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1.发明申请公开(公告)号：US20130004499A1
公开(公告)日：2013-01-03
申请号：US13579757
申请日：2011-02-18
申请人： Jiro Tanaka , Peter Sejer Andersen , Takafumi Okutomi , Tsuneyoshi Inaba , Keiko Otsuka , Hirotomo Akabane , Yukari Hoshina , Jun Saito , Hiroshi Nagaso , Masashi Kumagai , Yasuyo Hagiwara
发明人： Jiro Tanaka , Peter Sejer Andersen , Takafumi Okutomi , Tsuneyoshi Inaba , Keiko Otsuka , Hirotomo Akabane , Yukari Hoshina , Jun Saito , Hiroshi Nagaso , Masashi Kumagai , Yasuyo Hagiwara
CPC分类号： C07K16/1214 , A61K2039/505 , C07K16/44 , C07K2317/21 , C07K2317/24 , C07K2317/732 , C07K2317/734 , G01N2333/21
摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype E and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.
摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了结合血清型E的铜绿假单胞菌菌株的体外和体内具有优异抗菌活性的LPS的抗体。
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公开(公告)号：US20130004500A1
公开(公告)日：2013-01-03
申请号：US13579847
申请日：2011-02-18
申请人： Jiro Tanaka , Peter Sejer Andersen , Takafumi Okutomi , Tsuneyoshi Inaba , Keiko Otsuka , Hirotomo Akabane , Yukari Hoshina , Hiroshi Nagaso , Masashi Kumagai
发明人： Jiro Tanaka , Peter Sejer Andersen , Takafumi Okutomi , Tsuneyoshi Inaba , Keiko Otsuka , Hirotomo Akabane , Yukari Hoshina , Hiroshi Nagaso , Masashi Kumagai
CPC分类号： C07K16/1214 , A61K2039/505 , C07K16/44 , C07K2317/21 , C07K2317/24 , C07K2317/732 , C07K2317/734 , G01N2333/21
摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype A and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.
摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了与血清型A的铜绿假单胞菌菌株的LPS结合并且具有优异的体外和体内抗菌活性的抗体。
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公开(公告)号：US20130022604A1
公开(公告)日：2013-01-24
申请号：US13579826
申请日：2011-02-18
申请人： Jiro Tanaka , Peter Sejer Andersen , Takafumi Okutomi , Tsuneyoshi Inaba , Keiko Otsuka , Hirotomo Akabane , Yukari Hoshina , Hiroshi Nagaso , Masashi Kumagai
发明人： Jiro Tanaka , Peter Sejer Andersen , Takafumi Okutomi , Tsuneyoshi Inaba , Keiko Otsuka , Hirotomo Akabane , Yukari Hoshina , Hiroshi Nagaso , Masashi Kumagai
CPC分类号： C07K16/1214 , A61K2039/505 , C07K16/44 , C07K2317/21 , C07K2317/24 , C07K2317/732 , C07K2317/734 , G01N2333/21
摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype B and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.
摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了结合血清型B的铜绿假单胞菌菌株的体外和体内具有优异抗菌活性的LPS的抗体。
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4.发明申请公开(公告)号：US20130045207A1
公开(公告)日：2013-02-21
申请号：US13579748
申请日：2011-02-18
申请人： Jiro Tanaka , Peter Sejer Andersen , Takafumi Okutomi , Tsuneyoshi Inaba , Keiko Otsuka , Hirotomo Akabane , Yukari Hoshina , Hiroshi Nagaso , Masashi Kumagai
发明人： Jiro Tanaka , Peter Sejer Andersen , Takafumi Okutomi , Tsuneyoshi Inaba , Keiko Otsuka , Hirotomo Akabane , Yukari Hoshina , Hiroshi Nagaso , Masashi Kumagai
CPC分类号： C07K16/1214 , A61K2039/505 , C07K16/44 , C07K2317/21 , C07K2317/24 , C07K2317/732 , C07K2317/734 , G01N2333/21
摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype G and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.
摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了结合血清型G的铜绿假单胞菌菌株的体外和体内具有优异抗菌活性的LPS的抗体。
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5.发明申请公开(公告)号：US20130022603A1
公开(公告)日：2013-01-24
申请号：US13579764
申请日：2011-02-18
申请人： Jiro Tanaka , Peter Sejer Andersen , Takafumi Okutomi , Tsuneyoshi Inaba , Keiko Otsuka , Hirotomo Akabane , Yukari Hoshina , Hiroshi Nagaso , Masashi Kumagai
发明人： Jiro Tanaka , Peter Sejer Andersen , Takafumi Okutomi , Tsuneyoshi Inaba , Keiko Otsuka , Hirotomo Akabane , Yukari Hoshina , Hiroshi Nagaso , Masashi Kumagai
CPC分类号： C07K16/1214 , A61K2039/505 , C07K16/44 , C07K2317/21 , C07K2317/24 , C07K2317/732 , C07K2317/734 , G01N2333/21
摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype I and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.
摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了结合血清型I的铜绿假单胞菌菌株的LPS并在体外和体内具有优异抗菌活性的抗体。
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6.发明授权Prophylactic or therapeutic agents for allergic ophthalmic diseases or allergic nasal diseases, comprising tricyclic triazolobenzazepine derivative 失效过敏性眼科疾病或过敏性鼻疾病的预防或治疗剂，包括三环三唑并苯并吖嗪衍生物公开(公告)号：US07910575B2
公开(公告)日：2011-03-22
申请号：US12224594
申请日：2007-03-02
CPC分类号： C07D487/04 , A61K31/55
摘要： The present invention provides a pharmaceutical composition for use in the prophylaxis or treatment of allergic ophthalmic diseases or allergic nasal diseases, which comprises 7,8-dimethoxy-4(5H),10-dioxo-1H-1,2,3-triazolo[4,5-c][1]benzazepine, 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzazepine or a pharmaceutically acceptable salt thereof. The pharmaceutical composition according to the present invention has few side effects, exerts strong prophylactic and therapeutic effects in the late phase exhibiting pharmaceutical resistance to conventional instillations, and can be used appropriately for topical applications.
摘要翻译： 本发明提供一种用于预防或治疗过敏性眼科疾病或过敏性鼻疾病的药物组合物，其包含7,8-二甲氧基-4（5H），10-二氧代-1H-1,2,3-三唑并[ 4,5-c] [1]苯并氮杂，2-（1-异丙氧羰基氧基-2-甲基丙基）-7,8-二甲氧基-4（5H），10-二氧代-2H-1,2,3-三唑并[ 5-c] [1]苯并氮杂或其药学上可接受的盐。 根据本发明的药物组合物的副作用很小，对于对常规滴注具有药物耐药性的晚期具有强大的预防和治疗效果，并且可以适用于局部应用。
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7.发明申请Prophylactic or Therapeutic Agents For Allergic Ophthalmic Diseases or Allergic Nasal Diseases, Comprising Tricyclic Triazolobenzazepine Derivative 失效过敏性眼科疾病或过敏性鼻炎的预防或治疗药物，包括三环三氮代苯并吖庚因衍生物公开(公告)号：US20090012058A1
公开(公告)日：2009-01-08
申请号：US12224594
申请日：2007-03-02
IPC分类号： A61K31/55 , C07D487/04 , A61P27/02 , A61P27/16 , A61P37/08
CPC分类号： C07D487/04 , A61K31/55
摘要： The present invention provides a pharmaceutical composition for use in the prophylaxis or treatment of allergic ophthalmic diseases or allergic nasal diseases, which comprises 7,8-dimethoxy-4(5H),10-dioxo-1H-1,2,3-triazolo[4,5-c][1]benzazepine, 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzazepine or a pharmaceutically acceptable salt thereof. The pharmaceutical composition according to the present invention has few side effects, exerts strong prophylactic and therapeutic effects in the late phase exhibiting pharmaceutical resistance to conventional instillations, and can be used appropriately for topical applications.
摘要翻译： 本发明提供一种用于预防或治疗过敏性眼科疾病或过敏性鼻疾病的药物组合物，其包含7,8-二甲氧基-4（5H），10-二氧代-1H-1,2,3-三唑并[ 4,5-c] [1]苯并氮杂，2-（1-异丙氧羰基氧基-2-甲基丙基）-7,8-二甲氧基-4（5H），10-二氧代-2H-1,2,3-三唑并[ 5-c] [1]苯并氮杂或其药学上可接受的盐。 根据本发明的药物组合物的副作用很小，对于对常规滴注具有药物耐药性的晚期具有强大的预防和治疗效果，并且可以适用于局部应用。
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