公开(公告)号：US20130004499A1

公开(公告)日：2013-01-03

申请号：US13579757

申请日：2011-02-18

申请人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Jun Saito ,  Hiroshi Nagaso ,  Masashi Kumagai ,  Yasuyo Hagiwara

发明人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Jun Saito ,  Hiroshi Nagaso ,  Masashi Kumagai ,  Yasuyo Hagiwara

IPC分类号： C07K16/12 ,  C12N5/12 ,  A61P17/02 ,  A61P31/04 ,  A61P11/00 ,  C12N15/13 ,  A61K39/395

CPC分类号： C07K16/1214 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734 ,  G01N2333/21

摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype E and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.

摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了结合血清型E的铜绿假单胞菌菌株的体外和体内具有优异抗菌活性的LPS的抗体。

公开(公告)号：US20130004500A1

公开(公告)日：2013-01-03

申请号：US13579847

申请日：2011-02-18

申请人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

发明人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

IPC分类号： A61K39/40 ,  A61P31/04 ,  C07K16/12 ,  C12N15/13 ,  C12N5/16

CPC分类号： C07K16/1214 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734 ,  G01N2333/21

摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype A and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.

摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了与血清型A的铜绿假单胞菌菌株的LPS结合并且具有优异的体外和体内抗菌活性的抗体。

公开(公告)号：US20130022604A1

公开(公告)日：2013-01-24

申请号：US13579826

申请日：2011-02-18

申请人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

发明人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

IPC分类号： A61K39/40 ,  A61P31/04 ,  C12N5/16 ,  C07K16/12 ,  C12N15/13

CPC分类号： C07K16/1214 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734 ,  G01N2333/21

摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype B and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.

摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了结合血清型B的铜绿假单胞菌菌株的体外和体内具有优异抗菌活性的LPS的抗体。

公开(公告)号：US20130045207A1

公开(公告)日：2013-02-21

申请号：US13579748

申请日：2011-02-18

申请人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

发明人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

IPC分类号： C07K16/12 ,  A61P31/04 ,  A61K39/40 ,  C12N5/12 ,  C12N15/13

CPC分类号： C07K16/1214 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734 ,  G01N2333/21

摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype G and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.

摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了结合血清型G的铜绿假单胞菌菌株的体外和体内具有优异抗菌活性的LPS的抗体。

公开(公告)号：US20130022603A1

公开(公告)日：2013-01-24

申请号：US13579764

申请日：2011-02-18

申请人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

发明人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

IPC分类号： A61K39/40 ,  A61P31/04 ,  C12N5/16 ,  C07K16/12 ,  C12N15/13

CPC分类号： C07K16/1214 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734 ,  G01N2333/21

摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype I and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.

摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了结合血清型I的铜绿假单胞菌菌株的LPS并在体外和体内具有优异抗菌活性的抗体。

公开(公告)号：US07910575B2

公开(公告)日：2011-03-22

申请号：US12224594

申请日：2007-03-02

申请人： Takashi Shishikura ,  Tsuneyoshi Inaba ,  Yukari Hoshina ,  Hirotomo Akabane ,  Mitsuhiro Uchida

发明人： Takashi Shishikura ,  Tsuneyoshi Inaba ,  Yukari Hoshina ,  Hirotomo Akabane ,  Mitsuhiro Uchida

IPC分类号： A01N43/00 ,  A01N43/04

CPC分类号： C07D487/04 ,  A61K31/55

摘要： The present invention provides a pharmaceutical composition for use in the prophylaxis or treatment of allergic ophthalmic diseases or allergic nasal diseases, which comprises 7,8-dimethoxy-4(5H),10-dioxo-1H-1,2,3-triazolo[4,5-c][1]benzazepine, 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzazepine or a pharmaceutically acceptable salt thereof. The pharmaceutical composition according to the present invention has few side effects, exerts strong prophylactic and therapeutic effects in the late phase exhibiting pharmaceutical resistance to conventional instillations, and can be used appropriately for topical applications.

摘要翻译： 本发明提供一种用于预防或治疗过敏性眼科疾病或过敏性鼻疾病的药物组合物，其包含7,8-二甲氧基-4（5H），10-二氧代-1H-1,2,3-三唑并[ 4,5-c] [1]苯并氮杂，2-（1-异丙氧羰基氧基-2-甲基丙基）-7,8-二甲氧基-4（5H），10-二氧代-2H-1,2,3-三唑并[ 5-c] [1]苯并氮杂或其药学上可接受的盐。 根据本发明的药物组合物的副作用很小，对于对常规滴注具有药物耐药性的晚期具有强大的预防和治疗效果，并且可以适用于局部应用。

公开(公告)号：US20090012058A1

公开(公告)日：2009-01-08

申请号：US12224594

申请日：2007-03-02

申请人： Takashi Shishikura ,  Tsuneyoshi Inaba ,  Yukari Hoshina ,  Hirotomo Akabane ,  Mitsuhiro Uchida

发明人： Takashi Shishikura ,  Tsuneyoshi Inaba ,  Yukari Hoshina ,  Hirotomo Akabane ,  Mitsuhiro Uchida

IPC分类号： A61K31/55 ,  C07D487/04 ,  A61P27/02 ,  A61P27/16 ,  A61P37/08

CPC分类号： C07D487/04 ,  A61K31/55

摘要： The present invention provides a pharmaceutical composition for use in the prophylaxis or treatment of allergic ophthalmic diseases or allergic nasal diseases, which comprises 7,8-dimethoxy-4(5H),10-dioxo-1H-1,2,3-triazolo[4,5-c][1]benzazepine, 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzazepine or a pharmaceutically acceptable salt thereof. The pharmaceutical composition according to the present invention has few side effects, exerts strong prophylactic and therapeutic effects in the late phase exhibiting pharmaceutical resistance to conventional instillations, and can be used appropriately for topical applications.

摘要翻译： 本发明提供一种用于预防或治疗过敏性眼科疾病或过敏性鼻疾病的药物组合物，其包含7,8-二甲氧基-4（5H），10-二氧代-1H-1,2,3-三唑并[ 4,5-c] [1]苯并氮杂，2-（1-异丙氧羰基氧基-2-甲基丙基）-7,8-二甲氧基-4（5H），10-二氧代-2H-1,2,3-三唑并[ 5-c] [1]苯并氮杂或其药学上可接受的盐。 根据本发明的药物组合物的副作用很小，对于对常规滴注具有药物耐药性的晚期具有强大的预防和治疗效果，并且可以适用于局部应用。

公开(公告)号：US07858612B2

公开(公告)日：2010-12-28

申请号：US12449371

申请日：2008-12-17

申请人： Tomohisa Ninomiya ,  Takashi Shishikura ,  Mitsuhiro Uchida ,  Sho Takahata ,  Yukari Hoshina ,  Ken-ichi Kawano

发明人： Tomohisa Ninomiya ,  Takashi Shishikura ,  Mitsuhiro Uchida ,  Sho Takahata ,  Yukari Hoshina ,  Ken-ichi Kawano

IPC分类号： A61K31/5517

CPC分类号： C07D487/04 ,  A61K31/4192 ,  A61K31/55

摘要： The present invention relates to a method for maintaining the remission of or treating inflammatory bowel diseases, which comprises administering a maintenance therapeutically effective amount or a therapeutically effective amount of 7,8-dimethoxy-4(5H),10-dioxo-1H-1,2,3-triazolo[4,5-c][1]benzoazepine, a prodrug thereof, or a pharmaceutically acceptable salt thereof to a mammal, wherein the prodrug is 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzoazepine. The method according to the present invention is effective in the maintenance therapy and therapy of the inflammatory bowel diseases and has few side effects. Particularly, the method according to the present invention may exhibit strong maintenance therapeutic and therapeutic effects, even on severe cases having resistance to the conventional therapeutics.

摘要翻译： 本发明涉及一种维持炎症性肠病的缓解或治疗的方法，其包括给予维持治疗有效量或治疗有效量的7,8-二甲氧基-4（5H），10-二氧代-1H-1 ，2,3-三唑并[4,5-c] [1]苯并吖庚因，其前药或其药学上可接受的盐，其中前药为2-（1-异丙氧羰基氧基-2-甲基丙基） 8-二甲氧基-4（5H），10-二氧代-2H-1,2,3-三唑并[4,5-c] [1]苯并吖庚因。 根据本发明的方法在炎症性肠病的维持治疗和治疗中是有效的，并且副作用很小。 特别地，即使对具有对常规疗法的抗性的严重病例，根据本发明的方法也可表现出很强的维持治疗和治疗效果。

公开(公告)号：US20100130475A1

公开(公告)日：2010-05-27

申请号：US12449371

申请日：2008-12-17

申请人： Tomohisa Ninomiya ,  Takashi Shishikura ,  Mitsuhiro Uchida ,  Sho Takahata ,  Yukari Hoshina ,  Ken-ichi Kawano

发明人： Tomohisa Ninomiya ,  Takashi Shishikura ,  Mitsuhiro Uchida ,  Sho Takahata ,  Yukari Hoshina ,  Ken-ichi Kawano

IPC分类号： A61K31/55 ,  A61P1/00

CPC分类号： C07D487/04 ,  A61K31/4192 ,  A61K31/55

摘要： The present invention relates to a pharmaceutical composition for preventing or treating inflammatory bowel diseases, which comprises 7,8-dimethoxy-4(5H),10-dioxo-1H-1,2,3-triazolo[4,5-c][1]benzoazepine, a prodrug thereof, preferably 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzoazepine as a prodrug, or a pharmaceutically acceptable salt thereof. The pharmaceutical composition according to the present invention is effective in the prophylaxis and therapy of the inflammatory bowel diseases and has few side effects. Particularly, the pharmaceutical composition according to the present invention may exhibit strong prophylactic and therapeutic effects even on severe cases having resistance to the conventional therapeutics.

摘要翻译： 本发明涉及一种用于预防或治疗炎症性肠病的药物组合物，其包含7,8-二甲氧基-4（5H），10-二氧代-1H-1,2,3-三唑并[4,5-c] [ 1]苯并吖庚因，其前药，优选2-（1-异丙氧羰基氧基-2-甲基丙基）-7,8-二甲氧基-4（5H），10-二氧代-2H-1,2,3-三唑并[4,5- c] [1]苯并吖庚因作为前药，或其药学上可接受的盐。 根据本发明的药物组合物在预防和治疗炎症性肠病方面是有效的，并且副作用很少。 特别地，本发明的药物组合物即使对具有对常规疗法的抗性的严重病例也可能表现出强的预防和治疗效果。