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1.发明申请MAGNETIC RESONANCE IMAGING CONTRAST AGENTS CONTAINING WATER-SOLUBLE NANOPARTICLES OF MANGANESE OXIDE OR MANGANESE METAL OXIDE 审中-公开含有锰氧化物或锰氧化物的水溶性纳米颗粒的磁共振成像对比剂公开(公告)号：US20090220431A1
公开(公告)日：2009-09-03
申请号：US12095878
申请日：2006-12-01
申请人： Jin-Woo Cheon , Young-Wook Jun , Jae-Hyun Lee , Jung-Wook Suh , Jin-Suck Suh , Seung-Jin Ko , Yong-Min Huh , Ho-Taek Song
发明人： Jin-Woo Cheon , Young-Wook Jun , Jae-Hyun Lee , Jung-Wook Suh , Jin-Suck Suh , Seung-Jin Ko , Yong-Min Huh , Ho-Taek Song
CPC分类号： A61K49/06 , A61K49/0002 , A61K49/0043 , A61K49/0093 , A61K49/1833 , A61K49/1836 , A61K49/1851 , A61K49/1863 , A61K49/1869 , A61K49/1875 , B82Y5/00 , B82Y30/00 , C01G49/00 , C01G49/0072 , C01G49/08 , C01G51/00 , C01G53/00 , C01P2002/86 , C01P2004/03 , C01P2004/64 , C01P2006/42
摘要： The present invention relates to a manganese-containing metal oxide nanoparticle-based magnetic resonance imaging (MRI) contrast agent, which is characterized in that: The core of it comprises 1 to 1000 nm-sized manganese-containing metal oxide nanoparticles which include MnO a (0
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2.发明授权Water-soluble nanoparticles stabilized with multi-functional group ligands and method of preparation thereof 有权用多官能团配体稳定的水溶性纳米颗粒及其制备方法公开(公告)号：US08801955B2
公开(公告)日：2014-08-12
申请号：US13550082
申请日：2012-07-16
申请人： Jin-Woo Cheon , Young-Wook Jun , Jin-Sil Choi
发明人： Jin-Woo Cheon , Young-Wook Jun , Jin-Sil Choi
IPC分类号： B22F3/00 , C04B35/64 , H01F1/04 , C07F15/00 , C07C43/00 , A61K38/00 , C07K16/00 , C12P21/08 , C08F26/00 , C08F126/00 , C08F226/00 , C08L67/00 , C08L77/00 , C08G63/00 , A61K49/18 , A61K47/48 , B82Y5/00
CPC分类号： A61K47/48861 , A61K47/6923 , A61K47/6929 , A61K49/1836 , A61K49/1839 , A61K49/1866 , A61K49/1875 , B82Y5/00 , Y10S977/773 , Y10S977/795 , Y10S977/81 , Y10S977/811 , Y10S977/896
摘要： Disclosed are water-soluble nanoparticles. The water-soluble nanoparticles are each surrounded by a multifunctional group ligand including an adhesive region, a cross linking region, and a reactive region. In the water-soluble nanoparticles, the cross-linking region of the multifunctional group ligand is cross-linked with another cross-linking region of a neighboring multifunctional group ligand. Furthermore, the present invention provides a method of producing water-soluble nanoparticles, which includes (1) synthesizing water-insoluble nanoparticles in an organic solvent, (2) dissolving the water insoluble nanoparticles in a first solvent and dissolving water-soluble multifunctional group ligands in a second solvent, (3) mixing the two solutions from the step (2) to substitute surfaces of the water-insoluble nanoparticles with the multifunctional group ligands and dissolving a mixture in an aqueous solution to conduct a separation process, and (4) cross-linking the substituted multifunctional group ligands with each other.
摘要翻译： 公开了水溶性纳米颗粒。 水溶性纳米颗粒各自被包括粘合剂区域，交联区域和反应性区域的多官能团配体包围。 在水溶性纳米颗粒中，多官能团配体的交联区域与相邻的多官能团配体的另一个交联区域交联。 此外，本发明提供一种水溶性纳米粒子的制造方法，其特征在于，包括（1）在有机溶剂中合成水不溶性纳米粒子，（2）将水不溶性纳米粒子溶解在第一溶剂中，并溶解水溶性多官能团配体 在第二溶剂中，（3）将来自步骤（2）的两种溶液与多官能团配体的水不溶性纳米颗粒的替代表面混合，并将混合物溶解在水溶液中进行分离过程，和（4） 将取代的多官能团配体彼此交联。
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3.发明申请Water-Soluble Nanoparticles Stabilized with Multi-Functional Group Ligands and Method of Preparation Thereof 审中-公开用多官能团配体稳定的水溶性纳米颗粒及其制备方法公开(公告)号：US20080038361A1
公开(公告)日：2008-02-14
申请号：US11571397
申请日：2004-09-30
申请人： Jin-Woo Cheon , Young-Wook Jun , Jin-Sil Choi
发明人： Jin-Woo Cheon , Young-Wook Jun , Jin-Sil Choi
IPC分类号： B82B3/00 , A61K31/7105 , A61K31/711 , A61K38/16 , A61K38/18 , A61K38/20 , A61K38/21 , A61K38/22 , A61K38/49 , A61K39/00 , A61K39/395 , A61K9/51 , A61P35/00 , A61P43/00 , B32B9/00
CPC分类号： A61K47/6923 , A61K47/6929 , A61K49/1836 , A61K49/1839 , A61K49/1866 , A61K49/1875 , B82Y5/00 , Y10S977/773 , Y10S977/795 , Y10S977/81 , Y10S977/811 , Y10S977/896
摘要： Disclosed are water-soluble nanoparticles. The water-soluble nanoparticles are each surrounded by a multifunctional group ligand including an adhesive region, a cross linking region, and a reactive region. In the water-soluble nanoparticles, the cross-linking region of the multifunctional group ligand is cross-linked with another cross-linking region of a neighboring multifunctional group ligand. Furthermore, the present invention provides a method of producing water-soluble nanoparticles, which includes (1) synthesizing water-insoluble nanoparticles in an organic solvent, (2) dissolving the water insoluble nanoparticles in a first solvent and dissolving water-soluble multifunctional group ligands in a second solvent, (3) mixing the two solutions from the step (2) to substitute surfaces of the water-insoluble nanoparticles with the multifunctional group ligands and dissolving a mixture in an aqueous solution to conduct a separation process, and (4) cross-linking the substituted multifunctional group ligands with each other.
摘要翻译： 公开了水溶性纳米颗粒。 水溶性纳米颗粒各自被包括粘合剂区域，交联区域和反应性区域的多官能团配体包围。 在水溶性纳米颗粒中，多官能团配体的交联区域与相邻的多官能团配体的另一个交联区域交联。 此外，本发明提供一种水溶性纳米粒子的制造方法，其特征在于，包括（1）在有机溶剂中合成水不溶性纳米粒子，（2）将水不溶性纳米粒子溶解在第一溶剂中，并溶解水溶性多官能团配体 在第二溶剂中，（3）将来自步骤（2）的两种溶液与多官能团配体的水不溶性纳米颗粒的替代表面混合，并将混合物溶解在水溶液中进行分离过程，和（4） 将取代的多官能团配体彼此交联。
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公开(公告)号：US20080003159A1
公开(公告)日：2008-01-03
申请号：US10598480
申请日：2004-11-26
申请人： Jin-Woo Cheon , Jung-Wook Seo , Jae-Hyun Lee
发明人： Jin-Woo Cheon , Jung-Wook Seo , Jae-Hyun Lee
CPC分类号： C01G23/006 , B82Y25/00 , B82Y30/00 , C01B13/185 , C01G1/02 , C01G23/002 , C01G23/003 , C01G23/0536 , C01G25/00 , C01G25/006 , C01G41/02 , C01G45/02 , C01G49/0018 , C01G49/0072 , C01G49/02 , C01G49/08 , C01G51/00 , C01G53/00 , C01P2002/72 , C01P2004/04 , C01P2004/64 , C01P2006/42 , H01F1/0054 , H01F1/11 , H01F1/36 , Y10S977/773 , Y10S977/775 , Y10S977/776
摘要： This invention relates, in general, to a method of producing magnetic oxide nanoparticles or metal oxide nanoparticles and, more particularly, to a method of producing magnetic or metal oxide nanoparticles, which comprises (1) adding a magnetic or metal precursor to a surfactant or a solvent containing the surfactant to produce a mixed solution, (2) heating the mixed solution to 50-6001 C to decompose the magnetic or metal precursor by heating so as to form the magnetic or metal oxide nanoparticles, and (3) separating the magnetic or metal oxide nanoparticles. Since the method is achieved through a simple process without using an oxidizing agent or a reducing agent, it is possible to simply mass-produce uniform magnetic or metal oxide nanoparticles having desired sizes compared to the conventional method.
摘要翻译： 本发明一般涉及一种制备磁性氧化物纳米颗粒或金属氧化物纳米颗粒的方法，更具体地说，涉及制备磁性或金属氧化物纳米颗粒的方法，其包括（1）向磁性或金属氧化物纳米颗粒中加入磁性或金属前体至表面活性剂或 含有表面活性剂以制备混合溶液的溶剂，（2）将混合溶液加热至50-6001℃，通过加热分解磁性或金属前体，以形成磁性或金属氧化物纳米颗粒，和（3）分离磁性 或金属氧化物纳米颗粒。 由于该方法通过简单的方法实现，而不使用氧化剂或还原剂，与常规方法相比，可以简单地批量生产具有所需尺寸的均匀的磁性或金属氧化物纳米颗粒。
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公开(公告)号：US08066969B2
公开(公告)日：2011-11-29
申请号：US10598480
申请日：2004-11-26
申请人： Jin-Woo Cheon , Jung-Wook Seo , Jae-Hyun Lee
发明人： Jin-Woo Cheon , Jung-Wook Seo , Jae-Hyun Lee
IPC分类号： C01B13/14 , C01B13/00 , C01C1/00 , C01D1/02 , C01G49/00 , C01G51/04 , C01G37/14 , C01G9/02 , C01G11/02 , C01G13/02 , C01G3/02 , C01G5/00 , C01G7/00 , C01G45/02 , C01G47/00 , C01G99/00 , C01G37/02 , C01G49/02 , C01G51/02 , C01G53/04
CPC分类号： C01G23/006 , B82Y25/00 , B82Y30/00 , C01B13/185 , C01G1/02 , C01G23/002 , C01G23/003 , C01G23/0536 , C01G25/00 , C01G25/006 , C01G41/02 , C01G45/02 , C01G49/0018 , C01G49/0072 , C01G49/02 , C01G49/08 , C01G51/00 , C01G53/00 , C01P2002/72 , C01P2004/04 , C01P2004/64 , C01P2006/42 , H01F1/0054 , H01F1/11 , H01F1/36 , Y10S977/773 , Y10S977/775 , Y10S977/776
摘要： This invention relates, in general, to a method of producing magnetic oxide nanoparticles or metal oxide nanoparticles and, more particularly, to a method of producing magnetic or metal oxide nanoparticles, which comprises (1) adding a magnetic or metal precursor to a surfactant or a solvent containing the surfactant to produce a mixed solution, (2) heating the mixed solution to 50-6001 C to decompose the magnetic or metal precursor by heating so as to form the magnetic or metal oxide nanoparticles, and (3) separating the magnetic or metal oxide nanoparticles. Since the method is achieved through a simple process without using an oxidizing agent or a reducing agent, it is possible to simply mass-produce uniform magnetic or metal oxide nanoparticles having desired sizes compared to the conventional method.
摘要翻译： 本发明一般涉及一种制备磁性氧化物纳米颗粒或金属氧化物纳米颗粒的方法，更具体地说，涉及制备磁性或金属氧化物纳米颗粒的方法，其包括（1）向磁性或金属氧化物纳米颗粒中加入磁性或金属前体至表面活性剂或 含有表面活性剂以制备混合溶液的溶剂，（2）将混合溶液加热至50-6001℃，通过加热分解磁性或金属前体，以形成磁性或金属氧化物纳米颗粒，和（3）分离磁性 或金属氧化物纳米颗粒。 由于该方法通过简单的方法实现，而不使用氧化剂或还原剂，与常规方法相比，可以简单地批量生产具有所需尺寸的均匀的磁性或金属氧化物纳米颗粒。
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