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公开(公告)号：US20120322730A1
公开(公告)日：2012-12-20
申请号：US13589026
申请日：2012-08-17
IPC分类号： A61K38/18 , C07K14/505
CPC分类号： C07K14/505 , C07K2319/30 , C12N15/62
摘要： Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount of recombinant human erythropoietin to obtain a comparable target hematocrit and treat anemia. Alternatively, a lower molar amount of a hyperglycosylated analog may be administered to obtain a comparable target hematocrit and treat anemia. Also disclosed are new hyperglycosylated erythopoietin analogs, methods of production of the analogs, and compositions comprising the analogs.
摘要翻译： 公开了增加和维持哺乳动物血细胞比容的方法，包括施用红血球生成素的高糖蛋白类似物。 类似物可以比等效摩尔量的重组人促红细胞生成素施用频率更低，以获得可比较的目标血细胞比容并治疗贫血。 或者，可以施用较低摩尔量的高糖基化类似物以获得可比较的目标血细胞比容并治疗贫血。 还公开了新的高糖基化红细胞生成素类似物，类似物的生产方法和包含类似物的组合物。
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公开(公告)号：US20090017137A1
公开(公告)日：2009-01-15
申请号：US11977845
申请日：2007-10-26
CPC分类号： C07K14/505 , C07K2319/30 , C12N15/62
摘要： Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount of recombinant human erythropoietin to obtain a comparable target hematocrit and treat anemia. Alternatively, a lower molar amount of a hyperglycosylated analog may be administered to obtain a comparable target hematocrit and treat anemia. Also disclosed are new hyperglycosylated erythropoietin analogs, methods of production of the analogs, and compositions comprising the analogs.
摘要翻译： 公开了增加和维持哺乳动物血细胞比容的方法，包括施用红血球生成素的高糖蛋白类似物。 类似物可以比等效摩尔量的重组人促红细胞生成素施用频率更低，以获得可比较的目标血细胞比容并治疗贫血。 或者，可以施用较低摩尔量的高糖基化类似物以获得可比较的目标血细胞比容并治疗贫血。 还公开了新的高糖基化促红细胞生成素类似物，类似物的生产方法和包含类似物的组合物。
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公开(公告)号：US20110256586A1
公开(公告)日：2011-10-20
申请号：US13168913
申请日：2011-06-24
CPC分类号： C07K14/505 , C07K2319/30 , C12N15/62
摘要： Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount of recombinant human erythropoietin to obtain a comparable target hematocrit and treat anemia. Alternatively, a lower molar amount of a hyperglycosylated analog may be administered to obtain a comparable target hematocrit and treat anemia. Also disclosed are new hyperglycosylated erythopoietin analogs, methods of production of the analogs, and compositions comprising the analogs.
摘要翻译： 公开了增加和维持哺乳动物血细胞比容的方法，包括施用红血球生成素的高糖蛋白类似物。 类似物可以比等效摩尔量的重组人促红细胞生成素施用频率更低，以获得可比较的目标血细胞比容并治疗贫血。 或者，可以施用较低摩尔量的高糖基化类似物以获得可比较的目标血细胞比容并治疗贫血。 还公开了新的高糖基化红细胞生成素类似物，类似物的生产方法和包含类似物的组合物。
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公开(公告)号：US08268588B2
公开(公告)日：2012-09-18
申请号：US13168913
申请日：2011-06-24
IPC分类号： C12N15/00 , C12N5/00 , C12N1/00 , C07K14/505
CPC分类号： C07K14/505 , C07K2319/30 , C12N15/62
摘要： Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount of recombinant human erythropoietin to obtain a comparable target hematocrit and treat anemia. Alternatively, a lower molar amount of a hyperglycosylated analog may be administered to obtain a comparable target hematocrit and treat anemia. Also disclosed are new hyperglycosylated erythopoietin analogs, methods of production of the analogs, and compositions comprising the analogs.
摘要翻译： 公开了增加和维持哺乳动物血细胞比容的方法，包括施用红血球生成素的高糖蛋白类似物。 类似物可以比等效摩尔量的重组人促红细胞生成素施用频率更低，以获得可比较的目标血细胞比容并治疗贫血。 或者，可以施用较低摩尔量的高糖基化类似物以获得可比较的目标血细胞比容并治疗贫血。 还公开了新的高糖基化红细胞生成素类似物，类似物的制备方法和包含类似物的组合物。
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公开(公告)号：US07977311B2
公开(公告)日：2011-07-12
申请号：US11977851
申请日：2007-10-26
IPC分类号： C07K14/505 , A61K38/16
CPC分类号： C07K14/505 , C07K2319/30 , C12N15/62
摘要： Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount of recombinant human erythropoietin to obtain a comparable target hematocrit and treat anemia. Alternatively, a lower molar amount of a hyperglycosylated analog may be administered to obtain a comparable target hematocrit and treat anemia. Also disclosed are new hyperglycosylated erythopoietin analogs, methods of production of the analogs, and compositions comprising the analogs.
摘要翻译： 公开了增加和维持哺乳动物血细胞比容的方法，包括施用红血球生成素的高糖蛋白类似物。 类似物可以比等效摩尔量的重组人促红细胞生成素施用频率更低，以获得可比较的目标血细胞比容并治疗贫血。 或者，可以施用较低摩尔量的高糖基化类似物以获得可比较的目标血细胞比容并治疗贫血。 还公开了新的高糖基化红细胞生成素类似物，类似物的生产方法和包含类似物的组合物。
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公开(公告)号：US07973009B2
公开(公告)日：2011-07-05
申请号：US11977845
申请日：2007-10-26
IPC分类号： A61K38/18 , C07K14/505
CPC分类号： C07K14/505 , C07K2319/30 , C12N15/62
摘要： Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount of recombinant human erythropoietin to obtain a comparable target hematocrit and treat anemia. Alternatively, a lower molar amount of a hyperglycosylated analog may be administered to obtain a comparable target hematocrit and treat anemia. Also disclosed are new hyperglycosylated erythropoietin analogs, methods of production of the analogs, and compositions comprising the analogs.
摘要翻译： 公开了增加和维持哺乳动物血细胞比容的方法，包括施用红血球生成素的高糖蛋白类似物。 类似物可以比等效摩尔量的重组人促红细胞生成素施用频率更低，以获得可比较的目标血细胞比容并治疗贫血。 或者，可以施用较低摩尔量的高糖基化类似物以获得可比较的目标血细胞比容并治疗贫血。 还公开了新的高糖基化促红细胞生成素类似物，类似物的生产方法和包含类似物的组合物。
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公开(公告)号：US20090023636A1
公开(公告)日：2009-01-22
申请号：US11977851
申请日：2007-10-26
IPC分类号： C07K14/505 , A61K38/18 , A61P7/06
CPC分类号： C07K14/505 , C07K2319/30 , C12N15/62
摘要： Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount of recombinant human erythropoietin to obtain a comparable target hematocrit and treat anemia. Alternatively, a lower molar amount of a hyperglycosylated analog may be administered to obtain a comparable target hematocrit and treat anemia. Also disclosed are new hyperglycosylated erythopoietin analogs, methods of production of the analogs, and compositions comprising the analogs.
摘要翻译： 公开了增加和维持哺乳动物血细胞比容的方法，包括施用红血球生成素的高糖蛋白类似物。 类似物可以比等效摩尔量的重组人促红细胞生成素施用频率更低，以获得可比较的目标血细胞比容并治疗贫血。 或者，可以施用较低摩尔量的高糖基化类似物以获得可比较的目标血细胞比容并治疗贫血。 还公开了新的高糖基化红细胞生成素类似物，类似物的生产方法和包含类似物的组合物。
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公开(公告)号：US07304150B1
公开(公告)日：2007-12-04
申请号：US09723955
申请日：2000-11-27
IPC分类号： C07K14/505 , C07K16/46 , C07H21/00
CPC分类号： C07K14/505 , C07K2319/30 , C12N15/62
摘要： Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount of recombinant human erythropoietin to obtain a comparable target hematocrit and treat anemia. Alternatively, a lower molar amount of a hyperglycosylated analog may be administered to obtain a comparable target hematocrit and treat anemia. Also disclosed are new hyperglycosylated erythopoietin analogs, methods of production of the analogs, and compositions comprising the analogs.
摘要翻译： 公开了增加和维持哺乳动物血细胞比容的方法，包括施用红血球生成素的高糖蛋白类似物。 类似物可以比等效摩尔量的重组人促红细胞生成素施用频率更低，以获得可比较的目标血细胞比容并治疗贫血。 或者，可以施用较低摩尔量的高糖基化类似物以获得可比较的目标血细胞比容并治疗贫血。 还公开了新的高糖基化红细胞生成素类似物，类似物的生产方法和包含类似物的组合物。
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9.发明申请公开(公告)号：US20120129771A1
公开(公告)日：2012-05-24
申请号：US13364015
申请日：2012-02-01
申请人： Thomas C. Boone , Kenneth C. Wild , Karen C. Sitney , Hosung Min , Bruce Kimmel
发明人： Thomas C. Boone , Kenneth C. Wild , Karen C. Sitney , Hosung Min , Bruce Kimmel
IPC分类号： A61K38/10 , C07H21/00 , C12N15/63 , A61P25/00 , C07K14/00 , A61K38/16 , C07K17/02 , C07K7/08 , C12N15/11
CPC分类号： C07K16/22 , A61K38/00 , C07H21/04 , C07K7/08 , C07K14/001
摘要： The present invention relates to certain biologically active peptides and polypeptides which can be used as therapeutics or prophylactics against diseases or disorders linked to NGF as the causative agent. In one aspect of the present invention, pharmacologically active polypeptides comprising peptides linked to one or more Fc domains are provided.
摘要翻译： 本发明涉及某些生物活性肽和多肽，其可以用作治疗剂或预防药物以抵抗作为致病剂与NGF相关的疾病或病症。 在本发明的一个方面，提供了包含与一个或多个Fc结构域连接的肽的药理活性多肽。
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公开(公告)号：US07655765B2
公开(公告)日：2010-02-02
申请号：US12221421
申请日：2008-08-01
申请人： Colin Gegg , Fei Xiong , Karen C. Sitney
发明人： Colin Gegg , Fei Xiong , Karen C. Sitney
CPC分类号： C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2318/10 , C07K2319/30
摘要： The present invention concerns compositions of matter, for example, but not limited to, modified antibodies, in which one or more biologically active peptides are incorporated into a loop region of a non-terminal domain of an immunoglobulin Fc domain.
摘要翻译： 本发明涉及物质的组合物，例如但不限于经修饰的抗体，其中一种或多种生物活性肽掺入到免疫球蛋白Fc结构域的非末端结构域的环区中。
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