公开(公告)号：US08853180B2

公开(公告)日：2014-10-07

申请号：US13394786

申请日：2010-09-09

申请人： Zhenkun Lou ,  Jian Yuan

发明人： Zhenkun Lou ,  Jian Yuan

IPC分类号： C12N15/11 ,  A61K31/7105 ,  G01N33/50 ,  C12Q1/00 ,  A61K38/48

CPC分类号： A61K38/46 ,  A61K31/7105 ,  A61K38/4873 ,  A61K38/55 ,  C12Q1/005 ,  C12Q1/37 ,  C12Y306/04012 ,  G01N33/5011 ,  G01N33/573 ,  G01N2333/4748 ,  G01N2333/81 ,  G01N2500/00 ,  G01N2500/02

摘要： This document relates to methods and materials involved in modulating deubiquitinases (e.g., USP10 polypeptides) and/or ubiquitinated polypeptides (e.g., tumor suppressor polypeptides or mutant versions of tumor suppressor polypeptides). For example, methods and materials for increasing deubiquitinase (e.g., a USP10 polypeptide) expression or activity, methods and materials for decreasing deubiquitinase (e.g., a USP10 polypeptide) expression or activity, methods and materials for stabilizing tumor suppressor polypeptides (e.g., wild-type p53 polypeptides), methods and materials for de-stabilizing mutant versions of tumor suppressor polypeptides (e.g., mutant p53 polypeptides), and methods and materials for reducing cancer cell proliferation, increasing cancer cell apoptosis, and/or treating cancer (e.g., cancers having reduced levels of wild-type p53 polypeptides or cancers having increased levels of mutant p53 polypeptides) are provided. This document also provides methods and materials for identifying agonists or antagonists of USP10 polypeptide mediated stabilization of p53 polypeptides.

摘要翻译： 本文件涉及调节去泛素酶（例如，USP10多肽）和/或泛素化多肽（例如肿瘤抑制多肽或肿瘤抑制多肽的突变体形式）的方法和材料。 例如，用于增加去泛素化酶（例如，USP10多肽）表达或活性的方法和材料，用于降低去泛素酶（例如，USP10多肽）的表达或活性的方法和材料，用于稳定肿瘤抑制多肽的方法和材料（例如，野生型 - 类型p53多肽），用于去稳定肿瘤抑制多肽的突变型（例如，突变型p53多肽）的方法和材料，以及用于降低癌细胞增殖，增加癌细胞凋亡和/或治疗癌症（例如癌症）的方法和材料 提供具有降低水平的野生型p53多肽或具有增加的突变型p53多肽水平的癌症）。 本文件还提供了鉴定USP10多肽介导的p53多肽稳定化的激动剂或拮抗剂的方法和材料。

公开(公告)号：US08472664B1

公开(公告)日：2013-06-25

申请号：US13356743

申请日：2012-01-24

申请人： Yushi Jing ,  Jian Yuan

发明人： Yushi Jing ,  Jian Yuan

IPC分类号： G06K9/00 ,  G06K9/54

CPC分类号： G06K9/00671 ,  G01C21/20 ,  G01C21/30 ,  G01S5/16 ,  G06F17/30247 ,  G06K9/0063 ,  G06K9/6267

摘要： Systems and methods are disclosed for determining the location where an image was captured. In general, a device such as a smartphone may capture one or more images from a location, such as images of buildings, street signs and the like, and a central system may compare the submitted images to images in an image library to identify matches. The location of the match may then be provided back to the smartphone.

公开(公告)号：US20060173350A1

公开(公告)日：2006-08-03

申请号：US11034339

申请日：2005-01-11

申请人： Jian Yuan ,  Pei Cao ,  Richard Romley

发明人： Jian Yuan ,  Pei Cao ,  Richard Romley

IPC分类号： A61B8/14

CPC分类号： A61B8/12 ,  A61B8/085 ,  A61B8/4254 ,  A61B8/445 ,  A61B8/4461 ,  A61B8/4483 ,  A61B8/4488 ,  A61B8/483 ,  A61B8/5207 ,  A61B8/5223 ,  A61B8/5261 ,  G01S7/52034 ,  G01S7/52079 ,  G01S15/8915 ,  G01S15/894 ,  G01S15/8993 ,  G10K11/006 ,  G10K11/352

摘要： The systems and methods described herein allow for three dimensional imaging with a medical ultrasound imaging system having an orientation adjustable imaging device. The imaging device can include a transducer array configured to image an imaging field in two dimensions. The imaging device can also include an orientation adjustment unit configured to adjust the orientation of the array in a third dimension. The array can be configured to image the two dimensional imaging field at multiple different orientations. An image processing system can be communicatively coupled with the array and configured to assemble the image data collected across each imaging field at multiple orientations of the array. The assembled data can then be displayed as a three dimensional image.

摘要翻译： 本文描述的系统和方法允许具有具有定向可调成像装置的医学超声成像系统的三维成像。 成像装置可以包括被配置成在二维图像成像场中的换能器阵列。 成像装置还可以包括配置成在第三维度中调整阵列的取向的取向调整单元。 阵列可以被配置为以多个不同取向对二维成像场进行成像。 图像处理系统可以与阵列通信地耦合，并且被配置成在阵列的多个取向上组合在每个成像领域收集的图像数据。 然后可以将组装的数据显示为三维图像。

公开(公告)号：US08204200B2

公开(公告)日：2012-06-19

申请号：US12231454

申请日：2008-09-03

申请人： Jingxin Wang ,  Bing Li ,  Jian Yuan ,  Can Feng Chen

发明人： Jingxin Wang ,  Bing Li ,  Jian Yuan ,  Can Feng Chen

IPC分类号： H04M3/42 ,  H04M11/00 ,  H04M1/64

CPC分类号： H04M3/42017 ,  H04M1/72522 ,  H04M1/72558 ,  H04M1/72569 ,  H04M3/42102 ,  H04M7/129 ,  H04W4/16

摘要： Overriding a ring back signal involves receiving a ring back signal at a communications apparatus from a communication network in response to a user-initiated connection request. The ring back signal is rendered to a user of the communications apparatus, and a user input is received at the communications device to override the ring back signal. An alternate output is rendered to the user in place of the ring back signal.

摘要翻译： 覆盖回铃信号涉及响应于用户发起的连接请求从通信网络在通信设备处接收回铃信号。 将回铃信号呈现给通信设备的用户，并且在通信设备处接收用户输入以覆盖回铃信号。 替代输出被呈现给用户代替回铃信号。

公开(公告)号：US20070038111A1

公开(公告)日：2007-02-15

申请号：US11202674

申请日：2005-08-12

申请人： Paul Rehrig ,  Xiaoning Jiang ,  Wesley Hackenberger ,  Jian Yuan ,  Richard Romley

发明人： Paul Rehrig ,  Xiaoning Jiang ,  Wesley Hackenberger ,  Jian Yuan ,  Richard Romley

IPC分类号： A61B8/14

CPC分类号： B06B1/0629 ,  A61B8/06 ,  A61B8/12 ,  A61B8/14 ,  A61B8/445 ,  H01L41/187 ,  Y10T29/42

摘要： The present invention generally relates to medical devices, and more particularly to an improved medical imaging device. In one embodiment, an imaging device includes a drive shaft having proximal and distal ends received within the lumen; and an imaging transducer assembly coupled to the distal end of the drive shaft and positioned at the distal portion of the elongate member. The imaging transducer assembly includes one or more imaging transducers formed with a piezoelectric composite plate using photolithography based micromachining.

摘要翻译： 本发明一般涉及医疗装置，更具体地涉及一种改进的医学成像装置。 在一个实施例中，成像装置包括驱动轴，其具有容纳在内腔内的近端和远端; 以及耦合到所述驱动轴的远端并且定位在所述细长构件的远端部分处的成像换能器组件。 成像换能器组件包括使用基于光刻的微加工的压电复合板形成的一个或多个成像换能器。

公开(公告)号：US09044203B2

公开(公告)日：2015-06-02

申请号：US13462784

申请日：2012-05-02

申请人： Xiangdong Li ,  Jian Yuan ,  Lin Chen ,  Zhijun Li ,  Wanli Tong

发明人： Xiangdong Li ,  Jian Yuan ,  Lin Chen ,  Zhijun Li ,  Wanli Tong

IPC分类号： A61B5/02 ,  A61B5/00

CPC分类号： A61B5/6876 ,  A61B5/6884

摘要： A fixing device for attaching to a lumen wall, the device including a base (18) and a fixing mechanism (5) fixed on the base (18). The fixing mechanism (5) includes a housing (5a), at least a set of clamping brackets (3), and a rotating shaft (7). A bracket hole (3b) is formed on each clamp bracket (3), and the rotating shaft (7) passes through the bracket hole (3b) and fixes each set of the clamping brackets (3) on the housing (5a) of the fixing device.

摘要翻译： 一种用于附接到管腔壁的固定装置，该装置包括固定在基座（18）上的底座（18）和固定机构（5）。 固定机构（5）包括至少一组夹持支架（3）和旋转轴（7）的壳体（5a）。 在每个夹具托架（3）上形成一个托架孔（3b），旋转轴（7）穿过托架孔（3b），并将每组夹紧托架（3）固定在壳体（5a）上 固定装置。

公开(公告)号：US20120250847A1

公开(公告)日：2012-10-04

申请号：US13491481

申请日：2012-06-07

申请人： Jingxin Wang ,  Bing Li ,  Jian Yuan ,  Can Feng Chen

发明人： Jingxin Wang ,  Bing Li ,  Jian Yuan ,  Can Feng Chen

IPC分类号： H04M3/42

CPC分类号： H04M3/42017 ,  H04M1/72522 ,  H04M1/72558 ,  H04M1/72569 ,  H04M3/42102 ,  H04M7/129 ,  H04W4/16

摘要： Overriding a ring back signal involves receiving a ring back signal at a communications apparatus from a communication network in response to a user-initiated connection request. The ring back signal is rendered to a user of the communications apparatus, and a user input is received at the communications device to override the ring back signal. An alternate output is rendered to the user in place of the ring back signal.

摘要翻译： 覆盖回铃信号涉及响应于用户发起的连接请求从通信网络在通信设备处接收回铃信号。 将回铃信号呈现给通信设备的用户，并且在通信设备处接收用户输入以覆盖回铃信号。 替代输出被呈现给用户代替回铃信号。

公开(公告)号：US08131118B1

公开(公告)日：2012-03-06

申请号：US12023763

申请日：2008-01-31

申请人： Yushi Jing ,  Jian Yuan

发明人： Yushi Jing ,  Jian Yuan

IPC分类号： G06K9/54 ,  G01C21/00

CPC分类号： G06K9/00671 ,  G01C21/20 ,  G01C21/30 ,  G01S5/16 ,  G06F17/30247 ,  G06K9/0063 ,  G06K9/6267

摘要： Systems and methods are disclosed for determining the location where an image was captured. In general, a device such as a smartphone may capture one or more images from a location, such as images of buildings, street signs and the like, and a central system may compare the submitted images to images in an image library to identify matches. The location of the match may then be provided back to the smartphone.

摘要翻译： 公开了用于确定拍摄图像的位置的系统和方法。 通常，诸如智能电话的设备可以从诸如建筑物的图像，路标等的位置捕获一个或多个图像，并且中央系统可以将所提交的图像与图像库中的图像进行比较以识别匹配。 然后可以将匹配的位置提供回智能手机。

公开(公告)号：US20070282229A1

公开(公告)日：2007-12-06

申请号：US11573644

申请日：2004-09-28

申请人： Jian Yuan ,  Jiaxi Yuan

发明人： Jian Yuan ,  Jiaxi Yuan

IPC分类号： A61H1/00

CPC分类号： A61H9/0078 ,  A61H35/006 ,  A61H2205/10

摘要： The present invention relates to a footbath basin with pressure massage function, which comprising a body of footbath basin (11) and an air massage device (14) which comprises a plentiful of independent airbags. In the body of footbath basin (11), a pump (12), an input, and an air guide control device (13) are connected with the outputs of the pump of the body of footbath basin (11), the air guide control device (13) has a plentiful of outputs, at least two of which are connected with the input/output of the varied airbags of the air massage device (14) through an air tubes (17) respectively. The footbath basin with pressure massage function of the present invention may be cooperated with foot health care, and massage the other parts of the whole body simultaneously, enhance the whole blood circulation, make more effective health, and save time simultaneously.

摘要翻译： 本发明涉及一种具有压力按摩功能的足浴盆，其包括一个足浴盆（11）和一个空气按摩装置（14），其包括大量独立的安全气囊。 在足浴盆（11）的主体中，泵（12），输入和导气控制装置（13）与足浴盆（11）主体的泵的输出端连接，导气控制 装置（13）具有足够的输出，其中至少两个输出通过空气管（17）与空气按摩装置（14）的各种安全气囊的输入/输出相连接。 具有本发明的压力按摩功能的足浴盆可以与足部保健配合，同时按摩全身其他部位，增强全血循环，增加健康，节省时间。

公开(公告)号：US20060100522A1

公开(公告)日：2006-05-11

申请号：US10984664

申请日：2004-11-08

申请人： Jian Yuan ,  Pei Cao ,  Richard Romley

发明人： Jian Yuan ,  Pei Cao ,  Richard Romley

IPC分类号： A61B8/14

CPC分类号： A61B8/12 ,  A61B8/445 ,  A61B8/4483 ,  B06B1/0622 ,  H01L41/183

摘要： The embodiments described herein provide for an ultrasound imaging device having a piezocomposite transducer. The imaging device is preferably insertable within a living being and configured to image the interior of the living being. The piezocomposite transducer can be formed from piezoceramic and polymeric materials. The piezocomposite transducer can be configured as a single element transducer or as a transducer array having one or more elements. Also provided is a method of manufacturing a piezocomposite transducer and a method of imaging with a piezocomposite transducer.

摘要翻译： 本文描述的实施例提供了具有压电复合换能器的超声成像装置。 成像装置优选地可插入到生活中并被配置成对生物的内部进行成像。 压电复合传感器可以由压电陶瓷和聚合材料形成。 压电复合传感器可以被配置为单个元件换能器或具有一个或多个元件的换能器阵列。 还提供了制造压电复合传感器的方法和使用压电复合传感器成像的方法。