公开(公告)号：US09717616B2

公开(公告)日：2017-08-01

申请号：US13195354

申请日：2011-08-01

申请人： Pankaj Jay Pasricha

发明人： Pankaj Jay Pasricha

IPC分类号： A61F2/04 ,  A61F5/00

CPC分类号： A61F5/003 ,  A61F5/0003 ,  A61F5/0069 ,  G06F19/00

摘要： Methods and devices for treating obesity. Pressure is applied to gastric walls in at least one segment of a stomach such that the pressure distends the gastric walls and induces satiety. A hollow capsule can be used to distend the gastric walls. Alternatively, a doughnut-shaped ring may be inflated to an amount sufficient to create intragastric tension and induce satiety. A c-ring including at least one balloon may be placed at a segment of the stomach, where the balloon inflates to a size that creates tension at the segment. A biocompatible material can be injected into the fundus and antrum of the stomach to stiffen the gastric wall to create a fullness feeling.

公开(公告)号：US08594811B2

公开(公告)日：2013-11-26

申请号：US10922133

申请日：2004-08-19

申请人： Jiande Chen ,  Pankaj Jay Pasricha

发明人： Jiande Chen ,  Pankaj Jay Pasricha

IPC分类号： A61N1/05

CPC分类号： A61N1/36007

摘要： The present invention is directed to a method of regulating gastrointestinal action in a subject using a stimulatory electrode and a sensor to provide retrograde feedback control of electrical stimulation to the GI tract. The invention is further directed to a method for reducing weight in a subject, again using a stimulatory electrode and a sensor to provide retrograde feedback control of electrical stimulation to the stomach. The invention is further directed to a method of providing electrical field stimulation to a gastrointestinal organ, as well as a method of providing an electrical potential gradient in a gastrointestinal organ. Further provided is a method of stimulating the vagus nerve of a subject. Additionally provided is a method of placing a device in the gastrointestinal tract or wall of a subject from the exterior of the subject, using a needle to insert the device.

摘要翻译： 本发明涉及使用刺激电极和传感器调节受试者的胃肠作用的方法，以向胃肠道提供电刺激的逆行反馈控制。 本发明还涉及一种用于减轻受试者体重的方法，该方法再次使用刺激电极和传感器来向胃提供对电刺激的逆行反馈控制。 本发明还涉及向胃肠器官提供电场刺激的方法，以及在胃肠器官中提供电势梯度的方法。 还提供了刺激受试者的迷走神经的方法。 另外提供了一种使用针头将装置从受试者的外部放置在受试者的胃肠道或壁中以插入装置的方法。

公开(公告)号：US08467874B2

公开(公告)日：2013-06-18

申请号：US12839117

申请日：2010-07-19

申请人： Jiande Chen ,  Pankaj Jay Pasricha

发明人： Jiande Chen ,  Pankaj Jay Pasricha

IPC分类号： A61N1/36

CPC分类号： A61N1/36007 ,  A61N1/0502 ,  A61N1/0509 ,  A61N1/0551 ,  A61N1/0558

摘要： The disclosure provides a method of treatment for obesity, in an individual in need thereof, by administering electrical stimulation at dual sites in the gastrointestinal tract. The electrical stimulations are administered by positioning bipolar stimulatory electrodes in contact with the gastric and dudenol cavities, along afferent vagal neural pathways, in the gastrointestinal tract. The electrical stimulations thus administered, activate the vagal afferents associated with the gastric and dudenol sites in the gastrointestinal tract. The activation of vagal afferents modulates the gastrointestinal peptide satiety hormones. Further, the disclosure provides a method of treatment for eating disorders, in an individual in need thereof, by administering electrical stimulation at dual sites, along afferent vagal neural pathways, in the gastrointestinal tract. Also, provided is a method of regulating the appetite of an individual in need thereof, by administering electrical stimulation at dual sites in the gastrointestinal tract.

摘要翻译： 本公开提供了通过在胃肠道的双位点施用电刺激来治疗需要其的个体中的肥胖症的方法。 通过将双极刺激电极定位在胃肠道中沿着传入性迷走神经通路与胃和Dudenol腔相接触来施用电刺激。 如此施用的电刺激激活与胃肠道中的胃和dudenol位点相关的迷走神经传入。 迷走神经传入物的激活调节胃肠肽饱足激素。 此外，本公开内容提供了在有需要的个体中通过在胃肠道中沿传入迷走神经途径的双位点进行电刺激来进行进食障碍的治疗方法。 此外，提供了通过在胃肠道的两个部位施用电刺激来调节有此需要的个体的食欲的方法。

公开(公告)号：US08465499B2

公开(公告)日：2013-06-18

申请号：US11657328

申请日：2007-01-24

申请人： Yoshio Onuki ,  Satoshi Miyamoto ,  Koichi Kawashima ,  Pankaj Jay Pasricha

发明人： Yoshio Onuki ,  Satoshi Miyamoto ,  Koichi Kawashima ,  Pankaj Jay Pasricha

IPC分类号： A61B17/10

CPC分类号： A61B17/0469 ,  A61B17/0467 ,  A61B17/0482 ,  A61B17/0483 ,  A61B17/0487 ,  A61B17/32056 ,  A61B2017/0404 ,  A61B2017/0409 ,  A61B2017/0414 ,  A61B2017/0417 ,  A61B2017/0419 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/0472 ,  A61B2017/0474 ,  A61B2017/0475 ,  A61B2017/0477 ,  A61B2017/0488 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/061 ,  A61B2017/2905

摘要： A medical apparatus including: a projecting member; an introducing sheath; an extrusion member inside the introducing sheath, at a proximal side of the projecting member and movable in an axial direction with respect to the introducing sheath; a cover sheath outside the introducing sheath, the introducing sheath being movable between a first and second position with respect to the cover sheath; an introducing sheath manipulating section at a proximal side of the introducing sheath; an extrusion member manipulating section at a proximal side of the extrusion member; a cover sheath manipulating section at a proximal side of the cover sheath; and a release member on the cover sheath manipulating section and/or the introducing sheath manipulating section to release a fixation between the extrusion member manipulating section and the introducing sheath manipulating section when the introducing sheath is disposed on the first or second position.

摘要翻译： 一种医疗设备，包括：突出构件; 引入鞘; 所述挤压构件位于所述引导护套的内部，在所述突出构件的基端侧，并且相对于所述引导护套沿轴向移动; 所述引导护套可以在相对于所述覆盖护套的第一和第二位置之间移动; 导入鞘操作部，其在所述导入鞘的近侧; 在所述挤出部件的基端侧的挤出部件操作部; 覆盖护套的近侧的盖护套操作部; 以及当所述引导护套设置在所述第一或第二位置时，所述盖护套操作部和/或所述引导护套操作部上的释放构件，以释放所述挤出构件操作部与所述引入护套操作部之间的固定。

公开(公告)号：US08337395B2

公开(公告)日：2012-12-25

申请号：US12435144

申请日：2009-05-04

申请人： Keita Suzuki ,  Tetsuya Yamamoto ,  Yoshio Onuki ,  Satoshi Miyamoto ,  Masahiro Ishikawa ,  Anthony Nicholas Kalloo ,  Sergey Veniaminovich Kantsevoy ,  Pankaj Jay Pasricha ,  Sydney Sheung Chee Chung

发明人： Keita Suzuki ,  Tetsuya Yamamoto ,  Yoshio Onuki ,  Satoshi Miyamoto ,  Masahiro Ishikawa ,  Anthony Nicholas Kalloo ,  Sergey Veniaminovich Kantsevoy ,  Pankaj Jay Pasricha ,  Sydney Sheung Chee Chung

IPC分类号： A61B1/00

CPC分类号： A61B1/01 ,  A61B1/00154 ,  A61B1/0051 ,  A61B1/313 ,  A61B1/32 ,  A61B17/0401 ,  A61B17/0467 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0485 ,  A61B17/0487 ,  A61B17/0625 ,  A61B17/11 ,  A61B17/32053 ,  A61B17/32056 ,  A61B17/3415 ,  A61B50/10 ,  A61B50/13 ,  A61B2017/00309 ,  A61B2017/0409 ,  A61B2017/0417 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/047 ,  A61B2017/0472 ,  A61B2017/0474 ,  A61B2017/0475 ,  A61B2017/0488 ,  A61B2017/0496 ,  A61B2017/06019 ,  A61B2017/06052 ,  A61B2017/061 ,  A61B2017/22054 ,  A61B2017/22069 ,  A61B2017/2905 ,  A61B2017/3488 ,  A61B2090/061 ,  A61B2090/062

摘要： There is provided an endoscopic system.The system comprises a flexible endoscope insertable into a first tubular organ from a natural opening of a human body. The system further comprises an opening member which forms on a wall part of the first tubular organ an opening used to insert the endoscope into an abdominal cavity from the first tubular organ in the body, an anastomosing member which is able to anastomoses the first tubular organ with a second tubular organ in the abdominal cavity, and a cutting member with which the second tubular organ is able to be cut.

摘要翻译： 提供内窥镜系统。 该系统包括可从人体的天然开口插入第一管状器官的柔性内窥镜。 所述系统还包括开口构件，所述开口构件在所述第一管状器官的壁部上形成用于将所述内窥镜从所述主体中的所述第一管状器官插入腹腔的开口，能够吻合所述第一管状器官的吻合构件 在腹腔中具有第二管状器官，以及能够切割第二管状器官的切割构件。

公开(公告)号：US08105342B2

公开(公告)日：2012-01-31

申请号：US10430071

申请日：2003-05-06

申请人： Yoshio Onuki ,  Satoshi Miyamoto ,  Koichi Kawashima ,  Pankaj Jay Pasricha

发明人： Yoshio Onuki ,  Satoshi Miyamoto ,  Koichi Kawashima ,  Pankaj Jay Pasricha

IPC分类号： A61B17/10

CPC分类号： A61B17/0469 ,  A61B17/0467 ,  A61B17/0482 ,  A61B17/0483 ,  A61B17/0487 ,  A61B17/32056 ,  A61B2017/0404 ,  A61B2017/0409 ,  A61B2017/0414 ,  A61B2017/0417 ,  A61B2017/0419 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/0472 ,  A61B2017/0474 ,  A61B2017/0475 ,  A61B2017/0477 ,  A61B2017/0488 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/061 ,  A61B2017/2905

摘要： In the case where the living tissues in the patient's body is resected as well, it is possible to suture the resected portion immediately without replacement with another treatment device after resection. Thus, prevention of bleeding from the resected portion or earlier repair of an ulcer that occurs with the resected portion can be carried out for the patent lowly invasively and easily.

摘要翻译： 在患者体内的活组织也被切除的情况下，可以在切除后立即缝合切除部分而不用另外的治疗装置。 因此，可以防止来自切除部分的出血或对切除部分发生的溃疡的较早修复，对于专利可以低侵入地和容易​​地进行。

公开(公告)号：US20100099669A1

公开(公告)日：2010-04-22

申请号：US12653936

申请日：2009-12-21

申请人： Pankaj Jay Pasricha ,  Maria-Adelaide Micci

发明人： Pankaj Jay Pasricha ,  Maria-Adelaide Micci

IPC分类号： A61K31/5383 ,  A61P1/00 ,  A61K31/136 ,  A61K31/4965 ,  A61K31/40

CPC分类号： A61K31/135 ,  A61K31/445 ,  A61K31/4745 ,  A61K31/485 ,  A61K31/525 ,  A61K31/56 ,  A61K31/727

摘要： Provided herein are methods of treating gastrointestinal motility disorders by targeting the dopamine 3 receptor (D3R). A D3R agonist is administered to a subject to decrease gastrointestinal motility to treat the disorder. A D3R antagonist is administered to a subject to decrease gastrointestinal motility to treat the disorder.

摘要翻译： 本文提供了通过靶向多巴胺3受体（D3R）来治疗胃肠蠕动障碍的方法。 向受试者施用D3R激动剂以降低胃肠道运动以治疗该病症。 对受试者施用D3R拮抗剂以降低胃肠蠕动以治疗病症。

公开(公告)号：US5846567A

公开(公告)日：1998-12-08

申请号：US840783

申请日：1997-04-16

申请人： Anthony N. Kalloo ,  Pankaj Jay Pasricha

发明人： Anthony N. Kalloo ,  Pankaj Jay Pasricha

IPC分类号： A61K33/40 ,  A61K47/34

CPC分类号： A61K47/34 ,  A61K33/40 ,  Y10S514/834

摘要： A method, composition and kit for effecting hemostasis of a bleeding point and/or dissociating an adherent blood clot at a lesion site on an internal organ, include a composition comprising hydrogen peroxide and surfactant. The composition is applied to the site thereby effecting hemostasis and clot dissociation and clearing the field for endoscopy.

摘要翻译： 包含过氧化氢和表面活性剂的组合物包括用于实现止血点止血和/或解离内脏器官损伤部位的粘附血块的方法，组合物和试剂盒。 将组合物施用于该部位，从而进行止血和凝块解离并清除内窥镜检查领域。

公开(公告)号：US20110224491A1

公开(公告)日：2011-09-15

申请号：US13044484

申请日：2011-03-09

申请人： Pankaj Jay Pasricha

发明人： Pankaj Jay Pasricha

IPC分类号： A61B1/00

CPC分类号： A61B1/0052 ,  A61B1/00066 ,  A61B1/00068

摘要： A system is disclosed for assisting in endoscopic procedures. The method comprises a cap and a device for deploying a cap on the endoscope while the endoscope is positioned within a body lumen. A method of deploying a cap on an endoscope during an endoscopic procedure is disclosed. The method comprises providing a cap and a device for deploying the cap on the endoscope while the endoscope is positioned with a body lumen, advancing the endoscopic within a body lumen and deploying the cap on the endoscope.

摘要翻译： 公开了一种用于辅助内窥镜手术的系统。 该方法包括盖和用于在内窥镜位于体腔内部的情况下在内窥镜上展开帽的装置。 公开了在内窥镜过程中在内窥镜上展开帽的方法。 该方法包括在内窥镜与体腔定位的同时提供盖和用于将盖部署在内窥镜上的装置，使内窥镜在体腔内推进并将盖部署在内窥镜上。

公开(公告)号：US20110118812A1

公开(公告)日：2011-05-19

申请号：US13005535

申请日：2011-01-13

申请人： Pankaj Jay Pasricha ,  Jiande Chen

发明人： Pankaj Jay Pasricha ,  Jiande Chen

IPC分类号： A61N1/36

CPC分类号： A61N1/36007 ,  A61N1/36014 ,  A61N1/362

摘要： The present invention relates to a method of providing electrical stimulation to a liver of a subject which includes providing one or more stimulatory electrodes to the liver of the subject and providing electrical stimulation to the liver of the subject. The invention further relates to methods of reducing risk factors of metabolic syndrome, treating diabetes, treating a subject having eating disorders and reducing glucose levels of a subject using methods of the present invention.