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1.发明申请TRYPTOPHAN AS A FUNCTIONAL REPLACEMENT FOR ADP-RIBOSE-ARGININE IN RECOMBINANT PROTEINS 有权TRYPTOPHAN作为ADP-RIBOSE-ARGININE在重组蛋白中的功能替代公开(公告)号：US20090203878A1
公开(公告)日：2009-08-13
申请号：US12430023
申请日：2009-04-24
申请人： Joel Moss , Linda Stevens , Christelle Bourgeois , Rita Bortell
发明人： Joel Moss , Linda Stevens , Christelle Bourgeois , Rita Bortell
CPC分类号： A61K38/1709 , C07H21/04 , C07K1/107 , C07K14/4723 , C12N9/1077 , C12P21/02
摘要： A method is disclosed for producing a polypeptide with a modified activity or stability, by replacing an arginine residue capable of being ADP-ribosylated with a tryptophan or a phenylalanine. In one embodiment, compositions are provided that include polypeptides, such as alpha defensin, with arginine-to-tryptophan or arginine-to-phenylalanine substitutions, where the arginine residue is capable of being ADP-ribosylated. In another embodiment, methods are disclosed for modifying an immune response in a subject.
摘要翻译： 公开了通过用色氨酸或苯丙氨酸替代能够进行ADP-核糖基化的精氨酸残基来生产具有改变的活性或稳定性的多肽的方法。 在一个实施方案中，提供了包括多肽，例如α-防御素与精氨酸 - 至色氨酸或精氨酸 - 苯丙氨酸取代的组合物，其中精氨酸残基能够被ADP-核糖基化。 在另一个实施方案中，公开了用于修饰受试者的免疫应答的方法。
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2.发明授权Tryptophan as a functional replacement for ADP-ribose-arginine in recombinant proteins 有权色氨酸作为重组蛋白中ADP-核糖 - 精氨酸的功能替代物公开(公告)号：US07541139B2
公开(公告)日：2009-06-02
申请号：US10517565
申请日：2003-06-27
申请人： Joel Moss , Linda Stevens , Christelle Bourgeois , Rita Bortell
发明人： Joel Moss , Linda Stevens , Christelle Bourgeois , Rita Bortell
CPC分类号： A61K38/1709 , C07H21/04 , C07K1/107 , C07K14/4723 , C12N9/1077 , C12P21/02
摘要： A method is disclosed for producing a polypeptide with a modified activity or stability, by replacing an arginine residue capable of being ADP-ribosylated with a tryptophan or a phenylalanine. In one embodiment, compositions are provided that include polypeptides, such as alpha defensin, with arginine-to-tryptophan or arginine-to-phenylalanine substitutions, where the arginine residue is capable of being ADP-ribosylated. In another embodiment, methods are disclosed for modifying an immune response in a subject.
摘要翻译： 公开了通过用色氨酸或苯丙氨酸替代能够进行ADP-核糖基化的精氨酸残基来生产具有改变的活性或稳定性的多肽的方法。 在一个实施方案中，提供了包括多肽，例如α-防御素与精氨酸 - 至色氨酸或精氨酸 - 苯丙氨酸取代的组合物，其中精氨酸残基能够被ADP-核糖基化。 在另一个实施方案中，公开了用于修饰受试者的免疫应答的方法。
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3.发明授权Tryptophan as a functional replacement for ADP-ribose-arginine in recombinant proteins 有权色氨酸作为重组蛋白中ADP-核糖 - 精氨酸的功能替代物公开(公告)号：US07923535B2
公开(公告)日：2011-04-12
申请号：US12430023
申请日：2009-04-24
申请人： Joel Moss , Linda Stevens , Christelle Bourgeois , Rita Bortell
发明人： Joel Moss , Linda Stevens , Christelle Bourgeois , Rita Bortell
CPC分类号： A61K38/1709 , C07H21/04 , C07K1/107 , C07K14/4723 , C12N9/1077 , C12P21/02
摘要： A method is disclosed for producing a polypeptide with a modified activity or stability, by replacing an arginine residue capable of being ADP-ribosylated with a tryptophan or a phenylalanine. In one embodiment, compositions are provided that include polypeptides, such as alpha defensin, with arginine-to-tryptophan or arginine-to-phenylalanine substitutions, where the arginine residue is capable of being ADP-ribosylated. In another embodiment, methods are disclosed for modifying an immune response in a subject.
摘要翻译： 公开了通过用色氨酸或苯丙氨酸替代能够进行ADP-核糖基化的精氨酸残基来生产具有改变的活性或稳定性的多肽的方法。 在一个实施方案中，提供了包括多肽，例如α-防御素与精氨酸 - 至色氨酸或精氨酸 - 苯丙氨酸取代的组合物，其中精氨酸残基能够被ADP-核糖基化。 在另一个实施方案中，公开了用于修饰受试者的免疫应答的方法。
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4.发明申请Tryptophan as a functional replacement for adp-ribose-arginine in recombinant proteins 有权色氨酸作为重组蛋白中的阿糖核糖 - 精氨酸的功能替代物公开(公告)号：US20060074037A1
公开(公告)日：2006-04-06
申请号：US10517565
申请日：2003-06-27
申请人： Joel Moss , Linda Stevens , Christelle Bourgeois , Rita Bortell
发明人： Joel Moss , Linda Stevens , Christelle Bourgeois , Rita Bortell
CPC分类号： A61K38/1709 , C07H21/04 , C07K1/107 , C07K14/4723 , C12N9/1077 , C12P21/02
摘要： A method is disclosed for producing a polypeptide with a modified activity or stability, by replacing an arginine residue capable of being ADP-ribosylated with a tryptophan or a phenylalanine. In one embodiment, compositions are provided that include polypeptides, such as alpha defensin, with arginine-to-tryptophan or arginine-to-phenylalanine substitutions, where the arginine residue is capable of being ADP-ribosylated. In another embodiment, methods are disclosed for modifying an immune response in a subject.
摘要翻译： 公开了通过用色氨酸或苯丙氨酸替代能够进行ADP-核糖基化的精氨酸残基来生产具有改变的活性或稳定性的多肽的方法。 在一个实施方案中，提供了包括多肽，例如α-防御素与精氨酸 - 至色氨酸或精氨酸 - 苯丙氨酸取代的组合物，其中精氨酸残基能够被ADP-核糖基化。 在另一个实施方案中，公开了用于修饰受试者的免疫应答的方法。
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公开(公告)号：US20050123571A1
公开(公告)日：2005-06-09
申请号：US10863012
申请日：2004-06-07
申请人： Aldo Rossini , Rita Bortell , Dale Greiner , John Mordes , Silvia Corvera , Leanne Wilson-Fritch , Malini Pandarpurkar , Helle Markholst , Lars Hornum
发明人： Aldo Rossini , Rita Bortell , Dale Greiner , John Mordes , Silvia Corvera , Leanne Wilson-Fritch , Malini Pandarpurkar , Helle Markholst , Lars Hornum
IPC分类号： A61K39/00 , C07H21/04 , C07K14/47 , C12N20060101 , C12N9/64 , C12Q1/68 , G01N33/50 , G01N33/564 , G01N33/574
CPC分类号： G01N33/574 , C07K14/4747 , G01N33/5079 , G01N33/564 , G01N2510/00
摘要： The present invention relates, at least in part, to methods of modulating apoptosis in cells, comprising contacting the cell with a compound that modulates the expression, post-translational modification, or activity of Ian4, leucine-rich protein of 130 kD, GRP78, GRP94, or hsp60. The subject methods can be used to treat a variety of different disorders, for example, autoimmune disease and neoplasia. The invention also pertains to methods for identifying compounds that modulates the activity of Ian-4, leucine-rich protein of 130 kD, GRP78, GRP94, or hsp60.
摘要翻译： 本发明至少部分地涉及调节细胞凋亡的方法，包括使细胞与调节Ik4，130kD的富含亮氨酸的蛋白，GRP78的表达，翻译后修饰或活性的化合物接触， GRP94或hsp60。 本发明方法可用于治疗各种不同的疾病，例如自身免疫性疾病和瘤形成。 本发明还涉及用于鉴定调节Ik-4，富含亮氨酸的富含130kD的蛋白质，GRP78，GRP94或hsp60的活性的化合物的方法。
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