the method can prevent the growth of various bacteria, including putrefactive bacteria, E. coli and anaerobic bacteria, which are harmful to the human body, in the natural product, and it also can prevent the generation of bed smells in the natural product. The fermented extract prepared by the method has fewer side effects and is safer than fermented extracts prepared by conventional fermentation methods.

摘要翻译： 本发明涉及用盐发酵天然产物的方法和由此制备的发酵提取物。 该方法包括：向至少一种天然产物（包括药材和谷物）中加入预定量的盐; 自然发酵盐渍材料; 并用溶剂萃取发酵的盐化物质。 因此，该方法可以防止在天然产物中对人体有害的各种细菌，包括腐殖细菌，大肠杆菌和厌氧菌的生长，并且还可以防止在天然产物中产生床气味 。 通过该方法制备的发酵提取物具有较少的副作用，比通过常规发酵方法制备的发酵提取物更安全。

公开(公告)号：US20110014149A1

公开(公告)日：2011-01-20

申请号：US12745064

申请日：2008-11-13

申请人： Jun Seong Park ,  Jin Young Lee ,  Eun Joo Kim ,  Hye Yoon Park ,  Sung Il Park ,  Youn Joon Kim ,  Duck Hee Kim ,  Ih Seop Chang

发明人： Jun Seong Park ,  Jin Young Lee ,  Eun Joo Kim ,  Hye Yoon Park ,  Sung Il Park ,  Youn Joon Kim ,  Duck Hee Kim ,  Ih Seop Chang

IPC分类号： A61K8/97 ,  A61K36/736 ,  A61P17/00 ,  A61Q19/00 ,  A61Q19/10 ,  A61Q5/06 ,  A61Q5/02 ,  A61Q1/00

CPC分类号： A61Q19/00 ,  A61K8/97

摘要： Disclosed is a combination for skin external use, which contains as an active ingredient an herbal extract complex consisting of Chinese herbal extracts of Granate bark, seed of Prunus armeniaca, Coix lacuma-jobi, Saururus chinensis and Perilla frutescens var. aceta. More particularly, disclosed is a composition for skin external use containing an herbal extract complex, which is prepared by mixing the Chinese herbs with each other at an optimal ratio to prepare an herbal mixture and extracting the herbal mixture to prepare an herbal extract complex, and thus shows the effects of promoting the differentiation of skin keratinocytes, restoring impaired skin barrier function and increasing skin moisturization compared to extracts obtained by extracting each of the herbs alone.

摘要翻译： 本发明公开了一种皮肤外用组合物，其含有作为活性成分的草药提取物复合物，其由中国草药提取物，花生酸树皮，李子种子，枸杞子，中华堇和紫苏等组成。 乙酸 更具体地，公开了含有草药提取物复合物的皮肤外用组合物，其通过以最佳比例混合中草药以制备草药混合物并提取草药混合物以制备草药提取物复合物而制备，以及 从而显示了与通过单独提取每种草药获得的提取物相比，促进皮肤角质化细胞分化，恢复受损的皮肤屏障功能和增加皮肤保湿的效果。

公开(公告)号：US20100310485A1

公开(公告)日：2010-12-09

申请号：US12740212

申请日：2007-10-31

申请人： Jun Seong Park ,  Hye Yoon Park ,  Soo Mi Ahn ,  Byung Young Kang ,  Jin Young Lee ,  Eun Joo Kim ,  Duck Hee Kim ,  Ih Seop Jang

发明人： Jun Seong Park ,  Hye Yoon Park ,  Soo Mi Ahn ,  Byung Young Kang ,  Jin Young Lee ,  Eun Joo Kim ,  Duck Hee Kim ,  Ih Seop Jang

IPC分类号： A61K8/63 ,  C07J17/00 ,  A61Q19/02

CPC分类号： A61Q19/02 ,  A61K8/60 ,  A61K8/97

摘要： Disclosed herein is a whitening cosmetic composition containing plant-derived ginsenoside Fl (20-O-β-D-glucopyranosyl-20(S)-protopanaxatriol) as an active ingredient. More specifically, the ginsenoside Fl is obtained from particularly a ginseng extract using an acid, a base, an enzyme or microorganism, and a whitening cosmetic composition containing the ginsenoside Fl has an excellent effect of inhibiting melanin biosynthesis, and thus provides an excellent skin whitening effect.

摘要翻译： 本文公开了含有作为活性成分的植物来源的人参皂苷F1（20-O-＆bgr-D-吡喃葡萄糖基-20（S） - 原人参三醇）的美白化妆品组合物。 更具体地说，人参皂苷F1特别是使用酸，碱，酶或微生物获得的人参提取物和含有人参皂甙Fl的美白化妆品组合物具有优异的抑制黑色素生物合成的效果，因此提供优异的皮肤美白 影响。

公开(公告)号：US08916210B2

公开(公告)日：2014-12-23

申请号：US12744600

申请日：2008-02-18

申请人： Jin Young Lee ,  Jun Seong Park ,  Eun Joo Kim ,  Hye Yoon Park ,  Sung Il Park ,  Youn Joon Kim ,  Duck Hee Kim ,  Ih Seop Chang ,  Sun Young Kim ,  Hyun Soo Jo

发明人： Jin Young Lee ,  Jun Seong Park ,  Eun Joo Kim ,  Hye Yoon Park ,  Sung Il Park ,  Youn Joon Kim ,  Duck Hee Kim ,  Ih Seop Chang ,  Sun Young Kim ,  Hyun Soo Jo

IPC分类号： A61K36/00 ,  A21B1/02 ,  B01J19/00 ,  A47J31/32

CPC分类号： A47J31/32

摘要： Disclosed are an extractor having a “pottery with dark brown glaze” called “Onggi” in Korean, and a method of extracting using the same. The extractor includes a body, a body cover, a heating part, a pottery and a gas valve. The pottery is located within the body. The extractor extracts by injecting nitrogen gas, etc. into the body through a gas valve, thereby rendering the inside of the body to be high pressure state during extraction. Thus, the inside of the body is maintained under high pressure during extraction. Accordingly, an extract is located only within the pottery, and thus changes that can be caused while an extract contacts with the body can be prevented.

摘要翻译： 公开了一种提取器，其具有韩文中称为“Onggi”的“具有深棕色釉的陶器”，以及使用其提取的方法。 提取器包括主体，主体盖，加热部，陶器和气阀。 陶器位于身体内。 萃取器通过气阀将氮气等注入到体内，从而使提取过程中的身体内部成为高压状态。 因此，在提取期间，身体内部保持高压。 因此，提取物仅位于陶器内，因此可以防止在提取物与身体接触时可能引起的变化。