公开(公告)号：US20120230564A1

公开(公告)日：2012-09-13

申请号：US13510290

申请日：2010-11-16

申请人： Jiang Liu ,  Zhuo Zhang ,  Wing Kee Damon Wong ,  Ngan Meng Tan ,  Fengshou Yin ,  Beng Hai Lee ,  Huiqi Li ,  Joo Hwee Lim ,  Carol Cheung ,  Tin Aung ,  Tien Yin Wong ,  Ziyang Liang ,  Jun Cheng ,  Baskaran Mani

发明人： Jiang Liu ,  Zhuo Zhang ,  Wing Kee Damon Wong ,  Ngan Meng Tan ,  Fengshou Yin ,  Beng Hai Lee ,  Huiqi Li ,  Joo Hwee Lim ,  Carol Cheung ,  Tin Aung ,  Tien Yin Wong ,  Ziyang Liang ,  Jun Cheng ,  Baskaran Mani

IPC分类号： G06K9/46

CPC分类号： A61B3/0025 ,  A61B3/12 ,  A61B5/02007 ,  A61B5/7264 ,  A61B5/7267 ,  A61B5/7275 ,  G06T7/0012 ,  G06T7/40 ,  G06T2207/30041

摘要： A non-stereo fundus image is used to obtain a plurality of glaucoma indicators. Additionally, genome data for the subject is used to obtain genetic marker data relating to one or more genes and/or SNPs associated with glaucoma. The glaucoma indicators indicators and genetic marker data are input into an adaptive model operative to generate an output indicative of a risk of glaucoma in the subject. In combination, the genetic indicators and genome data are more informative about the risk of glaucoma than either of the two in isolation. The adaptive model may be a two-stage model, having a first stage in which individual genetic indicators are combined with respective portions of the genome data by first adaptive model modules to form respective first outputs, and a second stage in which the first outputs are combined by a second adaptive mode. Texture analysis is performed on the fundus images to classify them based on their quality, and only images which are determined to meet a quality criterion are subjected to an analysis to determine if they exhibit glaucoma indicators. Also, the images are put into a standard format. The system may include estimating the position of the optic cup by combining results from multiple optic cup segmentation techniques. The system may include estimating the position of the optic disc by applying edge detection to the funds image, excluding edge points that are unlikely to be optic disc boundary points, and estimating the position of an optic disc by fitting an ellipse to the remaining edge points.

摘要翻译： 使用非立体眼底图像来获得多个青光眼指示符。 此外，用于受试者的基因组数据用于获得与与青光眼相关的一个或多个基因和/或SNP相关的遗传标记数据。 青光眼指标指标和遗传标记数据被输入到适应模型中，该模型用于产生指示受试者青光眼风险的输出。 综合来看，遗传指标和基因组数据对于青光眼的风险比孤立的两者之一更有信息。 自适应模型可以是两阶段模型，其具有第一阶段，其中通过第一自适应模型模块将个体遗传指标与基因组数据的相应部分组合以形成相应的第一输出，第二阶段中，第一输出是 通过第二自适应模式组合。 对眼底图像进行纹理分析，根据其质量对其进行分类，仅对满足质量标准的图像进行分析，以确定其是否呈现青光眼指标。 此外，图像被放入标准格式。 该系统可以包括通过组合来自多个光学杯分割技术的结果来估计光学杯的位置。 该系统可以包括通过对资金图像应用边缘检测来估计视盘的位置，不包括不太可能是视盘边界点的边缘点，以及通过将椭圆拟合到剩余边缘点来估计视盘的位置 。

公开(公告)号：US09107617B2

公开(公告)日：2015-08-18

申请号：US13510290

申请日：2010-11-16

申请人： Jiang Liu ,  Zhuo Zhang ,  Wing Kee Damon Wong ,  Ngan Meng Tan ,  Fengshou Yin ,  Beng Hai Lee ,  Huiqi Li ,  Joo Hwee Lim ,  Carol Cheung ,  Tin Aung ,  Tien Yin Wong ,  Ziyang Liang ,  Jun Cheng ,  Baskaran Mani

发明人： Jiang Liu ,  Zhuo Zhang ,  Wing Kee Damon Wong ,  Ngan Meng Tan ,  Fengshou Yin ,  Beng Hai Lee ,  Huiqi Li ,  Joo Hwee Lim ,  Carol Cheung ,  Tin Aung ,  Tien Yin Wong ,  Ziyang Liang ,  Jun Cheng ,  Baskaran Mani

IPC分类号： A61B3/12 ,  A61B5/02 ,  A61B5/00

CPC分类号： A61B3/0025 ,  A61B3/12 ,  A61B5/02007 ,  A61B5/7264 ,  A61B5/7267 ,  A61B5/7275 ,  G06T7/0012 ,  G06T7/40 ,  G06T2207/30041

摘要： A non-stereo fundus image is used to obtain a plurality of glaucoma indicators. Additionally, genome data for the subject is used to obtain genetic marker data relating to one or more genes and/or SNPs associated with glaucoma. The glaucoma indicators and genetic marker data are input into an adaptive model operative to generate an output indicative of a risk of glaucoma in the subject. In combination, the genetic indicators and genome data are more informative about the risk of glaucoma than either of the two in isolation. The adaptive model may be a two-stage model, having a first stage in which individual genetic indicators are combined with respective portions of the genome data by first adaptive model modules to form respective first outputs, and a second stage in which the first outputs are combined by a second adaptive mode. Texture analysis is performed on the fundus images to classify them based on their quality, and only images which are determined to meet a quality criterion are subjected to an analysis to determine if they exhibit glaucoma indicators. Also, the images are put into a standard format. The system may include estimating the position of the optic cup by combining results from multiple optic cup segmentation techniques. The system may include estimating the position of the optic disc by applying edge detection to the funds image, excluding edge points that are unlikely to be optic disc boundary points, and estimating the position of an optic disc by fitting an ellipse to the remaining edge points.

摘要翻译： 使用非立体眼底图像来获得多个青光眼指示符。 此外，用于受试者的基因组数据用于获得与与青光眼相关的一个或多个基因和/或SNP相关的遗传标记数据。 青光眼指标和遗传标记数据被输入到适应模型中，该模型用于产生指示受试者青光眼风险的输出。 综合来看，遗传指标和基因组数据对于青光眼的风险比孤立的两者之一更有信息。 自适应模型可以是两阶段模型，其具有第一阶段，其中通过第一自适应模型模块将个体遗传指标与基因组数据的相应部分组合以形成相应的第一输出，第二阶段中，第一输出是 通过第二自适应模式组合。 对眼底图像进行纹理分析，根据其质量对其进行分类，仅对满足质量标准的图像进行分析，以确定其是否呈现青光眼指标。 此外，图像被放入标准格式。 该系统可以包括通过组合来自多个光学杯分割技术的结果来估计光学杯的位置。 该系统可以包括通过对资金图像应用边缘检测来估计视盘的位置，排除不太可能是视盘边界点的边缘点，以及通过将椭圆拟合到剩余边缘点来估计视盘的位置 。

公开(公告)号：US08687866B2

公开(公告)日：2014-04-01

申请号：US13409867

申请日：2012-03-01

申请人： Pina Marziliano ,  Jing Tian ,  Hon-Tym Wong ,  Baskaran Mani ,  Tin Aung

发明人： Pina Marziliano ,  Jing Tian ,  Hon-Tym Wong ,  Baskaran Mani ,  Tin Aung

IPC分类号： G06K9/00 ,  G01B11/02

CPC分类号： G06T7/75 ,  A61B3/102 ,  A61B3/117 ,  G06T2207/30041

摘要： An optical coherence tomography (OCT) image of the anterior chamber of an eye is processed to determine automatically a location in the image corresponding to Schwalbe's line. First, the method finds the location of the corneal endothelium. Then the method fits a model to the detected corneal endothelium. Then the method determines the location of Schwalbe's line based on the relationship between the detected corneal endothelium and the fitted model, such as where the detected corneal endothelium diverges most from the fitted model. The Schwalbe's line is used to obtain a numerical measure of the anterior chamber angle of the eye. The method can be used in a process for screening patients for glaucoma. In the case of patients found to be suffering from glaucoma, treatment can be performed.

摘要翻译： 处理眼睛前房的光学相干断层扫描（OCT）图像，以自动确定与施瓦尔线对应的图像中的位置。 首先，该方法找到角膜内皮的位置。 然后该方法适合于检测到的角膜内皮的模型。 然后，该方法基于检测到的角膜内皮和拟合模型之间的关系确定Schwalbe线的位置，例如检测到的角膜内皮从拟合模型发散最多的位置。 Schwalbe线用于获得眼睛前房角度的数值测量。 该方法可用于筛选患者青光眼的过程。 在发现患有青光眼的患者的情况下，可以进行治疗。

公开(公告)号：US20120271288A1

公开(公告)日：2012-10-25

申请号：US13409867

申请日：2012-03-01

申请人： Pina MARZILIANO ,  Jing Tian ,  Hon-Tym Wong ,  Baskaran Mani ,  Tin Aung

发明人： Pina MARZILIANO ,  Jing Tian ,  Hon-Tym Wong ,  Baskaran Mani ,  Tin Aung

IPC分类号： G06K9/00 ,  A61F9/011

CPC分类号： G06T7/75 ,  A61B3/102 ,  A61B3/117 ,  G06T2207/30041

摘要： An optical coherence tomography (OCT) image of the anterior chamber of an eye is processed to determine automatically a location in the image corresponding to Schwalbe's line. First, the method finds the location of the corneal endothelium. Then the method fits a model to the detected corneal endothelium. Then the method determines the location of Schwalbe's line based on the relationship between the detected corneal endothelium and the fitted model, such as where the detected corneal endothelium diverges most from the fitted model. The Schwalbe's line is used to obtain a numerical measure of the anterior chamber angle of the eye. The method can be used in a process for screening patients for glaucoma. In the case of patients found to be suffering from glaucoma, treatment can be performed.

摘要翻译： 处理眼睛前房的光学相干断层扫描（OCT）图像，以自动确定对应于施瓦尔线的图像中的位置。 首先，该方法找到角膜内皮的位置。 然后该方法适合于检测到的角膜内皮的模型。 然后，该方法基于检测到的角膜内皮和拟合模型之间的关系确定Schwalbe线的位置，例如检测到的角膜内皮从拟合模型发散最多的位置。 Schwalbe线用于获得眼睛前房角度的数值测量。 该方法可用于筛选患者青光眼的过程。 在发现患有青光眼的患者的情况下，可以进行治疗。