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    Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
    2.
    发明授权
    Acyloxyalkyl carbamate prodrugs, methods of synthesis and use 失效
    氨基甲酸氨基甲酸烷基酯前药，合成和使用方法

    公开(公告)号：US07749985B2

    公开(公告)日：2010-07-06

    申请号：US12506961

    申请日：2009-07-21

    申请人： Mark A. Gallop ,  Feng Xu ,  Thu Phan ,  Usha Dilip ,  Ge Peng

    发明人： Mark A. Gallop ,  Feng Xu ,  Thu Phan ,  Usha Dilip ,  Ge Peng

    IPC分类号： A61K31/66 ,  C07F9/02

    CPC分类号： C07F9/301

    摘要： Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs 3-aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.

    摘要翻译： 3-氨基丙基次膦酸的氨基甲酸烷基酯氨基甲酸酯前药及其类似物，3-氨基丙基次膦酸及其类似物的制备酰氨基烷基氨基甲酸酯前药的方法及其类似物，使用3-氨基丙基次膦酸及其类似物的酰氨基烷基氨基甲酸酯前药的方法和包含酰氨基烷基氨基甲酸酯前药3 - 氨基丙基次膦酸及其类似物用于治疗疾病或病症如轻度认知障碍，与阿尔茨海默氏病相关的认知障碍阿尔茨海默氏病，抑郁症，焦虑和癫痫。 还公开了适用于口服给药和缓释口服剂型的3-氨基丙基次膦酸的氨基氧基烷基氨基甲酸酯前药及其类似物。

    Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
    3.
    发明授权
    Acyloxyalkyl carbamate prodrugs, methods of synthesis and use 失效
    氨基甲酸氨基甲酸烷基酯前药，合成和使用方法

    公开(公告)号：US07585996B2

    公开(公告)日：2009-09-08

    申请号：US11901194

    申请日：2007-09-13

    申请人： Mark A. Gallop ,  Feng Xu ,  Thu Phan ,  Usha Dilip ,  Ge Peng

    发明人： Mark A. Gallop ,  Feng Xu ,  Thu Phan ,  Usha Dilip ,  Ge Peng

    IPC分类号： C07C271/06 ,  A61K31/662

    CPC分类号： C07F9/301

    摘要： Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs 3-aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.

    摘要翻译： 3-氨基丙基次膦酸的氨基甲酸烷基酯氨基甲酸酯前药及其类似物，3-氨基丙基次膦酸及其类似物的制备酰氨基烷基氨基甲酸酯前药的方法及其类似物，使用3-氨基丙基次膦酸及其类似物的酰氨基烷基氨基甲酸酯前药的方法和包含酰氨基烷基氨基甲酸酯前药3 - 氨基丙基次膦酸及其类似物用于治疗疾病或病症如轻度认知障碍，与阿尔茨海默氏病相关的认知障碍阿尔茨海默氏病，抑郁症，焦虑和癫痫。 还公开了适用于口服给药和缓释口服剂型的3-氨基丙基次膦酸的氨基氧基烷基氨基甲酸酯前药及其类似物。

    ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE
    6.
    发明申请
    ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE 失效
    丙烯酰基碳酸酯产品，合成和使用方法

    公开(公告)号：US20090286759A1

    公开(公告)日：2009-11-19

    申请号：US12506961

    申请日：2009-07-21

    申请人： Mark A Gallop ,  Feng Xu ,  Thu Phan ,  Usha Dilip ,  Ge Peng

    发明人： Mark A Gallop ,  Feng Xu ,  Thu Phan ,  Usha Dilip ,  Ge Peng

    IPC分类号： A61K31/662 ,  C07C271/06

    CPC分类号： C07F9/301

    摘要： Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs 3-aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.

    摘要翻译： 3-氨基丙基次膦酸的氨基甲酸烷基酯氨基甲酸酯前药及其类似物，3-氨基丙基次膦酸及其类似物的制备酰氨基烷基氨基甲酸酯前药的方法及其类似物，使用3-氨基丙基次膦酸及其类似物的酰氨基烷基氨基甲酸酯前药的方法和包含酰氨基烷基氨基甲酸酯前药3 - 氨基丙基次膦酸及其类似物用于治疗疾病或病症如轻度认知障碍，与阿尔茨海默氏病相关的认知障碍阿尔茨海默氏病，抑郁症，焦虑和癫痫。 还公开了适用于口服给药和缓释口服剂型的3-氨基丙基次膦酸的氨基氧基烷基氨基甲酸酯前药及其类似物。

    Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
    7.
    发明申请
    Acyloxyalkyl carbamate prodrugs, methods of synthesis and use 失效
    氨基甲酸氨基甲酸烷基酯前药，合成和使用方法

    公开(公告)号：US20080146526A1

    公开(公告)日：2008-06-19

    申请号：US11901194

    申请日：2007-09-13

    申请人： Mark A. Gallop ,  Feng Xu ,  Thu Phan ,  Usha Dilip ,  Ge Peng

    发明人： Mark A. Gallop ,  Feng Xu ,  Thu Phan ,  Usha Dilip ,  Ge Peng

    IPC分类号： A61K31/662 ,  C07C271/06 ,  A61P25/00

    CPC分类号： C07F9/301

    摘要： Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs 3-aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.

    摘要翻译： 3-氨基丙基次膦酸的氨基甲酸烷基酯氨基甲酸酯前药及其类似物，3-氨基丙基次膦酸及其类似物的制备酰氨基烷基氨基甲酸酯前药的方法及其类似物，使用3-氨基丙基次膦酸及其类似物的酰氨基烷基氨基甲酸酯前药的方法和包含酰氨基烷基氨基甲酸酯前药3 - 氨基丙基次膦酸及其类似物用于治疗疾病或病症如轻度认知障碍，与阿尔茨海默氏病相关的认知障碍阿尔茨海默氏病，抑郁症，焦虑和癫痫。 还公开了适用于口服给药和缓释口服剂型的3-氨基丙基次膦酸的氨基氧基烷基氨基甲酸酯前药及其类似物。

    Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
    8.
    发明授权
    Acyloxyalkyl carbamate prodrugs, methods of synthesis and use 有权
    氨基甲酸氨基甲酸烷基酯前药，合成和使用方法

    公开(公告)号：US07572830B2

    公开(公告)日：2009-08-11

    申请号：US11923507

    申请日：2007-10-24

    申请人： Mark A. Gallop ,  Fenmei Yao ,  Maria J. Ludwikow ,  Thu Phan ,  Ge Peng

    发明人： Mark A. Gallop ,  Fenmei Yao ,  Maria J. Ludwikow ,  Thu Phan ,  Ge Peng

    IPC分类号： A61K31/235

    CPC分类号： C07C269/06 ,  A61K31/27 ,  C07C271/22 ,  C07C2101/08 ,  C07C2101/14 ,  C07C2601/08 ,  C07C2601/14 ,  C07D213/79 ,  C07D307/30 ,  C07D307/68 ,  C07D333/32 ,  C07D333/38

    摘要： The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.

    摘要翻译： 本文的公开内容通常涉及（±）-4-氨基-3-（4-氯苯基）丁酸及其类似物的氨基氧基烷基氨基甲酸酯前药，其药物组合物，制备（±）-4-氨基-3- （4-氯苯基）丁酸及其类似物，使用（±）-4-氨基-3-（4-氯苯基）丁酸及其类似物的前药的方法及其药物组合物，用于治疗或预防常见疾病和/或 疾病如痉挛和/或酸反流疾病。 本文的公开内容还涉及适于口服给药的（±）-4-氨基-3-（4-氯苯基）丁酸及其类似物的氨氧基烷基氨基甲酸酯前药及其缓释口服剂型。