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公开(公告)号：US5985612A
公开(公告)日：1999-11-16
申请号：US467265
申请日：1995-06-06
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
摘要： A human natural killer cell enhancing factor C and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating viral infections, inflammation, neoplasia and damage from superoxide radicals. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
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公开(公告)号：US5985601A
公开(公告)日：1999-11-16
申请号：US461030
申请日：1995-06-05
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
CPC分类号： C07K14/8139 , A61K38/00
摘要： Disclosed is a human CysE polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for treating osteoporosis, tumor metastases, microbial infections, viral infection, septic shock, inflammation, retinal irritation, caries, cachexia and muscle wasting. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
摘要翻译： 公开了编码这种多肽的人CysE多肽和DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗骨质疏松症，肿瘤转移，微生物感染，病毒感染，脓毒性休克，炎症，视网膜刺激，龋齿，恶病质和肌肉消瘦的方法。 还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。
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公开(公告)号：US5977309A
公开(公告)日：1999-11-02
申请号：US23073
申请日：1998-02-13
申请人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
发明人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
IPC分类号： A61K38/00 , C07K14/475 , C12N15/12 , C12N15/63
CPC分类号： C07K14/475 , A61K38/00
摘要： A human cytostatin I polypeptide an DNA encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cancers, particularly breast cancer, leukemias, and other matastases.
摘要翻译： 公开了人细胞培养抑制因子I多肽编码这种多肽的DNA和通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗癌症，特别是乳腺癌，白血病和其它母细胞瘤的方法。
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公开(公告)号：US5844081A
公开(公告)日：1998-12-01
申请号：US470298
申请日：1995-06-06
申请人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
发明人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
IPC分类号： A61K38/00 , C07K14/475 , C12N15/12
CPC分类号： C07K14/475 , A61K38/00
摘要： A human cytostatin I polypeptide and DNA encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cancers, particularly breast cancer, leukemias, and other metastases.
摘要翻译： 公开了人类细胞抑素I多肽和编码这种多肽的DNA以及通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗癌症，特别是乳腺癌，白血病和其他转移的方法。
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公开(公告)号：US06287812B1
公开(公告)日：2001-09-11
申请号：US09361737
申请日：1999-07-28
申请人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
发明人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
IPC分类号： C12N1512
CPC分类号： C07K14/475 , A61K38/00
摘要： A human cytostatin I polypeptide and DNA encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cancers, particularly breast cancer, leukemias, and other matastases.
摘要翻译： 公开了人类细胞抑素I多肽和编码这种多肽的DNA以及通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗癌症，特别是乳腺癌，白血病和其它母细胞瘤的方法。
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公开(公告)号：US06255079B1
公开(公告)日：2001-07-03
申请号：US08467265
申请日：1995-06-06
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
IPC分类号： C07K1452
CPC分类号： C07K14/52 , A61K38/00 , Y10S514/885
摘要： A human natural killer cell enhancing factor C and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating viral infections, inflammation, neoplasia and damage from superoxide radicals. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
摘要翻译： 公开了一种编码这种多肽的人类天然杀伤细胞增强因子C和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽预防和/或治疗病毒感染，炎症，瘤形成和超氧自由基损伤的方法。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。
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公开(公告)号：US5658758A
公开(公告)日：1997-08-19
申请号：US409731
申请日：1995-03-24
申请人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
发明人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
IPC分类号： A61K38/00 , C07K14/475 , C12N15/12
CPC分类号： C07K14/475 , A61K38/00
摘要： A human cytostatin I polypeptide and DNA encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cancers, particularly breast cancer, leukemias, and other matastases.
摘要翻译： 公开了人类细胞抑素I多肽和编码这种多肽的DNA以及通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗癌症，特别是乳腺癌，白血病和其它母细胞瘤的方法。
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公开(公告)号：US06294164B1
公开(公告)日：2001-09-25
申请号：US09407891
申请日：1999-09-29
申请人： Jiar Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
发明人： Jiar Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
IPC分类号： A61K3819
CPC分类号： C07K14/52 , A61K38/00 , Y10S514/885
摘要： A human natural killer cell enhancing factor C and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating viral infections, inflammation, neoplasia and damage from superoxide radicals. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
摘要翻译： 公开了一种编码这种多肽的人类天然杀伤细胞增强因子C和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽预防和/或治疗病毒感染，炎症，瘤形成和超氧自由基损伤的方法。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。
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公开(公告)号：US20070298459A1
公开(公告)日：2007-12-27
申请号：US11780643
申请日：2007-07-20
申请人： Jian Ni , Guo-Liang Yu , Ping Fan , Reiner Gentz
发明人： Jian Ni , Guo-Liang Yu , Ping Fan , Reiner Gentz
CPC分类号： C07K16/1271 , A61K38/00 , C07K14/4747 , C07K14/70578 , C07K14/7151 , C07K2319/00 , C07K2319/30 , C12N2799/026
摘要： The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.
摘要翻译： 本发明涉及肿瘤坏死因子受体家族的新成员。 特别地，提供编码人TR9受体的分离的核酸分子。 还提供TR9多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR9受体活性的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US20060193861A1
公开(公告)日：2006-08-31
申请号：US11416310
申请日：2006-05-03
申请人： Reiner Gentz , Reinhard Ebner , Guo-Liang Yu , Steven Ruben , Jian Ni , Ping Feng
发明人： Reiner Gentz , Reinhard Ebner , Guo-Liang Yu , Steven Ruben , Jian Ni , Ping Feng
CPC分类号： A61K48/005 , A61K38/00 , A61K48/0058 , C07K14/4703 , C07K14/70578 , C07K14/7151 , C07K2319/00 , C07K2319/30 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides and antibodies that bind TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译： 本发明涉及新型肿瘤坏死因子受体蛋白。 特别地，提供编码人TNFR-6α和-6β蛋白的分离的核酸分子。 还提供TNFR-6α和-6β多肽和结合TNFR-6α和-6β多肽的抗体，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及鉴定TNFR-6α和-6β活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。
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