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    GASTROINTESTINAL ELECTRICAL STIMULATION FOR THE TREATMENT OF PANCREATITIS
    1.
    发明申请
    GASTROINTESTINAL ELECTRICAL STIMULATION FOR THE TREATMENT OF PANCREATITIS 有权
    用于治疗胰腺炎的胃肠电刺激

    公开(公告)号：US20110015695A1

    公开(公告)日：2011-01-20

    申请号：US12836377

    申请日：2010-07-14

    申请人： Pankaj Pasricha ,  Jiande Chen

    发明人： Pankaj Pasricha ,  Jiande Chen

    IPC分类号： A61N1/05

    CPC分类号： A61N1/36007 ,  A61N1/05 ,  A61N1/0517 ,  A61N1/0551

    摘要： A method of preventing acute pancreatitis comprising positioning stimulatory electrodes in the stomach of an individual in need thereof; and administering repetitive trains of short pulse gastrointestinal electrical stimulation effective for suppressing the inflammatory response in the pancreas is provided herein. The electrodes are placed by laproscopic, endoscopic or surgical means. The gastrointestinal stimulation activates vagal reflexes. The activation of the vagal reflexes is via the gastric and pancreatic afferents. The gastrointestinal stimulation also activates the axonal reflexes. The activation of the axonal reflexes is via the dichotomous branches of the spinal nerves. The electrical stimulation is administered concurrently with an endoscopic procedure or immediately following an endoscopic procedure. Also, provided herein is a method of preventing inflammation of a visceral organ comprising positioning a stimulatory electrode in proximity of descending efferents in the vagus, innervating the visceral organ, of an individual in need thereof, and administering repetitive trains of short pulse electrical stimulation effective in activating nicotinic receptors.

    摘要翻译： 一种预防急性胰腺炎的方法，包括在有需要的个体的胃中定位刺激电极; 并且提供了有效抑制胰腺炎症反应的短脉冲胃肠电刺激重复列车。 电极通过腹腔镜，内窥镜或外科手段放置。 胃肠道刺激激活迷走神经反射。 迷走神经反射的激活是通过胃和胰腺传入的。 胃肠道刺激也激活轴突反射。 轴突反射的激活是通过脊神经的二分支。 电刺激与内窥镜手术同时进行或立即进行内镜手术。 此外，本文提供了一种防止内脏器官炎症的方法，包括将刺激电极定位在迷走神经中的下降传出物附近，有意义的个体的内脏器官，并施用有效的短脉冲电刺激重复训练 在激活烟碱受体。

    GASTROINTESTINAL ELECTRICAL STIMULATION
    2.
    发明申请
    GASTROINTESTINAL ELECTRICAL STIMULATION 有权
    胃肠电刺激

    公开(公告)号：US20070162084A1

    公开(公告)日：2007-07-12

    申请号：US11681237

    申请日：2007-03-02

    申请人： Jiande Chen ,  Pankaj Pasricha

    发明人： Jiande Chen ,  Pankaj Pasricha

    IPC分类号： A61N1/00

    CPC分类号： A61N1/0509 ,  A61N1/36007

    摘要： The present invention is directed to a method of regulating gastrointestinal action in a subject using a stimulatory electrode and a sensor to provide retrograde feedback control of electrical stimulation to the GI tract.

    摘要翻译： 本发明涉及使用刺激电极和传感器调节受试者的胃肠作用的方法，以向胃肠道提供电刺激的逆行反馈控制。

    Gastrointestinal electrical stimulation
    3.
    发明申请
    Gastrointestinal electrical stimulation 有权
    胃肠电刺激

    公开(公告)号：US20050021101A1

    公开(公告)日：2005-01-27

    申请号：US10922133

    申请日：2004-08-19

    申请人： Jiande Chen ,  Pankaj Pasricha

    发明人： Jiande Chen ,  Pankaj Pasricha

    IPC分类号： A61N1/36 ,  A61N1/18

    CPC分类号： A61N1/36007

    摘要： The present invention is directed to a method of regulating gastrointestinal action in a subject using a stimulatory electrode and a sensor to provide retrograde feedback control of electrical stimulation to the GI tract. The invention is further directed to a method for reducing weight in a subject, again using a stimulatory electrode and a sensor to provide retrograde feedback control of electrical stimulation to the stomach. The invention is further directed to a method of providing electrical field stimulation to a gastrointestinal organ, as well as a method of providing an electrical potential gradient in a gastrointestinal organ. Further provided is a method of stimulating the vagus nerve of a subject. Additionally provided is a method of placing a device in the gastrointestinal tract or wall of a subject from the exterior of the subject, using a needle to insert the device.

    摘要翻译： 本发明涉及使用刺激电极和传感器调节受试者的胃肠作用的方法，以向胃肠道提供电刺激的逆行反馈控制。 本发明还涉及一种用于减轻受试者体重的方法，该方法再次使用刺激电极和传感器来向胃提供对电刺激的逆行反馈控制。 本发明还涉及向胃肠器官提供电场刺激的方法，以及在胃肠器官中提供电势梯度的方法。 还提供了刺激受试者的迷走神经的方法。 另外提供了一种使用针头将装置从受试者的外部放置在受试者的胃肠道或壁中以插入装置的方法。

    ILEAL ELECTRICAL STIMULATION
    4.
    发明申请
    ILEAL ELECTRICAL STIMULATION 有权
    ILEAL电刺激

    公开(公告)号：US20110066208A1

    公开(公告)日：2011-03-17

    申请号：US12865292

    申请日：2009-01-30

    申请人： Pankaj Pasricha ,  Jiande Chen

    发明人： Pankaj Pasricha ,  Jiande Chen

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36007

    摘要： The disclosure is a method of treatment for obesity, in an individual in need thereof comprising positioning stimulatory electrodes in the distal small intestines or ileum, and administering electrical stimulation in trains of pulses or repetitive pulses, where the electrical stimulation is effective, at least in part in, stimulating the vagal afferent and efferent activity, of the distal small intestines or ileum, in the individual. The stimulation of the vagal afferent and efferent activity leads to the regulation of the ileal brake. Specifically, the electrical stimulation is provided in trains of pulses. Also, described is a method of treatment for functional gastrointestinal disease by ileal electrical stimulation. Further this invention provides a method of treatment for an eating disorder comprising administering ileal electrical stimulation effective, at least in part, in stimulating the vagal and sympathetic pathways. The stimulatory electrodes are placed by laparoscopic, endoscopic or surgical means.

    摘要翻译： 本公开是在需要的个体中治疗肥胖症的方法，包括将远端小肠或回肠中的刺激电极定位，并且在电刺激有效的脉冲或重复脉冲列中给予电刺激，至少在 部分地，刺激远端小肠或回肠的迷走神经传入和传出活动。 迷走神经传入和传出活动的刺激导致回肠制动器的调节。 具体地说，在脉冲串中提供电刺激。 此外，描述了通过回肠电刺激治疗功能性胃肠道疾病的方法。 此外，本发明提供了一种饮食障碍的治疗方法，包括给予至少部分刺激迷走神经和交感神经通路有效的回肠电刺激。 刺激电极通过腹腔镜，内窥镜或外科手段放置。

    Hepatic electrical stimulation
    6.
    发明授权
    Hepatic electrical stimulation 有权
    肝电刺激

    公开(公告)号：US07881784B2

    公开(公告)日：2011-02-01

    申请号：US11763185

    申请日：2007-06-14

    申请人： Pankaj J. Pasricha ,  Jiande Chen

    发明人： Pankaj J. Pasricha ,  Jiande Chen

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36007 ,  A61N1/36014 ,  A61N1/362

    摘要： A method of providing electrical stimulation to a liver of a subject includes providing one or more stimulatory electrodes to the liver of the subject and providing electrical stimulation to the liver of the subject. The method further relates to methods of reducing risk factors of metabolic syndrome, treating diabetes, treating a subject having eating disorders and reducing glucose levels of a subject.

    摘要翻译： 向受试者的肝脏提供电刺激的方法包括向受试者的肝脏提供一个或多个刺激电极并且向受试者的肝脏提供电刺激。 该方法还涉及降低代谢综合征的危险因素，治疗糖尿病，治疗患有进食障碍的受试者和降低受试者的葡萄糖水平的方法。

    Ileal electrical stimulation
    8.
    发明授权
    Ileal electrical stimulation 有权
    回肠电刺激

    公开(公告)号：US08565885B2

    公开(公告)日：2013-10-22

    申请号：US12865292

    申请日：2009-01-30

    申请人： Jiande Chen ,  Pasricha Pankaj Jay

    发明人： Jiande Chen ,  Pasricha Pankaj Jay

    IPC分类号： A61N1/05

    CPC分类号： A61N1/36007

    摘要： The disclosure is a method of treatment for obesity, in an individual in need thereof comprising positioning stimulatory electrodes in the distal small intestines or ileum, and administering electrical stimulation in trains of pulses or repetitive pulses, where the electrical stimulation is effective, at least in part in, stimulating the vagal afferent and efferent activity, of the distal small intestines or ileum, in the individual. The stimulation of the vagal afferent and efferent activity leads to the regulation of the ileal brake. Specifically, the electrical stimulation is provided in trains of pulses. Also, described is a method of treatment for functional gastrointestinal disease by ileal electrical stimulation. Further this invention provides a method of treatment for an eating disorder comprising administering ileal electrical stimulation effective, at least in part, in stimulating the vagal and sympathetic pathways. The stimulatory electrodes are placed by laparoscopic, endoscopic or surgical means.

    摘要翻译： 本公开是在需要的个体中治疗肥胖症的方法，包括将远端小肠或回肠中的刺激电极定位，并且在电刺激有效的脉冲或重复脉冲列中给予电刺激，至少在 部分地，刺激远端小肠或回肠的迷走神经传入和传出活动。 迷走神经传入和传出活动的刺激导致回肠制动器的调节。 具体地说，在脉冲串中提供电刺激。 此外，描述了通过回肠电刺激治疗功能性胃肠道疾病的方法。 此外，本发明提供了一种饮食障碍的治疗方法，包括给予至少部分刺激迷走神经和交感神经通路有效的回肠电刺激。 刺激电极通过腹腔镜，内窥镜或外科手段放置。