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公开(公告)号：US07683068B2
公开(公告)日：2010-03-23
申请号：US11920286
申请日：2006-06-23
IPC分类号： A61K31/497 , A61K31/4035 , A61K31/4439 , C07D209/46 , C07D405/04 , C07D409/04 , A61P29/00
CPC分类号： C07D209/46 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
摘要： The present invention is directed to certain hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
摘要翻译： 本发明涉及可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P的某些加氢异吲哚啉化合物。本发明还涉及包含这些化合物作为活性成分的药物制剂和 使用化合物及其制剂治疗某些疾病，包括呕吐，尿失禁，抑郁和焦虑。
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公开(公告)号：US20090054462A1
公开(公告)日：2009-02-26
申请号：US11920286
申请日：2006-06-23
IPC分类号： A61K31/497 , C07D209/46 , C07D405/04 , C07D409/04 , A61K31/4035 , A61P29/00 , A61P11/00 , A61P13/00 , A61P1/00 , A61P25/00 , A61K31/4439 , C07D401/04 , C07D403/04
CPC分类号： C07D209/46 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
摘要： The present invention is directed to certain hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
摘要翻译： 本发明涉及可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P的某些加氢异吲哚啉化合物。本发明还涉及包含这些化合物作为活性成分的药物制剂和 使用化合物及其制剂治疗某些疾病，包括呕吐，尿失禁，抑郁和焦虑。
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公开(公告)号：US08124633B2
公开(公告)日：2012-02-28
申请号：US12593168
申请日：2008-04-07
IPC分类号： A61K31/422 , C07D209/02
CPC分类号： C07D209/44 , C07D413/04
摘要： The present invention is directed to certain hydroxymethyl ether hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, LUTS, depression, and anxiety.
摘要翻译： 本发明涉及某些可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P的羟甲基醚异二氢吲哚化合物。本发明还涉及包含这些化合物作为活性成分的药物制剂 以及化合物及其制剂在治疗某些疾病（包括呕吐，尿失禁，LUTS，抑郁和焦虑）中的用途。
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公开(公告)号：US20100105747A1
公开(公告)日：2010-04-29
申请号：US12593168
申请日：2008-04-07
IPC分类号： A61K31/422 , C07D209/02 , C07D413/04 , A61K31/40
CPC分类号： C07D209/44 , C07D413/04
摘要： The present invention is directed to certain hydroxymethyl ether hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, LUTS, depression, and anxiety.
摘要翻译： 本发明涉及某些可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P的羟甲基醚异二氢吲哚化合物。本发明还涉及包含这些化合物作为活性成分的药物制剂 以及化合物及其制剂在治疗某些疾病（包括呕吐，尿失禁，LUTS，抑郁和焦虑）中的用途。
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![Octahydropyrano[3,4-C]pyrrole tachykinin receptor antagonists](/abs-image/US/2010/01/26/US07652058B2/abs.jpg.150x150.jpg)
公开(公告)号：US07652058B2
公开(公告)日：2010-01-26
申请号：US11792514
申请日：2005-12-12
IPC分类号： A61K31/407 , C07D491/052
CPC分类号： C07D491/04
摘要： The present invention is directed to certain hydropyranopyrrolidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
摘要翻译： 本发明涉及可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P的某些氢吡喃并吡咯烷化合物。本发明还涉及包含这些化合物作为活性成分的药物组合物和 使用化合物及其制剂治疗某些疾病，包括呕吐，尿失禁，抑郁和焦虑。
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公开(公告)号：US07345083B2
公开(公告)日：2008-03-18
申请号：US11714352
申请日：2007-03-06
IPC分类号： A61K31/4035 , C07D209/44
CPC分类号： C07D209/44
摘要： The present invention is directed to certain hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
摘要翻译： 本发明涉及可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P的某些加氢异吲哚啉化合物。本发明还涉及包含这些化合物作为活性成分的药物制剂和 使用化合物及其制剂治疗某些疾病，包括呕吐，尿失禁，抑郁和焦虑。
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公开(公告)号：US07645790B2
公开(公告)日：2010-01-12
申请号：US10586727
申请日：2005-01-26
IPC分类号： A61K31/4035 , C07D209/44
CPC分类号： C07D209/44
摘要： The present invention is directed to certain hydroisoindoline compounds of formula I which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
摘要翻译： 本发明涉及某些可用作神经激肽-1（NK-1）受体拮抗剂和速激肽抑制剂，特别是物质P的式I的加氢异吲哚啉化合物。本发明还涉及包含这些化合物作为活性的药物制剂 成分以及化合物及其制剂在治疗某些疾病（包括呕吐，尿失禁，抑郁和焦虑）中的用途。
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公开(公告)号：US20080280966A1
公开(公告)日：2008-11-13
申请号：US10586727
申请日：2005-01-26
IPC分类号： A61K31/403 , C07D209/44
CPC分类号： C07D209/44
摘要： The present invention is directed to certain hydroisoindoline compounds of formula I which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
摘要翻译： 本发明涉及某些可用作神经激肽-1（NK-1）受体拮抗剂和速激肽抑制剂，特别是物质P的式I的加氢异吲哚啉化合物。本发明还涉及包含这些化合物作为活性的药物制剂 成分以及化合物及其制剂在治疗某些疾病（包括呕吐，尿失禁，抑郁和焦虑）中的用途。
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公开(公告)号：US07217731B2
公开(公告)日：2007-05-15
申请号：US11043213
申请日：2005-01-26
IPC分类号： A61K31/4035 , C07D209/44
CPC分类号： C07D209/44
摘要： The present invention is directed to certain hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
摘要翻译： 本发明涉及可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P的某些加氢异吲哚啉化合物。本发明还涉及包含这些化合物作为活性成分的药物制剂和 使用化合物及其制剂治疗某些疾病，包括呕吐，尿失禁，抑郁和焦虑。
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![Octahydropyrano[3,4-C]Pyrrole Tachykinin Receptor Antagonists](/abs-image/US/2008/05/08/US20080108689A1/abs.jpg.150x150.jpg)
公开(公告)号：US20080108689A1
公开(公告)日：2008-05-08
申请号：US11792514
申请日：2005-12-12
IPC分类号： A61K31/407 , C07D491/052 , A61P43/00
CPC分类号： C07D491/04
摘要： The present invention is directed to certain hydropyranopyrrolidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
摘要翻译： 本发明涉及可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P的某些氢吡喃并吡咯烷化合物。本发明还涉及包含这些化合物作为活性成分的药物组合物和 使用化合物及其制剂治疗某些疾病，包括呕吐，尿失禁，抑郁和焦虑。
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