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公开(公告)号：US5985612A
公开(公告)日：1999-11-16
申请号：US467265
申请日：1995-06-06
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
摘要： A human natural killer cell enhancing factor C and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating viral infections, inflammation, neoplasia and damage from superoxide radicals. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
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公开(公告)号：US5985601A
公开(公告)日：1999-11-16
申请号：US461030
申请日：1995-06-05
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
CPC分类号： C07K14/8139 , A61K38/00
摘要： Disclosed is a human CysE polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for treating osteoporosis, tumor metastases, microbial infections, viral infection, septic shock, inflammation, retinal irritation, caries, cachexia and muscle wasting. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
摘要翻译： 公开了编码这种多肽的人CysE多肽和DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗骨质疏松症，肿瘤转移，微生物感染，病毒感染，脓毒性休克，炎症，视网膜刺激，龋齿，恶病质和肌肉消瘦的方法。 还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。
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公开(公告)号：US5977309A
公开(公告)日：1999-11-02
申请号：US23073
申请日：1998-02-13
申请人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
发明人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
IPC分类号： A61K38/00 , C07K14/475 , C12N15/12 , C12N15/63
CPC分类号： C07K14/475 , A61K38/00
摘要： A human cytostatin I polypeptide an DNA encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cancers, particularly breast cancer, leukemias, and other matastases.
摘要翻译： 公开了人细胞培养抑制因子I多肽编码这种多肽的DNA和通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗癌症，特别是乳腺癌，白血病和其它母细胞瘤的方法。
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公开(公告)号：US5844081A
公开(公告)日：1998-12-01
申请号：US470298
申请日：1995-06-06
申请人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
发明人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
IPC分类号： A61K38/00 , C07K14/475 , C12N15/12
CPC分类号： C07K14/475 , A61K38/00
摘要： A human cytostatin I polypeptide and DNA encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cancers, particularly breast cancer, leukemias, and other metastases.
摘要翻译： 公开了人类细胞抑素I多肽和编码这种多肽的DNA以及通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗癌症，特别是乳腺癌，白血病和其他转移的方法。
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公开(公告)号：US06287812B1
公开(公告)日：2001-09-11
申请号：US09361737
申请日：1999-07-28
申请人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
发明人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
IPC分类号： C12N1512
CPC分类号： C07K14/475 , A61K38/00
摘要： A human cytostatin I polypeptide and DNA encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cancers, particularly breast cancer, leukemias, and other matastases.
摘要翻译： 公开了人类细胞抑素I多肽和编码这种多肽的DNA以及通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗癌症，特别是乳腺癌，白血病和其它母细胞瘤的方法。
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公开(公告)号：US06255079B1
公开(公告)日：2001-07-03
申请号：US08467265
申请日：1995-06-06
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
IPC分类号： C07K1452
CPC分类号： C07K14/52 , A61K38/00 , Y10S514/885
摘要： A human natural killer cell enhancing factor C and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating viral infections, inflammation, neoplasia and damage from superoxide radicals. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
摘要翻译： 公开了一种编码这种多肽的人类天然杀伤细胞增强因子C和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽预防和/或治疗病毒感染，炎症，瘤形成和超氧自由基损伤的方法。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。
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公开(公告)号：US5658758A
公开(公告)日：1997-08-19
申请号：US409731
申请日：1995-03-24
申请人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
发明人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
IPC分类号： A61K38/00 , C07K14/475 , C12N15/12
CPC分类号： C07K14/475 , A61K38/00
摘要： A human cytostatin I polypeptide and DNA encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cancers, particularly breast cancer, leukemias, and other matastases.
摘要翻译： 公开了人类细胞抑素I多肽和编码这种多肽的DNA以及通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗癌症，特别是乳腺癌，白血病和其它母细胞瘤的方法。
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公开(公告)号：US06294164B1
公开(公告)日：2001-09-25
申请号：US09407891
申请日：1999-09-29
申请人： Jiar Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
发明人： Jiar Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
IPC分类号： A61K3819
CPC分类号： C07K14/52 , A61K38/00 , Y10S514/885
摘要： A human natural killer cell enhancing factor C and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating viral infections, inflammation, neoplasia and damage from superoxide radicals. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
摘要翻译： 公开了一种编码这种多肽的人类天然杀伤细胞增强因子C和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽预防和/或治疗病毒感染，炎症，瘤形成和超氧自由基损伤的方法。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。
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公开(公告)号：US07820798B2
公开(公告)日：2010-10-26
申请号：US11837082
申请日：2007-08-10
申请人： Guo-Liang Yu , Jian Ni , Craig A. Rosen , Jun Zhang
发明人： Guo-Liang Yu , Jian Ni , Craig A. Rosen , Jun Zhang
CPC分类号： A61K51/08 , C07K16/241 , Y10S930/144
摘要： Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
摘要翻译： 公开了人类TNF-γ-α和TNF-γ-β多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽抑制细胞生长的方法，例如在肿瘤或癌症中，用于促进伤口愈合，提供抗感染，诱导炎症活性和刺激某些细胞类型的生长以治疗疾病， 示例再狭窄。 还公开了用于检测TNF-γ-α和TNF-γ-β核酸序列中的突变或TNF-γ-α和/或TNF-γ-β多肽的过表达的诊断方法。 还公开了抗这些多肽的拮抗剂及其作为治疗性恶病质，败血性休克，脑疟疾，炎症，关节炎和移植排斥的治疗剂的用途。
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公开(公告)号：US07597886B2
公开(公告)日：2009-10-06
申请号：US09899059
申请日：2001-07-06
申请人： Guo-Liang Yu , Jian Ni , Craig A. Rosen , Jun Zhang
发明人： Guo-Liang Yu , Jian Ni , Craig A. Rosen , Jun Zhang
IPC分类号： A61K39/395 , C07K14/525
CPC分类号： A61K31/713 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/525 , C07K14/70575 , C07K16/241 , Y02A50/412 , Y10S930/144
摘要： Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
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