-
公开(公告)号：US06727279B2
公开(公告)日：2004-04-27
申请号：US10225823
申请日：2002-08-21
申请人： Joachim Mittendorf , Jürgen Dressel , Michael Matzke , Jörg Keldenich , Frank Mauler , Jean-Marie-Victor de Vry , Jürgen Franz , Peter Spreyer , Verena Vöhringer , Joachim Schumacher , Michael-Harold Rock , Ervin Horvàth , Arno Friedl , Klaus-Helmut Mohrs , Siegfried Raddatz , Reinhard Jork
发明人： Joachim Mittendorf , Jürgen Dressel , Michael Matzke , Jörg Keldenich , Frank Mauler , Jean-Marie-Victor de Vry , Jürgen Franz , Peter Spreyer , Verena Vöhringer , Joachim Schumacher , Michael-Harold Rock , Ervin Horvàth , Arno Friedl , Klaus-Helmut Mohrs , Siegfried Raddatz , Reinhard Jork
IPC分类号： A61K3121
CPC分类号： C07D307/80 , C07C309/65 , C07C2602/08
摘要： The present invention relates to novel arylsulphonamides and analogues, to processes for their preparation and to their use for the prophylaxis and treatment of neurodegenerative disorders, in particular for the treatment of cerebral apoplexy, craniocerebral trauma, pain and spasticity.
摘要翻译： 本发明涉及新的芳基磺酰胺和类似物，其制备方法及其用于预防和治疗神经变性疾病，特别是用于治疗脑中风，颅脑创伤，疼痛和痉挛症的用途。
-
公开(公告)号：US06469054B1
公开(公告)日：2002-10-22
申请号：US09763215
申请日：2001-02-16
申请人： Joachim Mittendorf , Jürgen Dressel , Michael Matzke , Jörg Keldenich , Frank Mauler , Jean-Marie-Victor de Vry , Jürgen Franz , Peter Spreyer , Verena Vöhringer , Joachim Schumacher , Michael-Harold Rock , Ervin Horvàth , Arno Friedl , Klaus-Helmut Mohrs , Siegfried Raddatz , Reinhard Jork
发明人： Joachim Mittendorf , Jürgen Dressel , Michael Matzke , Jörg Keldenich , Frank Mauler , Jean-Marie-Victor de Vry , Jürgen Franz , Peter Spreyer , Verena Vöhringer , Joachim Schumacher , Michael-Harold Rock , Ervin Horvàth , Arno Friedl , Klaus-Helmut Mohrs , Siegfried Raddatz , Reinhard Jork
IPC分类号： A61K31343
CPC分类号： C07D307/80 , C07C309/65 , C07C2602/08
摘要： The present invention relates to novel arylsulphonamides and analogues, to processes for their preparation and to their use for the prophylaxis and treatment of neurodegenerative disorders, in particular for the treatment of cerebral apoplexy, craniocerebral trauma, pain and spasticity.
摘要翻译： 本发明涉及新的芳基磺酰胺和类似物，其制备方法及其用于预防和治疗神经变性疾病，特别是用于治疗脑中风，颅脑创伤，疼痛和痉挛症的用途。
-
3.发明授权Aryl sulfonamides and analogues thereof and their use in the treatment of neurodegenerative diseases 失效芳基磺酰胺及其类似物及其在治疗神经变性疾病中的应用公开(公告)号：US06573278B2
公开(公告)日：2003-06-03
申请号：US09878392
申请日：2001-06-11
申请人： Joachim Mittendorf , Jürgen Dressel , Michael Matzke , Jörg Keldenich , Klaus-Helmut Mohrs , Siegfried Raddatz , Jürgen Franz , Peter Spreyer , Verena Vöhringer , Joachim Schuhmacher , Michael-Harold Rock , Ervin Horváth , Arno Friedl , Frank Mauler , Jean Marie Viktor de Vry , Reinhard Jork
发明人： Joachim Mittendorf , Jürgen Dressel , Michael Matzke , Jörg Keldenich , Klaus-Helmut Mohrs , Siegfried Raddatz , Jürgen Franz , Peter Spreyer , Verena Vöhringer , Joachim Schuhmacher , Michael-Harold Rock , Ervin Horváth , Arno Friedl , Frank Mauler , Jean Marie Viktor de Vry , Reinhard Jork
IPC分类号： C07D40102
CPC分类号： C07D209/48 , C07C217/90 , C07C233/25 , C07C235/16 , C07C309/65 , C07C311/08 , C07C311/09 , C07C311/13 , C07C311/21 , C07C311/32 , C07C311/35 , C07C311/48 , C07C2602/10 , C07D209/44 , C07D213/34 , C07D213/61 , C07D213/73 , C07D213/76 , C07D215/26 , C07D217/02 , C07D217/04 , C07D233/28 , C07D239/47 , C07D275/02 , C07D295/096 , C07D295/135 , C07D295/192 , C07D307/68 , C07D401/12 , C07F9/4476
摘要： The present invention relates to new aryl ether sulphonamides and analogues, processes for their preparation and their use for the treatment of neurodegenerative disorders, in particular for the prophylaxis and treatment of neurodegenerative disorders, in particular for the treatment of cerebral apoplexy and craniocerebral trauma.
摘要翻译： 本发明涉及新的芳基醚磺酰胺及其类似物，其制备方法及其用于治疗神经变性疾病的用途，特别是用于预防和治疗神经变性疾病，特别是用于治疗脑中风和颅脑外伤。
-
4.发明授权Aryl sulfonamides and analogues thereof and their use in the treatment of neurodegenerative diseases 有权芳基磺酰胺及其类似物及其在治疗神经变性疾病中的应用公开(公告)号：US06262112B1
公开(公告)日：2001-07-17
申请号：US09367456
申请日：1999-11-15
申请人： Joachim Mittendorf , Jürgen Dressel , Michael Matzke , Jörg Keldenich , Klaus-Helmut Mohrs , Siegfried Raddatz , Jürgen Franz , Peter Spreyer , Verena Vöhringer , Joachim Schuhmacher , Michael-Harold Rock , Ervin Horváth , Arno Friedl , Frank Mauler , Jean Marie Viktor de Vry , Reinhard Jork
发明人： Joachim Mittendorf , Jürgen Dressel , Michael Matzke , Jörg Keldenich , Klaus-Helmut Mohrs , Siegfried Raddatz , Jürgen Franz , Peter Spreyer , Verena Vöhringer , Joachim Schuhmacher , Michael-Harold Rock , Ervin Horváth , Arno Friedl , Frank Mauler , Jean Marie Viktor de Vry , Reinhard Jork
IPC分类号： C07C31714
CPC分类号： C07D209/48 , C07C217/90 , C07C233/25 , C07C235/16 , C07C309/65 , C07C311/08 , C07C311/09 , C07C311/13 , C07C311/21 , C07C311/32 , C07C311/35 , C07C311/48 , C07C2602/10 , C07D209/44 , C07D213/34 , C07D213/61 , C07D213/73 , C07D213/76 , C07D215/26 , C07D217/02 , C07D217/04 , C07D233/28 , C07D239/47 , C07D275/02 , C07D295/096 , C07D295/135 , C07D295/192 , C07D307/68 , C07D401/12 , C07F9/4476
摘要： The present invention relates to new aryl ether sulphonamides and analogs, processes for their preparation and their use for the treatment of neurodegenerative disorders, in particular for the prophylaxis and treatment of neurodegenerative disorders, in particular for the treatment of cerebral apoplexy and craniocerebral trauma.
摘要翻译： 本发明涉及新的芳基醚磺酰胺及其类似物，其制备方法及其用于治疗神经变性疾病的用途，特别是用于预防和治疗神经变性疾病，特别是用于治疗脑中风和颅脑外伤。
-
公开(公告)号：US06545050B1
公开(公告)日：2003-04-08
申请号：US09763196
申请日：2001-02-16
申请人： Joachim Mittendorf , Jürgen Dressel , Michael Matzke , Jörg Keldenich , Frank Mauler , Jean-Marie-Viktor de Vry , Jürgen Franz , Peter Spreyer , Verena Vöhringer , Joachim Schumacher , Michael-Harold Rock , Ervin Horvàth , Arno Friedl
发明人： Joachim Mittendorf , Jürgen Dressel , Michael Matzke , Jörg Keldenich , Frank Mauler , Jean-Marie-Viktor de Vry , Jürgen Franz , Peter Spreyer , Verena Vöhringer , Joachim Schumacher , Michael-Harold Rock , Ervin Horvàth , Arno Friedl
IPC分类号： A61K3140
CPC分类号： C07C309/65 , C07C2602/08 , Y02P20/55
摘要： The present invention relates to novel amino acid esters of arylsulphonamides and analogues, to processes for their preparation and to their use for the prophylaxis and treatment of neurodegenerative disorders, in particular for the treatment of cerebral apoplexy, craniocerebral trauma, pain and spasticity.
摘要翻译： 本发明涉及芳基磺酰胺和类似物的新型氨基酸酯，其制备方法及其用于预防和治疗神经变性疾病，特别是用于治疗脑中风，颅脑创伤，疼痛和痉挛状态的用途。
-
公开(公告)号：US6162942A
公开(公告)日：2000-12-19
申请号：US367752
申请日：1999-08-17
IPC分类号： B01J31/24 , C07B61/00 , C07C253/14 , C07C255/50 , C07C255/54 , C07C255/56 , C07C315/04 , C07C317/44 , C07C253/00
CPC分类号： C07C253/14 , C07C315/04
摘要： A process for preparing aromatic nitriles from corresponding chloroaromatics by reaction with cyanides.
摘要翻译： PCT No.PCT / EP98 / 00696 Sec。 371日期1999年8月17日第 102（e）日期1999年8月17日PCT提交1998年2月9日PCT公布。 第WO98 / 37058号公报 日期1998年8月27日一种通过与氰化物反应从相应的氯代芳族化合物制备芳香族腈的方法。
-
公开(公告)号：US6002053A
公开(公告)日：1999-12-14
申请号：US156988
申请日：1998-09-18
摘要： 4,4,5,5,5-Pentafluoro-1-pentanol is prepared in a particularly advantageous manner from perfluoroethyl iodide by initially adding perfluoroethyl iodide in the presence of a radical initiator which does not carry any acyl groups to allyl alcohol and then hydrogenolytically dehalogenating the resulting 4,4,5,5,5-pentafluoro-2-iodo-1-pentanol in the presence of a catalyst, an acid binder and a diluent.
摘要翻译： 通过在自由基引发剂的存在下首先加入全氟乙基碘，通过全氟乙基碘特别有利的方式制备4,4,5,5,5-五氟-1-戊醇，该自由基引发剂不会将任何酰基带入烯丙醇，然后氢解 在催化剂，酸性粘合剂和稀释剂的存在下使所得的4,4,5,5,5-五氟-2-碘-1-戊醇脱卤。
-
公开(公告)号：US5874656A
公开(公告)日：1999-02-23
申请号：US946292
申请日：1997-10-07
申请人： Norbert Lui , Michael-Harold Rock
发明人： Norbert Lui , Michael-Harold Rock
IPC分类号： C07B39/00 , C07C17/093 , C07C17/18 , C07C25/13 , C07C25/18 , C07C41/22 , C07C43/225 , C07C209/74 , C07C211/52 , C07C319/20 , C07C323/09 , C07C21/18 , C07C43/02 , C07C209/00
CPC分类号： C07C17/093
摘要： o-Alkylfluorobenzenes are advantageously prepared by heating the corresponding chloroformates to from 70.degree. to 200.degree. C. in the liquid phase in the presence of hydrogen fluoride and in the presence of an inert diluent other than a halogenated alkane.
摘要翻译： O-烷基氟苯有利地通过在氟化氢的存在下和在卤化烷烃以外的惰性稀释剂存在下，在液相中将相应的氯甲酸酯加热至70至200℃来制备。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.053 秒)
