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公开(公告)号：US07635578B2
公开(公告)日：2009-12-22
申请号：US11894808
申请日：2007-08-20
申请人： Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
发明人： Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
CPC分类号： C07H19/14 , C07B2200/11 , C07H19/10 , C07H21/00 , C12Q1/68 , C12Q1/686 , C12Q1/6869 , C12Q1/6872 , C12Q1/6874 , C12Q1/6876 , C12Q2525/117 , C12Q2535/101 , C12Q2535/122 , C12Q2563/107 , C40B40/00 , C12Q2565/501 , C12Q2525/186
摘要： This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
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公开(公告)号：US20080199868A1
公开(公告)日：2008-08-21
申请号：US11894808
申请日：2007-08-20
申请人： Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
发明人： Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
CPC分类号： C07H19/14 , C07B2200/11 , C07H19/10 , C07H21/00 , C12Q1/68 , C12Q1/686 , C12Q1/6869 , C12Q1/6872 , C12Q1/6874 , C12Q1/6876 , C12Q2525/117 , C12Q2535/101 , C12Q2535/122 , C12Q2563/107 , C40B40/00 , C12Q2565/501 , C12Q2525/186
摘要： This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
摘要翻译： 本发明提供了通过在聚合酶反应中将核苷酸类似物掺入DNA的生长链中之后检测核苷酸类似物的同一性来提供将核酸连接到固体表面和测序核酸的方法。 本发明还提供核苷酸类似物，其包含通过可切割连接子连接至核苷酸类似物的独特标记，以及可脱氧化学基团以封端脱氧核糖3'-位上的-OH基团。
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公开(公告)号：US20080131895A1
公开(公告)日：2008-06-05
申请号：US11894690
申请日：2007-08-20
申请人： Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
发明人： Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
CPC分类号： C07H19/14 , C07B2200/11 , C07H19/10 , C07H21/00 , C12Q1/68 , C12Q1/686 , C12Q1/6869 , C12Q1/6872 , C12Q1/6874 , C12Q1/6876 , C12Q2525/117 , C12Q2535/101 , C12Q2535/122 , C12Q2563/107 , C40B40/00 , C12Q2565/501 , C12Q2525/186
摘要： This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
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公开(公告)号：US08088575B2
公开(公告)日：2012-01-03
申请号：US12804284
申请日：2010-07-19
申请人： Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
发明人： Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
CPC分类号： C07H19/14 , C07B2200/11 , C07H19/10 , C07H21/00 , C12Q1/68 , C12Q1/686 , C12Q1/6869 , C12Q1/6872 , C12Q1/6874 , C12Q1/6876 , C12Q2525/117 , C12Q2535/101 , C12Q2535/122 , C12Q2563/107 , C40B40/00 , C12Q2565/501 , C12Q2525/186
摘要： This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
摘要翻译： 本发明提供了通过在聚合酶反应中将核苷酸类似物掺入DNA的生长链中之后检测核苷酸类似物的同一性来提供将核酸连接到固体表面和测序核酸的方法。 本发明还提供核苷酸类似物，其包含通过可切割连接子连接至核苷酸类似物的独特标记，以及可脱氧化学基团以封端脱氧核糖3'-位上的-OH基团。
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公开(公告)号：US07790869B2
公开(公告)日：2010-09-07
申请号：US11810509
申请日：2007-06-05
申请人： Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
发明人： Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
CPC分类号： C07H19/14 , C07B2200/11 , C07H19/10 , C07H21/00 , C12Q1/68 , C12Q1/686 , C12Q1/6869 , C12Q1/6872 , C12Q1/6874 , C12Q1/6876 , C12Q2525/117 , C12Q2535/101 , C12Q2535/122 , C12Q2563/107 , C40B40/00 , C12Q2565/501 , C12Q2525/186
摘要： This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
摘要翻译： 本发明提供了通过在聚合酶反应中将核苷酸类似物掺入DNA的生长链中之后检测核苷酸类似物的同一性来提供将核酸连接到固体表面和测序核酸的方法。 本发明还提供核苷酸类似物，其包含通过可切割连接子连接至核苷酸类似物的独特标记，以及可脱氧化学基团以封端脱氧核糖3'-位上的-OH基团。
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公开(公告)号：US06664079B2
公开(公告)日：2003-12-16
申请号：US09972364
申请日：2001-10-05
申请人： Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
发明人： Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
IPC分类号： C12Q168
CPC分类号： C07H19/14 , C07B2200/11 , C07H19/10 , C07H21/00 , C12Q1/68 , C12Q1/686 , C12Q1/6869 , C12Q1/6872 , C12Q1/6874 , C12Q1/6876 , C12Q2525/117 , C12Q2535/101 , C12Q2535/122 , C12Q2563/107 , C40B40/00 , C12Q2565/501 , C12Q2525/186
摘要： This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
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公开(公告)号：US20120142006A1
公开(公告)日：2012-06-07
申请号：US13339089
申请日：2011-12-28
申请人： Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
发明人： Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
CPC分类号： C12Q1/6869 , C07B2200/11 , C07H19/10 , C07H19/14 , C07H21/00 , C12Q1/68 , C12Q1/686 , C12Q1/6872 , C12Q1/6874 , C12Q1/6876 , C12Q2525/117 , C12Q2525/186 , C12Q2535/101 , C12Q2535/122 , C12Q2563/107 , C12Q2565/501 , C40B40/00
摘要： This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
摘要翻译： 本发明提供了通过在聚合酶反应中将核苷酸类似物掺入DNA的生长链中之后检测核苷酸类似物的同一性来提供将核酸连接到固体表面和测序核酸的方法。 本发明还提供核苷酸类似物，其包含通过可切割连接子连接至核苷酸类似物的独特标记，以及可脱氧化学基团以封端脱氧核糖3'-位上的-OH基团。
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公开(公告)号：US20100317012A1
公开(公告)日：2010-12-16
申请号：US12804284
申请日：2010-07-19
申请人： Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
发明人： Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
CPC分类号： C07H19/14 , C07B2200/11 , C07H19/10 , C07H21/00 , C12Q1/68 , C12Q1/686 , C12Q1/6869 , C12Q1/6872 , C12Q1/6874 , C12Q1/6876 , C12Q2525/117 , C12Q2535/101 , C12Q2535/122 , C12Q2563/107 , C40B40/00 , C12Q2565/501 , C12Q2525/186
摘要： This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
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公开(公告)号：US07713698B2
公开(公告)日：2010-05-11
申请号：US11894690
申请日：2007-08-20
申请人： Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
发明人： Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
CPC分类号： C07H19/14 , C07B2200/11 , C07H19/10 , C07H21/00 , C12Q1/68 , C12Q1/686 , C12Q1/6869 , C12Q1/6872 , C12Q1/6874 , C12Q1/6876 , C12Q2525/117 , C12Q2535/101 , C12Q2535/122 , C12Q2563/107 , C40B40/00 , C12Q2565/501 , C12Q2525/186
摘要： This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
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公开(公告)号：US20080319179A1
公开(公告)日：2008-12-25
申请号：US11810509
申请日：2007-06-05
申请人： Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
发明人： Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
IPC分类号： C07H21/04
CPC分类号： C07H19/14 , C07B2200/11 , C07H19/10 , C07H21/00 , C12Q1/68 , C12Q1/686 , C12Q1/6869 , C12Q1/6872 , C12Q1/6874 , C12Q1/6876 , C12Q2525/117 , C12Q2535/101 , C12Q2535/122 , C12Q2563/107 , C40B40/00 , C12Q2565/501 , C12Q2525/186
摘要： This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
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