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1.发明申请公开(公告)号：US20130004499A1
公开(公告)日：2013-01-03
申请号：US13579757
申请日：2011-02-18
申请人： Jiro Tanaka , Peter Sejer Andersen , Takafumi Okutomi , Tsuneyoshi Inaba , Keiko Otsuka , Hirotomo Akabane , Yukari Hoshina , Jun Saito , Hiroshi Nagaso , Masashi Kumagai , Yasuyo Hagiwara
发明人： Jiro Tanaka , Peter Sejer Andersen , Takafumi Okutomi , Tsuneyoshi Inaba , Keiko Otsuka , Hirotomo Akabane , Yukari Hoshina , Jun Saito , Hiroshi Nagaso , Masashi Kumagai , Yasuyo Hagiwara
CPC分类号： C07K16/1214 , A61K2039/505 , C07K16/44 , C07K2317/21 , C07K2317/24 , C07K2317/732 , C07K2317/734 , G01N2333/21
摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype E and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.
摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了结合血清型E的铜绿假单胞菌菌株的体外和体内具有优异抗菌活性的LPS的抗体。
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公开(公告)号：US20130004500A1
公开(公告)日：2013-01-03
申请号：US13579847
申请日：2011-02-18
申请人： Jiro Tanaka , Peter Sejer Andersen , Takafumi Okutomi , Tsuneyoshi Inaba , Keiko Otsuka , Hirotomo Akabane , Yukari Hoshina , Hiroshi Nagaso , Masashi Kumagai
发明人： Jiro Tanaka , Peter Sejer Andersen , Takafumi Okutomi , Tsuneyoshi Inaba , Keiko Otsuka , Hirotomo Akabane , Yukari Hoshina , Hiroshi Nagaso , Masashi Kumagai
CPC分类号： C07K16/1214 , A61K2039/505 , C07K16/44 , C07K2317/21 , C07K2317/24 , C07K2317/732 , C07K2317/734 , G01N2333/21
摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype A and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.
摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了与血清型A的铜绿假单胞菌菌株的LPS结合并且具有优异的体外和体内抗菌活性的抗体。
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公开(公告)号：US20130022604A1
公开(公告)日：2013-01-24
申请号：US13579826
申请日：2011-02-18
申请人： Jiro Tanaka , Peter Sejer Andersen , Takafumi Okutomi , Tsuneyoshi Inaba , Keiko Otsuka , Hirotomo Akabane , Yukari Hoshina , Hiroshi Nagaso , Masashi Kumagai
发明人： Jiro Tanaka , Peter Sejer Andersen , Takafumi Okutomi , Tsuneyoshi Inaba , Keiko Otsuka , Hirotomo Akabane , Yukari Hoshina , Hiroshi Nagaso , Masashi Kumagai
CPC分类号： C07K16/1214 , A61K2039/505 , C07K16/44 , C07K2317/21 , C07K2317/24 , C07K2317/732 , C07K2317/734 , G01N2333/21
摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype B and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.
摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了结合血清型B的铜绿假单胞菌菌株的体外和体内具有优异抗菌活性的LPS的抗体。
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4.发明申请公开(公告)号：US20130045207A1
公开(公告)日：2013-02-21
申请号：US13579748
申请日：2011-02-18
申请人： Jiro Tanaka , Peter Sejer Andersen , Takafumi Okutomi , Tsuneyoshi Inaba , Keiko Otsuka , Hirotomo Akabane , Yukari Hoshina , Hiroshi Nagaso , Masashi Kumagai
发明人： Jiro Tanaka , Peter Sejer Andersen , Takafumi Okutomi , Tsuneyoshi Inaba , Keiko Otsuka , Hirotomo Akabane , Yukari Hoshina , Hiroshi Nagaso , Masashi Kumagai
CPC分类号： C07K16/1214 , A61K2039/505 , C07K16/44 , C07K2317/21 , C07K2317/24 , C07K2317/732 , C07K2317/734 , G01N2333/21
摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype G and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.
摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了结合血清型G的铜绿假单胞菌菌株的体外和体内具有优异抗菌活性的LPS的抗体。
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5.发明申请公开(公告)号：US20130022603A1
公开(公告)日：2013-01-24
申请号：US13579764
申请日：2011-02-18
申请人： Jiro Tanaka , Peter Sejer Andersen , Takafumi Okutomi , Tsuneyoshi Inaba , Keiko Otsuka , Hirotomo Akabane , Yukari Hoshina , Hiroshi Nagaso , Masashi Kumagai
发明人： Jiro Tanaka , Peter Sejer Andersen , Takafumi Okutomi , Tsuneyoshi Inaba , Keiko Otsuka , Hirotomo Akabane , Yukari Hoshina , Hiroshi Nagaso , Masashi Kumagai
CPC分类号： C07K16/1214 , A61K2039/505 , C07K16/44 , C07K2317/21 , C07K2317/24 , C07K2317/732 , C07K2317/734 , G01N2333/21
摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype I and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.
摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了结合血清型I的铜绿假单胞菌菌株的LPS并在体外和体内具有优异抗菌活性的抗体。
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公开(公告)号：US20090155279A1
公开(公告)日：2009-06-18
申请号：US12084205
申请日：2006-10-27
申请人： Jiro Tanaka , Fukuichi Ohsawa , Takafumi Okutomi , Hiroshi Nagaso , Masashi Kumagai , Takahisa Suzuki , Keiko Otsuka
发明人： Jiro Tanaka , Fukuichi Ohsawa , Takafumi Okutomi , Hiroshi Nagaso , Masashi Kumagai , Takahisa Suzuki , Keiko Otsuka
IPC分类号： A61K39/395 , C07K14/00 , A61K39/104 , C07K16/18 , C12N5/06
CPC分类号： C07K16/1214 , A61K39/00 , A61K2039/505 , A61K2039/52 , C07K14/21 , G01N33/56911
摘要： An object of the present invention is to provide a protein or peptide antigen and an antibody against it, for use in the diagnosis, prevention, or treatment of diseases associated with Pseudomonas aeruginosa. According to the present invention, there is provided a protein or peptide derived from Pseudomonas aeruginosa outer membrane protein PA5158 and an antibody against it, for use in the diagnosis, prevention, or treatment of diseases associated with Pseudomonas aeruginosa.
摘要翻译： 本发明的目的是提供蛋白质或肽抗原和抗体的抗体，用于诊断，预防或治疗与铜绿假单胞菌相关的疾病。 根据本发明，提供了来自绿脓假单胞菌外膜蛋白PA5158的蛋白质或肽，以及针对其的抗体，用于诊断，预防或治疗与铜绿假单胞菌相关的疾病。
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公开(公告)号：US08084044B2
公开(公告)日：2011-12-27
申请号：US12225821
申请日：2007-03-30
申请人： Jiro Tanaka , Fukuichi Ohsawa , Takafumi Okutomi , Hiroshi Nagaso , Masashi Kumagai , Takahisa Suzuki , Keiko Otsuka
发明人： Jiro Tanaka , Fukuichi Ohsawa , Takafumi Okutomi , Hiroshi Nagaso , Masashi Kumagai , Takahisa Suzuki , Keiko Otsuka
IPC分类号： A61K39/108
CPC分类号： C07K16/1214 , C07K14/21 , C07K2317/77
摘要： An object of the present invention is to provide a protein or peptide antigen and an antibody against it, for use in the diagnosis, prevention, or treatment of diseases associated with Pseudomonas aeruginosa. According to the present invention, there is provided a protein or peptide derived from Pseudomonas aeruginosa outer membrane protein PA0427 and an antibody against it, for use in the diagnosis, prevention, or treatment of diseases associated with Pseudomonas aeruginosa.
摘要翻译： 本发明的目的是提供蛋白质或肽抗原和抗体的抗体，用于诊断，预防或治疗与铜绿假单胞菌相关的疾病。 根据本发明，提供了来自绿脓假单胞菌外膜蛋白PA0427的蛋白质或肽，以及用于诊断，预防或治疗与绿脓假单胞菌相关疾病的抗体。
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公开(公告)号：US20090117121A1
公开(公告)日：2009-05-07
申请号：US12225821
申请日：2007-03-30
申请人： Jiro Tanaka , Fukuichi Ohsawa , Takafumi Okutomi , Hiroshi Nagaso , Masahi Kumagai , Takashisa Suzuki , Keiko Otsuka
发明人： Jiro Tanaka , Fukuichi Ohsawa , Takafumi Okutomi , Hiroshi Nagaso , Masahi Kumagai , Takashisa Suzuki , Keiko Otsuka
IPC分类号： A61K39/395 , C07K14/00 , C07K7/00 , A61K39/104 , G01N33/569 , C07K16/18 , C12N5/06
CPC分类号： C07K16/1214 , C07K14/21 , C07K2317/77
摘要： An object of the present invention is to provide a protein or peptide antigen and an antibody against it, for use in the diagnosis, prevention, or treatment of diseases associated with Pseudomonas aeruginosa. According to the present invention, there is provided a protein or peptide derived from Pseudomonas aeruginosa outer membrane protein PA0427 and an antibody against it, for use in the diagnosis, prevention, or treatment of diseases associated with Pseudomonas aeruginosa.
摘要翻译： 本发明的目的是提供蛋白质或肽抗原和抗体的抗体，用于诊断，预防或治疗与铜绿假单胞菌相关的疾病。 根据本发明，提供了来自绿脓假单胞菌外膜蛋白PA0427的蛋白质或肽，以及用于诊断，预防或治疗与绿脓假单胞菌相关疾病的抗体。
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