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    Safety and Efficacy with a CHO Cell Glycosylated Chimeric Antibody to TNF
    2.
    发明申请
    Safety and Efficacy with a CHO Cell Glycosylated Chimeric Antibody to TNF 审中-公开

    公开(公告)号：US20170247443A1

    公开(公告)日：2017-08-31

    申请号：US15403115

    申请日：2017-01-10

    申请人： Jian Cao ,  Jeffrey Su

    发明人： Jian Cao ,  Jeffrey Su

    IPC分类号： C07K16/24

    CPC分类号： C07K16/241 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/515

    摘要： There is disclosed a chimeric infliximab-like monoclonal antibody having at least 80% NANA glycosylation terminal sialic acid and a glycosylation pattern of Gal-α(2,3/6)-Gal that binds to tumor necrosis factor alpha (TNF). The disclosed infliximab-like monoclonal antibody is a chimeric antibody having the same amino acid sequence (light chain/heavy chain of SEQ ID NO. 1/SEQ ID NO. 2) as infliximab (Remicade®) which has at least 80% NGNA terminal sialic acid and a glycosylation pattern of Gal-α(1,3)-Gal.

    Polynucleotides encoding chemokine alpha-3
    3.
    发明授权
    Polynucleotides encoding chemokine alpha-3 失效
    编码趋化因子α-3的多核苷酸

    公开(公告)号：US06410268B1

    公开(公告)日：2002-06-25

    申请号：US08816772

    申请日：1997-03-18

    申请人： Jian Ni ,  Haodong Li ,  Jeffrey Su

    发明人： Jian Ni ,  Haodong Li ,  Jeffrey Su

    IPC分类号： C12N120

    CPC分类号： C07K14/522

    摘要： Human chemokine Alpha-3 polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, sepsis, wound healing and psoriasis and to stimulate stem cell mobilization. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, ARDS and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人趋化因子α-3多肽和编码这种趋化性细胞因子的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，败血症，伤口愈合和牛皮癣并刺激干细胞移动的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫和慢性和急性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧，ARDS和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

    Human chemotactic cytokine I polypeptides
    4.
    发明申请
    Human chemotactic cytokine I polypeptides 审中-公开
    人类趋化性细胞因子I多肽

    公开(公告)号：US20050069945A1

    公开(公告)日：2005-03-31

    申请号：US10994821

    申请日：2004-11-23

    申请人： Jian Ni ,  Guo-Liang Yu ,  Pedro Alfonso ,  Reiner Gentz ,  Jeffrey Su

    发明人： Jian Ni ,  Guo-Liang Yu ,  Pedro Alfonso ,  Reiner Gentz ,  Jeffrey Su

    IPC分类号： C07H21/04 ,  C07K14/52 ,  C12P21/02 ,  C12Q1/68

    CPC分类号： C07K14/52 ,  C07H21/04

    摘要： Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人类趋化性细胞因子I多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫，慢性和急性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

    Chemotactic cytokine III
    5.
    发明申请
    Chemotactic cytokine III 审中-公开
    趋化性细胞因子III

    公开(公告)号：US20060073573A1

    公开(公告)日：2006-04-06

    申请号：US11244394

    申请日：2005-10-06

    申请人： Jian Ni ,  Reiner Gentz ,  Guo-Liang Yu ,  Jeffrey Su ,  Patrick Dillon

    发明人： Jian Ni ,  Reiner Gentz ,  Guo-Liang Yu ,  Jeffrey Su ,  Patrick Dillon

    IPC分类号： C12P21/02 ,  C07H21/04 ,  C07K14/52

    CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K14/521 ,  Y02A50/423

    摘要： Human chemotactic cytokine III polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, cerebral ischemia, glomerulonephritis, HTLV-1 related diseases and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding chemotactic cytokine III and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人类趋化性细胞因子III多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 针对这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫和慢性和急性炎症和感染性疾病，过敏反应，前列腺素不依赖性发烧，脑缺血，肾小球肾炎，HTLV-1相关疾病和骨髓衰竭的治疗用途 也被披露。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子III的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

    DNA encoding the chemotactic cytokine III
    7.
    发明授权
    DNA encoding the chemotactic cytokine III 失效
    编码趋化性细胞因子III的DNA

    公开(公告)号：US5952197A

    公开(公告)日：1999-09-14

    申请号：US812003

    申请日：1997-03-05

    申请人： Jian Ni ,  Reiner Gentz ,  Guo-Liang Yu ,  Jeffrey Su ,  Patrick J. Dillon

    发明人： Jian Ni ,  Reiner Gentz ,  Guo-Liang Yu ,  Jeffrey Su ,  Patrick J. Dillon

    IPC分类号： A61K38/00 ,  C07K14/52 ,  C12N15/19 ,  C12N15/00 ,  C12N15/63

    CPC分类号： C07K14/52 ,  C07K14/521 ,  A61K38/00

    摘要： Human chemotactic cytokine III polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, cerebral ischemia, glomerulonephritis, HTLV-1 related diseases and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding chemotactic cytokine III and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人类趋化性细胞因子III多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 针对这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫和慢性和急性炎症和感染性疾病，过敏反应，前列腺素不依赖性发烧，脑缺血，肾小球肾炎，HTLV-1相关疾病和骨髓衰竭的治疗用途 也被披露。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子III的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

    Chemokine alpha 3
    8.
    发明授权
    Chemokine alpha 3 失效

    公开(公告)号：US06908986B2

    公开(公告)日：2005-06-21

    申请号：US10141938

    申请日：2002-05-10

    申请人： Jian Ni ,  Haodong Li ,  Jeffrey Su

    发明人： Jian Ni ,  Haodong Li ,  Jeffrey Su

    IPC分类号： C07K14/52 ,  A61K38/16 ,  C07K14/00

    CPC分类号： C07K14/522

    摘要： Human chemokine Alpha-3 polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, sepsis, wound healing and psoriasis and to stimulate stem cell mobilization. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, ARDS and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.

    Chemokine alpha 3
    9.
    发明申请
    Chemokine alpha 3 失效
    趋化因子α3

    公开(公告)号：US20050019834A1

    公开(公告)日：2005-01-27

    申请号：US10935306

    申请日：2004-09-08

    申请人： Jian Ni ,  Haodong Li ,  Jeffrey Su

    发明人： Jian Ni ,  Haodong Li ,  Jeffrey Su

    IPC分类号： C07K14/52 ,  G01N33/53 ,  C12N5/06 ,  C12P21/02

    CPC分类号： C07K14/522

    摘要： Human chemokine Alpha-3 polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, sepsis, wound healing and psoriasis and to stimulate stem cell mobilization. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, ARDS and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人趋化因子α-3多肽和编码这种趋化性细胞因子的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，败血症，伤口愈合和牛皮癣并刺激干细胞移动的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫和慢性和急性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧，ARDS和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。