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    Growth arrest specific gene 6 peptides, antibodies, compositions, methods and uses
    1.
    发明授权
    Growth arrest specific gene 6 peptides, antibodies, compositions, methods and uses 有权
    生长停滞特异性基因6肽，抗体，组合物，方法和用途

    公开(公告)号：US07547767B2

    公开(公告)日：2009-06-16

    申请号：US11602865

    申请日：2006-11-21

    申请人： Jing Yang ,  George Heavner ,  Robert Jordan ,  Jill Giles-Komar ,  Ray Sweet

    发明人： Jing Yang ,  George Heavner ,  Robert Jordan ,  Jill Giles-Komar ,  Ray Sweet

    IPC分类号： C07K16/46

    CPC分类号： C07K14/745 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/76

    摘要： The present invention provides novel proteins and peptides from the receptor binding region of human Growth Arrest Specific Gene 6 (Gas6) and antibodies, including specified portions or variants, specific for at least one such Gas6 peptide or fragment thereof. The aforesaid peptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-Gas6 antibodies. The invention also provides for the nucleic acids encoding such peptides and anti-Gas6 antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, including therapeutic formulations, administration and devices. Fifteen novel peptide sequences from the Gas6 G domain that are implicated in Gas6 interactions with its receptors are identified, isolated, and synthesized so as to allow generation of anti-Gas6 antibodies. The peptide sequences include three ESTs that encompass regions predicted to contribute to receptor binding or that can raise anti-Gas6 antibodies. This invention provides for such antibodies to be used in modulating or treating at least one Gas6-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, thromboembolic disease, ischemic disease, venous thromboembolism, arterial or venous thrombosis, pulmonary embolism, restenosis, diabetic angiopathy and allograft atherosclerosis.

    摘要翻译： 本发明提供了来自人生长抑制特异性基因6（Gas6）的受体结合区的新型蛋白质和肽，以及对至少一种这样的Gas6肽或其片段特异的包括特定部分或变体的抗体。 上述肽可用于产生人，灵长类动物，啮齿动物，哺乳动物，嵌合，人源化和/或CDR移植的抗Gas6抗体。 本发明还提供了编码这些肽和抗Gas6抗体的核酸，互补核酸，载体，宿主细胞，以及制备和使用它们的方法，包括治疗制剂，给药和装置。 鉴定，分离和合成来自Gas6G结构域的15个新的肽序列，其与其受体相关的Gas6相互作用，以便产生抗Gas6抗体。 肽序列包括三个EST，其包含预期有助于受体结合的区域或可产生抗Gas6抗体。 本发明提供这样的抗体用于调节或治疗细胞，组织，器官，动物或患者中的至少一种Gas6相关疾病。 这些疾病可以包括但不限于血栓栓塞性疾病，缺血性疾病，静脉血栓栓塞，动脉或静脉血栓形成，肺栓塞，再狭窄，糖尿病性血管病和同种异体移植动脉粥样硬化。

    Growth arrest specific gene 6 peptides, antibodies, compositions, methods and uses
    2.
    发明申请
    Growth arrest specific gene 6 peptides, antibodies, compositions, methods and uses 有权
    生长停滞特异性基因6肽，抗体，组合物，方法和用途

    公开(公告)号：US20070128200A1

    公开(公告)日：2007-06-07

    申请号：US11602865

    申请日：2006-11-21

    申请人： Jing Yang ,  George Heavner ,  Robert Jordan ,  Jill Giles-Komar ,  Ray Sweet

    发明人： Jing Yang ,  George Heavner ,  Robert Jordan ,  Jill Giles-Komar ,  Ray Sweet

    IPC分类号： A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C12N5/06 ,  C12N1/21

    CPC分类号： C07K14/745 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/76

    摘要： The present invention provides novel proteins and peptides from the receptor binding region of human Growth Arrest Specific Gene 6 (Gas6) and antibodies, including specified portions or variants, specific for at least one such Gas6 peptide or fragment thereof. The aforesaid peptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-Gas6 antibodies. The invention also provides for the nucleic acids encoding such peptides and anti-Gas6 antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, including therapeutic formulations, administration and devices. Fifteen novel peptide sequences from the Gas6 G domain that are implicated in Gas6 interactions with its receptors are identified, isolated, and synthesized so as to allow generation of anti-Gas6 antibodies. The peptide sequences include three ESTs that encompass regions predicted to contribute to receptor binding or that can raise anti-Gas6 antibodies. This invention provides for such antibodies to be used in modulating or treating at least one Gas6-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, thromboembolic disease, ischemic disease, venous thromboembolism, arterial or venous thrombosis, pulmonary embolism, restenosis, diabetic angiopathy and allograft atherosclerosis.

    摘要翻译： 本发明提供了来自人生长抑制特异性基因6（Gas6）的受体结合区的新型蛋白质和肽，以及对至少一种这样的Gas6肽或其片段特异的包括特定部分或变体的抗体。 上述肽可用于产生人，灵长类动物，啮齿动物，哺乳动物，嵌合，人源化和/或CDR移植的抗Gas6抗体。 本发明还提供了编码这些肽和抗Gas6抗体的核酸，互补核酸，载体，宿主细胞，以及制备和使用它们的方法，包括治疗制剂，给药和装置。 鉴定，分离和合成来自Gas6G结构域的15个新的肽序列，其与其受体相关的Gas6相互作用，以便产生抗Gas6抗体。 肽序列包括三个EST，其包含预期有助于受体结合的区域或可产生抗Gas6抗体。 本发明提供这样的抗体用于调节或治疗细胞，组织，器官，动物或患者中的至少一种Gas6相关疾病。 这些疾病可以包括但不限于血栓栓塞性疾病，缺血性疾病，静脉血栓栓塞，动脉或静脉血栓形成，肺栓塞，再狭窄，糖尿病性血管病和同种异体移植动脉粥样硬化。