公开(公告)号：US07268126B2

公开(公告)日：2007-09-11

申请号：US11233835

申请日：2005-09-21

申请人： Jia Liu ,  Naresh Nayyar ,  Ming Guo ,  Zhen-Ping Wu ,  Bennett Chaplin Borer ,  Aparna Nadig Srirangam ,  Mark Bryan Mitchell ,  Yi Li ,  Jan-Jon Chu

发明人： Jia Liu ,  Naresh Nayyar ,  Ming Guo ,  Zhen-Ping Wu ,  Bennett Chaplin Borer ,  Aparna Nadig Srirangam ,  Mark Bryan Mitchell ,  Yi Li ,  Jan-Jon Chu

IPC分类号： C07D487/06 ,  A61K31/55 ,  A61P35/00 ,  A61P35/28

CPC分类号： C07D487/06 ,  C07D487/04

摘要： The present invention relates to novel polymorphic and amorphous forms of a phosphate salt of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, and to processes for their preparation. Such polymorphic forms may be a component of a pharmaceutical composition and may be used to treat a mammalian disease condition mediated by poly(ADP-ribose) polymerase activity including the disease condition such as cancer.

摘要翻译： 本发明涉及8-氟-2- {4 - [（甲基氨基）甲基]苯基} -1,3,4,5-四氢-6H-氮杂基[5,4]的磷酸盐的新型多晶型和无定形形式 ，3-cd]吲哚-6-酮，以及其制备方法。 这样的多晶型物可以是药物组合物的组分，并且可以用于治疗由聚（ADP-核糖）聚合酶活性介导的哺乳动物疾病状况，包括疾病状况如癌症。

公开(公告)号：US20060100198A1

公开(公告)日：2006-05-11

申请号：US11233835

申请日：2005-09-21

申请人： Jia Liu ,  Naresh Nayyar ,  Ming Guo ,  Zhen-Ping Wu ,  Bennett Borer ,  Aparna Srirangam ,  Mark Mitchell ,  Yi Li ,  Jan-Jon Chu

发明人： Jia Liu ,  Naresh Nayyar ,  Ming Guo ,  Zhen-Ping Wu ,  Bennett Borer ,  Aparna Srirangam ,  Mark Mitchell ,  Yi Li ,  Jan-Jon Chu

IPC分类号： A61K31/55 ,  C07D487/04

CPC分类号： C07D487/06 ,  C07D487/04

摘要： The present invention relates to novel polymorphic and amorphous forms of a phosphate salt of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, and to processes for their preparation. Such polymorphic forms may be a component of a pharmaceutical composition and may be used to treat a mammalian disease condition mediated by poly(ADP-ribose) polymerase activity including the disease condition such as cancer.

摘要翻译： 本发明涉及8-氟-2- {4 - [（甲基氨基）甲基]苯基} -1,3,4,5-四氢-6H-氮杂基[5,4]的磷酸盐的新型多晶型和无定形形式 ，3-cd]吲哚-6-酮，以及其制备方法。 这样的多晶型物可以是药物组合物的组分，并且可以用于治疗由聚（ADP-核糖）聚合酶活性介导的哺乳动物疾病状况，包括疾病状况如癌症。

公开(公告)号：US20090048254A1

公开(公告)日：2009-02-19

申请号：US12063076

申请日：2006-07-27

申请人： Yi Li ,  Jia Liu ,  Anand Sistla ,  Bruce Joseph Elder ,  Yufeng Hong ,  Paul Kenneth Isbester ,  Grant Jackson Palmer ,  Jonathon Stuart Salsbury ,  Luckner Gerard Ulysse

发明人： Yi Li ,  Jia Liu ,  Anand Sistla ,  Bruce Joseph Elder ,  Yufeng Hong ,  Paul Kenneth Isbester ,  Grant Jackson Palmer ,  Jonathon Stuart Salsbury ,  Luckner Gerard Ulysse

IPC分类号： A61K31/5377 ,  C07D413/14 ,  A61P35/00

CPC分类号： C07D413/14 ,  C07D405/12

摘要： The invention relates to salts and free base forms of N,2-dimethyl-6-[7-(2-morpholinoethoxy)quinolin-4-yloxy]benzofuran-3-carboxamide. The invention further relates to pharmaceutical compositions of these salts and free base forms and methods of treating disorders such as cancer using such compositions.

摘要翻译： 本发明涉及N，2-二甲基-6- [7-（2-吗啉代乙氧基）喹啉-4-基氧基]苯并呋喃-3-甲酰胺的盐和游离碱形式。 本发明进一步涉及这些盐和游离碱形式的药物组合物以及使用这种组合物治疗疾病如癌症的方法。

公开(公告)号：US07928226B2

公开(公告)日：2011-04-19

申请号：US12063076

申请日：2006-07-27

申请人： Yi Li ,  Jia Liu ,  Anand Sistla ,  Bruce Joseph Elder ,  Yufeng Hong ,  Paul Kenneth Isbester ,  Grant Jackson Palmer ,  Jonathon Stuart Salsbury ,  Luckner Gerard Ulysse

发明人： Yi Li ,  Jia Liu ,  Anand Sistla ,  Bruce Joseph Elder ,  Yufeng Hong ,  Paul Kenneth Isbester ,  Grant Jackson Palmer ,  Jonathon Stuart Salsbury ,  Luckner Gerard Ulysse

IPC分类号： C07D413/14

CPC分类号： C07D413/14 ,  C07D405/12

摘要： The invention relates to salts and free base forms of N,2-dimethyl-6-[7-(2-morpholinoethoxy)quinolin-4-yloxy]benzofuran-3-carboxamide. The invention further relates to pharmaceutical compositions of these salts and free base forms and methods of treating disorders such as cancer using such compositions.

摘要翻译： 本发明涉及N，2-二甲基-6- [7-（2-吗啉代乙氧基）喹啉-4-基氧基]苯并呋喃-3-甲酰胺的盐和游离碱形式。 本发明进一步涉及这些盐和游离碱形式的药物组合物以及使用这种组合物治疗疾病如癌症的方法。

公开(公告)号：US09851071B2

公开(公告)日：2017-12-26

申请号：US13992144

申请日：2011-12-07

申请人： Fei Hu ,  Yi Li ,  Yi Yang

发明人： Fei Hu ,  Yi Li ,  Yi Yang

IPC分类号： F21V9/08 ,  F21S10/00 ,  G03B21/28 ,  F21V9/10 ,  G03B21/20 ,  G03B21/14 ,  F21V9/16 ,  F21V13/08 ,  G02B26/00 ,  G02B19/00 ,  F21Y101/00 ,  F21Y115/10

CPC分类号： G03B21/204 ,  F21K9/64 ,  F21S10/007 ,  F21V9/08 ,  F21V9/30 ,  F21V9/40 ,  F21V13/08 ,  F21Y2101/00 ,  F21Y2115/00 ,  F21Y2115/10 ,  G02B19/0028 ,  G02B19/0047 ,  G02B26/008 ,  G02F2002/006 ,  G03B21/14 ,  G03B21/2066 ,  G03B21/28 ,  H04N9/3114 ,  H04N9/3117 ,  H04N9/315 ,  H04N9/3155 ,  H04N2209/043

摘要： A light source comprising an excitation light source for providing excitation light, and an optical wavelength conversion member disposed at a distance from the excitation light source. The optical wavelength conversion member comprises an optical wavelength conversion material for converting the excitation light into stimulated light. The light source also comprises an optical-guiding member that allows the excitation light to be incident on the optical wavelength conversion material, and an optical-collecting member for collecting converted light originating from the optical wavelength conversion material. To separate the paths of the converted light and the excitation light, the etendue of the optical-guiding member is less than or equal to ¼ of the etendue of the optical-collecting member. This allows the optical-guiding member to draw in the excitation light while preventing the excessive escape of the converted light through the optical-guiding member.

公开(公告)号：US09665643B2

公开(公告)日：2017-05-30

申请号：US13340722

申请日：2011-12-30

申请人： Kang Li ,  Yi Li ,  Yiping Zhou ,  Zhengdong Lv ,  Yohn Cao

发明人： Kang Li ,  Yi Li ,  Yiping Zhou ,  Zhengdong Lv ,  Yohn Cao

IPC分类号： G06F17/30

CPC分类号： G06F17/30867 ,  G06F17/30687 ,  G06F17/30864

摘要： An entity-based search system is described herein that detects and recognizes entities in Internet-based content and uses this recognition to organize search results. The system associates one or more entity identifiers with a web page and stores this information as metadata of the page in a search engine index. This metadata will enable entity-based queries as well as rich data presentations in a search engine result page (SERP), including grouping results by entities, filtering results by one or more particular entities, or re-ranking search results based on user preference of entities. Thus, the entity-based search system allows users to identify a particular entity the user is interested in finding, and to receive search results directly related to that entity.

公开(公告)号：US09612511B2

公开(公告)日：2017-04-04

申请号：US13594187

申请日：2012-08-24

申请人： Fei Hu ,  Yi Li ,  Yi Yang

发明人： Fei Hu ,  Yi Li ,  Yi Yang

IPC分类号： G03B21/20 ,  G03B33/06

CPC分类号： G03B21/204 ,  G03B33/06

摘要： A solid state light source device for generating a constant broad band light useful in multiple SLM projectors. The light source device includes a blue or UV/near UV excitation light and a moving plate carrying wavelength conversion materials to convert the excitation light into a broad band light. The wavelength conversion materials include red, green, yellow and/or blue phosphors, and may pass some of the blue excitation light. The broad band light outputted by the phosphor plate includes at least two primary color components and has a constant intensity and spectrum as a function of time. The solid state light source device further includes a second light source such as a blue light source, and a light combination device which combines the output light of the moving phosphor plate and the light from the second light source into one beam of constant, broad band light.

公开(公告)号：US09500345B2

公开(公告)日：2016-11-22

申请号：US14346300

申请日：2012-08-10

申请人： Yi Yang ,  Yi Li

发明人： Yi Yang ,  Yi Li

IPC分类号： F21V17/02 ,  G03B21/20 ,  F21V9/16 ,  F21V13/02 ,  F21V13/08 ,  G01J1/04 ,  G03B21/16

CPC分类号： F21V17/02 ,  F21V9/30 ,  F21V13/02 ,  F21V13/08 ,  G01J1/0448 ,  G03B21/16 ,  G03B21/204 ,  G03B21/2093

摘要： A light source system and a projection system employing the same. The light source system includes a light source emitting an excitation light, a moving device carrying a wavelength conversion material and an adjustment device. The excitation light irradiates on the wavelength conversion material. When the moving device is in a periodical moving state, the light spot position irradiated by the excitation light on the moving device moves following a first working track. The adjustment device is used for adjusting the light spot position irradiated by the adjusted excitation light on the moving device so that it moves following a second working track. The first working track is separated from the second working track. The system can reduce the working load of the wavelength conversion material on the first working track, thus slowing the aging of the wavelength conversion material, and improving the life of the light source system.

摘要翻译： 光源系统和采用该光源系统的投影系统。 光源系统包括发射激发光的光源，携带波长转换材料的移动装置和调节装置。 激发光照射在波长转换材料上。 当移动装置处于周期性移动状态时，由移动装置上的激发光照射的光点位置在第一工作轨迹之后移动。 调整装置用于调整由移动装置上调节的激发光照射的光点位置，使其在第二工作轨迹之后移动。 第一个工作轨道与第二个工作轨道分开。 该系统可以降低第一工作轨道上的波长转换材料的工作负荷，从而减慢波长转换材料的老化，并提高光源系统的使用寿命。

公开(公告)号：USD769743S1

公开(公告)日：2016-10-25

申请号：US29534804

申请日：2015-07-31

申请人： Yi Li

设计人： Yi Li

公开(公告)号：US09346770B2

公开(公告)日：2016-05-24

申请号：US13704281

申请日：2011-06-18

申请人： Yaping Wang ,  Guojun Zheng ,  Peng Sun ,  Yi Li ,  Yingqiu Wu ,  Bin Liu ,  Xiaoyu Liu ,  Hua Bai ,  Hongyan Li ,  Xiaohe Zheng

发明人： Yaping Wang ,  Guojun Zheng ,  Peng Sun ,  Yi Li ,  Yingqiu Wu ,  Bin Liu ,  Xiaoyu Liu ,  Hua Bai ,  Hongyan Li ,  Xiaohe Zheng

IPC分类号： C07D263/32 ,  A61K31/421 ,  C07D413/10 ,  C07D277/24 ,  A61K31/439

CPC分类号： C07D263/32 ,  A61K31/439 ,  C07D277/24 ,  C07D413/10

摘要： Phenyl propanoic acid compounds having activating effect on peroxisome proliferator-activated receptors (PPARα,δ,γ) and a preparation method and uses thereof are provided in the present invention. The compounds can be used for treating or preventing diseases associated with peroxisome proliferator-activated receptors (PPARα,δ,γ).

摘要翻译： 在本发明中提供了对过氧化物酶体增殖物激活受体（PPARα，δ，γ）具有活化作用的苯基丙酸化合物及其制备方法和用途。 该化合物可用于治疗或预防与过氧化物酶体增殖物激活受体（PPARα，δ，γ）相关的疾病。