公开(公告)号：US20050175681A1

公开(公告)日：2005-08-11

申请号：US10517088

申请日：2003-01-03

申请人： Jianming Chen ,  Shen Gao ,  Shaomin Wei ,  Hulfen Lin ,  Yangmei Zhang ,  Fel Guan ,  Yanqiang Zhong ,  Huiliang Li ,  Qing Shi ,  Yiguang Guo ,  Luo Lu

发明人： Jianming Chen ,  Shen Gao ,  Shaomin Wei ,  Hulfen Lin ,  Yangmei Zhang ,  Fel Guan ,  Yanqiang Zhong ,  Huiliang Li ,  Qing Shi ,  Yiguang Guo ,  Luo Lu

IPC分类号： A61K9/127 ,  A61K31/07

CPC分类号： A61K9/127

摘要： The invention relates to liposomal vitamin A and method of its preparing. The liposome containing vitamin A as active agent, carriers (supporter) and lipids as adjuvents and liposome-forming materials. The process comprises: adding vitamin A and lipids to carriers, forming a liposomal vitamin A in the form of solid, then rehydrating to give a liposomal dispersion. The process can improve the stability of vitamin A and liposomal vitamin A. The present liposome is useful for the manufacture of pharmaceutical and cosmetic formulation.

摘要翻译： 本发明涉及脂质体维生素A及其制备方法。 含有维生素A作为活性剂的脂质体，载体（载体）和脂质作为佐剂和脂质体形成材料。 该方法包括：向载体中加入维生素A和脂质，形成固体形式的脂质体维生素A，然后再水化，得到脂质体分散体。 该方法可以改善维生素A和脂质体维生素A的稳定性。本脂质体可用于制造药物和化妆品制剂。

公开(公告)号：US20060210619A1

公开(公告)日：2006-09-21

申请号：US10544088

申请日：2004-01-30

申请人： Jianming Chen ,  Luo Lu ,  Shen Gao ,  Huifen Lin ,  Shaomin Wei ,  Yangmei Zhang ,  Huiliang Li ,  Yanqiang Zhong ,  Qing Shi ,  Yiquang Guo ,  Fei Guan ,  Wei Wang ,  Laiji Ma ,  Juan Gu

发明人： Jianming Chen ,  Luo Lu ,  Shen Gao ,  Huifen Lin ,  Shaomin Wei ,  Yangmei Zhang ,  Huiliang Li ,  Yanqiang Zhong ,  Qing Shi ,  Yiquang Guo ,  Fei Guan ,  Wei Wang ,  Laiji Ma ,  Juan Gu

IPC分类号： A61K9/127 ,  A61K31/704

CPC分类号： A61K31/704 ,  A61K8/14 ,  A61K8/63 ,  A61K9/127 ,  A61Q19/00

摘要： This invention belongs to the chemical field, which is related to the fields of pharmaceutical preparations and cosmetic, especially to asiaticoside-liposome and its use for preparing pharmaceutical preparations and cosmetic. In this invention, asiaticoside and lipid components are fused by heating or dissolved in organic solvents, then treated with the rotary thin layer evaporation technique, hydrated by adding aqueous solution under shaking to afford lipid dispersing aqueous solution, and then treated by using the technics of sonication, homogeneous emulsification, microjet and extruding filtration to enwrap asiaticoside in the middle of liposomal bilayer membranes to form the hydrophilic asiaticoside-liposome. Asiaticoside-liposome of this invention can enhance the stability, skin penetrability and hydrophilicity of asiaticoside, it can be used for the preparation of cosmetic and pharmaceutical preparations especially skin-penetrated pharmaceutical preparations, and it is more convenient and easy to prepare skin-penetrated pharmaceutical preparations and cosmetic containing asiaticoside.

摘要翻译： 本发明属于化学领域，涉及药物制剂和化妆品领域，尤其涉及积雪草苷脂质体及其制备药物和化妆品的用途。 在本发明中，积雪草苷和脂质组分通过加热或溶解在有机溶剂中熔融，然后用旋转薄层蒸发技术处理，通过在振荡下加入水溶液进行水合，得到脂质分散水溶液，然后使用 超声处理，均匀乳化，微喷射和挤出过滤，在脂质体双层膜中间包裹积雪草苷，形成亲水性积雪草苷 - 脂质体。 本发明的积雪草苷 - 脂质体可以增强积雪草苷的稳定性，皮肤渗透性和亲水性，可用于制备化妆品和药物制剂，特别是皮肤渗透性药物制剂，并且更方便和容易地制备皮肤渗透的药物 含有积雪草苷的制剂和化妆品。

公开(公告)号：US20060251708A1

公开(公告)日：2006-11-09

申请号：US10549987

申请日：2004-03-22

申请人： Jianming Chen ,  Shen Gao ,  Huiliang Li ,  Huifen Lin ,  Shaomin Wei ,  Yangmei Zhang ,  Luo Lu ,  Yangiang Zhong ,  Qing Shi ,  Yiguang Guo ,  Fei Guan ,  Wei Wang ,  Laiji Ma ,  Juan Gu

发明人： Jianming Chen ,  Shen Gao ,  Huiliang Li ,  Huifen Lin ,  Shaomin Wei ,  Yangmei Zhang ,  Luo Lu ,  Yangiang Zhong ,  Qing Shi ,  Yiguang Guo ,  Fei Guan ,  Wei Wang ,  Laiji Ma ,  Juan Gu

IPC分类号： A61K9/127 ,  A61K38/43

CPC分类号： A61K8/14 ,  A61K8/355 ,  A61K8/68 ,  A61K9/1271 ,  A61K31/122 ,  A61K31/164 ,  A61Q19/00

摘要： A coenzyme Q10 and ceramide-containing preliposome, and pharmaceutical preparations and cosmetics containing the same. The preliposome can further comprise other lipid components. A granular and lyophilized solid-preparation is produced by lyophilization or spray drying. Then, the coenzyme Q10-containing proliposome is obtained by adding water in the said solid-preparation and shaking. Transdermal absorption of coenzyme is improved together with the effect of coenzyme Q10 in cosmetics and the stability of coenzyme Q10 and liposome, which facilitate the formulation of cosmetics.

摘要翻译： 辅酶Q 10 N和含神经酰胺的前脂质体，以及含有它们的药物制剂和化妆品。 前脂质体可以进一步包含其它脂质成分。 通过冻干或喷雾干燥制备颗粒状和冻干固体制剂。 然后，通过在所述固体制剂中加水并摇动获得含辅酶Q 10的前体脂质体。 辅酶的经皮吸收与化妆品中辅酶Q 10 N的作用以及促进化妆品配方的辅酶Q 10和脂质体的稳定性一起得到改善。

公开(公告)号：US08586751B2

公开(公告)日：2013-11-19

申请号：US13377157

申请日：2010-06-10

申请人： George V. De Lucca ,  Qing Shi ,  Chunjian Liu ,  Jingwu Duan ,  Andrew J. Tebben

发明人： George V. De Lucca ,  Qing Shi ,  Chunjian Liu ,  Jingwu Duan ,  Andrew J. Tebben

IPC分类号： A61K31/4433 ,  C07D401/14

CPC分类号： C07D401/04 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D498/10

摘要： Disclosed are nicotinamide compounds of Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof. Also disclosed are methods of using such compounds in the treatment of at least one Btk associated condition, such as, for example, inflammatory disease, and pharmaceutical compositions comprising such compounds.

摘要翻译： 公开了式（I）的烟酰胺化合物或其立体异构体或其药学上可接受的盐。 还公开了使用这些化合物治疗至少一种Btk相关病症例如炎性疾病的方法和包含这些化合物的药物组合物。

公开(公告)号：US20120082702A1

公开(公告)日：2012-04-05

申请号：US13377157

申请日：2010-06-10

申请人： George V. DeLucca ,  Qing Shi ,  Chunjian Liu ,  Jingwu Duan ,  Andrew J. Tebben

发明人： George V. DeLucca ,  Qing Shi ,  Chunjian Liu ,  Jingwu Duan ,  Andrew J. Tebben

IPC分类号： A61K47/22 ,  A61K31/5377 ,  C07D401/14 ,  A61K31/497 ,  A61P37/08 ,  C07D401/04 ,  A61K31/4545 ,  A61K31/438 ,  A61P35/00 ,  A61P37/06 ,  C07D413/14 ,  C07D401/12

CPC分类号： C07D401/04 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D498/10

摘要： Disclosed are nicotinamide compounds of Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof. Also disclosed are methods of using such compounds in the treatment of at least one Btk associated condition, such as, for example, inflammatory disease, and pharmaceutical compositions comprising such compounds.

摘要翻译： 公开了式（I）的烟酰胺化合物或其立体异构体或其药学上可接受的盐。 还公开了使用这些化合物治疗至少一种Btk相关病症例如炎性疾病的方法和包含这些化合物的药物组合物。

公开(公告)号：US07186715B2

公开(公告)日：2007-03-06

申请号：US10466248

申请日：2002-01-23

申请人： Karin Briner ,  Christopher William Doecke ,  Vincent Mancuso ,  Michael John Martinelli ,  Timothy Ivo Richardson ,  Roger Ryan Rothhaar ,  Qing Shi ,  Chaoyu Xie

发明人： Karin Briner ,  Christopher William Doecke ,  Vincent Mancuso ,  Michael John Martinelli ,  Timothy Ivo Richardson ,  Roger Ryan Rothhaar ,  Qing Shi ,  Chaoyu Xie

IPC分类号： A61K31/496 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14

CPC分类号： A61K45/06 ,  C07D209/44 ,  C07D217/14 ,  C07D217/26 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

摘要： The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction

摘要翻译： 本发明涉及式I的黑皮质素受体激动剂，其可用于治疗肥胖症，糖尿病和男性和/或女性性功能障碍

公开(公告)号：US20050192269A1

公开(公告)日：2005-09-01

申请号：US11002951

申请日：2004-12-03

申请人： Richard Thompson ,  Stephen Wilkie ,  Douglas Stack ,  Eldon Vanmeter ,  Qing Shi ,  Thomas Britton ,  James Audia ,  Jon Reel ,  Thomas Mabry ,  Bruce Dressman ,  Cynthia Cwi ,  Steven Henry ,  Stacey McDaniel ,  Russell Stucky ,  Warren Porter

发明人： Richard Thompson ,  Stephen Wilkie ,  Douglas Stack ,  Eldon Vanmeter ,  Qing Shi ,  Thomas Britton ,  James Audia ,  Jon Reel ,  Thomas Mabry ,  Bruce Dressman ,  Cynthia Cwi ,  Steven Henry ,  Stacey McDaniel ,  Russell Stucky ,  Warren Porter

IPC分类号： A61K31/445 ,  A61K31/4706 ,  A61K31/501 ,  A61K31/55 ,  A61K38/00 ,  C07D401/12 ,  C07D403/12 ,  C07K5/097

CPC分类号： C07D401/12 ,  A61K38/00 ,  C07D403/12 ,  C07K5/0821 ,  C07K5/0823

摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

公开(公告)号：US06906056B2

公开(公告)日：2005-06-14

申请号：US10392332

申请日：2003-03-20

申请人： Richard C. Thompson ,  Stephen Wilkie ,  Douglas R. Stack ,  Eldon E. Vanmeter ,  Qing Shi ,  Thomas C. Britton ,  James E. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  Cynthia L. Cwi ,  Steven S. Henry ,  Stacey L. McDaniel ,  Russell D. Stucky ,  Warren J. Porter

发明人： Richard C. Thompson ,  Stephen Wilkie ,  Douglas R. Stack ,  Eldon E. Vanmeter ,  Qing Shi ,  Thomas C. Britton ,  James E. Audia ,  Jon K. Reel ,  Thomas E. Mabry ,  Bruce A. Dressman ,  Cynthia L. Cwi ,  Steven S. Henry ,  Stacey L. McDaniel ,  Russell D. Stucky ,  Warren J. Porter

IPC分类号： A61K31/445 ,  A61K31/4706 ,  A61K31/501 ,  A61K31/55 ,  A61K38/00 ,  C07D401/12 ,  C07D403/12 ,  C07K5/097 ,  C07D267/02 ,  A61P25/28 ,  C07D223/12 ,  C07D487/00

CPC分类号： C07D401/12 ,  A61K38/00 ,  C07D403/12 ,  C07K5/0821 ,  C07K5/0823

摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

公开(公告)号：US06838455B2

公开(公告)日：2005-01-04

申请号：US10326081

申请日：2002-12-23

申请人： James E. Audia ,  Warren J. Porter ,  Richard C. Thompson ,  Stephen C. Wilkie ,  Douglas R. Stack ,  Qing Shi

发明人： James E. Audia ,  Warren J. Porter ,  Richard C. Thompson ,  Stephen C. Wilkie ,  Douglas R. Stack ,  Qing Shi

IPC分类号： A61K38/00 ,  C07D401/12 ,  C07D403/12 ,  C07K5/097 ,  C07D487/00 ,  A61K31/55 ,  C07D243/12 ,  C07D487/04 ,  C07D491/00

CPC分类号： C07D401/12 ,  A61K38/00 ,  C07D403/12 ,  C07K5/0821 ,  C07K5/0823

摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及用这种药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。

公开(公告)号：US06552013B1

公开(公告)日：2003-04-22

申请号：US09338121

申请日：1999-06-22

申请人： James E. Audia ,  Warren J. Porter ,  Richard C. Thompson ,  Stephen C. Wilkie ,  Douglas R. Stack ,  Qing Shi

发明人： James E. Audia ,  Warren J. Porter ,  Richard C. Thompson ,  Stephen C. Wilkie ,  Douglas R. Stack ,  Qing Shi

IPC分类号： C07D24324

CPC分类号： C07D401/12 ,  A61K38/00 ,  C07D403/12 ,  C07K5/0821 ,  C07K5/0823

摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及用这种药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。