公开(公告)号：US20050250051A1

公开(公告)日：2005-11-10

申请号：US10718809

申请日：2003-11-24

申请人： Jin Kim ,  Soon Hwang ,  Young Byun ,  Euk Hwang ,  Sang Lee

发明人： Jin Kim ,  Soon Hwang ,  Young Byun ,  Euk Hwang ,  Sang Lee

IPC分类号： C22C1/10 ,  G03F7/00 ,  G03F7/004

CPC分类号： G03F7/0043 ,  G03F7/0042

摘要： An organometallic composition containing an organometallic compound (I) containing Ag, an organometallic compound (II) containing Au, Pd, or Ru, and an organometallic compound (III) containing Ti, Ta, Cr, Mo, Ru, Ni, Pd, Cu, Au, or Al, wherein the metal components of organometallic compounds (II) and (III), respectively, are present in an amount of 0.01˜10 mol % based on the amount of Ag in the organometallic compound (I), and a method of forming a metal alloy pattern using the same. Silver alloy patterns can be obtained through a simplified manufacturing process, which patterns have enhanced heat resistance, adhesiveness and chemical stability. The method may be applied to making a reflective film for LCD and metal wiring (gate, source, drain electrode) for flexible displays or flat panel displays, and further to CMP-free damascene processing and PR-free ITO film deposition.

摘要翻译： 含有含Ag的有机金属化合物（I），含有Au，Pd或Ru的有机金属化合物（II）和含有Ti，Ta，Cr，Mo，Ru，Ni，Pd，Cu的有机金属化合物（III）的有机金属组合物 ，Au或Al，其中有机金属化合物（II）和（III）的金属组分分别以有机金属化合物（I）中的Ag的量为0.01〜10mol％的量存在，以及 使用其形成金属合金图案的方法。 可以通过简化的制造工艺获得银合金图案，该图案具有增强的耐热性，粘合性和化学稳定性。 该方法可以应用于制造用于LCD和用于柔性显示器或平板显示器的LCD和金属布线（栅极，源极，漏极）的反射膜，并且还可用于制造无CMP的镶嵌加工和无PR的ITO膜沉积。

公开(公告)号：US20070299131A1

公开(公告)日：2007-12-27

申请号：US10581799

申请日：2004-12-24

申请人： Kyu Yi ,  Sun Lee ,  Nak Kim ,  Jee Suh ,  Soon Hwang ,  Byung Lee ,  Ho Seo ,  Sun Hwang ,  Sung Yoo ,  Kyung Lee

发明人： Kyu Yi ,  Sun Lee ,  Nak Kim ,  Jee Suh ,  Soon Hwang ,  Byung Lee ,  Ho Seo ,  Sun Hwang ,  Sung Yoo ,  Kyung Lee

IPC分类号： A61K31/341 ,  A61P9/00 ,  A61P9/10 ,  C07D307/04

CPC分类号： C07D307/68

摘要： The present invention relates to furancarbonylguanidine derivatives, a preparation method thereof and a pharmaceutical composition comprising the same. Furancarbonylguanidine derivatives of the present invention inhibit NHE-1 (sodium-hydrogen exchanger isoform 1), which helps recovery of heart function damaged from ischemia/reperfusion and decreases myocardial infarction rate, indicating that they have protective effect on myocardial cells. Thus, furancarbonylguanidine derivatives of the present invention can be effectively used for the prevention and the treatment of ischemic heart diseases such as myocardial infarction, arrhythmia, angina pectoris, etc, and also a promising candidate for a heart protecting agent applied to reperfusion therapy including thrombolytics or cardiac surgery including coronary artery bypass graft, percutaneous transluminal coronary angioplasty, etc.

摘要翻译： 本发明涉及呋喃羰基胍衍生物，其制备方法和包含其的药物组合物。 本发明的呋喃羰基胍衍生物抑制NHE-1（钠氢交换异构体1），其有助于恢复从缺血/再灌注损伤的心脏功能，并降低心肌梗死率，表明它们对心肌细胞具有保护作用。 因此，本发明的呋喃羰基胍衍生物可以有效地用于预防和治疗心肌梗死，心律失常，心绞痛等缺血性心脏病，也是应用于再灌注治疗的心脏保护剂的有希望的候选物，包括溶栓剂 或心脏手术，包括冠状动脉旁路移植术，经皮腔内冠状动脉血管成形术等

公开(公告)号：US20070251434A1

公开(公告)日：2007-11-01

申请号：US10599816

申请日：2004-08-25

申请人： Soon Hwang ,  Young Kim ,  Cheal Doh

发明人： Soon Hwang ,  Young Kim ,  Cheal Doh

IPC分类号： F23G5/00

CPC分类号： F23G5/085 ,  F23G5/0276 ,  F23G5/32 ,  F23G2202/104 ,  F23G2202/20 ,  F23G2204/201

摘要： The present invention relates to a cyclonic plasma pyrolysis/vitrification system pyrolyzing and vitrifying waste materials into exhaust gas and slag using a plasma torch. The plasma torch circulates the exhaust gas in a main reactor with a maximum circulating power by strong plasma jet, and makes flyashes contained in the circulating exhaust gas to be melted after being adsorbed at the inner walls or in the melted materials of waste at the bottom of the main reactor by a centrifugal force. Accordingly, discharge of flyashes containing toxic materials to the outside is prevented, and pyrolysis and gasification of the waste materials are induced by circulating the exhaust gas rapidly.

摘要翻译： 本发明涉及一种气溶胶等离子体热解/玻璃化系统，其使用等离子体焰炬将废料和废物玻璃化成废气和炉渣。 等离子体焰炬通过强等离子体射流在主反应器中循环具有最大循环功率的废气，并使包含在循环废气中的飞灰在吸附在内壁或底部的废物熔化物中后熔化 的主反应器通过离心力。 因此，防止含有有毒物质的飞灰向外部排放，并且通过快速循环废气来引起废物的热解和气化。

公开(公告)号：US20080038802A1

公开(公告)日：2008-02-14

申请号：US11587228

申请日：2005-04-27

申请人： Soon Hwang ,  Sun Chung

发明人： Soon Hwang ,  Sun Chung

IPC分类号： C12P41/00

CPC分类号： C12P41/005 ,  C12P7/62 ,  C12P13/001 ,  C12P13/002

摘要： The present invention relates to process for the preparing of optically active ester derivatives and their acid derivatives which are used intensively as important chiral intermediates from racemic β-hydroxybutyl ester derivatives. In more detail, this invention relates to the process for preparing optically active β-hydroxybutyl ester derivatives and their acid derivatives by stereospecific hydrolysis of racemic β-hydroxybutyl ester derivatives using Upases or lipase-producing microorganisms in the aqueous phase or organic phase including aqueous solvent. The method of making optically active ester derivatives and their acid derivatives by hydrolysis of β-hydroxybutyl ester derivatives represented by the general formula 1 in scheme 1 is easier and more economical comparing to the conventional methods and the products have high optical purity. Also separation of ester derivatives from acid derivatives is easy after reaction. Thus this method is a useful process on the industrial scale.

摘要翻译： 本发明涉及光学活性酯衍生物及其酸衍生物的制备方法，它们被广泛用作外消旋β-羟基丁酯衍生物的重要手性中间体。 更详细地说，本发明涉及使用在水相或有机相中使用Upase或脂肪酶产生微生物的外消旋β-羟基丁酯衍生物立体特异性水解制备光学活性β-羟基丁酯衍生物及其酸衍生物的方法，包括水溶剂 。 通过水解方案1中通式1所示的β-羟基丁酯衍生物制备光学活性酯衍生物及其酸衍生物的方法比常规方法更容易和更经济，并且产品具有高的光学纯度。 酯衍生物与酸衍生物的分离也很容易。 因此，这种方法在工业规模上是一个有用的过程。

公开(公告)号：US20070026508A1

公开(公告)日：2007-02-01

申请号：US10554962

申请日：2004-04-30

申请人： Soon Hwang ,  Do Kim ,  Hye Ryu

发明人： Soon Hwang ,  Do Kim ,  Hye Ryu

IPC分类号： C12P7/62 ,  C12P7/20

CPC分类号： C12P7/02 ,  C12P7/62 ,  C12P41/004

摘要： The present invention relates to a new process for the preparation of optically active alcohols represented by the general formula 2 and their esters represented by the general formula 3 by enzymatic method from racemic alcohols represented by the general formula 1 in scheme 1. In more details, this invention relates to a process for producing optically active alcohols and their esters which are used as pharmaceutical intermediates from alcohols represented by the general formula 1 by stereospecific transesterification of secondary hydroxyl group using lipases as catalyst with acyl donors in organic solvent or with acyl donors only without using organic solvent. According to this invention, optically active alcohols and esters of high optical purity in high yield can be produced by transforming the primary hydroxyl group of 1,2-diols by tosyl group and transesterifying the secondary hydroxyl group stereospecifically by lipase.

摘要翻译： 本发明涉及由方案1中通式1表示的外消旋醇通过酶法由制备由通式2表示的光学活性醇及其由通式3表示的酯的新方法。更具体地， 本发明涉及一种用于制备光学活性醇及其酯的方法，其通过使用脂肪酶作为催化剂的有机溶剂中的酰基供体的催化剂或仅与酰基供体的立体特异性酯交换作为由通式1表示的醇用作药物中间体 不使用有机溶剂。 根据本发明，可以通过将1,2-二醇的伯羟基转化成甲苯磺酰基并通过脂肪酶立体特异性酯交换酯化，可以制备高产率的高光学纯度的光学活性醇和酯。

公开(公告)号：US20060234362A1

公开(公告)日：2006-10-19

申请号：US10558057

申请日：2004-06-02

申请人： Soon Hwang ,  Do Hoon Kim ,  Hye Youn Ryu ,  Tae Im Lee ,  Sun Ho Chung

发明人： Soon Hwang ,  Do Hoon Kim ,  Hye Youn Ryu ,  Tae Im Lee ,  Sun Ho Chung

IPC分类号： C12P7/02

CPC分类号： C12P7/62 ,  C12P7/04 ,  C12P41/004

摘要： The present invention relates to a new process for the preparation of optically active alcohols represented by the general formula 2 and their esters represented by the general formula 3 in scheme 1. In more detail, this invention relates to the process for the preparation of optically active alcohols and their esters which are used as pharmaceutical intermediates by reacting the hydroxyl group stereospecifically by lipase after adding racemic alcohols represented by the general formula 1 and succinic anhydride as an acylating agent to the organic solvent. According to this invention, the primary hydroxyl group of 1,2-diols is transformed by other functional group and the secondary hydroxyl group is esterified stereospecifically with succinic anhydride as an acylating agent. Optically active alcohols and their esters of high optical purity in high yield can be produced by using succinic anhydride as an acylating agent because alcohols can be separated from their esters more easily than those of other conventional methods.

摘要翻译： 本发明涉及制备由通式2表示的光学活性醇的新方法及其在方案1中由通式3表示的酯。更详细地说，本发明涉及制备光学活性的方法 醇和它们的酯，其通过在将通式1表示的外消旋醇和琥珀酸酐作为酰化剂加入到有机溶剂中之后通过脂肪酶立体特异性地使羟基反应而用作药物中间体。 根据本发明，1,2-二醇的伯羟基被其它官能团转变，仲羟基与琥珀酸酐作为酰化剂立体特异性酯化。 通过使用琥珀酸酐作为酰化剂可以生产高产率的高光学纯度的光学活性醇及其酯，因为与其它常规方法相比，可以更容易地将醇与其酯分离。